Clinical trials: Coronary Computed Tomography Angiography
Chronic Total Occlusion of Coronary Artery, Calcification
Calcification on CTCA of a CTO and PCI Outcomes
A chronic total occlusion (CTO) is present in 15-20% of patients who are referred for invasive coronary angiography. CTO Percutaneous Coronary Intervention (PCI) procedure success rates have increased over the years and can be as…
- Conditions
- Chronic Total Occlusion of Coronary Artery, Calcification, Computed Tomography Angiography
- Trial name
- NCT06414551
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Myocardial Injury
A CCTA Guided Management Strategy Versus a Standard of Care Strategy in Type 2 NSTEMI
This study design is a prospective randomized control trial to compare outcomes between the utilization of coronary computed tomography angiography (CCTA) vs conservative treatment in type 2 NSTEMI.
- Trial name
- NCT06382402
- Testing
- CCTA scan
- Where
- United States
- Sponsor
- University of Louisville
Coronary Artery Disease
Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease
The primary hypothesis is that computed tomography (CT) is superior to invasive coronary angiography (ICA) concerning the primary endpoint MACE (MACE = major adverse cardiovascular event; defined as at least one of the following…
- Trial name
- DISCHARGE (NCT02400229)
- Testing
- Computed tomography angiography (cardiac CT), Invasive coronary angiography (ICA)
- Where
- 20 sites in Austria, Czechia and 13 more
- Volunteers
- 3,546 people
- Sponsor
- Charite University, Berlin, Germany
Coronary Artery Disease, Coronary Computed Tomographic Angiography
PUMCH Study Into Individualized Scanning for Coronary Artery Disease
Cardiac computed tomographic angiography (CCTA) is a non-invasive diagnostic imaging technique for visualization of the coronary arteries and thus, frequently used in the evaluation of coronary artery disease (CAD).
- Trial name
- COE (NCT05497466)
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Coronary Artery Disease, Aortic Aneurysm
Computed Tomography Dose Reduction Using Sequential or Fast Pitch Sprial Technique
This is a prospective, controlled observational trial of patients undergoing clinically indicated cardiothoracic computed tomography (CT), including pulmonary or aortic angiography and coronary CT angiography (CCTA).
- Conditions
- Coronary Artery Disease, Aortic Aneurysm, Pulmonary Embolism
- Trial name
- CTDOSE (NCT01272453)
- Where
- 9 sites in United States, Saudi Arabia
- Volunteers
- 2,640 people
- Sponsor
- Gilbert L. Raff, MD
Computed Tomography Angiography, Coronary Artery Disease
Detection of Proximal Coronary Artery Disease in the Work-up for Transcatheter Aortic Valve Implantation Using CTA (From the DEPICT CTA Database)
Background: Computed tomography angiography (CTA) is already used in the work-up for transcatheter aortic valve implantation (TAVI) and could partially replace invasive coronary angiography (CAG) to rule out proximal coronary…
- Conditions
- Computed Tomography Angiography, Coronary Artery Disease, Coronary Angriography, Aortic Valve Disease
- Trial name
- DEPICT CTA (NCT04491513)
- Testing
- Computed tomography angiography
- Where
- Netherlands
- Volunteers
- 1,060 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Aortic Aneurysm
Patient Tailored Contrast Volume for Preoperative CT Angiography of the Aorta
An in-house calculator was developed to calculate the appropriate contrast dose, rather than standardly administering a 120ml dose.
- Trial name
- NCT05716568
- Testing
- Contrast dose reduction, CT-angiography
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronary, Coronary Artery Disease
CAPRA-EVO: a Randomized Serial PCCT Trial of Early Evolocumab After ACS
The CAPRA-EVO trial is a single-center, randomized, open-label study with blinded endpoint assessment comparing early evolocumab plus standard lipid-lowering therapy versus standard-of-care lipid-lowering therapy in patients with…
- Trial name
- CAPRA-EVO (NCT07612774)
- Testing
- Evolocumab, Serial photon-counting coronary computed tomography angiography, Standard Lipid-Lowering Therapy
- Where
- 2 sites in China
- Volunteers
- 232 people
- Sponsor
- West China Hospital
Coronary Artery Disease
Computed Tomography Coronary Angiography (CTCA) and Coronary Flow in Stenosis Analysis
The investigators' rationale was to evaluate whether a 64-slice CT scanner allows accurate measurement of computed tomographic changes in coronary artery flow profiles and whether CT flow measurements are suitable for classifying…
- Trial name
- NCT00921440
- Volunteers
- 50 people
- Sponsor
- University of Cologne
Heart Diseases
Cost Effectiveness and Utility of Computed Tomography Angiography (CTA) and Cardiac Cath
This is a research study to determine patient preferences between two different diagnostic tests; a CT angiogram (CTA) and a catheter angiogram, both of which are used at the University to screen for and detect heart disease.
- Trial name
- NCT00722813
- Testing
- Survey
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Michigan
Lipidemia, Coronary Artery Disease
A CCTA Imaging Trial to Evaluate the Effect of Obicetrapib/Ezetimibe on Coronary Plaque
This placebo-controlled, double-blind, randomized, Phase 3 study is being conducted in adult participants with high-risk atherosclerotic cardiovascular disease (ASCVD) who are not adequately controlled by their maximally…
- Conditions
- Lipidemia, Coronary Artery Disease, Plaque, Atherosclerotic
- Trial name
- REMBRANDT (NCT06305559)
- Testing
- obicetrapib 10 mg + ezetimibe 10 mg FDC daily
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- NewAmsterdam Pharma
Acute Kidney Injury, Renal Insufficiency, Chronic
Safety of Iodinated Contrast in Liver Transplant Candidates With Decreased Renal Function Undergoing Coronary CT Angiography
This study evaluates the safety of iodinated contrast medium administered to liver transplant candidates with decreased renal function undergoing coronary CT angiography.
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Chronic, Contrast-induced Nephropathy, Liver Transplantation
- Trial name
- NCT03806725
- Testing
- Intravenous administration of iodinated contrast medium for coronary CT angiography
- Where
- United States
- Sponsor
- Stanford University
Coronary Angiography, Obesity
Optimizing Image Quality in Obese Patients Undergoing Coronary Computed Tomography (CT) Angiography
The purpose of this cardiovascular imaging research is to look at ways to improve the way we can look at the pictures of the heart.
- Conditions
- Coronary Angiography, Obesity, Coronary Disease
- Trial name
- BMI40 (NCT00468195)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Computed Tomography, Coronary Angiography
Incidental Findings on Coronary Computed Tomography Angiography
Coronary CT angiography (CCTA) is increasingly used for ischemic heart disease diagnosis. The rising number of CCTA tests has led to a significant increase in the number of finding unexpected incidental extracardiac diseases.
- Conditions
- Computed Tomography, Coronary Angiography, Incidental Findings
- Trial name
- NCT07275281
- Testing
- CCTA (Review of the scans)
- Where
- Jordan
- Volunteers
- 2,000 people
- Sponsor
- Jordan Collaborating Cardiology Group
Cardiovascular Disease
CT COMPARE: CT Coronary Angiography to Measure Plaque Reduction
Background: Coronary artery disease causes plaque in arteries. This can cause stroke or heart disease. Drugs called statins might shrink plaque.
- Trial name
- NCT02740699
- Testing
- Rosuvastatin, Atorvastatin, Cardiac Computed Tomography (CT)
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Disease, Coronary, Chest Pain
The Computed Tomography-derived Fractional Flow Reserve STAT Trial
This study is designed to directly compare Standard Care and CT fractional flow reserve (CTFFR) for diagnosis of chest pain patients with definite coronary artery disease (CAD) on heart computed tomography (CT) scans.
- Conditions
- Heart Disease, Coronary, Chest Pain, Acute Coronary Syndrome
- Trial name
- CTFFR-STAT (NCT03263806)
- Testing
- CTFFR-Guided Group Management, SOC Group Management
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Corewell Health East
Atherosclerosis
Incident COronary EveNts Identified by Computed Tomography
The Incident COronary EveNts Identified by Coronary Tomography (ICONIC) trial is a nested, case-control study derived from the dynamic CONFIRM registry, and is based on propensity scoring methods to match subjects with (cases) or…
- Trial name
- ICONIC (NCT02959099)
- Where
- 13 sites in United States, Austria and 6 more
- Volunteers
- 476 people
- Sponsor
- Weill Medical College of Cornell University
Coronary Stenosis, Aortic Valve Stenosis
Impact of Fast-rotation Coronary CT in Patients Undergoing Aortic Stenosis Workup
This study aims to evaluate the clinical value of a novel CT gantry supporting a .23 second rotation time and systematically compare it with 0.23 second rotation time, in patients with clinically indicated aortic CTA in the…
- Conditions
- Coronary Stenosis, Aortic Valve Stenosis, Cardiovascular Diseases
- Trial name
- FAST-CCT (NCT05709652)
- Testing
- Aortic CTA, .23s, Aortic CTA, .28s
- Where
- Switzerland
- Volunteers
- 124 people
- Sponsor
- David C. Rotzinger
Coronary Atherosclerosis
Evaluation of Subclinical COronary Atherosclerosis for Risk Stratification Using Coronary Computed Tomography (CT) Angiography
To evaluate the prognostic value of coronary CT angiography (CCTA) for risk stratification in asymptomatic adults in comparison with conventional risk stratification (CRS) and coronary artery calcium scoring (CACS).
- Trial name
- ESCORT (NCT01416532)
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Seoul National University Bundang Hospital
Diabetes Mellitus
Coronary CT Angiography in Asymptomatic Diabetes Mellitus
The study aims to examine if non-invasive imaging of the coronary arteries by CT angiography using an intra-venous injection of X-ray contrast medium in asymptomatic patients with adult onset diabetes mellitus can predict the…
- Trial name
- NCT00321542
- Testing
- Imaging study, No intervention
- Where
- Israel
- Volunteers
- 793 people
- Sponsor
- Carmel Medical Center