Clinical trials: Corneal Cross-Linking
Progressive Keratoconus
Safety and Efficacy of Corneal Cross-linking in Subjects With Keratoconus
Clinical Trial to Evaluate the Safety and Efficacy of Corneal Cross-linking in Subjects with Keratoconus.
- Trial name
- NCT05314738
- Testing
- NXL Energy 1, NXL Energy 2, NXL Energy 3
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Glaukos Corporation
Keratoconus
Iontophoretic Transepithelial Corneal Cross-linking in Pediatric Patients
To report three year follow up in pediatric patients with keratoconus after iontophoretic transepithelial corneal cross-linking (CXL) to assess preoperative factors that may influence ectasia progression
- Trial name
- NCT03661164
- Testing
- corneal cross linking
- Volunteers
- 22 people
- Sponsor
- Luca Buzzonetti
Keratoconus
Topo-pachimetric Accelerated Epi-On Cross-linking Compared to Dresden Protocol Using Riboflavin With Vitamin E TPGS
In the present study the investigators compare the clinical outcome corneal cross linking with either the stand-ard Dresden (sCXL) or the accelerated custom-fast (aCFXL) ultraviolet A irradiation protocol using…
- Trial name
- NCT05019768
- Testing
- accelerated custom-fast CXL, Standard CXL
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- Ciro Caruso
Keratoconus
Adapted Fluence Settings for Corneal Collagen Cross-linking in Mild to Moderate Progressive Keratoconus
the purpose of this study is to compare the efficacy and safety of a new method of corneal cross-linking that uses UV-A irradiation intensity of 9mW/cm2 for 7 minutes to well-known Accelerated corneal cross-linking (9 mW/cm2 UV-A…
- Trial name
- NCT02507362
- Testing
- adjusted corneal collagen cross-linking, accelerated corneal collagen cross-linking, riboflavin 0.1% combined with dextran 20 %
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
Keratoconus, Unstable
Treating Corneal Thinning Conditions With CCL Vario Riboflavin (CXL)
Study is testing the efficacy of treating corneal thinning conditions with Vitamin B2 (Riboflavin) and the application on UV Light.
- Trial name
- CXL (NCT04731727)
- Testing
- Riboflavin
- Volunteers
- 600 people
- Sponsor
- Kent Wellish MD
Keratoconus, Intraocular Pressure
Measuring the Changes of the Intraocular Pressure After Corneal Cross Linking Using Corvis CT
To evaluate the changes that occur in the intraocular pressure before and after corneal cross linking using Corvis CT.
- Trial name
- NCT07599020
- Testing
- Corvis Machine
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Tanta University
Keratoconus, Pellucid Marginal Degeneration
T-Cat Laser & Cross-linking for Keratoconus
The purpose of this study is to determine whether excimer laser corneal surface ablation (T-Cat) can be safely combined with simultaneous corneal collagen cross-linking treatment to produce an improved and stable corneal profile…
- Trial name
- T-Cat (NCT00777322)
- Testing
- Excimer laser ablation, and collagen cross-linking
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Corneal Ectasia
Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal Ectasia
This is a hospital-based interventional prospective study. Patients with clinical keratoconus or LASIK keratectasia presenting to the Singapore National Eye Centre who meet the eligibility criteria are recruited for this study.
- Trial name
- NCT01123057
- Testing
- riboflavin-induced collagen cross-linking treatment, Riboflavin-UVA induced collagen cross-linking treatment for corneal ectasia
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore National Eye Centre
Keratoconus, Collagen Diseases
Correlation Between Q-value Changes and Progression of Pediatric Keratoconus.
Keratoconus is a progressive corneal disease characterized by asymmetric corneal thinning and structural changes in corneal collagen which leads to decrease in visual acuity due to myopic shift, irregular astigmatism or corneal…
- Conditions
- Keratoconus, Collagen Diseases, Corneal Disease
- Trial name
- NCT05114928
- Testing
- Transepithelial Corneal Collagen Cross-linking, Scheimpflug camera
- Where
- Egypt
- Volunteers
- 9 people
- Sponsor
- Benha University
Keratoconus
German Corneal Cross Linking Register
Corneal Cross Linking is new treatment modality for patients with keratoconus. A keratoconus is characterized by progressive bulging and thinning of the eye's cornea.
- Trial name
- NCT00560651
- Testing
- CCL (Corneal Cross Linking)
- Where
- 2 sites in Germany
- Volunteers
- 356 people
- Sponsor
- Suphi Taneri
Corneal Epithelial Wound Healing
Cross-linked CMC and Silk Proteins in Corneal Re-epithelization
Data analyses and revision of the corneal re-epithelization in patients who underwent either PRK (Photorefractive Keratectomy), CXL (Corneal Cross-Linking), PTK (phototherapeutic keratectomy), or experienced a corneal abrasion.
- Trial name
- CLCS (NCT06840990)
- Testing
- CXC-SP, CTRL
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- D&V FARMA srl
Keratoconus
Simultaneous TransPRK and Corneal Collagen Cross-Linking
Young patients with keratoconus face two problems: disease progression and corneal shape irregularity leading to poor vision even in spectacles.
- Trial name
- TransPRKCXL (NCT02208089)
- Testing
- Transepithelial Photorefractive Keratectomy (TransPRK), Corneal Collagen Cross-Linking (CXL)
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- Bruce Allan
Keratoconus, Pellucid Marginal Corneal Degeneration
Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Collagen Cross-linking in Eyes With Corneal Thinning Conditions
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Degeneration, Corneal Ectasia
- Trial name
- NCT04667572
- Testing
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Cornea Associates of Texas
Keratoconus
The Additional Role of Supplemental Oxygen Therapy in Accelerated Corneal Collagen Cross-linking in Progressive Keratoconus. A Randomized Clinical Trial
It is aimed to investigate the role of supplemental systemic oxygen therapy during accelerated corneal collagen crosslinking (CXL).
- Trial name
- NCT04343326
- Testing
- perform corneal collagen cross linking accelerated and delivery of systemic oxygen, perform corneal collagen cross linking accelerated and without additional oxygen therapy, perform Conventiona corneal collagen cross linking
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Progressive Keratoconus, Thin Corneas
Corneal Thickness Changes During Corneal Collagen Cross-linking With Ultraviolet-A Irradiation and Riboflavin
The purpose of this study is to evaluate the corneal pachymetric variations during and after corneal collagen cross-linking (CXL) treatment with ultraviolet-A irradiation (UVA) and hypo-osmolar riboflavin solution in thin corneas.
- Trial name
- NCT01485211
- Testing
- cross-linking with hypo-osmolar riboflavin
- Volunteers
- 18 people
- Sponsor
- Instituto de Olhos de Goiania
Keratoconus
Photorefractive Keratectomy and Corneal Cross-linking in Keratoconus
Evaluation of the safety and efficacy of surface ablation followed by Collagen Cross-linking in patients with keratoconus
- Trial name
- NCT02189447
- Testing
- Simultaneous Photorefractive Keratectomy and Collagen Cross-linking in patients with keratoconus
- Volunteers
- 44 people
- Sponsor
- The Eye Center and The Eye Foundation for Research in Ophthalmology
Corneal Ectasia
Observational Registry to Assess the Durability of Effect of CXL in Patients With Corneal Ectasia After Refractive Surgery
The objectives of this post market registry are to evaluate the safety and durability of treatment effect up to 3 years following cross-linking performed with Photrexa Viscous (riboflavin 5'- phosphate in 20% dextran ophthalmic…
- Trial name
- CXL (NCT03319082)
- Testing
- Corneal Collagen Cross-linking
- Where
- 11 sites in United States
- Volunteers
- 200 people
- Sponsor
- Glaukos Corporation
Corneal Disease
Efficacy of Xiidra in Dry Eye Disease After Collagen Cross Linking
dry eye disease after corneal collagen cross linking affect ocular function leading to reduced vision, photophobia, glare, halos, and foreign body sensation.
- Trial name
- NCT05045053
- Testing
- Xiidra 5% Ophthalmic Solution
- Where
- United Arab Emirates
- Volunteers
- 40 people
- Sponsor
- Benha University
Keratoconus
One-Year Outcomes After Conventional vs Accelerated Epi-Off Corneal Cross-Linking in Progressive Keratoconus (Observational Cohort)
Prospective, observational (consecutive eligible eyes) continuation of a previously published 6-month cohort from the same center, extending follow-up to 12 months.
- Trial name
- KCXL-1Y (NCT07194538)
- Where
- Croatia
- Volunteers
- 20 people
- Sponsor
- Clinical Hospital Centre Zagreb
Infectious Keratitis
Cross Linking for Treatment of Corneal Infection
This study is comparing 45 minute and 30 minute treatment durations with the UVX corneal cross linking system to treat corneal infections.
- Trial name
- NCT00912509
- Testing
- riboflavin, UVX Light
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Price Vision Group