Clinical trials: Controlled Hypertension
Pulmonary Hypertension (Diagnosis), Pre-operative Assessment
GUARD-PH: Guided Use of AI-ECG for Risk Detection of PH in Surgery (GUARD-PH Trial)
This study is a prospective, open-label, randomized controlled trial designed to evaluate a new artificial intelligence (AI) tool for heart monitoring.
- Conditions
- Pulmonary Hypertension (Diagnosis), Pre-operative Assessment, Postoperative Complications (Cardiopulmonary), Treatment Outcomes
- Trial name
- GUARD-PH (NCT07344207)
- Testing
- Artificial Intelligence-Enabled Electrocardiography System
- Where
- Taiwan
- Volunteers
- 1,380 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Primary Open-angle Glaucoma, Ocular Hypertension
Levobetaxolol Hydrochloride Eye Drops for Treatment of Primary Open-angle Glaucoma or Ocular Hypertension
To evaluate the safety and efficacy of Levobetaxolol in Chinese patients with glaucoma.
- Trial name
- NCT02617459
- Testing
- Levobetaxolol eye drops, Betaxolol eye drops
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Blind Painful Eye, Refractory Glaucoma
Use of Intravitreal Triamcinolone and Retrobulbar Chlorpromazine as Alternatives to the Management of Painful Blind Eye
The purpose of this study is to evaluate the efficacy of intravitreal triamcinolone and retrobulbar chlorpromazine as alternatives in the management of ocular pain in blind eyes.
- Conditions
- Blind Painful Eye, Refractory Glaucoma, Control of Pain Through Drug Injection
- Trial name
- NCT01404364
- Testing
- Triamcinolone, Chlorpromazine
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Hospital Governador Celso Ramos
Type 2 Diabetes Mellitus, Hypertension
Blood Pressure Control for Type 2 Diabetes
The BP4DM study was initiated as a prospective randomized controlled trial to investigate the renal protection effect for tight blood pressure control for Taiwanese T2DM patients without previously diagnosed CV events.
- Trial name
- BM4DM (NCT03477786)
- Testing
- drug adjustment and behavioral modification
- Where
- 2 sites in Taiwan
- Volunteers
- 1,500 people
- Sponsor
- National Health Research Institutes, Taiwan
Open Angle Glaucoma or Ocular Hypertension
A Phase III Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution Compared With Latanoprost Ophthalmic Solution in Subjects With OAG or OHT
The purpose of this study is to investigate the intraocular pressure-lowering effect and the safety of DE-117 ophthalmic solution compared with Latanoprost ophthalmic solution in subjects with open angle glaucoma or ocular…
- Trial name
- NCT02981446
- Testing
- DE-117, Latanoprost ophthalmic solution
- Where
- Singapore
- Volunteers
- 370 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Hypertension
Reducing Clinical Inertia in Hypertension Treatment: A Pragmatic Trial
The goal of this project is to use health information technology and team-based care in novel ways to support the establishment of a Patient-Centered Medical Home model of care aimed at improving the diagnosis and management of…
- Trial name
- NCT01145391
- Testing
- Active Outreach to Patients and Providers
- Where
- United States
- Volunteers
- 591 people
- Sponsor
- University of Colorado, Denver
Hypertension, Primary Hypertension
Effectiveness of SMS Reminders of Blood Pressure-lowering Drugs Intake
By conducting the SPPA trial we try to find out, whether personalized Short Message Service (SMS) reminders of blood pressure-lowering medication can effectively increase patients' adherence to blood pressure-lowering medication.
- Conditions
- Hypertension, Primary Hypertension, Non-Adherence, Medication, Non-Adherence, Patient
- Trial name
- SPPA (NCT03105687)
- Testing
- SMS reminders of medicines intake
- Where
- 24 sites in Slovakia
- Volunteers
- 300 people
- Sponsor
- Comenius University
Hypertension, Stroke
Controlling Hypertension Outcomes by Improved Communication & Engagement
This randomized control study tested the feasibility of two communication enhancement interventions: one with veterans who had a stroke and demonstrated poorly controlled hypertension; the other with VA primary care providers who…
- Trial name
- CHOICE (NCT01134887)
- Testing
- Informational Guide for Patients, Video-Assisted Coaching, Monograph for Physicians
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- VA Office of Research and Development
Blood Pressure, Lifestyle Risk Reduction
Blood Pressure Control in ESH Excellence Centres
In the BP-CON-ESH study we are going to include and analyze treated hypertensive patients seen consecutively by the ESH Excellence Centres.
- Conditions
- Blood Pressure, Lifestyle Risk Reduction, White Coat Hypertension
- Trial name
- BP-CON (NCT04295434)
- Where
- 46 sites in Armenia, Austria and 20 more
- Volunteers
- 3,000 people
- Sponsor
- Clinical Hospital Centre Zagreb
Hypertension
Evaluation of the Effect of Telmisartan on Blood Pressure Control of High Risk Patients
The study is designed to evaluate the effect of treatment with Micardis/MicardisPlus on blood pressure and its ability to reduce different indicated cardiovascular risk scores.
- Trial name
- NCT01108809
- Testing
- Telmisartan or Telmisartan and Hydrochlorthiazide
- Where
- 49 sites in Romania
- Volunteers
- 295 people
- Sponsor
- Boehringer Ingelheim
CKD5 Stage Dialysis, Heart Failure
Sacubitril/Valsartan for CKD5 Stage Dialysis Patients
Hemodialysis or peritoneal dialysis CKD5 patients were randomly divided into Sacubitril/Valsartan and irbesartan treatment groups.
- Trial name
- NCT05243199
- Testing
- Sacubitril/Valsartan, Irbesartan
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Ruijin Hospital
Chronic Kidney Disease
Loop Diuretics in Chronic Kidney Disease
The purpose of this study is to verify the efficacy of diuretic therapy on blood pressure control and left ventricular mass in patients affected by chronic kidney disease
- Trial name
- NCT00478543
- Testing
- Furosemide
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Campania Luigi Vanvitelli
Hypertension
A Study Examining the Effects of Nebivolol Compared to Atenolol on Endothelial Function
This is a randomized, double-blind, placebo-controlled study comparing the efficacy of nebivolol and atenolol at improving small artery elasticity and reducing cardiovascular disease risk in subjects with early vascular disease.
- Trial name
- EVIDENCE (NCT01522950)
- Testing
- Nebivolol, atenolol
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Minnesota
Ocular Hypertension, Open Angle Glaucoma
Study of INS115644 Ophthalmic Solution in Subjects With Ocular Hypertension or Glaucoma
The purpose of this trial is to evaluate the safety and tolerability of INS115644 Ophthalmic Solution in subjects with bilateral ocular hypertension or early primary open angle glaucoma and to investigate the intraocular pressure…
- Trial name
- NCT00443924
- Testing
- INS115644 Ophthalmic Solution
- Volunteers
- 56 people
- Sponsor
- Merck Sharp & Dohme LLC
Sodium Lactate, Intracranial Hypertension
Sodium Lactate and Brain Relaxation (LSD)
Resection surgery of brain tumors by craniotomy requires efficient brain relaxation intraoperatively in order to avoid injuries caused by the brain retractors (such as ischemic-reperfusion and cerebral oedema).
- Conditions
- Sodium Lactate, Intracranial Hypertension, Brain Relaxation
- Trial name
- LSD (NCT04488874)
- Testing
- Sodium Lactate, Mannitol 20% Infusion
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Pre-eclampsia
Sildenafil Citrate for the Treatment of Established Pre-Eclampsia
To determine the efficacy and safety of sildenafil citrate in the treatment of established pre-eclampsia
- Trial name
- NCT00141310
- Testing
- Sildenafil citrate
- Where
- 10 sites in United Kingdom
- Volunteers
- 76 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Hypertension
Study Evaluating the Efficacy of Nifedipine GITS - Telmisartan Combination in Blood Pressure Control.
Patients having uncontrolled or poorly controlled hypertension are at risk of experiencing cardiovascular events such as myocardial infarction or stroke.
- Trial name
- NCT00750113
- Testing
- Nifidipine, Telmisartan, Nifedipine/Telmisartan
- Where
- 43 sites in Italy, Spain
- Volunteers
- 405 people
- Sponsor
- Bayer
Hypertension
Evaluation of Celecoxib Effects on Amlodipine in Subjects With Existing Hypertension Requiring Antihypertensives
The purpose of this study was to evaluate the effect of celecoxib on the efficacy and safety of amlodipine besylate on renal and vascular function in subjects with existing hypertension requiring antihypertensive therapy.
- Trial name
- NCT02979197
- Testing
- OE 10 mg amlodipine besylate tablet, OE 200 mg celecoxib capsule
- Where
- 9 sites in United Kingdom
- Volunteers
- 105 people
- Sponsor
- Kitov Pharma Ltd
Chronic Kidney Disease
Benidipine and Hydrochlorothiazide in Fosinopril Treated Chronic Kidney Disease Patients With Hypertension
The purpose of this study is to compare the effect of fosinopril plus benidipine vs. fosinopril plus hydrochlorothiazide on the renal function during the 6-month treatment in CKD patients with HTN.
- Trial name
- BEAHIT (NCT02646397)
- Testing
- Fosinopril, Benidipine, Hydrochlorothiazide
- Where
- China
- Volunteers
- 508 people
- Sponsor
- Shanghai Changzheng Hospital
Pre-Eclampsia, Hypertension in Pregnancy
Effectiveness of Higher Aspirin Dosing for Prevention of Preeclampsia in High Risk Obese Gravida
To compare the incidence of preeclampsia in obese pregnant women (BMI greater than 30) with a singleton gestation at less than 20 weeks and either a history of preeclampsia in a prior pregnancy or stage I hypertension or…
- Conditions
- Pre-Eclampsia, Hypertension in Pregnancy, Obesity
- Trial name
- ASPREO (NCT03961360)
- Testing
- Aspirin 81 mg, Aspirin 162 mg
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- The University of Texas Health Science Center, Houston