Clinical trials: Copd Exacerbation Acute
COPD Exacerbation
Short-course Antibiotic Treatment in AECOPD: a Meta-analysis of Double-blind Studies
Chronic obstructive pulmonary disease (COPD) is a common disease worldwide and a leading cause of death and disability globally.
- Trial name
- NCT05380375
- Where
- Tunisia
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Monastir
COPD Exacerbation
Efficacy of Nebulized Long-Acting Bronchodilators (Formoterol and Revefenacin) vs. Short-Acting Bronchodilators (Albuterol and Ipratropium) in Patients Presenting to the Emergency Department With Acute Exacerbation of COPD (ECOPD)
The primary aim is to determine whether nebulized Formoterol twice daily plus Revefenacin once daily is non-inferior to standard-of-care nebulized Albuterol and Ipratropium therapy four times daily in relieving dyspnea among…
- Trial name
- NCT07721922
- Testing
- Revefenacin, formoterol fumarate, Albuterol sulfate
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Chronic Obstructive Pulmonary Disease
Clinical Presentation and Outcome of COPD Patients With Acute Exacerbation Attending Sohag University Hospital
Chronic obstructive pulmonary disease (COPD) is a worldwide public health challenge because of high prevalence and related disability and mortality (1).
- Trial name
- NCT06684353
- Volunteers
- 200 people
- Sponsor
- Sohag University
Acute Exacerbation Copd
Impact of Air Quality on Exacerbations of COPD in the Somme
All COPD patients with a diagnosis of acute exacerbation in emergency room in University Hospital of Amiens-Picardie between 01/01/2017 and 31/12/2017.
- Trial name
- PolluBPCO (NCT03079661)
- Where
- France
- Volunteers
- 179 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pulmonary Disease, Chronic Obstructive
Oscillating Positive Expiratory Pressure Devices and Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Sputum production increases in acute exacerbation of COPD, both in amount and consistency. It increases airways obstruction and hence delays improvement and prolongs hospital stay.
- Trial name
- SIMPLE (NCT03299231)
- Testing
- OPEP Aerobika
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Ain Shams University
Chronic Obstructive Pulmonary Disease
A Study of the Inflammatory Pathways Associated With Chronic Obstructive Pulmonary Disease Exacerbations
The purpose of this study is to observe how the inflammatory pathways differ in subjects with chronic obstructive pulmonary disease (COPD) during an acute exacerbation of COPD (AECOPD).
- Trial name
- NCT01337661
- Where
- Ireland
- Volunteers
- 26 people
- Sponsor
- MedImmune LLC
COPD Exacerbation Acute
The Effect of Airway and Chest Wall Oscillation on Respiratory Functions in COPD Patients in Acute Exacerbation
Chronic obstructive pulmonary disease (COPD); It is a common, treatable and preventable disease characterized by progressive and irreversible airflow limitation and has systemic effects with respiratory system involvement.
- Trial name
- NCT06274957
- Testing
- CONTROL, PEP DEVICE, HFCWO DEVICE
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Saglik Bilimleri Universitesi
COPD, COPD Exacerbation Acute
The Italian Registry of Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a treatable but debilitating medical condition associated with persistent symptoms and chronic airflow obstruction.
- Conditions
- COPD, COPD Exacerbation Acute, Comorbid Chronic Lung Disease on Heart Failure, Mortality
- Trial name
- ICoRe (NCT06652776)
- Testing
- Pharmacological treatment
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University of Milan
COPD
Ultrasound of the Diaphragm Excursion Ratio as Physiological Biomarker in Acute Exacerbations of Chronic Obstructive Pulmonary Disease
3.1 Introduction and rationale In 2020 an estimate of 562.700 people had Chronic Obstructive Pulmonary Disease (COPD) in the Netherlands, resulting in 21.335 hospital admissions.[1] An acute exacerbation COPD (AECOPD) in…
- Trial name
- Undated 2 (NCT07259174)
- Where
- 2 sites in Netherlands
- Volunteers
- 186 people
- Sponsor
- Isala
Pulmonary Disease, Chronic Obstructive, Respiratory Tract Diseases
Post-hospitalisation Nutritional Support and Gait Speed in COPD
To determine the feasibility of delivering different community nutritional interventions to chronic obstructive pulmonary disease (COPD) patients at moderate or severe risk of malnutrition following a hospitalisation for an acute…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Tract Diseases, Lung Diseases, Obstructive, Bronchitis, Chronic
- Trial name
- NCT02261350
- Testing
- Food fortification, Oral Nutritional Supplements
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Pulmonary Disease, Chronic Obstructive
Etiology of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) in Japan
The purpose of this prospective, epidemiological, cohort study is to evaluate the lung microbiome in stable-state chronic obstructive pulmonary disease (COPD) in Japanese participants
- Trial name
- NCT03957577
- Testing
- Prospective observational cohort study
- Where
- 13 sites in Japan
- Volunteers
- 70 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Tiotropium In Early Chronic Obstructive Pulmonary Disease Patients in China
Chronic obstructive pulmonary disease (COPD) is one of the commonest respiratory diseases. During the early stage of COPD, patients only have mild respiratory symptoms or signs which may lead to under-diagnosis of the disease.
- Trial name
- Tie-COPD (NCT01455129)
- Testing
- Tiotropium
- Where
- 25 sites in China
- Volunteers
- 841 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Chronic Obstructive Pulmonary Disease (COPD), Inflammatory Disease
Endothelial Dysfunction in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
The purpose of the study is to determine a possible association between the clinical entity of exacerbation, markers of systemic inflammation and endothelial dysfunction in patients with COPD.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Inflammatory Disease, Endothelial Dysfunction
- Trial name
- EDAECOPD (NCT01460082)
- Where
- Austria
- Volunteers
- 29 people
- Sponsor
- LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology
Pulmonary Disease, Chronic Obstructive
Digihaler in Chronic Obstructive Pulmonary Disease (COPD)
This is a multi-center 3-month study to determine the variation in ProAir Digihaler metrics [peak inspiratory flow (PIF), inhalation volume, number of inhalation events] amongst COPD patients in the ambulatory setting.
- Trial name
- NCT05241288
- Testing
- Albuterol eMDPI DS
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- University of North Carolina, Chapel Hill
COPD Exacerbation Acute
A Study to Evaluate the Efficacy and Safety of Sitafloxacin in Adult Subjects With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease, that causes obstructed airflow from the lungs that causes persistent obstructive airflow limitation.
- Trial name
- NCT05400369
- Testing
- Sitafloxacin, Moxifloxacin Hydrochloride
- Where
- 18 sites in China
- Volunteers
- 140 people
- Sponsor
- Daiichi Sankyo
Procalcitonin, Chronic Obstructive Pulmonary Disease
A Trial of Procalcitonin in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Current antibiotic prescription for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is generally based on the Anthonisen criteria in The Global Initiative for Chronic Obstructive Pulmonary…
- Trial name
- NCT04682899
- Testing
- procalcitonin-guided antibiotic therapy, guideline-guided antibiotic therapy
- Volunteers
- 500 people
- Sponsor
- Capital Medical University
Extracorporeal CO2 Removal, Acute Respiratory Distress Syndrome
Effects of Blood Pulsatility on Von Willebrand Factor During ECCO2R
The primary objective of the study is to demonstrate that the ECCO2R pulsatile configuration prevents the Willebrand factor high molecular weight multimers decrease observed under continuous blood flow configurations.
- Conditions
- Extracorporeal CO2 Removal, Acute Respiratory Distress Syndrome, Chronic Obstructive Pulmonary Disease Exacerbation, Pulmonary Disease
- Trial name
- FLOW-ECCO2R (NCT05079009)
- Testing
- ECCO2R pulsatile configuration
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease
Exacerbation Prevention GOLD IV COPD With Non Invasive Mechanical Ventilation
The purpose of this study is to evaluate the efficacy of high-intensity non invasive mechanical ventilation (during one year to reduce the severity and frequency of acute exacerbation of chronic obstructive pulmonary disease…
- Trial name
- NCT01481727
- Testing
- BiPAP Pro 2, Phillips Respironics
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- National Institute of Respiratory Diseases, Mexico
Pulmonary Disease, Chronic Obstructive
Personalized Prediction Strategy for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
This is a 3-year longitudinal study designed to establish a personalized prediction and prevention system for acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- NCT03240315
- Where
- China
- Volunteers
- 442 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation Chronic Obstructive Pulmonary Disease
Muscle Oxygenation in Patients With COPD Exacerbation
Chronic obstructive pulmonary disease (COPD) is often complicated by acute exacerbations, which lead to functional impairments, increased dyspnea, and a rapid decline in lung function.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation Chronic Obstructive Pulmonary Disease, Muscle Oxygenation
- Trial name
- NCT07801547
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Hacettepe University