Clinical trials: Cortical Excitability
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Glutamate Probes in Adolescent Depression
The purpose of this study is to learn if measures of brain chemicals from a brain scan called Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) and brain activity (known as cortical excitability and inhibition) collected by…
- Conditions
- Major Depressive Disorder, Major Depressive Disorder, Recurrent, Major Depressive Disorder, Remitted
- Trial name
- GPII (NCT02307617)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Acquired Brain Injury, Stroke
TMS-EEG for Cortical Excitability
This research study is being done to look at the safety and diagnostic benefit of conducting an TMS(transcranial magnetic stimulation)-EEG measured before and after a brief experimental stimulation session using investigational…
- Conditions
- Acquired Brain Injury, Stroke, Traumatic Brain Injury, Healthy
- Trial name
- NCT05472363
- Testing
- Electroencephalogram, Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Stroke, Stroke Sequelae
Noninvasive VNS to Facilitate Excitability in Motor Cortex
Transcranial Magnetic Stimulation (TMS) positively influences motor rehabilitation in stroke recovery. Transcutaneous auricular vagus nerve stimulation (taVNS) has shown effects on cortical plasticity.
- Conditions
- Stroke, Stroke Sequelae, Motor Activity
- Trial name
- NCT04130646
- Testing
- Transcranial Magnetic Stimulation, transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Healthy
Cortical Excitability, Cognitive Functions, and Peripheral Signaling Molecules
It is widely known that exercise creates structural and functional changes in the brain. Synaptic plasticity develops through exercise, thus improving brain functions.
- Trial name
- NCT05689606
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Excitability of Diaphragmatic Primary Motor Cortex
Effect of Transcranial Direct Current Stimulation (tDCS) on the Excitability of the Diaphragmatic Primary Motor Cortex
Transcranial direct current stimulation (tDCS) is a non invasive, painless, harmless way to modulate cerebral cortex excitability.
- Trial name
- NCT01548586
- Testing
- Eldith DC stimulator ( Magstim Company Ltd. UK)
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Fibromyalgia
Brain Response to Single Dose of Pregabalin in Fibromyalgia
Fibromyalgia syndrome represents a "spectrum disorder" characterized by widespread chronic pain, fatigue, sleep disturbances, mood and cognitive alterations.
- Trial name
- NCT02639533
- Testing
- Pregabalin
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Motor Activity
iTBS Methods and Motor Cortex Excitability
In a recent publication by Gamboa et al. 20108 it was shown that extended theta-burst stimulation duration might have reverse effects on cortical excitability when compared to the original Huang et al. 2005 publication.
- Trial name
- NCT03584438
- Testing
- Real iTBS
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Acute and Partial Sleep Deprivation
Cortical Excitability and Decision Making After Total Sleep Deprivation and Sleep Restriction
The investigators examine changes in decision making, vigilance and cortical excitability in healthy male subjects undergoing total acute sleep deprivation (40 hours) on the one hand, and chronic partial sleep restriction (7…
- Trial name
- NCT02305225
- Testing
- Sleep Deprivation
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Christian Baumann
Cannabis Use Disorder, Moderate
Cortical Excitability and Role of rTMS in Cannabis Use Disorder
Repetitive transcranial magnetic stimulation (rTMS) and cortical excitability have a role in cannabis use disorder
- Trial name
- NCT04106336
- Testing
- rTMS
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Motor Activity, Motor Neuroplasticity
Modulation of Motor Cortex Excitability by TMS and tDCS (MAGS1)
Investigating modulation of motor cortex excitability by transcranial magnetic stimulation and transcranial direct current stimulation.
- Trial name
- NCT03481309
- Testing
- anodal tDCS, cathodal tDCS
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Metaplasticity, Healthy Subjects
Effects of Transcranial Direct Current Stimulation Associated With Physical Exercise: a Metaplasticity Study
This study aims to understand metaplasticity through the association of transcranial direct current stimulation (tDCS) and physical exercise.
- Trial name
- NCT02263092
- Testing
- Physical exercise, tDCS, Rest
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Amyotrophic Lateral Sclerosis
Brain Excitability and Connectivity in Sensory-motor Pathways in ALS
The main objective is to determine the origin of somatosensory alteration in patients with ALS and to evaluate its impact on brain activity by coupling different imaging modalities and indirect electrophysiology.
- Trial name
- SOM_ALS (NCT03694132)
- Testing
- functional MRI, structural MRI, EEG/MEG
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Major Depressive Disorder
In Vivo Cortical Excitability Modulation in Major Depressive Disorder
The pathophysiology of Major Depression Disorder (MDD) is unclear, with several theories for its neurobiological mechanisms. One possible explanation is the presence of altered neuroplasticity, which can be studied by…
- Trial name
- PDM-TMS (NCT05441969)
- Testing
- No intervention/expousure
- Where
- Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fundacao Champalimaud
Systemic Lupus Erythematosus
Fatigue, Depression, and Cortical Excitability in Systemic Lupus
Systemic lupus erythematosus is a chronic inflammatory autoimmune disease with an unknown cause and many challenges. Whilst corticosteroids and effective immunosuppressive therapy have transformed the management of patients with…
- Trial name
- NCT03165682
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Nicotine Use Disorder
Cortical Excitability and Role of rTMS in Nicotine Use Disorder
Cortical excitability and role of repetitive transcranial magnetic stimulation in nicotine use disorder. Estimation of cortical excitability in heavy smoker patients and determination of role of repetitive transcranial magnetic…
- Trial name
- NCT03264755
- Testing
- Repetitive transcranial magnetic stimulation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Parkinson' Disease
Effects of Physical Exercise Combined With Transcranial Direct Current Stimulation in Parkinson's Disease
A controlled, blinded, and randomized clinical study will be carried out in a large sample of people with Parkinson's disease, where the combined effects of physical exercise and transcranial direct curren stimlation (tDCS) on…
- Trial name
- ExtDCSPARK (NCT07524400)
- Testing
- real tDCS and exercise, Exercise
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Healthy, Brain Stimulation
Effects of Transcranial Electrical Stimulation on Task Performance in Healthy Adults
The objective of this randomized, double-blind, sham-controlled, crossover study is to evaluate the effects of transcranial electrical stimulation (tES) on complex cognitive task performance in healthy adult volunteers.
- Conditions
- Healthy, Brain Stimulation, Transcranial Direct Current Stimulation (tDCS), Cognition
- Trial name
- BRAIN-STIM (NCT06995560)
- Testing
- Active Transcranial Electrical Stimulation
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Substance Use Disorders
Transcranial Magnetic Stimulation in Substance Use Disorder Patients
To determine the effect of substance use disorder on cortical excitability using transcranial magnetic stimulation (TMS) , it's a scientific study
- Trial name
- NCT06066164
- Testing
- Transcranial magnetic stimulation (TMS)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Epilepsy
Cortical Excitability Changes Induced by Retigabine: a Transcranial Magnetic Stimulation Study
The objective of this study is to characterize the effects of a single-dose of retigabine on cortical excitability in healthy subjects, as quantified by means of TMS.
- Trial name
- CERETI (NCT01823159)
- Testing
- retigabine
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Cortical Excitability, Robotized TMS
Cortical Excitability Using Robotised and Neuronavigated Transcranial Magnetic Stimulation
This study has two main goals : to develop the cortcial excitbality (CE) measurement methodology using coupling between transcranial magnetic stimulation (TMS) and physiological recordings such as electroencephalography (EEG) and…
- Trial name
- ROBEXCI (NCT02168413)
- Where
- France
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble