Clinical trials: Controlled Hypertension
Essential Hypertension
Long Term Safety of SPA100 (Fixed-dose Combination of Aliskiren/Amlodipine) in Patients With Essential Hypertension
The purpose of this study is to evaluate the long-term safety and tolerability of the combination of aliskiren and amlodipine given to patients with essential hypertension.
- Trial name
- NCT01237873
- Testing
- Ali/Amlo 150/2.5 mg
- Where
- 13 sites in Japan
- Volunteers
- 150 people
- Sponsor
- Novartis Pharmaceuticals
Cardiovascular Disease, Pulmonary Arterial Hypertension
Effect of BIA 5 1058 on Cardiac Repolarization
The purpose is to evaluate the effect of single therapeutic (400 mg) and supratherapeutic (1200 mg) doses of BIA 5-1058 on the time-matched change from baseline in placebo-adjusted interval corrected (QT) for heart rate (HR)
- Conditions
- Cardiovascular Disease, Pulmonary Arterial Hypertension, Heart Failure
- Trial name
- NCT03489005
- Testing
- BIA 5-1058, Moxifloxacin 400 mg
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Pulmonary Arterial Hypertension
Exercise Intervention as an Adjunct to Medical Therapy in Newly Diagnosed Patients With Pulmonary Arterial Hypertension
The goal of this clinical trial is to learn if an exercise programme started shortly after diagnosis improves the fitness and mental wellbeing of patients with pulmonary hypertenion over and above medication alone.
- Trial name
- NCT07366879
- Testing
- Home-based, remotely delivered, supervised Exercise programme
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Golden Jubilee National Hospital
Hypertension
A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran
The purpose of this study is to evaluate the efficacy, pharmacodynamics (PD), and safety of ALN-AGT01 RVR in participants with mild to moderate hypertension pretreated with zilebesiran.
- Trial name
- NCT07553442
- Testing
- ALN-AGT01 RVR, Zilebesiran
- Where
- 3 sites in United States
- Volunteers
- 93 people
- Sponsor
- Alnylam Pharmaceuticals
Essential Hypertension, Metabolic Syndrome
A Clinical Trial to Evaluate the Blood Pressure Control of Telmisartan or Losartan in Essential Hypertensive Patients With Metabolic Syndrome
This is a multi-center, randomized, open-label, active comparator-controlled, phase 4 clinical trial to evaluate the blood pressure control of Telmisartan or Losartan in essential hypertensive patients with metabolic syndrome
- Trial name
- PRISTINE (NCT05843162)
- Testing
- Telmisartan, Losartan
- Volunteers
- 116 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Hypertension
DORADO-AC - Optimized Doses of Darusentan as Compared to an Active Control in Resistant Hypertension
This is a randomized, double-blind, placebo- and active-controlled study of a new experimental drug called darusentan. Darusentan is not currently approved by the United States Food and Drug Administration (FDA), which means that…
- Trial name
- Darusentan (NCT00389779)
- Testing
- Darusentan, Guanfacine
- Where
- 147 sites in United States, Argentina and 8 more
- Volunteers
- 849 people
- Sponsor
- Gilead Sciences
Hypertension
Controlling And Lowering Blood Pressure With the MobiusHDTM Device
To evaluate the safety and performance of the MobiusHD system in subjects with resistant hypertension.
- Trial name
- CALM-START (NCT02804087)
- Testing
- MobiusHD
- Where
- 4 sites in Netherlands
- Volunteers
- 4 people
- Sponsor
- Vascular Dynamics, Inc.
Primary Open Angle Glaucoma, Ocular Hypertension
A Study of Efficacy and Safety of PHP-201 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
This is a phase 3 study to confirm the efficacy in reduction of intraocular pressure and safety of PHP-201 ophthalmic solution in patients with primary open-angle glaucoma or ocular hypertension.
- Trial name
- NCT04863365
- Testing
- PHP-201 ophthalmic solution
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- pH Pharma
Hypertension
Dosing Study of the Effects of Nebivolol on Blood Pressure in Black Patients With Mild to Moderate Hypertension
The purpose of this study was to determine if nebivolol is superior to placebo for the treatment of elevated blood pressure in Black patients with mild to moderate hypertension.
- Trial name
- NCT00145236
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Mylan Bertek Pharmaceuticals
Chronic Kidney Diseases, Chronic Disease
Controlling Hypertension Through Education and Coaching in Kidney Disease
Chronic kidney disease (CKD) is a serious and growing public health problem. The purpose of this study is to find out if an educational worksheet, called the Encounter Decision Intervention (EDI), combined with health coaching…
- Conditions
- Chronic Kidney Diseases, Chronic Disease, Chronic Kidney Disease, Stage 3 (Moderate), Chronic Kidney Disease, Stage 4 (Severe)
- Trial name
- CHECK-D (NCT04087798)
- Testing
- Control-EDI, Intervention-EDI, Health coaching
- Where
- 11 sites in United States
- Volunteers
- 320 people
- Sponsor
- University of Michigan
Hypertension
Effectiveness of User and Expert Driven Internet-based Lifestyle Interventions on Hypertension Control
Hypertension is a leading risk factor for cardiovascular disease and mortality. Lifestyle counseling is recommended as a first line therapy for reducing blood pressure (BP) and risk for cardiovascular events.
- Trial name
- NCT03111836
- Testing
- Control Group, Expert-Driven Group, User-driven group
- Volunteers
- 129 people
- Sponsor
- University of Toronto
Preeclampsia
Hypertensive Disorders of Pregnancy in Adolescence and Primipaternity
Hypertensive disorders of pregnancy are one of the most frequent complications of pregnancy, being a serious health problem around the world.
- Trial name
- NCT01374477
- Where
- Panama
- Volunteers
- 110 people
- Sponsor
- Saint Thomas Hospital, Panama
Hypertension,Essential
Efficacy of Songling Xuemaikang Capsules on Grade 1 Hypertension: a Randomized Controlled Trial
The purpose of this study is: 1. To evaluate the efficacy of Songling Xuemaikang Capsules(SLXMKC) with grade 1 hypertension. 2. To reveal the potiential effects of SLXMKC on vascular function and structure of patients with grade…
- Trial name
- ESCIHP (NCT06093932)
- Testing
- Songling Xuemaikang Capsules, Lifestyle intervention
- Where
- 5 sites in China
- Volunteers
- 100 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Hypertension, Obesity
Effectiveness of Avapro in Obese Normotensive/Hypertensive African Americans
The purpose of this study is to test the hypothesis that hypertension increases the anti-natriuretic effects of an angiotensin receptor antagonist during mental stress in overweight/obese African-American's who retain sodium…
- Conditions
- Hypertension, Obesity, Stress, Psychological, Blood Pressure
- Trial name
- Avapro3 (NCT02386293)
- Testing
- Irbesartan
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Glaucoma
Ologen (OculusGen)-Glaucoma MMC Control Trial in India
The purpose of this study is to compare the safety and effectiveness of the ologen (OculusGen) Biodegradable Collagen Matrix Implant and the MMC group in filtration surgery.
- Trial name
- NCT00449098
- Testing
- OculusGen Biodegradable Collagen Matrix Implant, Trabeculectomy with MMC
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Pro Top & Mediking Company Limited
Raised Intraocular Pressure
A Phase IIa Study to Assess the Tolerability, Safety, and Efficacy of AZD4017 for Raised Intra-ocular Pressure
The purpose of this study is to evaluate the efficacy of systemically administered AZD4017, compared with placebo, over a 28-day period in patients with raised intra-ocular pressure (IOP).
- Trial name
- NCT01173471
- Testing
- AZD4017
- Where
- 11 sites in United States, Sweden and 1 more
- Volunteers
- 50 people
- Sponsor
- AstraZeneca
Elevated Blood Pressure
Mindfulness and Neural Cardiovascular Control in Humans
This study evaluates the impact of mindfulness-based stress reduction (MBSR) on sympathetic nerve activity and arterial stiffness.
- Trial name
- NCT03626363
- Testing
- Stress Management
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Michigan Technological University
Hypertension, Diabetes Mellitus
Generative AI for Medication Counselling and Adherence in Community Pharmacies
Medication counseling within community pharmacies is crucial for managing chronic diseases, yet significant challenges regarding correctness and completeness remain in Jordan.
- Conditions
- Hypertension, Diabetes Mellitus, Dyslipidemias, Cardiovascular Diseases
- Trial name
- NCT07649577
- Testing
- pharmacist-supervised AI-assisted medication counseling
- Where
- Jordan
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Petra
Essential Arterial Hypertension
Efficacy and Safety of Olmesartan Associated With Chlorthalidone in Essential Arterial Hypertension Control
The purpose of this study is to evaluate the non-inferiority clinical efficacy of two different drug associations in the essential hypertension control.
- Trial name
- NCT02493322
- Testing
- Olmesartan Medoxomil 20mg + Chlorthalidone 12,5mg, Olmesartan medoxomil 20mg + Chlortalidone 25mg, Olmesartan 20mg + hydrochlorothiazide 12,5mg
- Sponsor
- EMS
Congestive Heart Failure, Heart Failure, Left-Sided
Inhaled Beta-adrenergic Agonists to Treat Pulmonary Vascular Disease in Heart Failure With Preserved EF (BEAT HFpEF): A Randomized Controlled Trial
The enormous and rapidly growing burden of Heart Failure with Preserved Ejection Fraction (HFpEF) has led to a need to understand the pathogenesis and treatment options for this morbid disease.
- Conditions
- Congestive Heart Failure, Heart Failure, Left-Sided, Left-Sided Heart Failure
- Trial name
- BEAT HFpEF (NCT02885636)
- Testing
- Albuterol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.