Clinical trials: Coronary; Ischemic
Cardiogenic Shock
Clinical Study of Extra-Corporal Life Support in Cardiogenic Shock Complicating Acute Myocardial Infarction
This study compares standard treatment plus Extra-Corporal Life Support (ECLS) versus standard treatment alone in patients with cardiogenic shock due to myocardial infarction.
- Trial name
- ECLS-SHOCK (NCT02544594)
- Testing
- Extra-Corporal Life Support (ECLS)
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- LMU Klinikum
Coronary Artery Disease, Cardiac Surgical Procedures
Does Modified Ultrafiltration Improves Inflammatory Response and Cardiopulmonary Function After CABG Procedures?
The inflammatory response after cardiac surgery increases mortality and morbidity. Modified ultrafiltration (MUF) has been shown to decrease the post-cardiac surgery inflammatory response, to improve respiratory function, and…
- Trial name
- NCT01140113
- Testing
- Modified Ultrafiltration
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Campinas, Brazil
Coronary Stenosis, Coronary Disease
IRIS-Firehawk® Cohort in the IRIS-DES Registry
The objective of this study is to evaluate effectiveness and safety of Firehawk® stent in the "real world" daily practice as compared with other drug-eluting stents.
- Trial name
- IRIS Firehawk (NCT03380286)
- Testing
- Firehawk
- Where
- South Korea
- Sponsor
- Duk-Woo Park, MD
Coronary Artery Disease
The "CAD-Man" EXTEND Study
CAD-Man Extend is the long-term follow-up (clinical, laboratory, and computed tomography (CT) imaging) of a single-center, randomized, controlled CAD-Man trial comparing a CT-first strategy with a direct- invasive coronary…
- Trial name
- CAD-Man-EXTEND (NCT06237673)
- Testing
- CT, invasive coronary angiography (ICA)
- Where
- Germany
- Volunteers
- 318 people
- Sponsor
- Charite University, Berlin, Germany
STEMI
Cangrelor Following Ticagrelor Loading vs Ticagrelor Loading Alone in STEMI
Platelets and thrombus formation play a key role in the pathogenesis of acute coronary artery occlusion and subsequent myocardial infarction.
- Trial name
- NCT02943369
- Testing
- Ticagrelor 180 mg loading dose, Cangrelor 30 mcg/kg bolus + 4 mcg/kg/min
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Attikon Hospital
Coronary Artery Disease
Vis-Rx Prime Micro-Imaging Catheter Study
To study the performance of the Gentuity® HF-OCT (High Frequency Optical Coherence Tomography) Imaging System and Vis-Rx Prime® Micro-Imaging Catheter when used to obtain images of coronary arteries in patients who are undergoing…
- Trial name
- NCT06685783
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- Gentuity, LLC
Myocardial Infarction
A Study of RO4905417 in Patients With Non ST-Elevation Myocardial Infarction (Non-STEMI) Undergoing Percutaneous Coronary Intervention
This randomized, double-blind, placebo-controlled study will evaluate the efficacy and safety of RO4905417 in patients with non ST-elevation myocardial infarction (Non-STEMI) undergoing percutaneous coronary intervention (PCI).
- Trial name
- NCT01327183
- Testing
- Percutaneous Coronary Intervention (PCI), RO4905417
- Where
- 66 sites in United States, Canada and 2 more
- Volunteers
- 532 people
- Sponsor
- Hoffmann-La Roche
Acute Myocardial Infarction, STEMI
A Study of Acute Myocardial Infarction Using FDY-5301
The purpose of this study is to evaluate the safety, efficacy, and pharmacokinetics (PK) of three dose levels of FDY-5301 compared to placebo in STEMI patients undergoing PCI.
- Trial name
- NCT03470441
- Testing
- FDY-5301
- Where
- 23 sites in United States, Hungary and 2 more
- Volunteers
- 120 people
- Sponsor
- Faraday Pharmaceuticals, Inc.
Coronary Artery Disease, Ischemic Disease
Peripheral Stimulation Device to Improve Coronary Flow Reserve in Coronary Artery Disease
The purpose of the PERCCAD Study is to investigate the effect of the gekoTM device (a non-invasive calf muscle stimulator approved for use to improve blood flow by Health Canada) on coronary blood flow in order to assess its…
- Trial name
- PERCCAD (NCT01853410)
- Testing
- gekoTM
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Coronary Artery Disease, Acute Coronary Syndrome
PGD2 Formation in Vascular Injury
To investigate the biosynthesis of PGD2 during percutaneous transluminal coronary angioplasty (PTCA) procedure.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Stable Angina
- Trial name
- PGD2 (NCT01001260)
- Testing
- No ASA, Low dose ASA, 325 mg ASA
- Volunteers
- 51 people
- Sponsor
- University of Pennsylvania
Ischemic Heart Disease, Non-ischemic Cardiomyopathy
Serial Infusions of Allogeneic Mesenchymal Stem Cells in Cardiomyopathy Patients With Left Ventricular Assist Device
A study to assess the safety and preliminary efficacy of serial intravenous dose of Allogeneic Mesenchymal Bone Marrow Cells in subjects with heart failure and implanted left ventricular assist devices.
- Trial name
- STEM-VAD (NCT03925324)
- Testing
- Human Allogeneic Mesenchymal Bone Marrow Cells (aMBMC)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medstar Health Research Institute
Coronary Microvascular Perfusion in Patients With Ischemic Heart Disease
PGE1 Improves Coronary Microcirculation Dysfunction in Patients With CAD and Diabetes
This study is undertaken to determine if intravenous Lipo-PGE1 therapy would improve coronary microvascular perfusion in patients with ischemic heart disease by CMRI.
- Trial name
- NCT03159559
- Testing
- Lipo-PGE1
- Volunteers
- 60 people
- Sponsor
- Tongji Hospital
Coronary Artery Disease
Antithrombotic Regimens and Outcome
PROTOCOL SYNOPSIS Title: Comparison of bivalirudin and unfractioned heparin (UFH)+ protamine in elective percutaneous coronary interventions (PCI) Design: Prospective, randomized, controlled trial Hypothesis: Bivalirudin is…
- Trial name
- ARNO (NCT00448461)
- Testing
- heparin, bivalirudin
- Where
- Italy
- Volunteers
- 850 people
- Sponsor
- Careggi Hospital
Coronary Heart Disease
Safety and Efficacy of Prolonged Use of Bivalirudin 4 Hours After ePCI (COBER Study)
Since the development of percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD), unfractionated heparin (UFH) and low molecular weight heparin (LWMH) have been the preferred anticoagulants in…
- Trial name
- NCT04120961
- Testing
- prolonged continuous use of bivalirudin, bivalirudin use during ePCI
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Stable Angina, Unstable Angina
Safety and Effectiveness Evaluation of COBRA PzF Coronary Stent System: A Post Marketing Observational Registry
A multi-center, prospective, consecutive enrolled, observational registry. The population being studied includes all patients undergoing treatment of "de novo" lesions in native coronary vessels, saphenous vein graft and/or…
- Conditions
- Stable Angina, Unstable Angina, ACS - Acute Coronary Syndrome, STEMI
- Trial name
- eCOBRA (NCT03103620)
- Testing
- COBRA PzF Coronary Stent System
- Where
- 18 sites in France
- Volunteers
- 1,027 people
- Sponsor
- CeloNova BioSciences, Inc.
Atherosclerosis, Ischemia
Trial to Assess the Ocular Safety of Vorapaxar (SCH 530348) in Participants With Atherosclerosis (Study P05183)
This study is designed to evaluate the long-term ocular safety of SCH 530348 (vorapaxar) in participants with established atherosclerotic disease who are enrolled into the TRA 2°P - TIMI 50 Study (P04737) (NCT00526474).
- Conditions
- Atherosclerosis, Ischemia, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- NCT00617123
- Testing
- Vorapaxar 2.5 mg
- Volunteers
- 258 people
- Sponsor
- Merck Sharp & Dohme LLC
Ischemic Heart Disease Chronic, Diabetes Mellitus, Type 2
Lifestyle Intervention in Chronic Ischemic Heart Disease and Diabetes
Chronic ischemic heart disease and diabetes mellitus type II have one of the highest morbidity and mortality rates. Especially in the presence of both diseases, these risks increase exponentially.
- Trial name
- LeIKD (NCT03835923)
- Testing
- lifestyle intervention, usual care
- Where
- 10 sites in Germany
- Volunteers
- 502 people
- Sponsor
- Techniker Krankenkasse
Coronary Artery Disease
DCB Treatment in CTO Guided by IVUS
The percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) coronary artery disease is difficult, the success rate is low, and the incidence of re-occlusion and restenosis is high.
- Trial name
- NCT06050096
- Testing
- PCI
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xuzhou Central Hospital
Sleep Quality, Coronary Heart Disease
Effect of Atlas Cedarwood Essential Oil Aromatherapy on Sleep Quality Among Patients With Coronary Heart Disease
Sleep-wake disturbances were found to be a common problem among patients with CHD either earlier during hospitalization or/ and after discharge Although there is an evidence that sleep-wake disturbanes occur in high rate among…
- Trial name
- NCT03830554
- Testing
- Organic Atlas cedar wood essential oil (Cedrus Atantica)
- Where
- Jordan
- Volunteers
- 96 people
- Sponsor
- Rawan Alghzawi
Ischemic Heart Disease, Coronary Artery Disease
Coronary Computed Tomography Angiography For Optimized Invasive Coronary examInation
Coronary computed tomography angiography (CCTA) is a non-invasive method for visualization of the coronary arteries. The anatomical information obtained by CCTA, however, is rarely integrated into a subsequent coronary…
- Trial name
- CT-FOCI (NCT05218694)
- Testing
- CCTA guided focused coronary angiography examination.
- Where
- Denmark
- Volunteers
- 122 people
- Sponsor
- Aarhus University Hospital Skejby
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