Clinical trials: Covid-19 Patients
No-Show Patients, Therapeutic Adherence and Compliance
Evaluation of the Relationship Between Missed Appointments and Adherence to Medical Indications
We will conduct a cross-sectional study involving adults with type 2 diabetes mellitus. Our primary objective is to evaluate the association between nonattendance and participants' adherence to both pharmacological and…
- Conditions
- No-Show Patients, Therapeutic Adherence and Compliance, Type 2 Diabetes Mellitus, COVID-19
- Trial name
- NCT06501456
- Where
- Argentina
- Volunteers
- 46 people
- Sponsor
- Hospital Italiano de Buenos Aires
COVID-19
Study on Safety and Clinical Efficacy of AZVUDINE in Initial Stage COVID-19 Patients (SARS-CoV-2 Infected)
Phase III, single-center with co-participating units, randomized, double-blind, parallel, placebo-controlled clinical study
- Trial name
- NCT05033145
- Testing
- AZVUDINE
- Where
- 7 sites in Brazil
- Volunteers
- 312 people
- Sponsor
- HRH Pharmaceuticals Limited
Pneumonia, Viral, Covid19
Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19
Introduction: SARS-CoV2 infection produces severe pneumonia with pulmonary alveolar collapse. There is no specific treatment to date.
- Conditions
- Pneumonia, Viral, Covid19, ARDS, Oxidative Stress
- Trial name
- ANTIOX-COVID (NCT04570254)
- Testing
- Vitamin C, Vitamin E, Melatonin
- Where
- Mexico
- Volunteers
- 110 people
- Sponsor
- Unidad Temporal COVID-19 en Centro Citibanamex
COVID-19
The Proof of Concept Phase 2 Study to Evaluate the Safety and Efficacy of Clevudine in Patients With Mild and Moderate COVID-19
The purpose of this clinical trial is to assess the safety and efficacy of Clevudine 150 mg versus placebo once daily administration with standard of care therapy for 10 days in patients with mild and moderate COVID-19.
- Trial name
- NCT04891302
- Testing
- Clevudine
- Where
- 11 sites in South Korea
- Volunteers
- 104 people
- Sponsor
- Bukwang Pharmaceutical
Covid19
Intramuscular and Intravenous VIR-7831 (Sotrovimab) for Mild/Moderate COVID-19.
The COMET-TAIL main study evaluated efficacy, safety, and tolerability of IM sotrovimab versus IV sotrovimab in high-risk patients for the treatment of mild/moderate COVID-19.
- Trial name
- NCT04913675
- Testing
- sotrovimab
- Where
- 50 sites in United States, France and 1 more
- Volunteers
- 1,065 people
- Sponsor
- Vir Biotechnology, Inc.
COVID, ARDS, Human
Compassionate Use Open-Label Anti-CD14 Treatment in Patients With SARS-CoV-2 (COVID-19)
This protocol proposes to use IC14, a recombinant chimeric monoclonal antibody (mAb) recognizing human CD14, to block CD14-mediated cellular activation in patients early in the development of ARDS.
- Conditions
- COVID, ARDS, Human, Ards, SARS-CoV2
- Trial name
- NCT04346277
- Testing
- IC14, a monoclonal antibody against CD14
- Where
- Italy
- Sponsor
- Implicit Bioscience
Covid19, SARS-CoV Infection
IVIG in Patients With Severe COVID-19 Requiring Mechanical Ventilation
The purpose of this Pilot Study is to establish a hypothesis of whether or not intravenous immunoglobulin (IVIG) may impact the hospital length of stay, if started within 48 of mechanical ventilation in patients infected with…
- Trial name
- NCT04616001
- Testing
- IVIG
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sharp HealthCare
Chronic Obstructive Pulmonary Disease, Chronic Cough
Study of AffloVest in At-Risk Respiratory Patients During COVID-19 Pandemic
The purpose of the study is to investigate the addition of high frequency chest wall oscillation (HFCWO) therapy to the prescribed care regimen to support the diaphragm during airway clearance among post-COVID patients with COPD…
- Conditions
- Chronic Obstructive Pulmonary Disease, Chronic Cough, Covid19
- Trial name
- NCT04654481
- Testing
- HCFWO, Standard Care Plus Monitoring
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Covid19, Physical Disability
Effects of COVID-19 Hospitalization on Physical Performance
Coronavirus disease (COVID-19) has resulted in millions of hospital admissions. The physical consequences caused by COVID-19 hospitalization could jeopardize the overall health status of patients through a decrease in functional…
- Trial name
- NCT04751630
- Testing
- Therapeutic Exercise
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Universitat Internacional de Catalunya
Cystic Fibrosis, COPD
High Resolution Micro OCT Imaging
The purpose of this study is to learn about using the imaging to make images of the lungs and nose with the long-term goal of the research leading to potential treatments and new therapies for patients with cystic fibrosis.
- Conditions
- Cystic Fibrosis, COPD, PCD - Primary Ciliary Dyskinesia, Covid19
- Trial name
- NCT03256773
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Covid19
Comparison of Remdesivir Versus Lopinavir/ Ritonavir and Remdesivir Combination in COVID-19 Patients
Comparison outcomes of a large cohort of moderate and severe COVID-19 patients received remdesivir alone with patients who received remdesivir in combination with lopinavir/ ritonavir in addition to standard management.
- Trial name
- NCT04738045
- Testing
- Remdesivir, Lopinavir/ Ritonavir and Remdesivir combination
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ahmed Essam
COVID-19 Pneumonia
RALE Versus CORADS/CT-Severity Score in COVID-19
Rationale Patients with severe coronavirus disease 2019 (COVID-19) frequently fulfill the criteria for acute respiratory distress syndrome (ARDS), with extensive and bilateral abnormalities on the chest radiography (CXR) and the…
- Trial name
- RALE-CORADS (NCT05047653)
- Testing
- RALE score vs. severity score
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
COVID-19, Immunodeficiency
OPtimisation of Antiviral Therapy in Immunocompromised COVID-19 Patients: a Randomized Factorial Controlled Strategy Trial
The overall purpose of the trial is to evaluate the efficacy and safety of possible combination antiviral therapy DAA (remdesivir + nirmatrelvir/r)∞ versus the reference monotherapy (nirmatrelvir/r alone) and to assess the…
- Trial name
- OPTICOV (NCT05587894)
- Testing
- Paxlovid 5 days, Paxlovid 10 days, Veklury
- Where
- 18 sites in France, Italy and 1 more
- Volunteers
- 256 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Satisfaction, Patient, Covid19
Virtual White Boards for Patient Satisfaction
Communication with patients on their clinical status is important in delivering care in the emergency department. During times of high volume or complex patients, there may be lapses in communicating with patients about their…
- Conditions
- Satisfaction, Patient, Covid19, Emergencies, Satisfaction
- Trial name
- NCT04497922
- Testing
- e-ink screen, Treatment as usual
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital
Covid19
Cytokine Status of Covid-19 Patients
COVID-19, spreading rapidly all over the world, causes serious morbidity and mortality. In severe COVID-19 infections, after pulmonary inflammation, cardiovascular organ failure, cytokine storm, hemophagocytosis, septic shock…
- Trial name
- NCT04531345
- Testing
- Flow cytometric analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
COVID-19, SARS-CoV 2
CONVALESCENT PLASMA FOR ILL PATIENTS BY COVID-19
The present study will try to respond first in an initial phase, what is the minimum effective dose necessary of convalescent plasma for getting better in severly ill (not intubated) or very severely ill (intubated) patients.
- Conditions
- COVID-19, SARS-CoV 2, Convalescence, Plasma
- Trial name
- COPLASCOV19 (NCT04356482)
- Testing
- convalescent plasma
- Where
- 3 sites in Mexico
- Volunteers
- 90 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
COVID
Efficacy of Pentoxifylline as Add on Therapy in COVID19 Patients
With potential antiviral effects on severe acute respiratory syndrome (SARS) and as a methyl-xanthine derived inhibitor of phosphodiesterase-4, pentoxifylline basically functions as a hemorrheologic agent for a better circulation…
- Trial name
- NCT04433988
- Testing
- Pentoxifylline
- Where
- Egypt
- Sponsor
- Sadat City University
SARS-CoV-2 Infection
Halodine Nasal Antiseptic in Patients With COVID-19
Povidone iodine (PVP-I) is a well-known broad spectrum, resistance free antimicrobial agent that has a long history of safe and effective use.
- Trial name
- NCT04517188
- Testing
- Povidone-Iodine Solution 1.25% w/w [0.125% available iodine] USP
- Volunteers
- 40 people
- Sponsor
- Halodine LLC
Chronic Heart Failure, Chronic Kidney Diseases
ODYSSEE-vCHAT Mental Health Program for Heart Failure and Kidney Disease Patients
INTRODUCTION Psychological distress and reduced quality of life are prevalent in patients with chronic heart failure (CHF) and advanced chronic kidney disease (CKD).
- Trial name
- ODYSSEEvCHAT (NCT05560737)
- Testing
- ODYSSEE-vCHAT
- Where
- 4 sites in Canada
- Volunteers
- 215 people
- Sponsor
- University Health Network, Toronto
Covid19
OCTA Study: Retinal Vascular Changes in Patients With SARS-CoV-2 Infection
This study evaluates the retinal vascular features using optical coherence tomography angiography in patients that have been affected by COVID-19.
- Trial name
- NCT04601012
- Testing
- Optical coherence tomography angiography
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federico II University
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