Clinical trials: Coronary Atherosclerosis
Diabetes Mellitus, Type 2
A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to compare the effect of ticagrelor versus placebo in patients with Type 2 Diabetes Mellitus.
- Trial name
- THEMIS (NCT01991795)
- Testing
- Ticagrelor 60 mg
- Where
- 1,237 sites in United States, Argentina and 41 more
- Volunteers
- 19,271 people
- Sponsor
- AstraZeneca
Myocardial Infarction
AIDAVA G1 LDL-C Substudy Protocol
This retrospective substudy describes low-density lipoprotein cholesterol (LDL-C) changes and treatment-target attainment among patients with previous myocardial infarction who participated in the AIDAVA first-generation (G1)…
- Trial name
- NCT07839845
- Where
- Estonia
- Volunteers
- 37 people
- Sponsor
- North Estonia Medical Centre
Endothelial Dysfunction
Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Progenitor Cells and Coronary Atherosclerosis in Humans
AIM III is a prospective, randomized, double-blinded, placebo controlled trial. The study is directly connected to IRB 08-008161 as a specific aim of the National Institute of Health (NIH) grant.
- Trial name
- NCT01067339
- Testing
- darapladib
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mayo Clinic
ST Elevation Myocardial Infarction, C-Reactive Protein
CRP Apheresis in STEMI
Background: In patients with acute ST-elevation myocardial infarction (STEMI), the amount of infarcted myocardium (infarct size) is known to be a major predictor for adverse remodeling and recurrent adverse cardiovascular events.
- Conditions
- ST Elevation Myocardial Infarction, C-Reactive Protein, Apheresis, Myocardial Injury
- Trial name
- NCT04939805
- Testing
- Selective CRP apheresis using the PentraSorb®-CRP system
- Where
- 5 sites in Austria, Germany
- Volunteers
- 202 people
- Sponsor
- Medical University Innsbruck
Ischemic Heart Disease
DETErmination of the Duration of the Dual Antiplatelet Therapy by the Degree of the Coverage of The Struts on Optical Coherence Tomography From the Randomized Comparison Between Everolimus-eluting Stents(EES) Versus Biolimus A9-eluting Stents(BES)
The purpose of the study is 1> to compare neointimal stent coverage after OCT-guided vs. Angio-guided PCI, 2> to compare neointimal stent coverage at 3 months after EES vs BES implantation, 3> to determine the duration of dual…
- Trial name
- DETECT-OCT (NCT01752894)
- Testing
- Angio-guided PCI with EES or BES, OCT-guided PCI with EES or BES, PCI with BES under angio-guide or OCT guide
- Where
- South Korea
- Volunteers
- 776 people
- Sponsor
- Yonsei University
Stent Thrombosis, Acute Coronary Syndrome
Stent Thrombosis In Acute Coronary Syndromes
The purpose of this study is to better understand what treatment methods result in the best outcomes for patients who have heart attacks due to blood clots forming within stents.
- Trial name
- NCT00931502
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of California, Davis
Coronary Arterial Disease (CAD)
Reconsidering Long-Term Apirin in the Elderly in Secondary Prevention of Coronary Artery Disease Norway
Lifelong aspirin has been a cornerstone of secondary prevention after coronary artery disease (CAD), based on trials conducted 40-50 years ago.
- Trial name
- RELEASE-Norway (NCT07854795)
- Testing
- Discontinuation of aspirin (ATC-code B01AC06 and N02BA01)
- Where
- 9 sites in Norway
- Volunteers
- 7,000 people
- Sponsor
- Vestre Viken Hospital Trust
Chronic Stable Angina
Study to Assess Efficacy of Nicorandil+Atenolol vs Atenolol in Treatment of Chronic Stable Angina.
This study is to determine the anti-anginal and anti-ischemic effect of k-channel opener, nicorandil in patients of chronic stable angina.
- Trial name
- NCT01397994
- Testing
- Nicorandil, Atenolol
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Ferozsons Laboratories Ltd.
Angina (Stable), INOCA (Ischemia With Non Obstructive Coronary Artery Disease)
Diagnostic and Clinical Management of Non-Obstructive Myocardial Ischemia in Patients With Long Covid-19 Syndrome and New Onset Chest Pain
Long Covid-19 INOCA is an investigator-initiated, prospective, randomized, sham-controlled, single center study. Its objective is to investigate the benefits of tailored medical therapy according to the results of the coronary…
- Conditions
- Angina (Stable), INOCA (Ischemia With Non Obstructive Coronary Artery Disease), Long COVID-19 Syndrome
- Trial name
- NCT07559994
- Testing
- Coronary functional test
- Where
- Spain
- Volunteers
- 108 people
- Sponsor
- Fundacion Investigacion Interhospitalaria Cardiovascular
Coronary Stenosis
Randomized Trial Evaluating Slow-Release Formulation TAXUS Paclitaxel-Eluting Coronary Stents to Treat De Novo Coronary Lesions
The primary objective of this study is to further evaluate the safety and effectiveness of the TAXUS Express2 Paclitaxel-Eluting Coronary Stent System in long lesion lengths, small and large vessel diameters and with multiple…
- Trial name
- NCT00301522
- Testing
- TAXUS Paclitaxel-Eluting Coronary Stent, Slow-Formulation, Express2
- Where
- 72 sites in United States
- Volunteers
- 1,108 people
- Sponsor
- Boston Scientific Corporation
Coronary Artery Disease
Evaluation of Zotarolimus Eluting Stent at 3 Months Using Optical Coherence Tomography
Neointimal coverage over stent strut is important for preventing the stent thrombosis. But, there is no data for the duration of complete formation of neointima om zotarolimus eluting stent (ZES).
- Trial name
- ENDEAVOR OCT (NCT00815139)
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Angina, Stable
Ad5FGF-4 In Patients With Refractory Angina Due to Myocardial Ischemia
The purpose of this study is to determine whether a single intracoronary infusion of an adenovirus serotype 5 virus expressing the gene for human fibroblast growth factor-4 (Ad5FGF-4) is effective in improving angina-limited…
- Trial name
- AFFIRM (NCT02928094)
- Testing
- Ad5FGF-4
- Volunteers
- 160 people
- Sponsor
- Angionetics Inc.
Coronary Microvascular Dysfunction (CMD), Stable Angina Pectoris
A Multi-center, Real-World Clinical Trial of caIMR on Two Specific Kinds of Patients.
The coronary angiography-derived index of microcirculatory resistance (caIMR) can be used to provide a binary assessment whether patients（with stable angina, unstable angina, suspected myocardial ischemia, or coronary artery…
- Conditions
- Coronary Microvascular Dysfunction (CMD), Stable Angina Pectoris, Unstable Angina Pectoris, Myocardial Ischemia, Angina Pectoris
- Trial name
- FlashV (NCT06945094)
- Testing
- caIMR
- Volunteers
- 508 people
- Sponsor
- Ge Junbo
Coronary Artery Disease
Simultaneous Assessment of FFR and SPECT
The overall purpose of this research study is to identify the disparity in ischemia measurement between fractional flow reserve (FFR) used in the cardiac catheterization laboratory and myocardial perfusion stress- single-photon…
- Trial name
- NCT02749045
- Testing
- SPECT imaging
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Prem Soman
Angina Pectoris, Coronary Microvascular Disease
Comprehensive Treatment of Angina in Women With Microvascular Dysfunction
Angina is the most common symptom of coronary heart disease among women but unlike men most women do not have stenosis of the coronary arteries.
- Trial name
- CORA (NCT02910154)
- Testing
- Diet, Training, Medication (with statin and ACE-inhibition)
- Where
- 2 sites in Denmark
- Volunteers
- 62 people
- Sponsor
- Bispebjerg Hospital
Coronary Artery Disease
Optimal Duration of DAPT Following Treatment With Endeavor (Zotarolimus-eluting Stent) in Real-world Japanese Patients
A prospective multicenter registry in real-world Japanese patients undergoing DAPT for three months after stenting. To assess the long-term safety of Endeavor Zotarolimus-eluting stent through noninferiority in the primary…
- Trial name
- OPERA (NCT01325935)
- Testing
- Clopidogrel
- Where
- 112 sites in Japan
- Volunteers
- 1,187 people
- Sponsor
- Associations for Establishment of Evidence in Interventions
ST Elevation Myocardial Infarction, Coronary Stenting
Revascularization StrategIes for ST Elevation Myocardial Infarction Trial
This study is being conducted in patients with a major heart attack caused by a blocked artery undergoing Percutaneous Coronary Intervention (PCI) to open up the blockage.
- Conditions
- ST Elevation Myocardial Infarction, Coronary Stenting, Primary Angioplasty
- Trial name
- ASSIST-MI (NCT03263468)
- Testing
- Same sitting PCI with complete revascularization, Staged PCI with complete revsacularization >48 hours pf primary PCI
- Volunteers
- 3,520 people
- Sponsor
- Unity Health Toronto
Acute Myocardial Infarction
Effects of Percutaneous Coronary Intervention in Patients With Cardiac Arrest After Acute Myocardial Infarction: a 2-Year Study
The purpose of this study is To assess percutaneous coronary intervention 's effect on short- and long- term outcomes, and complication incidence in resuscitated victims of cardiac arrest after acute myocardial infarction
- Trial name
- NCT02576691
- Testing
- percutaneous coronary intervention
- Volunteers
- 2,363 people
- Sponsor
- Yuanli Lei
Coronary Artery Disease, Heart Failure
PULsecath mechanicaL Support Evaluation
The objective of this study is to determine ventricular loading conditions during and after PulseCath® iVAC2L support, and assess its impact on specific load dependent humoral factors and cardiac enzymes.
- Conditions
- Coronary Artery Disease, Heart Failure, Cardiogenic Shock
- Trial name
- PULSE (NCT03200990)
- Testing
- iVAC2L pVAD
- Where
- 3 sites in France, Netherlands and 1 more
- Volunteers
- 32 people
- Sponsor
- Erasmus Medical Center
Heart Failure, Coronary Artery Disease
IMAGE-HF Project I-A: Cardiac Imaging in Ischemic Heart Failure (AIMI-HF)
Medical imaging is one of the fastest growing sectors in health care and increases in utilization underscore the need to ensure imaging technology is developed and used effectively.
- Conditions
- Heart Failure, Coronary Artery Disease, Ischemic Cardiomyopathy
- Trial name
- AIMI-HF (NCT01288560)
- Testing
- Advanced cardiac imaging, Standard Cardiac Imaging
- Where
- 20 sites in United States, Argentina and 3 more
- Volunteers
- 1,390 people
- Sponsor
- Ottawa Heart Institute Research Corporation
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