Clinical trials: Controlled Hypertension
Isolated Systolic Hypertension
Systolic Hypertension in Europe Placebo-Controlled Trial
The Syst-Eur Trial is a concerted action of the European Community's Medical and Health Research Programme. The trial is carried out in consultation with the World Health Organization, the International Society of Hypertension…
- Trial name
- Syst-Eur (NCT02088450)
- Testing
- Active treatment with nitrendipine (10-40 mg/day).
- Volunteers
- 4,695 people
- Sponsor
- KU Leuven
Primary Open Angle Glaucoma, Ocular Hypertension
Ph2 Placebo-Controlled Study for Safety & Ocular Efficacy of SBI-100 Ophthalmic Emulsion in Pts w/ Elevated Eye Pressure
The goal of this clinical trial is to test in patients with glaucoma and elevated pressure in the eye. The main questions it aims to answer are: • ability to lower pressure in the eye • safety in the eye and the body of patients…
- Trial name
- NCT06144918
- Testing
- SBI-100 Ophthalmic Emulsion, 0.5%, SBI-100 Ophthalmic Emulsion, 1.0%
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Skye Bioscience, Inc.
Pulmonary Hypertension
Does Oral Sildenafil (Viagra) Decrease Mean Pulmonary Artery Pressure After Cardiac Surgery?
Post-operative pulmonary hypertension is a risk factor for right ventricular failure and an increasing cause of morbidity and mortality in patients undergoing high-risk cardiac surgery.
- Trial name
- NCT00334490
- Testing
- Sildenafil
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Hypertension, Hemodialysis
Improving Blood Pressure Control in End-Stage Renal Disease Through a Supportive-Educative Nursing Intervention
The major purpose of this quantitative study is to determine if a 3 month supportive educative nursing intervention incorporating Blood Pressure (BP) education and BP, salt and fluid monitoring, in addition to goal setting and…
- Trial name
- NCT01052220
- Testing
- BP education and BP self-regulation, Supportive Educative Nursing Intervention
- Where
- 2 sites in United States
- Volunteers
- 118 people
- Sponsor
- Wayne State University
Hypertension
3 x 3 Factorial Trial of Telmisartan and Hydrochlorothiazide in Patients With Essential Hypertension
1. To investigate the dose response of the combination therapy, Telmisartan and Hydrochlorothiazide for the Japanese patients with Essential Hypertension. 2. To compare this dose response with that in the US study.
- Trial name
- NCT00153049
- Testing
- Telmisartan, Hydrochlorothiazide, Telmisartan + Hydrochlorothiazide
- Where
- 24 sites in Japan
- Volunteers
- 583 people
- Sponsor
- Boehringer Ingelheim
Sarcopenia, Hypertension
Effects of Variable Load Exercise on Aging Atrophy
The primary aim of this research proposal is to examine whether this novel training program approach is capable to tackle excessive loss in muscle mass, function and contractile capacity with aging.
- Conditions
- Sarcopenia, Hypertension, Muscle Atrophy
- Trial name
- NCT03690258
- Testing
- Variable load exercise
- Where
- 2 sites in Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital of Split
Hypertension
Effect of a Polyphenol Rich Diet on Vascular and Platelet Function
Previous work has shown that increasing fruit and vegetable intake in patients with high blood pressure improves cardiovascular function.
- Trial name
- PPhIT (NCT01319786)
- Testing
- Two portions of fruit and vegetables per day (excluding berries and dark chocolate), Six portions of fruit and vegetables per day (one of which must be berries) and 50g dark chocolate.
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- Queen's University, Belfast
Hypertension
Isometric Exercise for Hypertension
Background: Isometric resistance exercises (IREs) have great potential to improve blood pressure (BP) control. Methods: This is a pilot randomized controlled trial that will involve 50 patients with hypertension (HT) who do not…
- Trial name
- NCT06515054
- Testing
- wall squat, passive stretching
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Hypertension
A Blood Pressure-Lowering Diet for Preventing and Managing Hypertension
This cluster-randomized controlled trial will evaluate whether a 3-month culturally adapted blood pressure-lowering dietary, called the Eastern Blood Pressure-Lowering Diet, can improve blood pressure and related health outcomes…
- Trial name
- NCT07735091
- Testing
- Standard Hypertension Management, Eastern Blood Pressure-Lowering Diet
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Peking University
Hypertension (HTN)
Effects of a Health Literacy-tailored Self-management Intervention on People With Hypertension
This project aims to investigate the effects of a health literacy-tailored self-management intervention among people with hypertension and low health literacy.
- Trial name
- NCT07369479
- Testing
- health literacy-tailored self-management intervention
- Volunteers
- 170 people
- Sponsor
- Chinese University of Hong Kong
Diabetes Mellitus Type 2, Diabetes Mellitus Type 2 in Obese
The Effects of Nutritional Intervention on Health Parameters in Participants With Type 2 Diabetes Mellitus
The goal of this clinical trial is to evaluate the effects of nutritional intervention on anthropometric, biochemical and cardiovascular parameters in participants with type 2 diabetes mellitus.
- Conditions
- Diabetes Mellitus Type 2, Diabetes Mellitus Type 2 in Obese, Diabetes, Diabetes Mellitus Non-insulin-dependent
- Trial name
- NCT06235762
- Testing
- Nutritional Intervention
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Sao Jose do Rio Preto Medical School
Primary Open-angle Glaucoma, Ocular Hypertension
A Clinical Study to Evaluate the Efficacy and Safety of CKD-351
The purpose of this study is to evaluate efficacy and safety of CKD-351.
- Trial name
- NCT03762369
- Testing
- CKD-351, Latanoprost, D930
- Where
- South Korea
- Volunteers
- 384 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Hypertension
Flaxseed in Controlling Blood Pressure of Patients
Hypertension is one of the major risk factor for global mortality. Approximately half of 17 million cardiovascular deaths worldwide are accounted for HTN.
- Trial name
- NCT04759508
- Testing
- Flax Oil Capsule
- Volunteers
- 72 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Hypertension
We Talk About Our Hypertension
The proposed pilot community-based research project will examine the feasibility, acceptability, and potential efficacy of the Storytelling intervention compared with usual care in hypertension control among rural residents in 4…
- Trial name
- NCT02483780
- Testing
- Storytelling
- Where
- Vietnam
- Volunteers
- 160 people
- Sponsor
- Institute of Population, Health and Development, Vietnam
Chronic Thromboembolic Pulmonary Hypertension
Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension
Study to evaluate if macitentan is efficient, safe and tolerable enough to be used for treatment of inoperable chronic thromboembolic pulmonary hypertension (CTEPH).
- Trial name
- MERIT-1 (NCT02021292)
- Testing
- Macitentan
- Where
- 36 sites in Belgium, China and 14 more
- Volunteers
- 80 people
- Sponsor
- Actelion
Gestational Hypertension, Toxemia
A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy
The investigators aim to determine if Vitamin D prophylaxis in pregnancy reduces the incidence of hypertensive disorders of pregnancy.
- Conditions
- Gestational Hypertension, Toxemia, Superimposed Preeclampsia, Eclampsia
- Trial name
- NCT02920593
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Stroke, Acute, Cerebrovascular Disorders
Intensive Ambulance-delivered Blood Pressure Reduction in Hyper-Acute Stroke Trial
A multicentre, ambulance-delivered, prospective, randomized, open-label, blinded endpoint (PROBE) study to assess the effects of hyperacute intensive blood pressure (BP) lowering initiated in ambulance setting on (i) functional…
- Trial name
- INTERACT4 (NCT03790800)
- Testing
- urapidil
- Where
- 4 sites in China
- Volunteers
- 2,425 people
- Sponsor
- The George Institute for Global Health, China
Primary Open Angle Glaucoma
Vision Preservation and Restoration Following a 6 Month Trial of GlaucoCetin
This study is looking at changes in vision and visual function before and after a six month trial of a daily medical food called GlaucoCetin, formulated with ingredients to support and protect the optic nerve cells.
- Trial name
- NCT04784234
- Testing
- GlaucoCetin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wills Eye
Cirrhosis, Esophageal and Gastric Varices
Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis
The APIXABAN-PK trial is a prospective, randomized, single-blind, placebo-controlled study designed to evaluate the efficacy and safety of apixaban in combination with carvedilol versus placebo with carvedilol in preventing…
- Conditions
- Cirrhosis, Esophageal and Gastric Varices, Ascites, Hepatic Encephalopathy
- Trial name
- APIXABAN-PK (NCT07521332)
- Testing
- Apixaban, Carvedilol
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Asian Institute Of Medical Sciences
Essential Hypertension
Efficacy and Safety of Valsartan/Amlodipine Compared to Amlodipine in Patients With Essential Hypertension
This study was designed to compare the efficacy, tolerability, and safety of the combination valsartan/amlodipine 160/5 mg versus amlodipine 10 mg in patients with essential hypertension not adequately controlled (defined as mean…
- Trial name
- NCT00437645
- Testing
- Valsartan 160 mg capsules, Amlodipine 5 mg capsules
- Where
- 12 sites in Argentina, Chile and 10 more
- Volunteers
- 1,183 people
- Sponsor
- Novartis Pharmaceuticals
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