Clinical trials: Corneal Opacity
T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma
Non-gene Edited Anti-CD7 CAR T Cells for Relapsed/Refractory T Cell Malignances
This is a phase I, interventional, single arm, open label, treatment study to evaluate the safety and tolerability of non-gene edited anti-CD7 CAR (also called anti-CD7 CAR) T cells in patients with relapsed and/or refractory T…
- Conditions
- T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma, T-cell Non-Hodgkin Lymphoma
- Trial name
- NCT04934774
- Testing
- CD7 CAR T cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- iCell Gene Therapeutics
Corneal Opacities
Corneal Opacities in Children
A prospective observational study on corneal opacities in infants and children (1 month to 18 years old) will be conducted at CHLA. Most of these cases will be due to congenital corneal opacity (e.g.
- Trial name
- OCT (NCT02117323)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Oregon Health and Science University
Keratoconus
PRoTECT: Corneal Wavefront Guided PRK + Epi-off CXL vs. PTK+Epi-off CXL in Keratoconus
Keratoconus causes irregular astigmatism and reduced vision. Epi-off corneal crosslinking (CXL) stabilizes the cornea but often leaves higher-order aberrations uncorrected.
- Trial name
- PRoTECT (NCT07372911)
- Testing
- Schwind AMARIS excimer laser, Corneal collagen crosslinking epi-off accelerated
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Corneal Opacity
Comparison of Ultrasonic Pachymetry With Orbscan in Corneal Haze
This study is planned to compare the results of ultrasonic and Orbscan pachymetry in corneal haze not related to surgery. Corneal haze is graded with slit-lamp by a single examiner.
- Trial name
- NCT00439114
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baskent University
Cataract, Lens Opacities
Feasibility Investigation of Biometry and Tomography Measurements in a Heterogeneous Patient Cohort
The planned clinical investigation will be conducted to acquire raw data for the development of the algorithm. The data acquisition is intended to obtain first impressions of the potential performance of the changed hardware and…
- Conditions
- Cataract, Lens Opacities, Artificial Lens Implant, Corneal Astigmatism
- Trial name
- BioBase (NCT05458661)
- Testing
- Clinical Prototype BioBase (SN 07 and SN 08)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec AG
Keratoconus, Corneal Opacity
OCT in Diagnosis of Irregular Corneas
This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions.
- Conditions
- Keratoconus, Corneal Opacity, Corneal Dystrophy
- Trial name
- NCT03504800
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Intraocular Pressure, Corneal Opacity
Loteprednol vs. Prednisolone and Fluorometholone
Corneal haze, in which the cornea becomes cloudy, is a well-known and a potentially vision-threatening postoperative complication of photorefractive keratectomy (PRK).
- Trial name
- NCT03123614
- Testing
- Loteprednol Etabonate 0.5% Oph Gel, Prednisolone Acetate 1% Oph Susp
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Utah
Corneal Disease, Corneal Opacity
First in Human (FIH) Study to Assess Safety and Efficacy of the CorNeat KPro for the Treatment of Corneal Blindness
Prospective, open label, single arm, First in Human (FIH) clinical study to assess safety and efficacy of the CorNeat Keratoprosthesis, a synthetic cornea, for the treatment of corneal blindness
- Conditions
- Corneal Disease, Corneal Opacity, Corneal Injuries
- Trial name
- NCT04485858
- Testing
- CorNeat KPro
- Where
- 8 sites in United States, Canada and 3 more
- Volunteers
- 10 people
- Sponsor
- CorNeat Vision Ltd.
Corneal Injuries, Corneal Burns
Stem Cells Therapy for Corneal Blindness
This is a investigative initiated, comparative pilot clinical trial to ascertain the safety of application of ex-vivo cultivated limbal stem cells in human eyes for treating different superficial corneal pathologies.
- Conditions
- Corneal Injuries, Corneal Burns, Corneal Scars and Opacities
- Trial name
- ExCell (NCT02948023)
- Testing
- Ex-vivo cultivated limbal stem cell pool
- Where
- India
- Volunteers
- 100 people
- Sponsor
- L.V. Prasad Eye Institute
Cataract, Lens Subluxation
Efficacy of an Ocular Bandage Contact Lens for the Treatment of Dry Eye After Complicated and Combined Cataract Surgery
To study the efficacy of an ocular bandage contact lens for the treatment of dry eye after complicated and combined cataract surgery
- Conditions
- Cataract, Lens Subluxation, Hypermature Cataract, Corneal Opacity
- Trial name
- NCT04120389
- Testing
- bandage contact lenses(PureVision; Bausch & Lomb Inc., Rochester, NY), phacoemulsification
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Corneal Scars and Opacities
Limbus-derived Stem Cells for Prevention of Postoperative Corneal Haze
This is a investigator-initiated pilot clinical trial to ascertain the safety and efficacy of application of ex-vivo cultivated limbal stem cells in human eyes for treating Corneal Haze after Photo-Therapeutic/Refractive…
- Trial name
- NCT03295292
- Testing
- Stem cells, Vehicle
- Where
- India
- Volunteers
- 15 people
- Sponsor
- L.V. Prasad Eye Institute
Senile Cataract
Phacoemulsification in Patients With Corneal Opacities
In this retrospective case series, the feasibility of performing phacoemulsification using slit illumination in eyes with corneal opacity was assessed.
- Trial name
- NCT05014269
- Testing
- Phacoemulsification in eyes with corneal opacities
- Volunteers
- 10 people
- Sponsor
- Assiut University
Corneal Opacity
OCT-guided LALAK in Children
The primary goal of the trial is to determine if laser-assisted lamellar anterior keratoplasty (LALAK) will reduce the risks of post-operative complications such as adhesions, glaucoma and cataract that are associated with…
- Trial name
- LALAK (NCT01579643)
- Testing
- OCT guided laser-assisted lamellar anterior keratoplasty (LALAK), Penetrating Keratoplasty (KP)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Oregon Health and Science University
Corneal Opacity, Keratoconus
OCT-guided LALAK for KCN
The purpose of this study is to determine if a new procedure, called laser-assisted lamellar anterior keratoplasty (LALAK), can achieve the same level of vision with a lower risk of potential complications after surgery compared…
- Trial name
- NCT01901614
- Testing
- LALAK, IEK, Retrobulbar Block or General Anesthesia
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Cataract Extraction
A Randomized Study of Intraocular Caliper-assisted Capsulotomy for Age-related Cataract Patients With Corneal Limbus Opacity
The purpose of this study is to compare the accuracy of capsulotomy assisted by intraocular caliper and Verion navigation system in phacoemulsification surgery and postoperative visual quality for age-related cataract patients…
- Trial name
- NCT04977102
- Testing
- Intraocular caliper-assisted capsulotomy, Verion navigation system-assisted capsulotomy
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Corneal Opacity
Characteristics of Trachomatous Corneal Opacity in Fayoum University Hospital
The purpose of this study is to assess the characteristics of trachomatous corneal opacity in patients with signs of trachoma using Anterior segment Optic coherence tomography and Pentacam
- Trial name
- Trachoma (NCT06000150)
- Testing
- Corneal topography
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Omar Said
Corneal Opacity, Keratitis, Herpetic
Topical Anesthesia for Closed PKP vs Retrobulbar Anesthesia for Open-sky PKP
Penetrating keratoplasty (PKP) is an open-sky surgery that fundamentally has not changed for more than 100 years. Because conventional PKP is associated with the potential for the development of devastating complications such as…
- Conditions
- Corneal Opacity, Keratitis, Herpetic, Corneal Ulcer, Corneal Dystrophies, Hereditary
- Trial name
- NCT02826174
- Testing
- closed PKP under topical anesthesia, open-sky PKP under retrobulbar anesthesia, Anti-Rejection Agents
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wenzhou Medical University
Corneal Scars and Opacities
To Evaluate the Clinical Safety and Efficacy of Limbal Stem Cell for Treatment of Superficial Corneal Pathologies".
This study proposes to investigate the transplantation of ex-vivo cultivated allogenic limbal stromal cells for the treatment of the corneal pathologies.
- Trial name
- NCT04932629
- Testing
- Ex-vivo cultivated Allogeneic limbal stromal stem cells
- Volunteers
- 20 people
- Sponsor
- L.V. Prasad Eye Institute
CORNEAL OPACITY WITH POOR PROGNOSIS FOR CORNEAL TRANSPLANT
SINGLE PATIENT EXPANDED ACCESS OF A PROSPECTIVE, MULTICENTER CLINICAL TRIAL DESIGNED TO EVALUATE THE SAFETY AND PROBABLE BENEFIT OF THE KERAKLEAR NON-PENETRATING KERATOPROSTHESIS IN SUBJECTS WITH CORNEAL OPACITY WITH POOR PROGNOSIS FOR CORNEAL TRANSPLANT
This is for a "Single Patient Expanded Access" of an on-going study (IRB#2017-3526). In the on-going study, the maximum number of subject will be 35 subjects (35 eyes) will be implanted with the KeraKlear device and will be…
- Trial name
- NCT03812341
- Testing
- Experimental
- Where
- United States
- Sponsor
- University of California, Irvine
Corneal Opacity
Clinical Outcomes of the Gore Synthetic Cornea Device
Study objective is to evaluate the initial safety and effectiveness of the GORE Synthetic Cornea Device in the treatment of loss of corneal clarity in patients who are candidates for corneal transplantation
- Trial name
- NCT06174376
- Testing
- GORE Synthetic Cornea Device
- Where
- 2 sites in Mexico
- Volunteers
- 10 people
- Sponsor
- W.L.Gore & Associates