Clinical trials: Corneal Injuries
Keratitis
A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically Ill
Corneal damage in critically ill patients is common. There are currently two popular methods of treatment in the UK; hydrogel dressings and lubricating ointment.
- Trial name
- NCT00513734
- Testing
- Hydrogel dressing, Lacrilube ointment
- Volunteers
- 40 people
- Sponsor
- Barts & The London NHS Trust
Corneal Abrasion, Eye Trauma
Bandage Contact Lenses for Corneal Abrasions
Two percent of all patients presenting to the Emergency Departments have complaints involving the eye. Corneal abrasions are a common diagnosis with patients with eye pain and often cause significant discomfort.
- Trial name
- NCT03206723
- Testing
- Bandage contact lens, Eyedrop, Hydrocodone
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Corneal Abrasion
Treatment of Corneal Abrasions With Topical Tetracaine
Corneal abrasion (CA) is one of the most common eye injuries, accounting for 10% of eye-related emergency visits.1 A 1985 survey showed that around 3% of all visits to US general practitioners were for corneal abrasions.
- Trial name
- NCT02771392
- Testing
- Ophthalmic Tetracaine, Normal Saline
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Cataract
Impact of a Corneal Pre-cut on Wound Architecture and Astigmatism in Cataract Surgery - a Pilot Study
We would like to evaluate the use of a 600μm pre-cut regarding wound architecture and surgically induced astigmatism as compared to a stab-incision (a corneal incision without a pre-cut).
- Trial name
- NCT02155270
- Testing
- Corneal precut 600µm, Corneal stabincision
- Where
- Austria
- Volunteers
- 55 people
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Cataracts Infantile, Subluxation of Lens
Anterior Versus Posterior Artisan Intraocular Lens Fixation in Aphakic Children With Insufficient Capsular Support.
The Artisan lens (Artisan Aphakic, Ophtec BV) is an iris- claw lens designed for implantation in children with insufficient capsular support.
- Conditions
- Cataracts Infantile, Subluxation of Lens, Intraocular Lens Complication, Corneal Endothelial Cell Loss
- Trial name
- NCT06396156
- Testing
- Anterior enclavation, Posterior enclavation
- Where
- 2 sites in Egypt
- Volunteers
- 32 people
- Sponsor
- Cairo University
Corneal Diseases, Keratoconus
Keratoconus, Corneal Diseases and Transplant Registry
The cornea is the clear layer in front of the iris and pupil. It protects the iris and lens and helps focus light on the retina.
- Conditions
- Corneal Diseases, Keratoconus, Corneal Ulcer, Corneal Trauma
- Trial name
- KCDTR (NCT04164407)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Montpellier
Corneal Disease, Corneal Opacity
Study to Evaluate the Clinical Safety and Performance of the CorNeat KPro for Treatment of Corneal Blindness
A Single Arm, Pivotal, Open Label, Multicenter Clinical Investigation to Evaluate the Clinical Safety and Performance of the CorNeat Keratoprosthesis, for Treatment of Corneal Blindness
- Conditions
- Corneal Disease, Corneal Opacity, Corneal Injuries
- Trial name
- NCT05694247
- Testing
- CorNeat KPro
- Where
- 6 sites in Canada, France and 2 more
- Volunteers
- 15 people
- Sponsor
- CorNeat Vision Ltd.
Corneal Injuries
Peri-operative Application of Eyeprotx General Anesthesia Goggles As Prevention Against Corneal Injury Post Intubation.
This is a randomized controlled trial that seeks to examine the effectiveness of Eyeprotx™ protective goggles in comparison to traditional methods against ocular injury that can occur perioperatively under general anesthesia.
- Trial name
- NCT03762889
- Testing
- Eyeprotx™ General Anesthesia Protective Goggles, Eyelid Tape, Eye Ointment
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
Corneal Foreign Body Following Blast Injury
Visual Prognosis in Non-Penetrating Corneal Blast Injuries
The purpose of this study is to assess visual quality of patients with non-penetrating, non-metallic, stable corneal foreign bodies.
- Trial name
- NCT00414219
- Testing
- Visual quality of patients with corneal eye injuries
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Corneal Epithelial Wound
Topical Insulin Versus Autologous Serum After Corneal Surgeries
The aim of the study is to test whether use of topical insulin or autologous serum eye-drops can promote corneal epithelial healing following photorefractive keratectomy (PRK).
- Trial name
- NCT05331859
- Testing
- Insulin, autologous serum (AS), conventional
- Where
- 2 sites in Egypt
- Volunteers
- 250 people
- Sponsor
- Benha University
Eye Burns
Low Dose Doxycycline in the Treatment of Corneal Burn
To evaluate the safety and efficacy of oral low dose doxycycline in the treatment of corneal burn.
- Trial name
- NCT01886560
- Testing
- Doxycycline
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sun Yat-sen University
Myopia, Hyperopia
Comparison of Acular LS Versus Nevanac for Pain Control in Eyes Undergoing PRK
To determine the ability of two topical Nonsteroidal Anti-inflammatory drops (Acular LS \& Nevanac) to help control pain following Photorefractive Keratectomy (PRK).
- Trial name
- NCT00347204
- Testing
- ketorolac (Acular LS), Nepafenac (Nevanac)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Center For Excellence In Eye Care
Corneal Scars and Opacities
Limbus-derived Stem Cells for Prevention of Postoperative Corneal Haze
This is a investigator-initiated pilot clinical trial to ascertain the safety and efficacy of application of ex-vivo cultivated limbal stem cells in human eyes for treating Corneal Haze after Photo-Therapeutic/Refractive…
- Trial name
- NCT03295292
- Testing
- Stem cells, Vehicle
- Where
- India
- Volunteers
- 15 people
- Sponsor
- L.V. Prasad Eye Institute
Corneal Injury, Exposure Keratopathy
Eyelid Taping Alone Versus Taping With Lubricant Eye Drops for Perioperative Corneal Protection
During general anesthesia, the eye's natural protective reflexes are suppressed, which can lead to corneal drying and injury. To prevent this, anesthesiologists routinely tape the eyelids closed.
- Conditions
- Corneal Injury, Exposure Keratopathy, Perioperative Complications
- Trial name
- NCT07562594
- Testing
- Hypoallergenic Eyelid Taping, Hypoallergenic Eyelid Taping With Lubricant Eye Drops
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Chemical Injuries, Unspecified Complication of Corneal Transplant
Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
The purpose of the pilot study is to test the efficacy and safety of riboflavin/Ultraviolet A (UVA) cross-linked human donor corneas as carriers for the Boston Keratoprosthesis (Boston KPro) in patients with higher risk for…
- Conditions
- Chemical Injuries, Unspecified Complication of Corneal Transplant, Autoimmune Diseases, Ocular Cicatricial Pemphigoid
- Trial name
- NCT01582880
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Joseph B. Ciolino, MD
Corneal Epithelial Wound Healing
Effect of Topical Fluoroquinolones on Epithelial Wound Healing After PRK
The prescribed antibiotic for prophylaxis of infection following PRK should be effective at eradicating a potential infection. In addition, the antibiotic should have a rapid onset of action, effectively penetrate the target…
- Trial name
- NCT00569881
- Testing
- gatifloxacin and moxifloxacin
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Donnenfeld, Eric, M.D.
Conjunctival Infections, Irritations and Inflammations, Hypertrophy; Conjunctiva
Influence of Cosmetic Color Tinted Contact Lenses on the Ocular Surface
More than 1 million people worldwide wear soft contact lenses for refractive error correction. However, severe sight threatening complications due to contact lens wear such as contact lens-related microbial keratitis (CLMK) are…
- Conditions
- Conjunctival Infections, Irritations and Inflammations, Hypertrophy; Conjunctiva, Corneal Pannus, Corneal Epithelial Wound
- Trial name
- NCT01441648
- Testing
- contact lens wear
- Where
- Taiwan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Eye Injuries
Comparison of the Effects on Promoting Corneal Epithelial Wound Healing Between Human Auto-Serum and Cord Blood Serum
Human serum eye drops have been successfully used in the treatment of severe ocular surface disorders and the enhancement of corneal wound healing.
- Trial name
- NCT00598299
- Testing
- venous puncture, obtain serum from perripheral blood or cord blood
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Vision Disability
Correlation of Scheimpflug Densitometry Measurements of Corneal Haze With Disability Glare
Disability glare is described as "halos" or "starbursts" around bright sources of light that can cause discomfort and reduce vision.
- Trial name
- NCT02244892
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center
Corneal Abrasions
Proparacaine vs Placebo for Corneal Injuries
Introduction: Traumatic injuries to the outer covering of the eye (the cornea) are a common emergency department complaint. They cause significant patient distress including pain, loss of sleep and missed work days.
- Trial name
- Dogma (NCT00620997)
- Testing
- Proparacaine drops 0.05%, saline drops
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- London Health Sciences Centre