Clinical trials: Coronary Bifurcations
Coronary Stenosis
Bifurcation Stenting Using 2 Link Stent Nobori Versus 3 Link Stent Xience
The primary objective of this study is to make a comparison of safety and efficacy of DESs with different link number (2-link Nobori and 3-link Xience) in patients with de novo true bifurcation lesions.
- Trial name
- BEGIN (NCT01574586)
- Testing
- Bifurcation stenting
- Where
- Japan
- Volunteers
- 240 people
- Sponsor
- Kurashiki Central Hospital
Coronary Angiography
Predilation of Side Branch During Percutaneous Treatment of Bifurcation Lesions With Provisional T Stenting
Percutaneous treatment of bifurcation lesion is a complex procedure. After main vessel stent implantation, the side branch became jailed and the carina can be displaced resulting in complete occlusion of this vessel.
- Trial name
- NCT01090856
- Testing
- Pre-dilation side branch
- Where
- Spain
- Volunteers
- 420 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
In-stent Coronary Artery Restenosis
Prognostic Assessment of Different Pattern of Bifurcation Restenosis
The LATINA registry aims at assessing a new classification of bifurcation restenosis in the prediction of major adverse cardiac events in patients who have previously undergone a succesful percutaneous bifurcation intervention.
- Trial name
- LATINA (NCT01411475)
- Testing
- Bifurcation restenosis classification
- Where
- 2 sites in Italy
- Sponsor
- Ospedale Santa Maria Goretti
Coronary Bifurcation Lesions
Optical Coherence Tomography (OCT) Findings and Coronary Bifurcation Lesions
To determine the clinical prevalence of vulnerable plaque using OCT in patients with coronary bifurcation lesion.
- Trial name
- NCT03172845
- Testing
- percutaneous coronary intervention
- Where
- China
- Volunteers
- 304 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Bifurcation Lesion, Coronary Artery Disease
INSPIRON Sirolimus Eluting Stent Performance in Bifurcation Coronary Arteries Treated Using Provisional Technique
Evaluate the efficacy of the Inspiron Sirolimus Eluting Stent on bifurcation coronary artery lesions, in order to preserve and not compromize the side branch using the provisional stent technique.
- Trial name
- insProvisional (NCT03780192)
- Testing
- Inspiron Sirolimus Eluting Stent
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Scitech Produtos Medicos SA
Coronary Artery Disease, Myocardial Ischemia
AngioSculpt® Coronary Bifurcation Study
The purpose of this study is to evaluate a new angioplasty catheter, AngioSculpt® for the treatment of bifurcation lesions (blockages occurring at branch points) in coronary arteries.
- Trial name
- AGILITY (NCT00686647)
- Testing
- AngioSculpt® Scoring Balloon Catheter, AngioSculpt Scoring Balloon Catheter
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- AngioScore, Inc.
Atherosclerosis, Coronary
Fluid-dynamics in Bifurcation PCI
Investigator-initiated, international, multicentre, observational study with two cohorts. The two study cohorts will be: Cohort A: to understand if the local blood flow patterns (associated with low WSS), as evaluated by…
- Trial name
- FORECAST (NCT03174418)
- Testing
- Coronary angiography and optical coherence tomography
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Catholic University of the Sacred Heart
Ischemic Heart Disease
Comparison of Results Achieved by Different Ballooning Techniques in Bifurcation Stenting
Single-stent strategy with provisional approach represents the gold standard for percutaneous coronary intervention of bifurcation lesions, and, according to European Bifurcation Club, performing provisional approach presents two…
- Trial name
- CRABBIS (NCT05559424)
- Testing
- OCT
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Catholic University of the Sacred Heart
Coronary Diseases, Left Main Coronary Artery Disease
Clinical Efficacy and Safety of a Prospective, Multicenter Drug Coated Balloon for Left Main Artery Disease in China
This is a prospective and observational study. Patients with primary mediana 010 or 001 left main bifurcation lesions were treated with drug ball coated balloon from November 2018 to November 2020 in four hospitals in Huaihai…
- Conditions
- Coronary Diseases, Left Main Coronary Artery Disease, Bifurcation Lesions
- Trial name
- NCT04641468
- Testing
- DCB
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xuzhou Third People's Hospital
Ischemic Heart Disease, Restenosis
Treatment of Bifurcation Lesions by SINGLE STENT and KISSing Balloon Trial
The use of DES have not diminished the need of improved treatment strategies , especially the treatment of bifurcation lesions still leave much to be clarified.
- Trial name
- SINGLEKISS (NCT00798954)
- Testing
- Sirolimus-eluting coronary stent (Cypher), Paclitaxel-eluting stent (TAXUS)
- Where
- 17 sites in Japan
- Volunteers
- 800 people
- Sponsor
- Vulnerable Plaque Society
Coronary Bifurcation Lesions
ACOART SCB BIF: Treatment of Coronary Bifurcation Lesion by Sirolimus Coated Balloon vs Paclitaxel Coated Balloon
The aim of this randomized controlled trial is to examine the treatment of coronary bifurcation lesion with a sirolimus coated balloon versus a paclitaxel coated balloon.
- Trial name
- NCT04899583
- Testing
- Sirolimus Coated Balloon Catheter, a Paclitaxel Coated Balloon Catheter
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Acotec Scientific Co., Ltd
Coronary Artery Disease
Modified Jailed Balloon Technique vs Jailed Wire Technique in Coronary Bifurcation Intervention
Randomized clinical trial between jailed wire technique and modified jailed balloon technique. Both are techniques designed to protect side branches during provisional bifurcation stenting.
- Trial name
- NCT07873879
- Testing
- jailed wire technique, Modified jailed balloon technique
- Volunteers
- 140 people
- Sponsor
- Assiut University
Left Main Coronary Artery Disease
Mini Crush or Double Kissing Crush Stenting Techniques For Complex Left Main Bifurcation Lesions
The Crush technique has evolved significantly since its introduction to the literature by Colombo et al in 2003, with multiple iterations including mini-crush (MC) and double kissing-crush (DKC) stenting techniques.
- Trial name
- NCT06546748
- Where
- Turkey (Türkiye)
- Volunteers
- 531 people, healthy volunteers welcome
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention (PCI)
Double Kissing-crush vs Controlled Balloon-crush Techniques For Complex Coronary Bfurcation Lesions
The Crush technique for coronary bifurcation lesions has evolved significantly since its introduction to the literature by Colombo et al. in 2003, with several iterations, including double kissing balloon inflation.
- Conditions
- Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention (PCI), Bifurcation Coronary Disease
- Trial name
- NCT06931574
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
CAD
Safety and Efficacy of the DEVOIR Sirolimus-Coated Coronary Balloon in the Real-world Clinical Practice
The study is a prospective, non-randomized, multicenter, post-marketing surveillance study evaluating the CE-marked DEVOIR Sirolimus-Coated Coronary Balloon in 4 subgroups regarding device approved indications: In-stent…
- Trial name
- NCT02853994
- Volunteers
- 500 people
- Sponsor
- MINVASYS
Coronary Disease
Keep bIfurcation Single Stenting Simple
KISS study is an investigator-initiated, multi-centre, prospective, randomized (1:1), parallel, two-arm, non-inferiority trial aiming to compare two bifurcation PCI procedures for Side Branch protection
- Trial name
- KISS (NCT04285372)
- Testing
- Side branch protection/ballooning, No side branch protection/ballooning
- Where
- 20 sites in France, Italy and 4 more
- Volunteers
- 596 people
- Sponsor
- Ceric Sàrl
Coronary Artery Disease, Chronic Total Occlusion of Coronary Artery
DYNAMX Bioadaptor ImplanTation for the trEatment of Complex Coronary Lesions
The aim of the DYNAMITE study is to investigate the (a) acute procedural and (b) 9-month follow-up performance of DynamX Drug-Eluting Coronary Bioadaptor System implantation in complex coronary lesions.
- Conditions
- Coronary Artery Disease, Chronic Total Occlusion of Coronary Artery, Bifurcation of Coronary Artery, Multi Vessel Coronary Artery Disease
- Trial name
- DYNAMITE (NCT05464147)
- Testing
- DynamX Drug-Eluting Coronary Bioadaptor System
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Elixir Medical Corporation
Myocardial Ischemia, Ischemia
Bifurcation ABSORB OCT Trial
The Bifurcation ABSORB OCT Trial is a prospective, randomized (1:1) evaluation of the efficacy and performance of single ABSORB everolimus eluting bioresorbable vascular scaffold provisional strategy in the treatment of (a)…
- Conditions
- Myocardial Ischemia, Ischemia, Coronary Disease, Heart Diseases
- Trial name
- BISORB OCT (NCT02928198)
- Testing
- ABSORB BVS
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- J.J. Wykrzykowska
Stable Angina, Unstable Angina
Assessment of Diagonal Branch Territory
This study was performed to investigate the anatomical attributes that determine myocardial territory of diagonal branches and to develop a prediction model for clinically relevant branches using myocardial perfusion imaging…
- Trial name
- NCT03935542
- Where
- South Korea
- Volunteers
- 355 people
- Sponsor
- Bon-Kwon Koo
Coronary Artery Disease, Coronary Stenosis
Ultrathin DES in Complex PCI Scenarios: the ULTRA a Multicenter Study
ULTRA is a multicenter, observational, retrospective registry, enrolling consecutive patients treated with ultrathin coronary DES (coronary stent with strut thickness < 70 um) for coronary bifurcation lesions, left main disease…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Stent Restenosis, Left Main Coronary Artery Disease
- Trial name
- ULTRA (NCT05205148)
- Testing
- Percutaneous coronary intervention with the following platforms: Orsiro; Mistent; BioMime; Supraflex Cruz
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- A.O.U. Città della Salute e della Scienza