Clinical trials: Coronary; Ischemic
Coronary Arteriosclerosis, Angina Unstable
Stents, Drug Eluting Stents, and CABG- Financial and Clinical Impact.
Options for coronary revascularization include stent implantation and coronary bypass surgery. Both modalities have their unique advantages and disadvantages in terms of clinical outcomes as well as financial impact on the…
- Conditions
- Coronary Arteriosclerosis, Angina Unstable, Myocardial Infarction
- Trial name
- NCT00394680
- Volunteers
- 700 people
- Sponsor
- Shaare Zedek Medical Center
ST-elevation Myocardial Infarction (STEMI)
The Impact of Post Stenting Balloon Dilatation on Coronary Microcirculation in STEMI Patients Undergoing PPCI
This study aims to assess the impact of NC balloon post-dilatation on coronary microcirculation in patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).
- Trial name
- POSTDILSTEMI (NCT02788396)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Myocardial Infarction, Cerebral Infarction
Acute Myocardial Infarction and Acute Cerebral Infarction (AMIAC) Registry and Follow-up
A registry of consecutive patients who were admitted and diagnosed with acute myocardial infarction or acute cerebral infarction were conducted at the Guangdong General Hospital or the First Affiliated Hospital of Guangzhou…
- Conditions
- Myocardial Infarction, Cerebral Infarction, Chronic Kidney Diseases, Mortality
- Trial name
- AMIAC (NCT03166696)
- Where
- 3 sites in China
- Volunteers
- 30,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Coronary Artery Disease (CAD), ST-elevation Myocardial Infarction (STEMI)
Drug-coatEd Balloon Multicentric Registry in Spain and PORTugal
Drug-eluting stents (DES) have been the main treatment option for coronary angioplasty (PCI) for many years. The antiproliferative drug in DES has the effect of preventing in-stent restenosis, which is typically a consequence of…
- Trial name
- DESPORT (NCT07477405)
- Volunteers
- 1,200 people
- Sponsor
- Portuguese Association of Interventional Cardiology
Coronary Artery Disease
Angiography-derived FFR GPS in Predicting Post-PCI Physiological and Clinical Outcomes
To investigate the feasibility of physiological map generated from angiography-derived fractional flow reserve (FFR) (angio-FFR) pullback and its value in predicting physiological and clinical outcomes after stenting.
- Trial name
- Angio-GPS (NCT05496023)
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 329 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease
EDUCATE: The MEDTRONIC Endeavor Drug Eluting Stenting: Understanding Care, Antiplatelet Agents and Thrombotic Events
EDUCATE is a prospective, multi-center study designed to collect real-world safety and clinical outcomes in subjects receiving one or more Endeavor Zotarolimus-Eluting Stents and either clopidogrel and aspirin or prasugrel and…
- Trial name
- EDUCATE (NCT01069003)
- Testing
- Thienopyridine Therapy, Surveillance Arm
- Where
- United States
- Volunteers
- 2,272 people
- Sponsor
- Medtronic Vascular
Heart Failure, Coronary Artery Disease
Dobutamine vs Adenosine CMR Study
This is a single centre, prospective diagnostic accuracy study to assess the comparative sensitivity of dobutamine versus adenosine for detection of severe non-infarct epicardial coronary artery stenosis in subjects with reduced…
- Conditions
- Heart Failure, Coronary Artery Disease, Cardiac MRI
- Trial name
- DISCORDANCE (NCT03661827)
- Testing
- Stress Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 69 people
- Sponsor
- University of Leicester
Myocardial Infarction
High-Intensity Interval Training Early After Left Ventricular Myocardial Infarction
Several studies have shown that high-intensity interval training (HIIT) is more effective than moderate-intensity continuous exercise training (MICE) at improving functional capacity and quality of life in stable cardiac patients…
- Trial name
- HIIT-EARLY (NCT02627586)
- Testing
- HIIT, MICE
- Where
- Switzerland
- Volunteers
- 75 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiovascular Diseases, Heart Diseases
Biobehavioral Predictors of Coronary Angioplasty Outcome
To examine some of the psychosocial predictors of poor outcome among revascularized coronary artery disease patients.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00005554
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Fracture of Stent of Coronary Artery, External Causes of Morbidity and Mortality
Novara Registry of Platinum-Chromium Platform Stents
Recent reports have described cases of novel thin-strut coronary stent longitudinal deformation during or after deployment and a biomechanical analysis have suggested increased susceptibility for such a complication for the…
- Conditions
- Fracture of Stent of Coronary Artery, External Causes of Morbidity and Mortality, Myocardial Infarction, Coronary Vessel Disorders
- Trial name
- PROMETEUS (NCT01759719)
- Testing
- coronary angioplasty with PtCr stent implantation
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Myocardial Infarction, Myocardial Injury
Cardiac Troponin Fragmentation After Heavy Physical Exercise The MaraCat2 Study
Cardiac troponins are highly sensitive and specific biomarkers of cardiac injury and are in a key role in the diagnosis of acute myocardial infarction (MI).
- Trial name
- MaraCat2 (NCT06000930)
- Testing
- Troponin fragmentation
- Where
- Finland
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Turku
Cardiac Arrest
Remote Ischemic Conditioning to Enhance Resuscitation (RICE) Pilot
Following resuscitation from out-of-hospital cardiac arrest (OHCA), reperfusion injury can cause cell damage in the heart and brain.
- Trial name
- NCT04265807
- Testing
- Active Remote Ischemic Conditioning
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Coronary Disease Undergoing CABG
Assessment of Hemodynamic Response During Intubation Between Rigid Laryngoscopy and Track Light in Coronary Patients
Opioids provide greater patient comfort during intubation, but are not able to abolish completely the release adrenergic hormones during the laryngoscopy, which may cause undesirable hemodynamic changes.
- Trial name
- NCT01682707
- Testing
- laryngoscopy, track light
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Juiz de Fora
Heart Failure With Reduced Ejection Fraction, Cardiogenic Shock
Pulmonary Artery Catheterization and Carvedilol Early Initiation in Cardiogenic SHOCK Due to HFrEF
This study aims to compare the impact of hemodynamic monitoring using pulmonary artery catheter (PAC) on survival and inotropic agent reduction in patients with cardiogenic shock caused by heart failure with reduced ejection…
- Trial name
- PACE-SHOCK (NCT06078436)
- Testing
- Pulmonary artery catheter
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Min-Seok Kim
Heart Failure, Acute Coronary Syndrome
Bace1as Role in Heart Failure (BACE1AS-HF)
The objective of this project is 1) to explore the clinical relevance of BACE1-AS and BACE1 as therapeutic targets and 2) to evaluate their potentiality as biomarkers in ischemic heart failure (HF).
- Trial name
- BACE1AS-HF (NCT06213493)
- Testing
- measurement of RNAs
- Where
- Italy
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Myocardial Infarction, Ventricular Tachyarrhythmia
Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Ischemic Ventricular Tachyarrhythmias
The study evaluates whether catheter based radiofrequency ablation is superior to optimized antiarrhythmic medical therapy in preventing ventricular tachyarrhythmia relapses in patients with ischemic heart disease and implantable…
- Trial name
- MANTRA-VT (NCT02303639)
- Testing
- Radiofrequency catheter ablation, Antiarrhythmic drug therapy
- Where
- 2 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Central Finland Hospital District
Hypertension, Coronary Disease
Analyzing How Genetics May Affect Response to High Blood Pressure Medications
High blood pressure is one of the most common health problems in the United States. There are many medications to treat high blood pressure, but there is a large variance in how people respond to these medications.
- Conditions
- Hypertension, Coronary Disease, Cerebrovascular Accident
- Trial name
- NCT00563901
- Where
- 2 sites in United States
- Volunteers
- 37,939 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Coronary Artery Disease, Myocardial Infarction
Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in Europe
The "EUropean Comparative Effectiveness Research to assess the use of primary prophylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD)" is a modular research project to study the effectiveness of prophylactic ICDs in a…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Dilated Cardiomyopathy, Implantable Defibrillator User
- Trial name
- EU-CERT-ICD (NCT02064192)
- Where
- 42 sites in Belgium, Bulgaria and 14 more
- Volunteers
- 2,285 people
- Sponsor
- University Medical Center Goettingen
Cardiovascular Diseases, Coronary Disease
Inflammation Markers Over Time in Cardiovascular Disease
To determine inflammation markers over time in cardiovascular disease. To test the hypothesis that measures of coagulation and fibrinolysis correlate with the incidence of coronary heart disease (CHD) and other thrombosis related…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Thrombosis
- Trial name
- NCT00005692
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Defects, Congenital
Neuroprotective Effects of Remote Ischemic Preconditioning (RIPC) During Infant Cardiac Surgery
The purpose of this study is to look at whether the use of a simple technique before surgery, which involves inflating a blood pressure cuff on the infant's leg, can improve development of language, motor and thinking skills at…
- Trial name
- NCT01835392
- Testing
- Remote Ischemic Preconditioning, Control
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Nemours Children's Clinic
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