Clinical trials: Coronary Atherosclerosis
Coronary Artery Disease
Quantification of Myocardial Blood Flow Using Dynamic PET/CTA Fused Imagery
This observational prospective clinical study is to develop software tools to fuse coronary anatomy data obtained from CT coronary angiography with dynamic PET data to noninvasively measure absolute myocardial blood flow, flow…
- Trial name
- NCT04221594
- Testing
- Invasive Cardiac Catheterization (ICA), Coronary Computed Tomographic Angiogram (CCTA), Dynamic Cardiac Positron Emission Tomography (dPET)
- Where
- 6 sites in United States, South Korea
- Volunteers
- 68 people
- Sponsor
- Emory University
Coronary Artery Disease
Evaluation of a Thin Strut Metallic Stent: the Elixir DynamX Clinical Study
The DynamX (Bioadaptor) study is a prospective, consecutive enrollment study designed to enroll up to 50 patients requiring treatment of a single, de novo lesion ≤ 24 mm in length located in a vessel ≥ 2.5 mm and ≤ 3.5 mm in…
- Trial name
- NCT03429894
- Testing
- Percutaneous Coronary Intervention
- Where
- 2 sites in Belgium, Italy
- Volunteers
- 50 people
- Sponsor
- Elixir Medical Corporation
Coronary Heart Disease, Smoking Cessation
Health Education and Counseling in Smoking Cessation Behavior, Smoking Decisional Balance, and Self-efficacy
Most male smokers with coronary heart disease resume smoking after hospital discharge. The main reason for failure to quit smoking is lack of motivation.
- Conditions
- Coronary Heart Disease, Smoking Cessation, Smoking Behaviors
- Trial name
- NCT05905666
- Testing
- health education and counseling
- Where
- Taiwan
- Volunteers
- 108 people
- Sponsor
- Taipei Medical University WanFang Hospital
Coronary Heart Disease, Stroke
Heart Disease on the Mend
The primary objective of this study was to evaluate the effectiveness of a multifactor cardiovascular disease (CVD) risk reduction program using team case management in high risk patients who have low family incomes and limited…
- Conditions
- Coronary Heart Disease, Stroke, Hyperlipidemia, Hypertension
- Trial name
- NCT00127751
- Testing
- Enhance health lifestyle changes and medication compliance
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Stanford University
Acute Coronary Syndrome, Type 2 Diabetes
A Phase 2 Study to Determine the Effects of BXT-51072 in Diabetic Patients Undergoing Angioplasty (PCI)
The purpose of this study is to determine the safety and feasibility of BXT-51072 as a cardioprotective agent in diabetics undergoing elective angioplasty / percutaneous intervention (PCI), a procedure to "open" coronary…
- Trial name
- NCT00320502
- Testing
- BXT-51072
- Where
- 4 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Synvista Therapeutics, Inc
Stable Coronary Artery Disease
Impact of Intensive Exercise Training on Coronary Collateral Circulation in Patients With Stable CAD
Exercise training in patients with coronary artery disease is able to correct several risk factors. Furthermore endothelial function can be improved.
- Trial name
- NCT01209637
- Testing
- exercise training, Intensive exercise training
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Leipzig
Coronary Restenosis
Trial of a Novel Paclitaxel-coated Balloon With Citrate Excipient for Restenosis in -Limus Analogue DES
Hypothesis: Angioplasty with a novel paclitaxel-coated balloon (PCB; Agent, Boston Scientific) with citrate-based excipient will be non-inferior to conventional paclitaxel-coated balloon with iopromide excipient (PCB) for the…
- Trial name
- ISAR-DESIRE 3A (NCT02367495)
- Testing
- PCB
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Coronary Disease
Study of Otamixaban Versus Unfractionated Heparin (UFH) and Eptifibatide in Non-ST Elevation Acute Coronary Syndrome
Primary objective: To demonstrate the clinical efficacy of otamixaban (dose effect via 5 intravenous [IV] regimens) in patients with moderate-to-high-risk non-ST elevation acute coronary syndromes (ACS) and planned early invasive…
- Trial name
- SEPIA-ACS1 (NCT00317395)
- Testing
- Otamixaban (XRP0673), unfractionated heparin, eptifibatide
- Where
- 36 sites in United States, Argentina and 34 more
- Volunteers
- 3,241 people
- Sponsor
- Sanofi
Angina Pectoris, Stable
Effects of Ivabradine on Residual Myocardial Ischemia After PCI
This is a randomized pharmacological study evaluating the effects of ivabradine in patients with residual angina after PCI. The role of ivabradine in patients with angina, without systolic dysfunction, is not yet clear.
- Trial name
- NCT03866395
- Testing
- Ivabradine
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Azienda Policlinico Umberto I
Non-ST-segment Elevation Myocardial Infarction, Chronic Kidney Disease
Optimised Procedure in Patients With NSTEMI and CKD
Aim of the study is the determination of the ideal timepoint for the treatment of patients with acute Non-ST-segment Elevation Myocardial Infarction (NSTEMI) and an acute or chronic kidney disease (CKD) with a GRACE score < 140.
- Trial name
- NSTEMI-CKD (NCT02543177)
- Testing
- coronary angiography, ischemic precondition, prior kidney irrigation
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- RWTH Aachen University
Acute Coronary Syndrome
Guided Optimisation of Long-term Disease rEduction in secoNdary Prevention of CVD
The goal of this observational study is to evaluate the implementation of a 'first-time-right' pharmacological treatment strategy in patients hospitalized with coronary artery disease.
- Trial name
- GOLDEN (NCT06637657)
- Testing
- No intervention (observational study)
- Where
- Netherlands
- Volunteers
- 5,586 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Coronary Artery Disease
Different Platelet Activities Between Intracoronary and Peripheral Blood in Coronary Artery Disease Patients
Antiplatelet treatment is important for coronary artery disease(CAD) patients .Some patients are resistant to antiplatelet treatment based on platelet function tests(PFT).Currently the results of PFT are mainly based on the…
- Trial name
- DPABIAP (NCT03078257)
- Testing
- tirofiban in PV, tirofiban in IC, antiplatelet thrombolysin
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
ST-elevation Myocardial Infarction (STEMI)
Use of BVS in ST-segment Elevation Myocardial Infarction (STEMI): the BVS STEMI STRATEGY-IT Prospective Registry
BVS STEMI STRATEGY-IT is a spontaneous, prospective, non-randomized, single-arm multicenter registry on consecutive STEMI patients eligible to undergo primary percutaneous coronary intervention (PPCI) with BVS implantation on the…
- Trial name
- STRATEGY-IT (NCT02601781)
- Testing
- Primary percutaneous coronary intervention (PPCI), Bioresorbable Vascular Scaffold (BVS ABSORB)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Azienda Ospedaliera Bolognini di Seriate Bergamo
Ischemic Heart Disease
Hyperbaric Oxygen Therapy in Patients With Chronic Stable Ischemic Heart Disease: An Option for Therapeutic Angiogenesis?
Hyperbaric oxygen therapy (HBOT) is proposed as a possible in vivo angiogenic stimulator for improving microvascular myocardial perfusion and anginal symptoms as assessed by myocardial perfusion imaging and angina questionnaire…
- Trial name
- NCT02760394
- Testing
- HBOT
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Assaf Harofeh MC
Coronary Artery Disease
Diagnostic Accuracy of Quantitative Flow Ratio
The aim of this study was to investigate the accuracy of quantitative flow ratio (QFR) for predicting fractional flow reserve (FFR) ≤0.80 in an independent core laboratory.
- Trial name
- NCT06305572
- Testing
- QFR
- Where
- South Korea
- Volunteers
- 280 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease, Diabetes
Clinical Trial of Abluminus DES+ Sirolimus Eluting Stent Versus Everolimus-eluting DES
The objective of the study is to compare angiographic and clinical performance of Abluminus DES+ versus Everolimus-eluting DES in patients with diabetes mellitus.
- Trial name
- NCT03399994
- Testing
- device implantation during coronary angioplasty
- Where
- 6 sites in Italy
- Volunteers
- 137 people
- Sponsor
- Fondazione Evidence per Attività e Ricerche Cardiovascolari ONLUS
Atrial Fibrillation
Fish Oil for Reduction of Atrial Fibrillation After Cardiac Surgery
The primary objective of this study is to determine if omega-3 polyunsaturated fatty acids reduce atrial fibrillation and other outcomes after cardiac surgery.
- Trial name
- FISH (NCT00446966)
- Testing
- Omega Three Polyunsaturated fatty acids
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Chirag Sandesara
Shock, Cardiogenic, Heart Failure
Effects of Pyruvate in Patients With Cardiogenic Shock and Intra-aortic Balloon Counterpulsation
Pyruvate is an intermediate of energy metabolism and was shown to possess pronounced positive inotropic effects in vitro and in vivo without altering myocardial oxygen consumption.
- Conditions
- Shock, Cardiogenic, Heart Failure, Acute Myocardial Infarction
- Trial name
- NCT00604331
- Testing
- Pyruvate
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Herzzentrum Goettingen
Death, Sudden, Cardiac, HEART ARREST
Blood Management During ECMO for Cardiac Support
Extracorporeal membrane oxygenation (ECMO) is a lifesaving procedure used to treat severe forms of heart and/or lung failure. It works by the principal of replacing the function of these organs by taking blood from the patient…
- Conditions
- Death, Sudden, Cardiac, HEART ARREST, Shock, Cardiogenic, Arrhythmias, Cardiac
- Trial name
- OBLEX (NCT03714048)
- Where
- Australia
- Volunteers
- 561 people
- Sponsor
- St Vincent's Hospital, Sydney
Coronary Artery Disease, Myocardial Ischemia
The Positive Prognostic Value of Stress Echocardiography - AMPHIPOLIS STUDY
This is a prospective, multicenter, observational study of patients with recent stress echocardiography positive for myocardial ischemia.
- Trial name
- AMPHIPOLIS (NCT06839755)
- Where
- Greece
- Volunteers
- 390 people
- Sponsor
- Hellenic Society of Cardiology
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