Clinical trials: Coronavirus (SARS-CoV)
Coronavirus Infection, Type 2 Diabetes
Effects of DPP4 Inhibition on COVID-19
The purpose of this research is to see if the DPP4 inhibitor linagliptin, an oral medication commonly used to treat type 2 diabetes,can help with diabetes control and reduce the severity of the COVID-19 infection
- Trial name
- NCT04341935
- Testing
- Linagliptin, Insulin regimen
- Where
- United States
- Sponsor
- University of Miami
COVID-19
Prognosis of Coronavirus Disease 2019 (COVID-19) Patients Receiving Receiving Antihypertensives
Coronavirus disease 2019 (COVID-19) ,caused by the newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus, has shown substantial global spread affecting over 2 million people and claiming over 120,000…
- Trial name
- NCT04357535
- Testing
- Angiotensin-Converting Enzyme Inhibitors (ACE-I) and Angiotensin II Receptor Blockers (ARB)
- Where
- Saudi Arabia
- Volunteers
- 314 people
- Sponsor
- Hakeam Abdulaziz Hakeam
SARS CoV 2 Infection, COVID-19
I VACCIN Hospitalization of COVID-19 Patients
A REALLIFE evaluation of rate of hospitalized patients in Intensive Care Units and in medical Units of non -vaccinated patients vs vaccinated patients
- Trial name
- NCT05244343
- Where
- Tunisia
- Volunteers
- 1,096 people
- Sponsor
- Eshmoun Clinical Research Center
Covid19, Coronavirus Infection
MOIST Study: Multi-Organ Imaging With Serial Testing in COVID-19 Infected Patients
While many people with COVID-19 suffer from respiratory disease, there is growing evidence that the virus also affects other organs.
- Conditions
- Covid19, Coronavirus Infection, SARS-CoV Infection
- Trial name
- MOIST (NCT04525404)
- Testing
- MRI (heart, brain, lungs, liver), Bloodwork, Cognitive testing
- Where
- 2 sites in Canada
- Volunteers
- 215 people
- Sponsor
- University of Alberta
Covid19, SARS-CoV Infection
IVIG in Patients With Severe COVID-19 Requiring Mechanical Ventilation
The purpose of this Pilot Study is to establish a hypothesis of whether or not intravenous immunoglobulin (IVIG) may impact the hospital length of stay, if started within 48 of mechanical ventilation in patients infected with…
- Trial name
- NCT04616001
- Testing
- IVIG
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sharp HealthCare
SARS-CoV 2 Infection, Covid19
Qualitative Evaluation of Tear Fluid and Blood for Auto Antibodies Produced in Response to COVID-19
This study objective is to collect tear and blood samples from individuals with positive SARS-COV2 diagnosis and test those samples for the presence of various SARS-COV2 viral antigens and autoantibodies.
- Trial name
- NCT04542980
- Testing
- SARS-CoV2 Autoantibody detection
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Namida Lab
COVID-19, SARS-CoV Infection
Chloroquine Diphosphate in the Prevention of SARS in Covid-19 Infection
This is a double-blind, randomized, placebo-controlled clinical trial. A total of 210 individuals aged over 18 years old, without a diagnosis of severe respiratory disease, who came to the study site with clinical and…
- Conditions
- COVID-19, SARS-CoV Infection, Severe Acute Respiratory Syndrome (SARS) Pneumonia, Clinical Trial
- Trial name
- CloroCOVID19II (NCT04342650)
- Testing
- Chloroquine Diphosphate
- Where
- Brazil
- Volunteers
- 152 people
- Sponsor
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
Post-Acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS)
Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS
Long COVID is defined by a range of symptoms affecting multiple organs that persist for more than three months following an acute SARS-CoV-2 infection.
- Conditions
- Post-Acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS), SARS CoV 2 Infection, Long COVID19
- Trial name
- NCT07189936
- Testing
- To Measure levels of circulating monocyte/ T cell doublets at Baseline, To measure levels of circulating monocyte/ T cell doublets after 28 days of 2 HOBA treatment, To Measure Splanchnic venous capacitance after 28 days of Treatment with 2HOBA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
SARS-CoV 2 Pneumonia
Calcifediol in the Treatment of SARS-CoV-2 Disease (COVID-19).
Descriptive, retrospective, observational, anonymous, study to evaluate the potential effect of incorporating calcifediol into the therapeutic protocol of patients hospitalized for COVID-19 on mortality and other outcome…
- Trial name
- COVIDIOL (NCT06279910)
- Testing
- Calcifediol
- Where
- Spain
- Volunteers
- 230 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
SARS CoV 2 Infection, SARS-CoV-2 Acute Respiratory Disease
Efficacy and Safety of Nasal Spray Solution Containing Human IgG1 Anti-COVID-19 Antibody Cocktail
Hypromellose-based nasal spray solution containing human IgG1 anti-SARS-CoV-2 antibody cocktail is a medical device innovated to provide the dual-action physical barrier on nasal mucosa that aids the natural defence in which the…
- Trial name
- NCT05358873
- Testing
- Human IgG1 anti-SARS-CoV-2 antibody cocktail
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Corona Virus Infection, Acute Respiratory Distress Syndrome
Post-exposure Prophylaxis / Preemptive Therapy for SARS-Coronavirus-2
Study Objective: 1. To test if post-exposure prophylaxis with hydroxychloroquine can prevent symptomatic COVID-19 disease after known exposure to the SARS-CoV-2 coronavirus. 2.
- Conditions
- Corona Virus Infection, Acute Respiratory Distress Syndrome, SARS-CoV Infection, Coronavirus
- Trial name
- COVID-19 PEP (NCT04308668)
- Testing
- Hydroxychloroquine
- Where
- 5 sites in United States, Canada
- Volunteers
- 1,312 people
- Sponsor
- University of Minnesota
SARS CoV 2 Infection
Consequences in ICU of Vaccination Status of Covid-19 Patients
It is a retrospective cohort study aiming to describe the characteristics, management and prognosis of vaccinated patients hospitalized in the intensive care unit (ICU), in comparison with non-vaccinated patients.
- Trial name
- CIVIC (NCT06191341)
- Where
- France
- Volunteers
- 1,058 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Covid19, SARS-CoV Infection
SARS-CoV-2 Human Challenge Characterisation Study
This is a dose optimisation study in healthy adults aged 18-30 who will be experimentally inoculated with SARS-CoV-2. The aim is to cause PCR-confirmed upper respiratory infection in the majority of challenged individuals with…
- Conditions
- Covid19, SARS-CoV Infection, Corona Virus Infection, Coronavirus
- Trial name
- NCT04865237
- Testing
- SARS-CoV-2 Virus 1x10^1 TCID50, Remdesivir, SARS-CoV-2 Virus 1x10^2 TCID50
- Where
- 2 sites in United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Imperial College London
COVID-19, SARS-CoV 2
Efficacy and Safety Evaluation of Mesenchymal Stem Cells for the Treatment of Patients With Respiratory Distress Due to COVID-19
Randomized, double-blind, parallel, two-arms clinical trial to assess the efficacy and safety of 2 infusions of Wharton-Jelly mesenchymal stromal cells (day 1 and day 3, endovenously at 1E6cells/Kg per dose) in patients with…
- Conditions
- COVID-19, SARS-CoV 2, Adult Respiratory Distress Syndrome
- Trial name
- COVIDMES (NCT04390139)
- Testing
- XCEL-UMC-BETA
- Where
- 5 sites in Spain
- Volunteers
- 26 people
- Sponsor
- Banc de Sang i Teixits
SARS-CoV Infection
Tocilizumab in COVID-19 Lahore General Hospital
The most accepted description of severe COVID-19 disease is development and over production of pro-inflammatory cytokines. Autopsy studies have been done on COVID-19 patients proved that severe disease is resulted due to deviant…
- Trial name
- TC19LGH (NCT04560205)
- Testing
- Tocilizumab
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Lahore General Hospital
SARS-CoV Infection, Severe Acute Respiratory Syndrome (SARS) Pneumonia
Methylprednisolone in the Treatment of Patients With Signs of Severe Acute Respiratory Syndrome in Covid-19
This is a double-blind, randomized, placebo-controlled, phase IIb clinical trial to assess the efficacy of injectable methylprednisolone sodium succinate (MP) in patients with severe acute respiratory syndrome (SARS) in COVID-19…
- Trial name
- MetCOVID (NCT04343729)
- Testing
- Methylprednisolone Sodium Succinate
- Where
- Brazil
- Volunteers
- 416 people
- Sponsor
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
Covid19, SARS-CoV Infection
The Effect of Melatonin and Vitamin C on COVID-19
This is a double-blind placebo controlled trial that seeks to evaluate the impact of melatonin and vitamin C on symptoms and outcomes of patients with COVID-19.
- Trial name
- NCT04530539
- Testing
- Vitamin C, melatonin, Symptom Survey
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Lancaster General Hospital
SARS-CoV Infection, COVID 19
The Efficacy of Different Anti-viral Drugs in COVID 19 Infected Patients
The (World Health Organization) WHO NOR- (Coronavirus infectious disease) COVID 19 study is a multi-centre, adaptive, randomized, open clinical trial to evaluate the safety and efficacy of hydroxychloroquine, remdesivir and…
- Conditions
- SARS-CoV Infection, COVID 19, Acute Respiratory Distress Syndrome ARDS
- Trial name
- NCT04321616
- Testing
- Hydroxychloroquine, Remdesivir, (Standard of Care) SoC
- Where
- Norway
- Volunteers
- 700 people
- Sponsor
- Oslo University Hospital
SARS-CoV 2, COVID-19
Cardiac COVID-19 Health Care Workers
The study will analyze the prevalence of cardiac involvement of health care workers from the University Hospital of Salamanca (HUSA) who have overcome SARS-CoV-2 infection.
- Conditions
- SARS-CoV 2, COVID-19, Coronavirus, Cardiac Magnetic Resonance
- Trial name
- CCC (NCT04413071)
- Testing
- Passed infection of SARS-CoV-2
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- AORTICA Group
SARS-CoV Infection
A Feasibility Study Using the CoronaCheck Device to Identify Incident Cases of SARS CoV-2 Covid-19
Point of care testing is urgently required to enable the immediate detection of SARS-CoV-2 infection to allow effective transmission prevention precautions to succeed.
- Trial name
- NCT04742712
- Testing
- CoronaCheck Device
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust