Clinical trials: Coronary Stent Implantation
Platelet Inhibition, Coronary Stent Implantation
Individualizing Dual Antiplatelet Therapy After Percutaneous Coronary Intervention - The IDEAL-PCI Registry
The purpose of this study is to determine the efficacy and safety of a routine individualized antiplatelet therapy after coronary stent implantation by evaluating "on-treatment" platelet reactivity with Multiple Electrode…
- Trial name
- IDEAL-PCI (NCT01515345)
- Testing
- prasugrel or ticagrelor, Clopidogrel
- Where
- Austria
- Volunteers
- 1,008 people
- Sponsor
- Kaiser Franz Josef Hospital
Angina Pectoris
Myocardial Ischemia After Coronary Sinus Reduction Stent Implantation
Chronic angina pectoris refractory to medical and revascularization therapies is a disabling medical condition and a major public health problem. Patients with refractory angina have limited treatment options.
- Trial name
- MICS-Reduce (NCT06033495)
- Testing
- Coronary sinus reduction stent
- Volunteers
- 15 people
- Sponsor
- Oslo University Hospital
Chronic Total Occlusion of Coronary Artery
EvaLuAtion On the cHaracteristics of the True/False lUmen and Its Prognostic Value for cOronary CTO Patients Just Before Stent Implantation
IVUS will be used to evaluate the ratio of false lumen to occluded segment, the ratio of false lumen to stent length, the location characteristics of false lumen and its prognostic value for perioperative complications, 1-year…
- Trial name
- NCT04965207
- Volunteers
- 1,000 people
- Sponsor
- Shanghai 10th People's Hospital
Coronary Artery Disease, Coronary Disease
Optimal dRug Eluting steNts Implantation Guided By Intravascular Ultrasound and Optical coheRence tomoGraphy ORENBURG
The objective of this research is to assess the clinical results of implantation of different drug eluting stents under "aggressive" intravascular ultrasound (IVUS) guided all the way up to 24 months after operation and to…
- Conditions
- Coronary Artery Disease, Coronary Disease, Heart Diseases
- Trial name
- ORENBURG (NCT01917201)
- Testing
- IVUS-guided group, Non-IVUS group
- Where
- Russia
- Volunteers
- 1,000 people
- Sponsor
- The Orenburg Regional Clinical Hospital
Coronary Artery Disease
(EASY)-IMProving Adherence to Clopidogrel Trial (IMPACT))
The purpose of this study is to test the impact of a multidisciplinary approach to improve the adhesion and persistence to Clopidogrel therapy.
- Trial name
- EASY-IMPACT (NCT01134679)
- Testing
- Multi-disciplinary disease management approach
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Laval University
Acute Coronary Syndrome, Coronary Stent Implantation
A Study of Low and Standard-dose Ticagrelor After Intervention for ACS Patients
This study is to evaluate the safety and efficacy of 60mg ticagrelor plus 100mg Aspirin to prevent major adverse cardiovascular and cerebrovascular events in one years after drug-eluting stents implantation for Chinese ACS…
- Trial name
- TIGER (NCT04255602)
- Testing
- Ticagrelor 60mg, Ticagrelor 90mg
- Where
- 8 sites in China
- Volunteers
- 2,120 people
- Sponsor
- Shanghai Tong Ren Hospital
Coronary Artery Disease, Atherosclerosis
Biological Efficacy of Clopidogrel After Implantation of Drug-eluting Stents (SPACE)
The risk of thrombotic complications after implantation of drug-eluting stents (DES) may be increased in patients with diabetes mellitus (DM) or metabolic syndrome (MS).
- Conditions
- Coronary Artery Disease, Atherosclerosis, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- SPACE (NCT00298428)
- Testing
- blood samples
- Where
- 2 sites in France
- Volunteers
- 159 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation (AF), Coronary Artery Disease
OPTIA-AF Trial: Rhythm-Guided Antithrombotic Strategy After AF Ablation
The OPTIA-AF trial is a prospective, multicenter randomized controlled trial designed to evaluate a rhythm-guided antithrombotic strategy in patients with atrial fibrillation (AF) who maintain durable sinus rhythm after catheter…
- Conditions
- Atrial Fibrillation (AF), Coronary Artery Disease, Drug-eluting Stent
- Trial name
- OPTIA-AF (NCT07496281)
- Testing
- Oral anticoagulation, Single antiplatelet therapy
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Angina Pectoris, Silent Ischemia
Second Generation" Drug-Eluting Stents Implantation Followed by Six Versus Twelve-Month - Dual Antiplatelet Therapy
Prospective, randomized, non-inferiority, multicenter, international study.In total 4000 patients (70 centers in Europe) with de novo lesions in native coronary arteries who meet the eligibility criteria randomized to 6 versus 12…
- Trial name
- NCT00944333
- Testing
- Clopidogrel
- Where
- Italy
- Volunteers
- 1,378 people
- Sponsor
- Fondazione Evidence per Attività e Ricerche Cardiovascolari ONLUS
Coronary Artery Disease (CAD)
GLOBAL LEADERS: A Clinical Study Comparing Two Forms of Anti-platelet Therapy After Stent Implantation
After a stent procedure, it is common practice to prescribe anti-platelet medication to prevent the blood from clotting. The main objective of this study is to determine if there is a better medication strategy to prevent blood…
- Trial name
- NCT01813435
- Testing
- Ticagrelor, Acetylsalicylic Acid, Clopidogrel
- Where
- 130 sites in Australia, Austria and 16 more
- Volunteers
- 15,991 people
- Sponsor
- ECRI bv
Coronary Artery Disease
Relationship Between Initial Plaque Characteristics and Stent Surface Coverage Patterns
Vulnerable plaque characterized by thin fibrous cap and large lipid core is an independent risk factor for most of acute cardiac event.
- Trial name
- NCT01024179
- Testing
- Polymer-based sirolimus-eluting stent (Partner stent )
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Harbin Medical University
Coronary Disease
Anatomic Versus Physiologic Guidance for Complete Revascularization With DES Eluting in Patients With CAD
This study is to compare clinical outcomes between quantitative coronary angiography-guided anatomic complete revascularization and fractional flow reserve-guided physiologic complete revascularization in patients with…
- Trial name
- ASSIST (NCT05529459)
- Testing
- Percutaneous Coronary Intervention
- Where
- 17 sites in South Korea
- Volunteers
- 2,400 people
- Sponsor
- Seung-Whan Lee, M.D., Ph.D.
Cardiovascular Diseases
Photon-Counting Cardiac CT in Post-PCI Patients
This study takes patients who have undergone percutaneous coronary intervention as the research subjects and employs a prospective observational cohort design, aiming to develop and validate a "one-stop" photon-counting computed…
- Trial name
- NCT07763340
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Disease
Optimization of Percutaenous Coronary Intervention With Liberal Use of Post-dilatation
To achieve optimal long-term clinical results after percutaneous coronary intervention (PCI), adequate deployment of stents is essential.
- Trial name
- OPTIMIZE-PCI (NCT06558474)
- Testing
- Liberal post-dilatation strategy during PCI
- Where
- Netherlands
- Volunteers
- 12,000 people
- Sponsor
- Cathreine BV
Coronary Artery Disease, Atrial Fibrillation
Rivaroxaban Estimation With Warfarin in Atrial Fibrillation Patients With Coronary Stent Implantation Study (REWRAPS)
Antiplatelet therapy is indispensable for the prevention of stent thrombosis in patients who underwent coronary artery stenting.
- Conditions
- Coronary Artery Disease, Atrial Fibrillation, Stroke, Fetal Blood Loss
- Trial name
- REWRAPS (NCT02024230)
- Testing
- Rivaroxaban or Warfarin
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Fujita Health University
Coronary Artery Disease
IVUS-guided DES Implantation in Coronary Calcification
Coronary calcified lesion is associated with a poor clinical outcome. Intravascular ultrasound (IVUS) provides anatomic information in detail about reference vessel dimensions and lesion characteristics including severity of…
- Trial name
- ULTIMATE IV (NCT05800002)
- Testing
- Intravascular ultrasound, Angiography
- Where
- China
- Volunteers
- 864 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Disease
Web basEd soCial Media tecHnology to Improvement in Adherence to Dual anTiplatelet Therapy Following Drug-Eluting Stent Implantation
Few studies have attempt to improve DAPT adherence through social media. The investigators will explore the prevalence of DAPT discontinuation and prove the hypothesis that using social media will improve DAPT adherence among…
- Trial name
- WeChat (NCT03732066)
- Testing
- Usual Text Messages, Personalized Reminders, Interactive Responses
- Where
- China
- Volunteers
- 760 people
- Sponsor
- Guangdong Provincial People's Hospital
Coronary Artery Disease, Diabetes
Comparison of Zotarolimus-Eluting Stent vs Sirolimus-Eluting Stent for Diabetic Patients
The purpose of this study is to establish the safety and effectiveness of coronary stenting with the Zotarolimus-Eluting stent compared to the Sirolimus-Eluting stent in the treatment of de novo coronary stenosis in patients with…
- Trial name
- ESSENCE-DM2 (NCT01186107)
- Testing
- Endeavor Resolute stent, Cypher stent
- Where
- 11 sites in South Korea
- Volunteers
- 256 people
- Sponsor
- Seung-Jung Park
Calcified Coronary Lesions
Effectiveness and Safety of a Novel Intravascular Lithotripsy System in Severely Calcified Coronary Lesions(COCALP)
This study is a prospective, multicenter, single-arm trial designed to investigate the effectiveness and safety of this intravascular lithotripsy system to treat severely calcified coronary lesions before stenting.
- Trial name
- COCALP (NCT06787547)
- Testing
- IVL(Sonico-CX)
- Where
- 11 sites in China
- Volunteers
- 266 people
- Sponsor
- Spectrumedics Medical Technology(Shanghai)Co.,Ltd
Coronary Artery Disease
Short-Term Exposure to Lipophilic Anti-proliferative Drugs Delivered by Angiographic Contrast Media
This was a randomized, placebo-controlled, multi-centre study, double-blind within each dose level, with four ascending dose levels to test the tolerability and safety of iopromide-paclitaxel in patients with de novo lesions in…
- Trial name
- NCT01140204
- Testing
- Implantation of a bare metal stent
- Where
- 2 sites in Germany
- Volunteers
- 32 people
- Sponsor
- University Hospital, Saarland