Clinical trials: Coronary Patient
Heart Failure, Heart Failure, Systolic
COmparing arNi and Ace For Improving Erectile Dysfunction in mEN With reduCed Ejection Fraction Heart Failure
The purpose of this study was to determine the effect of sacubitril/valsartan (LCZ696) vs. Enalapril on improvement in erectile function and ability in male patients with chronic heart failure with reduced ejection fraction and…
- Conditions
- Heart Failure, Heart Failure, Systolic, Erectile Dysfunction
- Trial name
- CONFIDENCE-HF (NCT03917459)
- Testing
- LCZ696, Enalapril
- Where
- 13 sites in Germany
- Volunteers
- 27 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure, Heart Failure, Systolic
Renal Denervation in Patients With Heart Failure Secondary to Chagas Disease
It is a randomized prospective controlled study of transcatheter renal denervation in patients with systolic heart failure secondary to Chagas' disease.
- Conditions
- Heart Failure, Heart Failure, Systolic, Chagas Disease, Chagas Cardiomyopathy
- Trial name
- NCT02099903
- Testing
- transcatheter renal denervation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- InCor Heart Institute
Congenital Heart Disease
Evaluation of Coagulation Testing in Patients Undergoing Cardiac Surgery
Neonates, children with single ventricle congenital heart disease, and those undergoing multiple complex cardiac surgeries are at high risk of increased perioperative blood loss, and blood product transfusions.
- Trial name
- NCT02410473
- Testing
- Discarded blood samples, Discarded Urine Sample
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Boston Children's Hospital
Heart Failure
Food Supplementation Delivered Conditionally vs Not Among Patients With Heart Failure
The current study proposes to investigate if the provision of healthy food can improve outcomes following discharge after HF hospitalization.
- Trial name
- FOOD-HF (NCT06115369)
- Testing
- Medically Tailored Meals Delivered Conditionally, Medically Tailored Meals Delivered Unconditionally, Produce Boxes delivered Conditionally
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Heart Failure With Preserved Ejection Fraction
Patient-reported Outcomes in Vericiguat-treated Patients With HFpEF
The primary hypothesis in this trial is that the treatment with vericiguat 10 mg or 15 mg in patients with HFpEF improves the KCCQ PLS (Kansas City Cardiomyopathy Questionnaire Physical limitation score) compared to placebo after…
- Trial name
- VITALITY-HFpEF (NCT03547583)
- Testing
- Vericiguat (BAY1021189) 2.5 mg, 5 mg or 10 mg IR tablets
- Where
- 177 sites in United States, Argentina and 19 more
- Volunteers
- 789 people
- Sponsor
- Bayer
Aortic Stenosis
Implantable Sensor in Aortic Stenosis
To establish the relationship between a panel of biological markers obtained from the REVEAL Linq device and exercise performance as judged by cardiopulmonary exercise testing
- Trial name
- ISAS (NCT06826183)
- Testing
- REVEAL Linq device
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Barts & The London NHS Trust
Ischemic Heart Disease, Atherosclerosis
Graft Patency as a Predictor of Health-related Quality of Life.
The health-related quality of life questionnaire "EQ-5D" has been collected in connection with several interventional and observational studies where the no-touch vein harvesting technique in CABG has been used.
- Trial name
- NCT02547194
- Where
- Sweden
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Örebro County Council
Heart Failure, Sleep Apnea Syndromes
ECG Derived Respiration for Automated Screening of Sleep Disordered Breathing in Chronic Heart Failure Patients
The prevalence of sleep disordered breathing (SDB) reaches more than 50% in chronic heart failure patients (CHF). The main consequence is an increase risk of fatal and non-fatal cardiovascular events.
- Conditions
- Heart Failure, Sleep Apnea Syndromes, Polysomnography
- Trial name
- NCT02116686
- Testing
- ventilatory polygraphic recordings
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Atrial Fibrillation, Stroke
Screening Versus Routine Practice in Detection of Atrial Fibrillation in the Elderly Population of Lieto
The aim of this study is to evaluate the feasibility of patient education on feeling the own pulse irregularity in the elderly population of Lieto. Prevalence of atrial fibrillation (AF) rises with age.
- Trial name
- LietoAF (NCT01721005)
- Testing
- Subject education to pulse palpation
- Where
- Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Turku
Right Bundle-Branch Block
Adaptive Cardiac Resynchronization Therapy in Patients With RBBB
This study will address whether acute adaptive RV pacing in sinus rhythm patients with severe LV systolic dysfunction and RBBB is superior to no ventricular pacing, and is as effective as echocardiographically optimized…
- Trial name
- NCT05936294
- Testing
- Optimization of CRT Device
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Henry Ford Health System
Heart Failure
Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device (LVAD) and Medical Management
The purpose of this study is to evaluate and compare the effectiveness of the HeartMate II (HM II) Left Ventricular Assist Device (LVAD) support versus OMM in ambulatory NYHA Class IIIB/IV heart failure patients who are not…
- Trial name
- ROADMAP (NCT01452802)
- Testing
- HM II (HeartMate II LVAD), OMM (Optimal Medical Management)
- Where
- 52 sites in United States
- Volunteers
- 200 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease
Follow-up of Coronary Artery Bypass Graft Patency by Multislice Computed Tomography
Coronary artery disease is a major cause of morbidity and mortality across the world and coronary artery bypass surgery (CABG) is the most common surgical procedure for treatment.
- Trial name
- NCT00712153
- Volunteers
- 36 people
- Sponsor
- Far Eastern Memorial Hospital
Elective Coronary Artery Bypass Grafting (CABG) Surgery, Coronary Artery Disease
Sleep-disordered Breathing and Perioperative Atrial Fibrillation in Cardiac Surgery
In patients undergoing elective coronary artery bypass grafting (CABG) surgery, coronary artery disease, sleep-disordered breathing (SDB), atrial fibrillation (AF) perioperative atrial fibrillation and complications will be…
- Conditions
- Elective Coronary Artery Bypass Grafting (CABG) Surgery, Coronary Artery Disease, Sleep-disordered Breathing (SDB), Atrial Fibrillation
- Trial name
- CONSIDER-AF (NCT02877745)
- Testing
- Stratification, no intervention
- Where
- Germany
- Volunteers
- 1,200 people
- Sponsor
- Michael Arzt
Turner Syndrome, Ovarian Insufficiency
Cryopreservation of Ovarian Cortex in Girls With Turner Syndrome
Ovarian insufficiency is common in Turner syndrome related to premature and rapid follicular apoptosis and spontaneous pregnancies are rare in this population.
- Trial name
- CRYO-X0 (NCT01410045)
- Testing
- Ovariectomy
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Coronary Syndrome
Coronary Flow Reserve in Patients With Bio-active Stent or Everolimus-eluting Stent Implanted in Acute Coronary Syndrome
The aim of the trial is to assess coronary artery reactivity using adenosine-induced coronary flow reserve (CFR) by transthoracic echocardiography in patients with Bio-active stent (BAS) and Everolimus-eluting stent (EES) distal…
- Trial name
- BASE-CFR (NCT01080872)
- Testing
- CFR
- Where
- 2 sites in Finland
- Volunteers
- 40 people
- Sponsor
- The Hospital District of Satakunta
TURP Syndrome, Spinal Anesthesia
Comparison of Hemodynamic Effect Between the Spinal Anesthesia and Saddle Block Using Levobupivacaine During Transurethral Resection of the Prostate in Cardiac Elderly Patients
Transurethral resection of the prostate (TURP) is the most common surgical intervention for patients with benign prostatic hyperplasia.
- Trial name
- NCT06014957
- Testing
- spinal anesthesia, saddle block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- New Valley University
Cardiomyopathy
Intracoronary Transplantation of Bone Marrow Derived Mononuclear Cells in Pediatric Cardiomyopathy
According to the high morbidity and mortality of idiopathic Dilated CardioMyopathy (IDCM) in pediatric, new modality of treatment is emerging. There are some case reports of administration of stem cell therapy.
- Trial name
- NCT02256501
- Testing
- Mono Nuclear Cell (MNC) transplantation
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Nasser Aghdami MD., PhD
Aortic Valve Stenosis, Cardiac Amyloidosis
Targeted Testing for ATTR Among Aortic Stenosis Patients-Pilot
Our ultimate goal is to design a multi-center randomized trial to test the hypothesis that targeted testing for transthyretin cardiac amyloid (ATTR) will improve survival and health status among aortic stenosis patients who…
- Trial name
- NCT04363294
- Testing
- PYP scan
- Sponsor
- University of Texas Southwestern Medical Center
Valvular Heart Disease
Impact of Perioperative Shedding of the Endothelial Glycocalyx on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery.
Endothelial glycocalyx, the luminal structure of healthy vasculature, plays critical roles in regulation of inflammatory responses, vascular permeability, blood coagulation.
- Trial name
- NCT03197051
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Yonsei University
Acute Coronary Syndrome
Allopurinol in Acute Coronary Syndrome
The pathogenesis of coronary heart disease is closely related to inflammation. IL-1 beta is an effective target for anti-inflammatory treatment of coronary heart disease.
- Trial name
- NCT03745729
- Testing
- allopurinol sustained-release capsules
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
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