Clinical trials: Coronary Calcified Disease
Aortic Valve Stenosis
The Effect of Lipitor on Aortic Stenosis
The purpose of this study is to find out if an approved medicine that is used to lower cholesterol called Lipitor can slow or stop progressive narrowing of the aortic heart valve in patients with a condition called aortic…
- Trial name
- NCT00590135
- Testing
- atorvastatin (Lipitor)
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- The Cleveland Clinic
Cardiovascular Disease
Biological Phosphocalcic Metabolism and Coronary Artery Calcifications
Study a sample of patients in primary prevention, moderate cardiovascular risk (n = 83 patients), with normal, non-diabetic renal function.
- Trial name
- BIOCAC (NCT02792868)
- Testing
- 24 h urines analyses
- Where
- France
- Volunteers
- 83 people
- Sponsor
- French Cardiology Society
Cardiovascular Disease, Atherosclerosis
Cardiovascular Molecular Calcification Assessed by 18F-NaF PET CT
The purpose of the CAMONA study is to demonstrate the feasibility of cardiovascular molecular calcification (CMC) assessment by means of 18F-sodium-fluoride (18F-NaF) positron emission tomography (PET) computed tomography (CT) in…
- Conditions
- Cardiovascular Disease, Atherosclerosis, Angina Pectoris
- Trial name
- CAMONA (NCT01724749)
- Where
- 2 sites in Denmark
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Aortic Valve Stenosis, AV Block
Edwards SAPIEN 3 PPI Registry
There are patient related risk factors for PPI that can be identified and assessed in retrospective pooling of 1000+ TAVI patient datasets.
- Conditions
- Aortic Valve Stenosis, AV Block, Bundle-Branch Block
- Trial name
- Conduct (NCT03497611)
- Testing
- transcatheter valve implantation
- Where
- 4 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Coronary Disease, Cardiovascular Diseases
Epidemiology of Breast Arterial Calcification
To test the hypothesis that breast arterial calcification (BAC) seen on mammograms can identify women with an increased risk of coronary artery disease (CAD).
- Conditions
- Coronary Disease, Cardiovascular Diseases, Heart Diseases
- Trial name
- NCT00091780
- Sponsor
- Mayo Clinic
Coronary Artery Disease (CAD), Calcific Coronary Arteriosclerosis
Overviewing Real-World Outcomes to Boost Interventional Management of CAlcified Coronary Lesions: the OROBICA Registry.
The OROBICA (Overviewing Real-World Outcomes to Boost Interventional Management of CAlcified Coronary Lesions) Registry is a multicenter, ambispective, real-world observational study designed to evaluate clinical, procedural…
- Conditions
- Coronary Artery Disease (CAD), Calcific Coronary Arteriosclerosis, Intravascular Lithotripsy; Rotational Atherectomy; OFDI, Orbital Atherectomy
- Trial name
- OROBICA (NCT07566403)
- Testing
- Percutaneous coronary intervention with or without stent implantation
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- Papa Giovanni XXIII Hospital
Aortic Stenosis, Aortic Valve Disease
Role of Aortic Valve Composition in Pathophysiology and Diagnosis of Aortic Stenosis
The study aims to evaluate composition differences of aortic valves in different stages and phenotypes of aortic stenosis using non-invasive imaging and histology.
- Conditions
- Aortic Stenosis, Aortic Valve Disease, Aortic Valve Calcification
- Trial name
- COMP-AS (NCT06136689)
- Where
- 2 sites in Poland
- Volunteers
- 55 people
- Sponsor
- Medical University of Warsaw
Aortic Stenosis, Aortic Sclerosis
Risk Factors Associated With Calcification of the Aortic Valve
The purpose of this study is to determine the degree of endothelial dysfunction and inflammation in calcific aortic valve disease associated with coronary artery disease(CAD).
- Trial name
- NCT00375336
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- Charles University, Czech Republic
AORTIC VALVE DISEASES, Calcification; Heart
Molecular Imaging to Identify Predictors of Aortic Valve Disease Activity
This is a prospective study that aims to develop clinical calculators that will report on the underlying rate of aortic valve calcification.
- Trial name
- NCT07819344
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease
Comparison of DCB and DES for Severe Calcification of de Novo Lesion in Elderly CHD
The goal of this clinical trial was to compare the effectiveness of drug balloons versus drug-coated stents in calcified lesions in elderly coronary artery disease.
- Trial name
- NCT05750771
- Testing
- DES, DCB
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Coronary Artery Disease, Coronary Artery Calcification
Coronary Artery Calcification Assessed on PET Scanner (PET : Positron Emission Tomography)
Calcification artery calcium (CAC) scoring is a valuable tool for determining the risk of major adverse cardiac events. It was found that CAC can be quantitatively assessed, by manual scoring or using deep-learning, on low-dose…
- Trial name
- CALCOTEP (NCT06379295)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Aortic Valve Stenosis, Aortic Valve Calcification
REpositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus™ Valve SystEm
This is a prospective, single-arm feasibility study designed to assess the acute safety and performance of the Lotus Valve System for transcatheter aortic valve replacement in symptomatic patients with calcified aortic valve…
- Conditions
- Aortic Valve Stenosis, Aortic Valve Calcification, Aortic Valve Disease
- Trial name
- REPRISE I (NCT01383720)
- Testing
- Lotus Valve System
- Where
- 3 sites in Australia
- Volunteers
- 11 people
- Sponsor
- Boston Scientific Corporation
Aortic Valve Stenosis, Multidetector Computed Tomography
The Aortic Valve DECalcification (AVADEC) Trial
Aortic stenosis is a common heart valve disease and due to the growing elderly population the prevalence is increasing. The disease is progressive with increasing calcification of the valve cusps.
- Conditions
- Aortic Valve Stenosis, Multidetector Computed Tomography, Vitamin K 2, Randomised Clinical Trial
- Trial name
- AVADEC (NCT03243890)
- Testing
- Menaquinone-7 720 µg/day including the recommended daily dose of vitamin D (25 µg/day).
- Where
- Denmark
- Volunteers
- 389 people
- Sponsor
- Axel Diederichsen
Coronary Artery Disease
IVUS-guided DES Implantation in Coronary Calcification
Coronary calcified lesion is associated with a poor clinical outcome. Intravascular ultrasound (IVUS) provides anatomic information in detail about reference vessel dimensions and lesion characteristics including severity of…
- Trial name
- ULTIMATE IV (NCT05800002)
- Testing
- Intravascular ultrasound, Angiography
- Where
- China
- Volunteers
- 864 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Atherosclerosis
Examining the Genetic Predictors of Coronary Artery Calcification in African Americans
Coronary artery disease (CAD) is an important health concern for African Americans, who are diagnosed with CAD at high rates. Coronary artery calcification, which is characterized by calcium deposits in the coronary arteries, is…
- Trial name
- NCT00925561
- Where
- United States
- Volunteers
- 752 people
- Sponsor
- University of Michigan
Renal Transplant
Effects of Zortress® + Tacrolimus vs. Standard Immunosuppression on Progression of Coronary Artery Calcifications and Bone Disease in de Novo Renal Transplant Recipients
Primary objectives: A. To evaluate the effect of Zortress® versus standard immunosuppression therapy on progression of CAC as evidenced by changes in Agatston scores from baseline and at 6, and 12 months in renal transplantation…
- Trial name
- NCT01612299
- Testing
- Zortress® /Everolimus
- Where
- United States
- Sponsor
- University of Kentucky
Chronic Kidney Disease, Vitamin D Deficiency
Effect of Vitamin D Supplementation on Coronary Calcification and Parathyroid Hormone in CKD Patients
The investigators hypothesize that the chronic kidney disease patients who suffer from vitamin D deficiency will be benefit from given Vitamin D2 because coronary artery calcification and hyperparathyroidism will be improved.
- Trial name
- EVIDENCE (NCT01672047)
- Testing
- Vitamin D2
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Peking University People's Hospital
Coronary Artery Calcification, Cardiovascular Risk
Artificial Intelligence - Based Opportunistic Coronary Artery Calcium Scoring on Routine Chest-CT Scan
This retrospective, non-interventional study externally validates a pre-trained open-weight deep-learning algorithm (Swin-UNETR) for the opportunistic quantification of coronary artery calcium (CAC) on non-gated routine chest CT…
- Conditions
- Coronary Artery Calcification, Cardiovascular Risk, Coronary Artery Disease, End-Stage Renal Disease Requiring Haemodialysis
- Trial name
- NCT07808593
- Volunteers
- 1,950 people
- Sponsor
- University of Cologne
Cardiovascular Diseases, Coronary Disease
Coronary Calcification Progression Study
To investigate use of Fast Gated Helical Computed Tomography (FGHCT) measures of coronary artery calcium (CAC), FGHCT-CAC, for discrimination of coronary artery disease (CAD) and to quantify progression of coronary artery calcium…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases
- Trial name
- NCT00006526
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aortic Valve Disease, Valve Heart Disease
Freestyle-Perimount Calcification Comparison
The aim of this study is to evaluate the rate and anatomy of the aortic wall and leaflet calcification of the FS prosthesis implanted as full root in patients younger than 60 years compared to a stented bioprostheses (Perimount…
- Trial name
- NCT04359030
- Testing
- Multislice CT scanning for aortic wall calcification, Transthoracic stress echocardiography
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Ziekenhuis Oost-Limburg