Clinical trials: Cornea Disease
Corneal Injuries
Peri-operative Application of Eyeprotx General Anesthesia Goggles As Prevention Against Corneal Injury Post Intubation.
This is a randomized controlled trial that seeks to examine the effectiveness of Eyeprotx™ protective goggles in comparison to traditional methods against ocular injury that can occur perioperatively under general anesthesia.
- Trial name
- NCT03762889
- Testing
- Eyeprotx™ General Anesthesia Protective Goggles, Eyelid Tape, Eye Ointment
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
Myopia, Hyperopia
Corneal Epithelial Thickness Mapping by Anterior Segment Optical Coherence Tomography in Patients With Refractive Errors
This study evaluates corneal epithelial thickness using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors.
- Conditions
- Myopia, Hyperopia, Astigmatism, Emmetropia
- Trial name
- NCT07647146
- Where
- Egypt
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Sohag University
Keratoconjunctivitis Sicca
Effects of Systane Versus Saline in Maintaining Tear Film Stability at Determined Time Points
To evaluate tear film stability of a market lubricant therapeutic eye drop versus saline when using Evaporometry and Interferometry in patients with a diagnosis of Keratoconjunctivitis Sicca (KCS).
- Trial name
- NCT00345241
- Testing
- Systane Ocular Drops (OTC)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Corneal Epitheliopathy, Glaucoma
Efficacy of 20% Autologous Serum Drops in the Treatment of Corneal Epitheliopathy Associated With Antihypertensive Glaucoma Drops.
Introduction: Glaucoma is the second leading cause of blindness globally. Most anti-hypertensive drops contain preservatives harmful to the corneal epithelium, with up to 78% of treated patients reporting dry eye symptoms.
- Conditions
- Corneal Epitheliopathy, Glaucoma, Corneal Disease, Dry Eye
- Trial name
- NCT06294015
- Testing
- 20% ASED + AT, 0.9% NS + AT
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Cornea
Multi-center Clinical Trial on Corneal Morphology Analysis in Chinese Population
Based on the corneal morphometry instrumentation Oculus Pentacam, which is commonly used before and after clinical refractive surgery, we will collect the corneal morphological and biologic parameters of the population under…
- Trial name
- NCT03010748
- Testing
- Scheimpflug tomography system (Pentacam) measurement
- Where
- China
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Dry Eye Syndromes, Corneal Disease
Prospective Study to Validate the Imaging Biomarker for NCP (R33)
The aim of this study is establish the reliability and clinical utility of microneuromas as identified via in vivo confocal microscopy as the diagnostic biomarker for NCP.
- Trial name
- NCT05653921
- Testing
- In vivo confocal microscopy (IVCM)
- Where
- 2 sites in United States
- Volunteers
- 438 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Trachoma
A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation: The ASANTE Trial
Infection with C. Trachomatis has decreased substantially in trachoma endemic areas following repeated annual mass drug administration (MDA) with azithromycin, although not as rapidly as anticipated.
- Trial name
- ASANTE (NCT01767506)
- Testing
- Surveillance and treatment with azithromycin of newcomer and traveler families, Usual care
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cornea, Refractive Surgery
Evaluation of the Effect of Myopic Femtosecond Laser Assisted-LASIK on Anterior Chamber Flare Values and Corneal Endothelial Cells: A Prospective Before-and-After Study
This study aimed to investigate whether femtosecond laser-assisted LASIK (FS-LASIK) surgery causes inflammation in the anterior chamber and to analyze its effect on endothelial cells.
- Conditions
- Cornea, Refractive Surgery, Anterior Chamber Inflammation
- Trial name
- NCT04899258
- Testing
- Femtosecond laser assisted LASIK
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Cornea; Ectasia, Refractive Errors
Corneal Elastography and Patient Specific Modeling
The goal of this research is to develop measurement tools and simulation technology for characterizing and predicting individual responses to corneal treatments and for advancing understanding of corneal ectasia risk factors.
- Conditions
- Cornea; Ectasia, Refractive Errors, Keratoconus
- Trial name
- NCT03030755
- Testing
- Optical coherence tomography
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Map Dot Fingerprint Dystrophy, Post-penetrating Keratoplasty
Brillouin Microscopy Used to Evaluate Corneal Mechanical Properties
This study aims to explore the mechanical properties of the cornea using a non-invasive imaging technique called Brillouin microscopy.
- Conditions
- Map Dot Fingerprint Dystrophy, Post-penetrating Keratoplasty, Post-Descemet Membrane Endothelial Keratoplasty, Healthy Corneas
- Trial name
- NCT06914817
- Testing
- Brillouin optical scanning system (Intelon Optics) (BOSS)
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Wavefront Aberration, Corneal, Refractive Errors
Digital Wavefront Sensing
A holographic optical coherence tomography (H-OCT) setup is used to detect the wavefront by means of phase reconstruction.
- Trial name
- DWS (NCT04597255)
- Testing
- Holographic optical coherence tomography
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pregnancy
The Influence of Hormonal Changes During Pregnancy on Corneal Biomechanics in Humans
The intraocular pressure in the human bulbus requires that the "wall" of the eye shows a certain (bio)mechanical strength. The human cornea represents the anterior portion of this wall.
- Trial name
- NCT01629264
- Testing
- Ocular Response Analyzer, Scheimpflug measurement, Blood sample
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Keratoconus
Keratoconus Detection by Ultrasound
Keratoconus (KC) is a corneal disease which will in many cases ultimately require corneal transplantation to maintain vision. Early detection, which is not possible with current technology, would allow early treatment and prevent…
- Trial name
- NCT01403129
- Testing
- Artemis Ultrasound Exam, Optical Coherence Tomography (OCT) Exam
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Columbia University
Corneal Neovascularization
Clinical Evaluation of Safety and Tolerability of KDR2-2 Eye Drops in Healthy Volunteers With Pharmacokinetic Assessment
A Phase 1 randomized, double blinded, placebo-controlled, single dose escalation (SDE) and repeat dose escalation (RDE) study to evaluate safety and tolerability, and PK of KDR2-2 in healthy volunteers.
- Trial name
- NCT04620109
- Testing
- KDR2-2
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Guangzhou HuiBoRui Biological Pharmaceutical Technology Co. Ltd
Pellucid Marginal Corneal Degeneration, Keratoconus
A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea
The purpose of this research study is to find out if the new Brillouin Ocular Scanner can measure the variation (difference) of the corneal elastic changes involved in the onset of corneal ectasia, induced by LASIK surgery and…
- Conditions
- Pellucid Marginal Corneal Degeneration, Keratoconus, Keratectasia
- Trial name
- NCT03220529
- Testing
- Brillouin Ocular Scanner
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cataract, Pseudophakia
Evaluation Study for a Non-Contact Biometer
The purpose of this study is to determine whether a new non-contact biometer, is as accurate as the the available gold-standard.
- Conditions
- Cataract, Pseudophakia, Myopia, Hyperopia
- Trial name
- NCT00494390
- Where
- Switzerland
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Glaucoma, Retinal Disease
OCT Agreement and Crossed Precision Study
The purpose of this study is to asses the agreement of the RS-3000 Lite and RS-3000 Advance to the RS-3000, assess the crossed precision of each study device and to assess the transference of a reference database from the RS-3000…
- Conditions
- Glaucoma, Retinal Disease, Corneal Disease
- Trial name
- NCT02050880
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Nidek Co. LTD.
Retinal Diseases, Fuchs Endothelial Dystrophy
DISCOVER Study: Microscope-integrated Intraoperative OCT Study
Optical coherence tomography (OCT )provides high resolution information regarding the anatomic structure of the tissues of the eye in a cross-sectional and 3 dimensional view.
- Conditions
- Retinal Diseases, Fuchs Endothelial Dystrophy, Macular Hole, Epiretinal Membrane
- Trial name
- DISCOVER (NCT02423213)
- Where
- United States
- Volunteers
- 2,911 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Keratoconus
Distinguishing Healthy and Keratoconic Eyes Using Ultrahigh-Resolution OCT
The OCT used in this trial offers the advantage of both a non-contact method and a very high axial resolution. Determined parameters with the highest potential of diagnostic discrimination between eyes with Keratoconus and…
- Trial name
- NCT03184610
- Testing
- OCT-scanning
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cornea, Refraction Error
Corneal Topography and High Order Aberrations in Regular Contraceptive Pills
Effect of regular usage of contraceptive pills on corneal topography and corneal high-order aberrations
- Trial name
- NCT07693673
- Testing
- Hormonal Contraception, Combined Oral Contraceptive (COC)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Elshimaa A.Mateen