Clinical trials: Cortical Excitability
Cannabis Use Disorder, Moderate
Cortical Excitability and Role of rTMS in Cannabis Use Disorder
Repetitive transcranial magnetic stimulation (rTMS) and cortical excitability have a role in cannabis use disorder
- Trial name
- NCT04106336
- Testing
- rTMS
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Parkinson's Disease
Effects of RAC With Locomotion Training on Cortical Excitability and Behavior in Patients With PD
In this study, 51 subjects include 17 freezers,17 non-freezers and 17 aged-matched healthy subjects will be recruited. We will compare the cortical excitability, gait performance, and stepping-in-place performance before and…
- Trial name
- NCT03656796
- Testing
- Treadmill training with auditory cues, Treadmill training without auditory cues
- Where
- Taiwan
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Aging
Effect of Aging on Cortical Excitability and Motor Learning
The objective of the current proposal is to identify 1) how aging-related changes in GABAergic cortical inhibition affect motor performance, and 2) how aerobic exercise may improve inhibitory function and facilitate motor…
- Trial name
- ACE (NCT03750903)
- Testing
- Aerobic Exercise, Stretching and Balance Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Parkinson Disease, Motor Cortex
Effects of rTMS on Balance Performance and Functional Mobility in Parkinson's Disease
This study aimed to investigate the effects of rTMS on balance performance and functional mobility in people with PD. Additionally, it further examines the effects of single-session low-frequency and high-frequency repetitive…
- Conditions
- Parkinson Disease, Motor Cortex, Excitability, Balance
- Trial name
- NCT07195773
- Testing
- rTMS
- Where
- Taiwan
- Volunteers
- 21 people
- Sponsor
- Chung Shan Medical University
Temporal Lobe Epilepsy
Electrical Brain Stimulation to Reduce Epileptic Seizures
OBJECTIVES: About 15% of patients suffering from focal epilepsy are refractory to available pharmacological treatments. Until now, the only hope for such patients has been the development of new pharmaceutical treatments or…
- Trial name
- NCT00344877
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Low Back Pain
Dry Needling Effects on Cortical Excitability
The investigators plan to use a pre-test post-test research design to investigate whether dry needling (DN) has an effect on cortical excitability in patients with chronic low back pain (CLBP), specifically in patients who have…
- Trial name
- NCT05111691
- Testing
- Dry needling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Texas Woman's University
Progressive Supranuclear Palsy, Corticobasal Degeneration
Repetitive Transcranial Magnetic Stimulation (TMS) for Progressive Supranuclear Palsy and Corticobasal Degeneration
Drug therapy of atypical parkinsonism is generally considered either ineffective or minimal 1. Therefore, there is an urgent need to find alternative therapies to treat atypical parkinsonian disorders.
- Conditions
- Progressive Supranuclear Palsy, Corticobasal Degeneration, Parkinsonism
- Trial name
- NCT01174771
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Transcutaneous Nerve Stimulation
Effect of Transcutaneous Nerve Stimulation on Primary Motor Cortex to Modulate Cortical Excitability and Hemodynamic Response During Implicit Motor Learning: A TMS and NIRS Study
Noninvasive brain stimulation was recently gradually be emphasized. The electrical current applied on scalp can effective modulate cortical excitability.
- Trial name
- NCT02115841
- Testing
- "Enraf-Nonius" Muscle stimulator
- Where
- Taiwan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Stroke
Changes in Brain Activity Associated With Upper Limb Motor Recovery
This study is to investigate changes in brain activities in acute stroke patients , and to correlate findings with clinical outcome measures.
- Trial name
- NCT02325427
- Testing
- tDCS
- Where
- Singapore
- Volunteers
- 8 people
- Sponsor
- National University Hospital, Singapore
Young Adults
Cortical Excitability and Typing Performance After Action Observation and Motor Execution
Goal: This study will aim to investigate the effects of different motor stimulation strategies-motor execution (ME) and action observation (AO)-on cortical excitability and typing performance in healthy individuals.
- Trial name
- NCT07009561
- Testing
- Motor Execution Typing Task, Action Observation of Typing Task
- Where
- United Arab Emirates
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Cortical Excitability, Psychiatric Disorder
Effects of L-theanine on Motor Cortex Excitability in Healthy Subjects: A Paired-Pulse TMS Study
Major depressive disorder (MDD) is a serious mental illness and the leading cause of disability worldwide. New pharmacotherapeutic agents with complementary neurobiological mechanism and better side effect profile are of great…
- Trial name
- NCT04749745
- Testing
- L-theanine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Cortical Excitability, Multiple Sclerosis
Effect of Galvanic Vestibular Stimulation on Cortical Excitability and Hand Dexterity in Multiple Sclerosis Patients
This study will be conducted to investigate the following: 1. The impact of implementing GVS in MS rehabilitation on cortical excitability. 2. The influence of GVS on upper limb function in patients diagnosed with MS.
- Trial name
- GVS on MS (NCT06195644)
- Testing
- Galvanic vestibular stimulation, MovAlyzeR® software from Neuroscript, BODYFIT Mini Portable Pedal Home Exerciser (cyclic ergometer)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Transcranial Direct Current Stimulation, Hypnosis
Effect of Hypnosis Combined With Tdcs on Pain Perception and Cortical Excitability in Fibromyalgia
Fibromyalgia is a public health condition, which causes great functional disability. Conventional treatment modalities have been shown a very poor therapeutic response, in that most individuals end up becoming poly-medicated and…
- Conditions
- Transcranial Direct Current Stimulation, Hypnosis, Fibromyalgia
- Trial name
- NCT05066568
- Testing
- Active Tracranial Direct Current Stimulation, Hypnotic analgesia suggestion, Rest
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Electrophysiologic Property of Brain
Impact of Celecoxib on Electrophysiological Property in Brain of Healthy Volunteer
the purposes of this study are to evaluate the acute electrophysiological response in brain cortex to single oral dose of celecoxib (400mg once) in healthy volunteer and the electrophysiological alteration in brain cortex by…
- Trial name
- NCT02711579
- Testing
- Celecoxib
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cortical Excitability, Brain Stimulation
Cortical Excitability Changes on the Sensorimotor Cortex Induced by Caffeine Consumption: A TMS Study
Caffeine is a widely used psychostimulant drug and acts as a competitive antagonist at adenosine receptors. Its effect is on neurons and glial cells of all brain areas.
- Trial name
- NCT03720665
- Testing
- Caffeine_TMS
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Fibromyalgia, Chronic Pain
Cortical Excitability Modulation With ctDCS in Fibromyalgia.
Fibromyalgia is a syndrome characterized by chronic generalized musculoskeletal pain, accompanied by other symptoms such as fatigue, sleep disturbance and depression.
- Trial name
- ctDCS (NCT05963321)
- Testing
- TDCS
- Where
- 2 sites in Brazil
- Volunteers
- 92 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Incontinence, Constipation
Biofeedback and Cortical Excitability
Looking for a modification of the cortical excitability of the motor area corresponding to the external anal sphincter after biofeedback sessions.
- Trial name
- Biofeedback (NCT00653887)
- Testing
- Biofeedback
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
ADHD - Attention Deficit Disorder With Hyperactivity
Brain Stimulation and Attention Control in Children With ADHD
The goal of this clinical trial is to learn if brain stimulation can help children ages 6 to 12 with attention-deficit/hyperactivity disorder (ADHD) improve their attention and self-control.
- Trial name
- NCT07182344
- Testing
- Intermittent Theta Burst Stimulation to Right DLPFC
- Where
- 2 sites in Kazakhstan
- Volunteers
- 40 people
- Sponsor
- Neurolab Plus
Dystonia
Brain Function in Focal Dystonia
Objectives The main objectives of this proposal are (1) to characterize motor learning abnormalities in patients with focal dystonia; (2) to show, using transcranial magnetic stimulation, that this abnormal motor learning went…
- Trial name
- NCT00102999
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Amyotrophic Lateral Sclerosis
Brain Excitability and Connectivity in Sensory-motor Pathways in ALS
The main objective is to determine the origin of somatosensory alteration in patients with ALS and to evaluate its impact on brain activity by coupling different imaging modalities and indirect electrophysiology.
- Trial name
- SOM_ALS (NCT03694132)
- Testing
- functional MRI, structural MRI, EEG/MEG
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France