Clinical trials: Covid-19 Patients
COVID-19
A Safety and Efficacy Study of Hymecromone Tablets for the Treatment of Patients With COVID-19.
The coronavirus (SARS-CoV-2) is a new strain of coronavirus found in human in 2019, which causes epidemic worldwide. A study found that the increase in hyaluronic acid levels is closely related to the clinical symptoms of…
- Trial name
- NCT05386420
- Testing
- Hymecromone tablets
- Where
- China
- Volunteers
- 304 people
- Sponsor
- Shanghai Zhongshan Hospital
COVID-19 Pneumonia
Multiparametric Assessment of Peripheral Blood and Tissue Myeloid Cells. Phenotype for Precision Medicine in Patients With SARS-Cov-2 Infection
We hypothesise that patients with SARS-Cov-2 infection are characterized by progressive changes in distribution of distinct lung macrophages populations mediated by influx of circulating monocytes into the lungs .
- Trial name
- NCT05767853
- Testing
- Immune-phenotyping of tissue and peripheral blood myeloid compartment
- Where
- 2 sites in Italy, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
COVID-19
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
The purpose of this clinical trial is to learn about the safety, pharmacokinetics (pharmacokinetics helps us understand how the drug is changed and eliminated from your body after you take it), and efficacy (how well a study…
- Trial name
- NCT05261139
- Testing
- nirmatrelvir, ritonavir
- Where
- 73 sites in United States, Bulgaria and 5 more
- Volunteers
- 160 people
- Sponsor
- Pfizer
Covid19, Viral Infection
Assessment of the Clinical Effectiveness of a Herbal Extract (Cretan IAMA) in Patients With Viral Respiratory Infections, Including COVID-19, in Primary Healthcare Settings, and Co-assessment of Its Prophylactic Effect in People Cohabiting With These Patients
This single-arm, open-label small interventional proof-of-concept (POC) study study aims: 1. to assess the clinical outcomes of patients exhibiting viral respiratory infection (VRI) symptoms and seeking primary healthcare (PHC)…
- Conditions
- Covid19, Viral Infection, Respiratory Viral Infection
- Trial name
- COVID-19-IAMA (NCT04705753)
- Testing
- Cretan IAMA
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- University of Crete
COVID-19
Interferon Gamma Induced Protein 10 (IP-10) in a Clinical Decision Support Protocol in COVID-19 Patients
The proposed project will pilot incorporation of rapid serial measurements of IP-10 into a CDS tool for moderate and severe COVID-19 patients.
- Trial name
- NCT04389645
- Testing
- IP-10 in CDS protocol
- Where
- Israel
- Volunteers
- 52 people
- Sponsor
- MeMed Diagnostics Ltd.
COVID-19 Acute Respiratory Distress Syndrome
When to Apply to Which Patient in MSC?
Mesenchymal stem cell (MSC) therapy is among the promising treatments for acute respiratory distress syndrome (ARDS). Our study aimed to investigate the clinical efficacy of MSC treatment in COVID-19 patients, to determine when…
- Trial name
- MSC (NCT05240430)
- Testing
- Mesenchymal Stem Cell Antigen-1, Human
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Trabzon Kanuni Education and Research Hospital
Moderate Covid19
The Efficacy of Leukotriene Inhibitor in Adult Patients With Moderate SARS-COV-2 Symptoms (COVID19)
There is an urgent need to explore therapeutic options for SARS-CoV-2 in order to face the pandemic. The selected intervention was based on that zafirlukast will have dual effect; first it will block the virus replication through…
- Trial name
- PROMISE (NCT04871828)
- Testing
- Leukotriene Receptor Antagonist
- Where
- Saudi Arabia
- Volunteers
- 66 people
- Sponsor
- King Abdullah International Medical Research Center
Covid19
Andrographis Paniculata vs Boesenbergia Rotunda vs Control in Asymptomatic COVID-19
The purpose of this study is to examine the effect of Andrographis Extract, Boesenbergia Extract compared to standard treatment in asymptomatic COVID patients.
- Trial name
- NCT05019326
- Testing
- Andrographis Paniculata, Boesenbergia, Standard supportive treatment
- Where
- Thailand
- Volunteers
- 3,060 people
- Sponsor
- Mahidol University
Long COVID, Post-Acute COVID-19 Syndrome
Effectiveness and Safety of Mesenchymal Stem Cell Therapy in Long COVID Patients
The goal of this clinical trial is to evaluate the effectiveness and safety of mesenchymal stem cell therapy in long-COVID patients.
- Trial name
- NCT06492798
- Testing
- umbilical cord mesenchymal stem cell
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Changhai Hospital
Covid19
Impact of the COVID-19 Pandemic on Vaccination
The vaccination policy is drawn up in France by the French Minister of Health, who makes public the vaccination schedule after the opinion of the High Authority of Health.
- Trial name
- COVIDVacImpac (NCT04657263)
- Testing
- Vaccine coverage assessment
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Covid19, Chronic Kidney Disease 5D
Immune Response in Dialysis Patients Vaccinated Against COVID-19
This is a prospective cohort study aimed to evaluate short- and mid-term immune response after SARS-CoV-2 vaccination using Gam-COVID-Vac (Sputnik V) vaccine in dialysis patients compared to the control group (medical staff).
- Trial name
- Sputnik-HD (NCT04805632)
- Where
- Russia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Saint Petersburg State University, Russia
Coronavirus
Silmitasertib (CX-4945) in Patients With Severe Coronavirus Disease 2019 (COVID-19)
This multi-center, open-label, 2 arm parallel-group, randomized, interventional prospective exploratory study in 40 patients aimed to evaluate safety and explore putative clinical benefits of Silmitasertib 1000 mg BID dose in…
- Trial name
- CX4945 (NCT04668209)
- Testing
- Silmitasertib
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- University of Arizona
Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe)
Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)
This is a multi-center, randomized, placebo controlled, interventional phase 2A trial to evaluate the safety profile and potential efficacy of multi-dosing of mesenchymal stromal cells (MSC) for patients with SARS-CoV-2…
- Conditions
- Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe), COVID-19 Pneumonia
- Trial name
- NCT04466098
- Testing
- Mesenchymal stromal cells
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Hematologic Diseases
Evaluation of the Immune Response to Sars-Covid-19 Vaccines in Haematological Patients: Prospective Single Center Study
The main objective of this study is to investigate the humoral immune response to COVID-19 vaccines in haematological patients, by testing SARS-CoV-2 seroconversion
- Trial name
- Hema-C19-Vax (NCT05074706)
- Testing
- IgG antibodies to Sars-Cov-2, QuantiFERON SARS-CoV-2 test
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- University of Milano Bicocca
COVID-19
Hypertonic Saline for COVID-19 Symptoms
Rationale: Coronavirus disease 2019 (COVID-19) is spreading rapidly in the world with no proven effective therapy to date. Some patients with COVID-19 develop sever respiratory disease requiring ICU care.
- Trial name
- NCT04465604
- Testing
- Wearing surgical face mask sprayed with hypertonic saline
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
COVID, SARS-CoV 2
Factors Associated With Clinical Outcomes in Patients Hospitalized for Covid-19 in GHT-93 Est
Healthcare centers treated several hundreds of patients with Covid-19 and prospectively gathered information in electronic format between March, 2020 to April, 2020.
- Trial name
- NCT04366206
- Where
- 2 sites in France
- Volunteers
- 143 people
- Sponsor
- Centre Hospitalier Intercommunal Robert Ballanger
Covid19, Respiratory Disease
Post COVID19 Functional and Cognitive Assessments
The main objective of the proposed study is to evaluate the impact of coronavirus (2019-nCoV), hereafter COVID -19, on patients' loss of functional capacity after completion of hospital treatment.
- Conditions
- Covid19, Respiratory Disease, Walking, Difficulty, Cognitive Decline
- Trial name
- PostCovidZRS (NCT04860206)
- Where
- Slovenia
- Volunteers
- 43 people
- Sponsor
- Science and Research Centre Koper
Sedation Complication, Covid19
EEG-based Sedation Protocol for Patients on Mechanical Ventilation Due to SARS-CoV-2 Pneumonia
Deep sedation in patients with COVID-19 may be challenging in many aspects. The use of an EEG-based protocol to guide deep sedation may be useful in this particular population, considering their unusually high sedation…
- Trial name
- NCT04699916
- Testing
- EEG based protocol for deep sedation
- Where
- Chile
- Volunteers
- 50 people
- Sponsor
- University of Chile
SARS-CoV2 Infection
Receptive Music Therapy on Anxiety and Vital Parameters in Hospitalized Covid-19 Patients.
Hospitalized patients for Covid-19 are extremely isolated from their families for a long and uncertain period of time .This traumatic separation makes patients vulnerable to different degrees of stress disorders as well as…
- Trial name
- MADC-19 (NCT05077306)
- Testing
- music therapy group
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
SARS-CoV 2, COVID-19
Test and Treat COVID 65plus+
Patients over equal or older than 65 yearswill be treated with a hydroxychloroquine versus placebo reduced loading dose of 600mg on the first day followed with 400mg/day divided in 2x200mg for 6 more days resulting in a total…
- Trial name
- COVID65plus (NCT04351516)
- Testing
- Hydroxychloroquine
- Where
- 2 sites in Germany
- Sponsor
- University Hospital Tuebingen
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