Clinical trials: Corneal Disease
Cataract
Comparison of Wound Integrity for Clear Corneal Cataract Incisions
This is a randomized controlled trial to evaluate the safety and efficacy of two different closing methods for clear corneal cataract incisions
- Trial name
- NCT05242653
- Testing
- pressure by a cotton swab, stromal hydration with the balanced salt solution（BSS）
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Corneal Ulcer (Diagnosis)
Diagnosing Corneal Infection
Microbial keratitis is a common and serious eye disease in Edinburgh. Prompt treatment with antibiotics can prevent sight loss, and identification of the micro-organism and its antibiotic sensitivities are key to appropriate…
- Trial name
- NCT04230811
- Testing
- Corneal impression membrane (Millicell Cell Culture Insert, 12mm, hydrophilic PTFE 0.4µm (PICM01250))
- Where
- United Kingdom
- Sponsor
- University of Edinburgh
Sjogren's Syndrome, Dry Eye
AST Combined With 0.05% Cyclosporin Eye Drop Improve Corneal Nerve Density in Patients With SS Dry Eye
The objective of the present study was to evaluate the efficacy of autologous serum tears combined with 0.05% cyclosporin eye drop in treating Sjögren's syndrome dry eye and their effect on corneal nerves.
- Conditions
- Sjogren's Syndrome, Dry Eye, Ocular Surface Disease
- Trial name
- AST/SS (NCT06013436)
- Testing
- Autologous serum tears combined with 0.05% cyclosporin eye drop
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Keratoconus
Cross Linking Corneal Biomechanical Evaluation of CATS Tonometer Prism
The purpose of this study is to determine if the device, CATS tonometer prism, measures intraocular pressure significantly differently than the current standard of care tonometer prism (Goldmann) before and after a corneal…
- Trial name
- NCT04180111
- Testing
- CATS Tonometer
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Intuor Technologies, Inc.
Aphakia, Corneal Astigmatism
Clareon Toric Study (T2-T9)
The purpose of this post-market study is to describe the long-term safety and performance of Clareon Toric Intraocular Lenses (IOLs).
- Trial name
- NCT06285695
- Testing
- Clareon Toric IOL, Cataract surgery
- Where
- 6 sites in Canada
- Volunteers
- 129 people
- Sponsor
- Alcon Research
Keratoconjunctivitis Sicca
Efficacy Study of Cyclosporine Ophthalmic Emulsion in Patients With Dry Eye Disease
This study will evaluate the efficacy of cyclosporine ophthalmic solution vs. other non-prescription treatments in patients with dry eye disease.
- Trial name
- NCT00717418
- Testing
- cyclosporine ophthalmic emulsion 0.05%, artificial tears
- Where
- United States
- Volunteers
- 781 people
- Sponsor
- Allergan
Aniridia
Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia
This study will examine specific gene changes in patients with aniridia, a disease in which the iris (colored part of the eye) is absent or partially absent, and will correlate the changes with clinical manifestations of the…
- Trial name
- NCT00265590
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Eye Institute (NEI)
Corneal Ulcer
Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients
The propose of this study is to determine the efficacy of 2% xylocaine in reducing pain due to subconjunctival antibiotic and antifungal injection.
- Trial name
- NCT00789646
- Testing
- Lidocaine/NSS, NSS/Lidocaine
- Volunteers
- 10 people
- Sponsor
- Mahidol University
Myopia, Cornea
Euclid Phoenix Lens Design Trial
The "first fit" success rate of the current Euclid orthokeratology "MAX" lens design will be compared to that of the new Euclid orthokeratology MAX "Phoenix" lens design in 30 children.
- Trial name
- NCT06389916
- Testing
- Euclid orthokeratology MAX (current design), Euclid orthokeratology MAX Phoenix (new design)
- Where
- 5 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Euclid Systems Corporation
Myopia
Corneal Topography Asymmetry Indices Changes After Corneal Refractive Surgery
To evaluate the changes that occur in the corneal indices after corneal refractive surgery either PRK or LASIK.
- Trial name
- NCT04589091
- Testing
- Refractive surgery
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Keratitis
Contact Lenses and Infiltrative Keratitis
To quantify and compare baseline tear proteins and ocular response in contact lens wearers with a history of corneal infiltrative events, to those without a history of complications.
- Trial name
- CLIK (NCT02186431)
- Testing
- senofilcon A
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- State University of New York College of Optometry
Keratoconus, Ectasia Corneal
Comparison of Standard vs. Accelerated Corneal Crosslinking
The study objective is to compare accelerated and standard corneal crosslinking for treatment of progressive keratoconus or corneal ectasia.
- Trial name
- NCT03922542
- Testing
- riboflavin 0.1%
- Where
- United States
- Volunteers
- 508 people
- Sponsor
- Price Vision Group
Corneal Abrasions, Corneal Infiltrates
High-resolution Imaging of Corneal Lesions With Optical Coherence Tomography (OCT) - A Pilot Study
Corneal lesions such as corneal abrasions and corneal infiltrates are common in clinical practice. The current study seeks to investigate whether high-resolution OCT is suitable for imaging of these corneal lesions.
- Trial name
- NCT01753583
- Testing
- Optical Coherence Tomography (OCT), Slit lamp biomicroscopy
- Where
- Austria
- Volunteers
- 4 people
- Sponsor
- Medical University of Vienna
Cataract
Calhoun Vision Light Adjustable Lens (LAL) in Subjects With Pre-Existing Corneal Astigmatism
The purpose is to evaluate the Calhoun Vision Light Adjustable Lens (LAL) and Light Delivery Device (LDD) for reducing astigmatism and improving uncorrected vision after implantation.
- Trial name
- NCT01496066
- Testing
- LAL (Light Adjustable Lens) and Light Deliver Device (LDD), Monofocal control IOL
- Where
- 17 sites in United States
- Volunteers
- 600 people
- Sponsor
- Calhoun Vision, Inc.
Keratoconus
Efficacy of Customized Corneal Cross-linking vs. Standard Corneal Cross-linking
The standard or Dresden protocol was established in 2003 and treats the entire cornea. However, recent ultra-structural research showed that keratoconus is localized.
- Trial name
- C-CROSS (NCT04532788)
- Testing
- Customized crosslinking, Standard crosslinking
- Where
- 3 sites in Netherlands
- Volunteers
- 124 people
- Sponsor
- Maastricht University Medical Center
Keratoconus
Central Versus Peripheral Air Injection for DALK (Deep Anterior Lamellar Keratoplasty)
Different techniques of deep anterior lamellar keratoplasty (DALK) have been introduced to create a uniform recipient bed, thereby reducing complications, such as interface irregularity and opacification encountered with…
- Trial name
- NCT02485951
- Testing
- Central air injection, Peripheral air injection
- Where
- Iran
- Volunteers
- 49 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Corneal Dystrophy
Correlation Between In-vivo Anatomy of Corneal Dystrophies as Assessed by High- Resolution Optical Coherence Tomography (OCT) Measurement and Histological Examination
Corneal dystrophies are usually classified histopathologically according to the layer of the cornea that is affected. The International Committee for the Classification of Corneal Dystrophies (IC3D) takes this anatomical…
- Trial name
- NCT03461991
- Testing
- Ultrahigh resolution Spectral Domain OCT
- Where
- 2 sites in Austria
- Volunteers
- 2 people
- Sponsor
- Medical University of Vienna
Corneal Endothelial Decompensation, Fuchs' Endothelial Dystrophy
Impact of Donor Diabetes on DMEK Success and Endothelial Cell Loss
This double-masked multi-center trial will evaluate the association of diabetes in the cornea donor with transplant success and loss of endothelial cells through 1 year following Descemet membrane endothelial keratoplasty (DMEK).
- Trial name
- DEKS (NCT05134480)
- Testing
- Descemet membrane endothelial keratoplasty
- Where
- 2 sites in United States
- Volunteers
- 1,097 people
- Sponsor
- Case Western Reserve University
Keratoconus, Cornea Ectasia
Safety and Efficacy of Corneal Crosslinking Using the PXL-Platinum 330 for Eyes With Corneal Ectatic Conditions
To evaluate the safety and effectiveness of the PXL Platinum 330 device for performing Corneal Crosslinking in patients with corneal thinning conditions.
- Trial name
- NCT04240457
- Testing
- Epithelial-on Corneal Crosslinking with the PXL 330 Platinum system.
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Arbor Center for Eye Care
Corneal Diseases
Using in Vivo Confocal Microscope to Evaluate the Corneal Wound Healing After Various Ocular Surgeries
Although epi-keratome laser-assisted in situ keratomileusis (Epi-LASIK), penetrating keratoplasty and pars plana vitrectomy with corneal epithelial debridement for diabetic retinopathy are surgeries commonly performed, the…
- Trial name
- NCT00491439
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital