Clinical trials: Coronary Artery Bypass Surgery
Coronary Artery Bypass Graft
Pulmonary Rehabilitation and Quality of Life
In this study, the effect of a pulmonary rehabilitation (PR) program on the respiratory function and quality of life of patients undergoing CABG surgery with an open-heart technique is examined.
- Trial name
- NCT04214275
- Testing
- pulmonary rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Chronic Ischemic Cardiomyopathy, Coronary Artery Bypass Surgery
Human Umbilical Cord Stroma MSC in Myocardial Infarction
The purpose of this phase 1/2 clinical trial is to evaluate the efficacy and safety of allogeneic human umbilical cordstroma derived multipotent stem cells (hUCS-MSCs) in myocardial infarction (MI).
- Trial name
- HUC-HEART (NCT02323477)
- Testing
- stem cell transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Ankara University
Arteriosclerosis of Arterial Coronary Artery Bypass Graft
Long Term Follow-up of Open Versus Endoscopic Radial Artery Harvest With CT Angiography
The objectives of the study are two-fold: 1. To determine the mean 5 year patency rate of the radial artery graft (Open vs. Endoscopic) of patients who have already had CABG surgery and who previously participated in the centre's…
- Trial name
- NCT01559376
- Where
- 2 sites in Canada
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Coronary Artery Disease, Coronary Artery Bypass Grafting
CCTA-Based vs CAG-Based CABG: A Multicenter Pragmatic Non-Inferiority Trial
The goal of this clinical trial is to find out if using a non-invasive heart scan (called coronary computed tomography angiography, or CCTA) to plan coronary artery bypass grafting (CABG) works as well as the standard invasive…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Coronary Computed Tomography Angiography, Coronary Angiography (CAG)
- Trial name
- CtaCAB (NCT07769008)
- Testing
- CCTA-based CABG, CAG-based CABG
- Where
- China
- Volunteers
- 826 people
- Sponsor
- Ruijin Hospital
Chronic Coronary Syndrome, Stable Coronary Artery Disease CAD
Comparing High and lOw-dose asPirin With Dual anTIplatelet Therapy for Three Months Using prasUgrel and aSpirin Following Coronary Artery Bypass Grafting. (OPTIMUS-CABG Trial)
The purpose of this study is to compare the effect of prasugrel plus low-dose aspirin versus high dose aspirin alone (300mg) and versus low dose aspirin alone (75 mg) in patients with chronic coronary disease undergoing coronary…
- Trial name
- OPTIMUS-CABG (NCT07195149)
- Testing
- High-Dose Aspirin 300 mg, DAPT (Low-Dose Aspirin 75 mg + Prasugrel 10 mg), Low-Dose Aspirin 75 mg
- Where
- 18 sites in Poland
- Volunteers
- 1,703 people
- Sponsor
- Dolnośląskie Centrum Chorób Serca im.prof. Zbigniewa Religi MEDINET Sp. z o.o.
Peak Expiratory Flow Rate, Coronary Artery Bypass Graft Surgery
Additional Effects of Flutter With Conventional Chest Physiotherapy on Peak Expiratory Flow Rate and Chest Expansion in Post CABG Patients With COPD
Flutter therapy is an oscillating positive expiratory pressure (OPEP) technique that combines positive expiratory pressure with airway oscillations to facilitate mobilization and clearance of respiratory secretions.
- Conditions
- Peak Expiratory Flow Rate, Coronary Artery Bypass Graft Surgery, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT07875049
- Testing
- Conventional Chest Physiotherapy, Flutter device with conventional chest physiotherapy
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- Foundation University Islamabad
Cardiac Surgery, Coronary Artery Bypass Surgery
Comparing Angiomax to Heparin With Protamine Reversal in Patients OPCAB
The purpose of this study is to examine the safety and efficacy of Angiomax as an alternative anticoagulant to heparin with protamine reversal in patients undergoing off-pump coronary artery bypass graft surgery.
- Trial name
- OPCAB (NCT00073593)
- Testing
- Bivalirudin, Heparin, Protamine
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Medicines Company
Renal Insufficiency, Acute, Cardiac Surgery Associated - Acute Kidney Injury
Renal Resistive Index in Early Detection of Postoperative Acute Kidney Injury
The primary aim of our study was to investigate the role of renal doppler ultrasonography (USG) and preoperative/postoperative renal resistive index (RRI) in the early prediction of AKI.
- Trial name
- NCT06791304
- Where
- Turkey (Türkiye)
- Volunteers
- 143 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Coronary Artery Disease, Cardiopulmonary Bypass
Propofol Pharmacokinetics and Pharmacodynamics During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) is known to alter pharmacokinetics (PK) and brain sensitivity to several drugs, including propofol.
- Conditions
- Coronary Artery Disease, Cardiopulmonary Bypass, Coronary Artery Bypass Graft
- Trial name
- NCT00622791
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Coronary Heart Disease
Statin for Depression in Patients Undergoing Coronary Artery Bypass Graft
Depression is frequently observed in patients with coronary heart disease (CHD) and represents a significant risk factor for major cardiovascular events.
- Trial name
- Stress CABG (NCT01624857)
- Testing
- Rosuvastatin
- Where
- China
- Volunteers
- 400 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease, Aortic Valve Disease
Comparison of Priming Constituents in Patients Undergoing CPB Assisted Cardiac Surgery: HES 130/0.4 or Albumin 5%
The purpose of the study is to determine which priming fluid is the safest for use for priming the heart-lung machine used during cardiopulmonary bypass for patients undergoing cardiac surgery.
- Conditions
- Coronary Artery Disease, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- NCT01849757
- Testing
- prime crystalloid, Human Albumin, Voluven
- Where
- Canada
- Sponsor
- University of Saskatchewan
Infection Due to Coronary Artery Bypass Graft (Diagnosis)
Surgical Wound Infection Prevention Bundle in Patients Undergoing Coronary Bypass Graft Surgery
estimate the utilization of locally customized surgical wound infection bundle to prevent and or control of infection in patients undergoing CABG surgery in Sohag
- Trial name
- NCT07003750
- Testing
- Surgical wound infection prevention bundle
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
Coronary Artery Disease
Ten-Year Outcomes of PRE-COMBAT Trial
This study evaluates Ten-Year Outcomes of PREmier of Randomized Comparison of Sirolimus-Eluting Stent Implantation Versus Coronary Artery Bypass Surgery for Unprotected Left Main Coronary Artery Stenosis(PRECOMBAT trial).
- Trial name
- PRECOMBAT (NCT03871127)
- Testing
- Percutaneous coronary intervention, coronary artery bypass graft
- Where
- 9 sites in South Korea
- Volunteers
- 600 people
- Sponsor
- Seung-Jung Park
Coronary Artery Bypass Grafting, Hypotension
The PRESSURE CABG Cardiac Surgery Trial
This study will be a pragmatic, prospective, single-centre, unit-based cluster crossover, open-label registry trial. The cardiac surgical intensive care unit (CSICU) will be cluster assigned to alternating MAP targets in 6-month…
- Trial name
- PRESSURECABG (NCT04197700)
- Testing
- Target MAP Management
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University of Alberta
Coronary Artery Bypass Grafting (CABG)
Improving the Quality of Coronary Artery Bypass Grafting
This is a healthcare quality improvement study focused on increasing the utilization of arterial grafts in isolated coronary artery bypass grafting (CABG).
- Trial name
- CABG Quality (NCT07377149)
- Testing
- Interventions for healthcare professionals in hospitals with low usage rates, Interventions for healthcare professionals in hospitals with high usage rates
- Volunteers
- 8,700 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease, Percutaneous Coronary Intervention
Cloud-based ECG Monitoring and Healthcare Model Building on the Population With Coronary Artery Revascularization
Percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) are the golden treatments for stable coronary artery disease (CAD) combined with heart failure (HF).
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Coronary Artery Bypass Graft
- Trial name
- NCT04485143
- Testing
- Wisdom bracelet
- Volunteers
- 700 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Coronary Artery Bypass Graft (CABG), Cardioplegia
Cardioplegic Protection of the Heart
This study seek to compare two different solutions used to protect the heart during cardiac surgery. 40 adult patients planned for coronary artery bypass surgery with cardiopulmonary bypass machine assistance will be included in…
- Conditions
- Coronary Artery Bypass Graft (CABG), Cardioplegia, Cardiopulmonary Bypass, Perioperative Myocardial Injury
- Trial name
- NCT07386990
- Testing
- Modified Buckberg cardioplegic solution, Modified St Thomas´ cardioplegic solution
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Cardiac Surgery, Peri Operative Medicine
Risk Factors of Atrial Fibrillation After Cardiac Surgery
Supraventricular arrhythmias complicate more than 40% of cardiac surgeries and are associated with an increased risk of bleeding, stroke, heart failure, and death.
- Conditions
- Cardiac Surgery, Peri Operative Medicine, Thoracic Surgery, Cardiopulmonary Bypass
- Trial name
- PFAS (NCT07625033)
- Where
- France
- Volunteers
- 918 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Heart Disease, Ischemic Heart Disease
Stem Cell Injection to Treat Heart Damage During Open Heart Surgery
Background: Bone marrow stromal stem cells (also known as mesenchymal stem cells) have been isolated and are found to make large amounts of growth factors.
- Conditions
- Heart Disease, Ischemic Heart Disease, Coronary Artery Disease, Coronary Artery Disease (CAD)
- Trial name
- NCT01557543
- Testing
- Cell Therapy
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Anemia, Renal Impairment
Blood Products in Cardiac Surgery
Blood transfusion is a common procedure essential for the treatment of patients undergoing cardiac surgery. Inappropriate transfusions, however, not only incur needless healthcare costs, but increase unnecessary risks due to…
- Conditions
- Anemia, Renal Impairment, Thrombocytopenia
- Trial name
- BiCS (NCT02068755)
- Volunteers
- 31,000 people
- Sponsor
- University of Turku
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