Clinical trials: Cortical Activation
Stroke, Healthy
fNIRS Study of Effort-dependent Brain Activations During Pointing Movements of the Upper Limb in Post-stroke Patients and Healthy Subjects
Background: Following a stroke, as part of neurorehabilitation, the intensity of effort is important to promote neural changes and stimulate motor recovery.
- Trial name
- BIROBONIRS (NCT06116006)
- Testing
- Upper limb pointing movements in 3 experimental conditions
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Clinique Les Trois Soleils
Children With Autism Spectrum Disorder, Typical Developed Children
Investigating Handwriting Characteristics and Underlying Factor in Children With Autism Spectrum Disorder
The mechanism of the motor problem in children with autism spectrum disorder (ASD) in handwriting has been investigated in the following three aspects, including collecting dynamic handwriting performance, exploring the related…
- Trial name
- NCT06228885
- Testing
- handwriting experiment and motor ability test
- Where
- Taiwan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Low Back Pain
The Investigation of Underlying Mechanism of Lumbar Multifidus Muscle Activation Deficits
The goal of this clinical trial is to investigate mechanism underlying lumbar multifidus muscle (LM) activation deficits in adults with chronic low back pain (CLBP).
- Trial name
- NCT05961774
- Testing
- Transcranial magnetic stimulation, Neuromuscular electrical stimulation
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Multiple Sclerosis
The Neural Mechanisms of Split-belt Treadmill Adaptation in People With Multiple Sclerosis
Majority of people with multiple sclerosis experience difficulty with balance and mobility, leading to an increased risk of falls.
- Trial name
- NCT05878873
- Testing
- Split-belt Treadmill, Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Healthy, Gait Disorders, Neurologic
Exoskeleton and Brain Activity With fNIRS
Background. Force control is one of the major parameter of motor activity. There is few study concerning the cortical activity imply for different levels of force during gait. Objective.
- Trial name
- ExoNIRS (NCT05298943)
- Testing
- walking in 4 situations
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Shoulder Pain, Chronic Pain
Feasibility of Near-infrared Spectroscopy to Measure Cortical Pain Pathway (Brain) Activation During Dry Needling
The benefit experienced by some patients when treated with dry needling,1 combined with the field-expedient nature of this intervention, make dry needling uniquely suited for the military healthcare environment.
- Conditions
- Shoulder Pain, Chronic Pain, Musculoskeletal Injury
- Trial name
- NCT04170803
- Testing
- Dry Needling
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Army-Baylor University Doctoral Program in Physical Therapy
Cervical Spinal Cord Injury, Tetraplegia/Tetraparesis
Spinal Cord Associative Plasticity Study
Spinal cord associative plasticity (SCAP) is a combined cortical and spinal electrical stimulation technique developed to induce recovery of arm and hand function in spinal cord injury.
- Conditions
- Cervical Spinal Cord Injury, Tetraplegia/Tetraparesis, Cervical Myelopathy
- Trial name
- SCAP (NCT05163639)
- Testing
- Non-invasive pairing of cortical and spinal stimulation, Intraoperative pairing of cortical and spinal stimulation, Non-invasive repeated pairing of cortical and spinal stimulation (SCAP)
- Where
- 3 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Columbia University
Corticospinal Excitability, Cortical Activation
LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension
Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research.
- Trial name
- LAMI (NCT06478303)
- Testing
- Motor imagery, Action reading, Motor localizer
- Where
- 2 sites in France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Deglutition Disorders, Lateral Medullary Syndrome
Cortical Function Changes During Swallowing in Patients With Dysphagia in Lateral Medullary Syndrome
The goal of this observational study is to detect the alteration of cortical activation and functional connectivity during swallowing in patients with Lateral Medullary Syndrome (LMS) dysphagia by functional near infrared…
- Trial name
- NCT06208020
- Testing
- Functional near-infrared spectroscopy (fNIRS) detection
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Mild Cognitive Impairment (MCI)
VR Hand Exercises: Impact on Cognition and Dexterity in MCI
This study aims to investigate the effects of virtual reality (VR)-based hand exercises on cognitive functions and hand skills in older adults with mild cognitive impairment (MCI).
- Trial name
- NCT07005271
- Testing
- virtual reality, Conventional treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Istinye University
Healthy Aging, Cognitive Benefits
Cardiorespiratory Fitness and Acute High-Intensity Exercise Effects on Brain and Cognitive Function in Older Adults
The goal of this clinical trial is to learn whether a single session of high-intensity interval exercise (HIIT) affects cognitive performance and brain activity in older adults, and whether cardiorespiratory fitness influences…
- Conditions
- Healthy Aging, Cognitive Benefits, Cardio Respiratory Fitness, Brain Activity
- Trial name
- ExBrain (NCT07727577)
- Testing
- High-Intensity Interval Training
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Colby-Sawyer College
Healthy, Memory Impairment
The Effects AZD8529 on Ketamine-induced Impairment of Working Memory in Healthy Volunteers
The purpose of this study is to assess if ketamine will induce, in healthy volunteers, impairment of working memory and if the drug AZD8529 will block the effects of ketamine on working memory as assessed by functional magnetic…
- Trial name
- NCT00985933
- Testing
- AZD8529
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Low Back Pain
Therapeutic Effects of Horticulture on Anterior Cingulate Cortex Activation in People With Chronic Low Back Pain
Chronic low back leads to a significant socio-economic burden. It is associated with physical and psychosocial deconditioning. Even a short "nature experience" has positive effects on the affective and cognitive factors involved…
- Trial name
- HORTICARE (NCT04656158)
- Testing
- Physical activity involving exposure to nature: Therapeutic horticulture
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Subcortical Aphasia, Ischemic Stroke
Language Functional Reorganization in Subcortical Infarction Patients
Post stroke aphasia (PSA) is one of the most frequently happened deficiency of stoke, affecting speaking,comprehension, writing and reading of language.
- Trial name
- NCT03668132
- Testing
- ischemic brain damage
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Excessive Sleepiness
Study to Evaluate Armodafinil Treatment in Improving Prefrontal Cortical Activation and Working Memory Performance
The primary objective of this study is to determine whether treatment with armodafinil will provide improvements in prefrontal cortical activation in patients with OSAHS (Obstructive Sleep Apnea/Hypopnea Syndrome) who have…
- Trial name
- NCT00711516
- Testing
- Armodafinil
- Where
- 9 sites in United States
- Volunteers
- 40 people
- Sponsor
- Cephalon
Cerebral Palsy, Children
Cerebral Palsy and the Study of Brain Activity During Motor Tasks
Background: Two ways to study the brain while people are moving are near-infrared spectroscopy (NIRS) and electroencephalography (EEG). NIRS uses light to look at blood flow in the brain when it is active.
- Trial name
- NCT01829724
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Brain
Cortical Activity During Vojta Stimulation in Healthy Adults
The present study is focused on the importance of sensory stimuli at the tactile and proprioceptive level that occur during the activation of the pectoral area, following the treatment protocol of Vojta Therapy (VT), and which…
- Trial name
- NCT04317950
- Testing
- Vojta
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Josue Fernandez Carnero
Depression
Activation on LDPC Cortex With Different Acupoints: An fNIRS Study
This is a randomized, open-labelled study to study the effect of the different acupoints combination under TCM treatment principles by fNIRS.
- Trial name
- NCT02711527
- Testing
- Acupunture group A, Acupunture group B
- Where
- Hong Kong
- Volunteers
- 36 people
- Sponsor
- The University of Hong Kong
Ondine Syndrome, Healthy
Cognitive Consequences of an Activation of the Cortical Drive to Breath (VENTIPSY)
The purpose of the study is to measure the negative cognitive consequences of the ventilation under pathological or experimental cortical drive to breath.
- Conditions
- Ondine Syndrome, Healthy, Amyotrophic Lateral Sclerosis
- Trial name
- VENTIPSY (NCT03095729)
- Testing
- Neuropsychological tests
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Amputees
Cortical Activation in Individuals With Finger Amputation During Mirror Versus Imagery Treatment
Goals : ( a) to examine differences in cortical activity during hand movements with a mirror compared to imagery of the same movements, and (b) to examine correlation between cortical activity during imagery or mirror treatment…
- Trial name
- NCT02838485
- Testing
- Mirror, Imagery
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization