Clinical trials: Covid-19 Patients
Covid19
TREATMENT WITH ANTI-SARS-COV-2 IMMUNOGLOBULIN IN PATIENTS WITH COVID-19
A Phase I/II clinical trial for safety and efficacy evaluation of treatment with anti-SARS-CoV-2 equine immunoglobulin (F(ab')2) in hospitalized patients with COVID-19 not requiring of invasive ventilation support.
- Trial name
- NCT04573855
- Testing
- Anti-SARS-CoV-2 immunoglobulin
- Volunteers
- 41 people
- Sponsor
- D'Or Institute for Research and Education
SARS-CoV-2 Infection
T Cell Therapy Opposing Novel COVID-19 Infection in Immunocompromised Patients
This is an open label, phase I dose-escalation study to evaluate the safety of coronavirus-specific T cell (CST) therapy for prevention of SARS-CoV-2 infection in immunocompromised patients following hematopoietic stem cell…
- Trial name
- TONI (NCT05141058)
- Testing
- Coronavirus-specific T cell (CST)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Children's National Research Institute
Hematopoietic and Lymphatic System Neoplasm
Self-Amplifying mRNA COVID-19 Vaccine (LUNAR-COV19) Versus Comirnaty Vaccine in Adult Hematopoietic Cell Transplant Patients
This phase IIb trial compares the effect of LUNAR-COV19 vaccine to Comirnaty vaccine in treating adult patients who have received a hematopoietic cell transplant (HCT).
- Trial name
- NCT07390968
- Testing
- SARS-CoV-2 mRNA Vaccine ARCT-021, Tozinameran, Biospecimen Collection
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Fred Hutchinson Cancer Center
End Stage Kidney Disease, Kidney Transplantion
The Response of the Immune System of Patients With End Stage Kidney Disease on Dialysis and Kidney Transplant Recipients Vaccinated for COVID-19
Observational study of patients with End Stage Kidney Disease on dialysis and Kidney Transplant Recipients, before and after vaccination for SARS-COV 2, after written consent, with the aim of laboratory efficacy of the vaccine…
- Conditions
- End Stage Kidney Disease, Kidney Transplantion, Covid19, Vaccination
- Trial name
- NCT04932876
- Testing
- SARS - COV 2 VACCINE
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Ioannina
Covid19
DNA Damage and Oxidative Stress in Hospitalized COVID-19 Patients
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic challenging health systems worldwide.
- Trial name
- ABCD (NCT04784468)
- Testing
- No intervention
- Where
- Austria
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Oral Health and COVID 19
Oral Manifestation of COVID 19 Patient: A Cross Sectional Study on Egyptian Population
The oral manifestation of COVID 19 that could help in the diagnosis of patient
- Trial name
- NCT04391881
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- Cairo University
Cancer
Oncology-patient-reported Anxiety, Mood, and QoL During the COVID-19 Pandemic
ONCOVID is a prospective cohort study investigating oncology-patient-reported anxiety, mood, and quality of life during the COVID-19 pandemic.
- Trial name
- ONCOVID (NCT04340219)
- Testing
- Survey administration
- Where
- Belgium
- Volunteers
- 394 people
- Sponsor
- University Hospital, Ghent
COVID-19
Efficacy of Addition of Naproxen in the Treatment of Critically Ill Patients Hospitalized for COVID-19 Infection
The symptoms of respiratory distress caused by COVID-19 may be reduced by drugs combining anti-inflammatory and antiviral effects.
- Trial name
- ENACOVID (NCT04325633)
- Testing
- 1: Naproxen, 2: Standard of care
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplant Infection, Covid19
Humoral Immunity Against SARS-CoV-2 in Liver Transplanted Patients After COVID-19 in Comparison With Immunocompetent Patients
This is a prospective study analyzing the development of humoral immune response against SARS-Cov-2 in patients with previous Covid19: the aim is to compare the incidence, titration and evolution of IgG an IgM in a prospective…
- Conditions
- Liver Transplant Infection, Covid19, Mortality, Immune Response
- Trial name
- NCT04410471
- Testing
- CLIA of IgG and IgM against SARS-Cov-2
- Where
- 2 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Magdalena Salcedo
COVID-19, SARS-CoV 2
Efficacy of Intravenous Melatonin on Mortality in Adult Patients Admitted to the Intensive Care Unit With COVID-19
There is an urgent need to evaluate effective treatments for COVID-19 patients. Melatonin has significant anti-inflammatory and antioxidant properties and it lacks of side-effects.
- Conditions
- COVID-19, SARS-CoV 2, Coronavirus Infection
- Trial name
- MELCOVID (NCT04568863)
- Testing
- Melatonin intravenous
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Pharmamel S.L.
Tracheal Stenosis
Observational Study for the Evaluation of Tracheal Stenosis in COVID-19 Patients
Define the actual incidence of tracheal stenosis in patients who underwent either prolonged intubation or tracheostomy and to compare incidence, clinical course and outcome between COVID-19 and non-COVID-19 patients.
- Trial name
- TS1 (NCT04686721)
- Testing
- Chest CT scan + baseline spirometry
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Clinico Humanitas
Covid19
The Role of CT Chest Scan in the Pre-anesthetic Assessment of Suspected or Confirmed COVID -19 Patients
The role of CT scan of the chest in Pre-anesthetic assessment of the severity of COVID-19 and the correlations between CT measurements of the aortic and pulmonary arteries diameters and severity of pneumonia.
- Trial name
- NCT04560530
- Testing
- Non-enhanced CT scan of the chest
- Where
- Saudi Arabia
- Volunteers
- 76 people
- Sponsor
- Tanta University
Acute Lung Injury, Acute Kidney Injury
Safety and Efficacy Evaluation of CO2 Removal in Combination With Continuous Veno-Venous Hemodialysis/Hemodiafiltration Therapy
Objective of the study is to assess the safety and efficacy of CO2 removal by the multiECCO2R (CO2 Removal System) on the multiFiltrate/multiFiltrate Pro in veno-venous extracorporeal circulation during continuous renal…
- Conditions
- Acute Lung Injury, Acute Kidney Injury, Hypercapnia, Covid19
- Trial name
- multiECCO2R (NCT04871893)
- Testing
- multiECCO2R blood-gas exchanger
- Where
- 6 sites in Germany
- Volunteers
- 28 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Cancer, Immunotherapy
Retrospective Study of COVID-19 Vaccines in Patients Undergoing Immunotherapy for Cancer.
The investigators wish to set up a pharmaco-epidemiological cohort within the Hospital Territorial Groups of the Cévennes-Gard Camargue, East-Hérault and Haute-Garonne and West Tarn on a specific population, patients undergoing…
- Trial name
- IVACOV (NCT05025514)
- Where
- 5 sites in France
- Volunteers
- 125 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Rheumatism
Assessment of the Psychological Impact of the COVID19 (SARS-CoV-2) Pandemic on Patients With Chronic Inflammatory Rheumatism
Patients with chronic inflammatory rheumatism (RIC) or autoimmune diseases, rheumatoid arthritis and spondyloarthritis, are regularly monitored in consultation as part of a "treat to target" strategy with rapid adaptation of…
- Trial name
- RICOVID19 (NCT04723407)
- Testing
- questionnaires
- Where
- France
- Volunteers
- 950 people
- Sponsor
- University Hospital, Limoges
Hemiplegia, Muscle Spasticity
Tele-physiotherapy on Post-stroke Hemiplegia Patients
The present preliminary randomized trial will be performed to compare the effectiveness of telephyisiotherapy plus physical exercises versus other conventional techniques (electromyographic biofeedback or conventional…
- Trial name
- NCT06048432
- Testing
- Conventional Physiotherapy + telephysiotherapty
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Covid19, Vitamin D
Efficacy of Vitamin D Treatment in Pediatric Patients Hospitalized by COVID-19
Open controlled clinical trial. Hospitalized pediatric patients with COVID-19 will be included. Upon admission to hospital serum determination of vitamin D, interleukins, ferritin and Dimer D will be performed.
- Conditions
- Covid19, Vitamin D, Children, Only
- Trial name
- COVID-19 (NCT04502667)
- Testing
- Cholecalciferol
- Where
- Mexico
- Volunteers
- 45 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
COVID-19
A Study to Evaluate OP-101 (Dendrimer N-acetyl-cysteine) in Severe Coronavirus Disease 2019 (COVID-19) Patients
The primary purpose of Stage-I of this study is to evaluate the safety and tolerability of OP-101 in patients with severe COVID-19 and of Stage 2 of this study is to evaluate the efficacy of OP-101 in patients with severe…
- Trial name
- PRANA (NCT04458298)
- Testing
- OP-101
- Where
- 8 sites in United States
- Volunteers
- 28 people
- Sponsor
- Ashvattha Therapeutics, Inc.
Severe COVID-19 Disease
Study on the Safety and Efficacy of Convalescent Plasma in Patients With Severe COVID-19 Disease
Currently, there is no specific treatment or vaccine for SARS-CoV-2 available, some drugs are being investigated as treatment, but the effect is unknown.
- Trial name
- PC-COVID-HCM (NCT04542967)
- Testing
- Biological
- Where
- Mexico
- Volunteers
- 150 people
- Sponsor
- Hospital Central Militar
Covid19, Pneumonia
Intravenous Immunoglobulin (IVIG, Bioven) Efficacy Assess for COVID-19 / SARS-CoV-2 Severe Pneumonia Complex Treatment
Pneumonia caused by coronavirus infection COVID-19 is characterized by a combination of several dangerous factors that consistently worsen the patient's condition: viral lung damage early in the disease; a sharp increase in…
- Trial name
- NCT04500067
- Testing
- IVIG
- Where
- 9 sites in Ukraine
- Volunteers
- 76 people
- Sponsor
- Biopharma Plasma LLC
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