Clinical trials: Covid-19 Patients
COVID-19
A Phase II/III Study of Sargramostim
This is a randomized, placebo-controlled, double-blind, group comparison, multicenter study to evaluate the efficacy and safety of inhalation administration of sargramostim for 5 days, in principle (up to 10 days) as Add-on…
- Trial name
- NCT04642950
- Testing
- Sargramostim
- Where
- 7 sites in Japan
- Volunteers
- 70 people
- Sponsor
- Nobelpharma
Covid19
Assessing the Impact of COVID-19 Patients Long Distance Transfers Between Intensive Care Units
The TRANSCOV cohort is a multicentre observational retrospective study aiming at assessing the health impact of extra regional transfers of critically ill COVID-19 patients.
- Trial name
- TRANSCOV (NCT04930120)
- Testing
- Inter ICU long distance patient transfer
- Where
- France
- Volunteers
- 3,060 people
- Sponsor
- Ecole des Hautes Etudes en Santé Publique
SARS-CoV2 Infection
Qualitative and Functional Investigation of Lipids in Patients With SARS-CoV2 Infection - In Search of Atherogenic Sequelae
Currently, the world is facing a SARS-CoV2 coronavirus epidemic, which is responsible for COVID-19. In France, this virus has already infected several million people and is responsible for the death of more than 127,000.
- Trial name
- COVI-LIPI-D (NCT05476224)
- Testing
- Blood sample of 30 ml
- Where
- France
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
COVID-19
The LUSZ COVID-19 Severity Index: A Prognostic and Predictive Score of Mortality for Hospitalized Patients With Covid-19
The coronavirus disease 2019 (COVID-19) has spread rapidly and caused a global pandemic, as defined by the WHO, within a short period of time.
- Trial name
- LUSZ_SCORE (NCT05848427)
- Testing
- LUSZ P
- Where
- 2 sites in Lebanon
- Volunteers
- 1,000 people
- Sponsor
- Lebanese University
Long COVID
Rehabilitation and Return to Everyday Life for Patients With Long COVID
This non-randomised controlled trial will investigate if patients with long COVID receiving a structured and group-based rehabilitation intervention (The Long COVID Rehabilitation Intervention) will report a difference in mean…
- Trial name
- NCT06544382
- Testing
- The Long COVID Rehabilitation Intervention, Usual care
- Where
- Denmark
- Volunteers
- 914 people
- Sponsor
- Defactum, Central Denmark Region
COVID-19
Convalescent Plasma as Therapy for Covid-19 Severe SARS-CoV-2 Disease (CONCOVID Study)
Passive immunization with immunoglobulins is occasionally used as therapy for the treatment of viral infectious diseases. Immunoglobulins are used for the treatment of CMV disease, and is effective as prophylaxis when given soon…
- Trial name
- ConCoVid-19 (NCT04342182)
- Testing
- Convalescent plasma
- Where
- 18 sites in Netherlands
- Volunteers
- 86 people
- Sponsor
- Erasmus Medical Center
COVID, Hypoxic Respiratory Failure
Incline Positioning in COVID-19 Patients for Improvement in Oxygen Saturation
COVID-19 is a respiratory illness caused by SARS-CoV-2 with a range of symptoms from mild, self-limiting respiratory tract infections to severe progressive pneumonia, multiorgan dysfunction and death.
- Trial name
- UPSAT (NCT04344561)
- Testing
- Postural Positioning
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Johns Hopkins University
Rheumatoid Arthritis, COVID
Anti-rheumatic Drug Use and Risk of COVID-19 Infection in Rheumatoid Arthritis Patients
Rheumatoid arthritis (RA) patients have an underlying immune deficiency and typically treated with immunosuppressive drugs, which may increase the risk of COVID-19 infection.
- Trial name
- NCT04434118
- Testing
- Traditional antirheumatic drugs
- Where
- Egypt
- Sponsor
- Sadat City University
Covid19
Efficacy of Convalescent Plasma to Treat COVID-19 Patients, a Nested Trial in the CORIMUNO-19 Cohort
The coronavirus disease 2019 (COVID-19) viral pneumonia is now a worldwide pandemic caused by the Severe acute respiratory virus coronavirus 2 (SARS-CoV-2).
- Trial name
- CORIPLASM (NCT04345991)
- Testing
- Transfusion of COVID-19 convalescent plasma
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19
HLA-G Immuno-Inhibitor Checkpoint Study in Patients With COVID-19 Infection: Molecular and Cellular Assessment
The aim of the research is to study the immune checkpoint linked to the HLA-G molecule in the dysregulation of the control of COVID-19 infection.
- Trial name
- HLA-G-COVID (NCT04613297)
- Testing
- Baseline and during hospitalization blood samples, Baseline blood sample
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Hopital Foch
COVID
Caregiver Serological Monitoring Extended Secondarily to Patients With the SARS-CoV-2 Coronavirus
Hospital mortality attributed to SARS-CoV-2 in France increased daily by 28% in the week before confinement. The week following this decision, the daily increase was 30%.
- Trial name
- CoVid3S (NCT04441710)
- Testing
- Questionnaire
- Where
- 4 sites in France
- Volunteers
- 2,777 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Covid19, SARS-CoV 2 Infection
Effect of Local Treatment(Carrageenan Nasal Spray and PVP-I Mouthwash) in Reducing Viral Load in Patients With COVID-19
The goal of this study is to recruit confirmed Covid-19 patients, to evaluate whether the topical anti-septic can improve clinical outcome in early Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection.
- Trial name
- LT-COVID19 (NCT05049213)
- Testing
- Carrageenan nasal spray and 1% PVP- mouthwash and gargle
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- National Taiwan University Hospital
Disease, Viral, Cytokine Release Syndrome
Th1/Th2/Th17/TREG and TLRs Activation/KIR for COVID 19 Prediction of Outcome
To ascertain globally the changes in the cytokines involved and TLRs/KIR activation in patients admitted to the hospital with a COVID-19 diagnosis, and the changes after initiation of the different therapies
- Conditions
- Disease, Viral, Cytokine Release Syndrome, TLRs
- Trial name
- Resistir (NCT04403061)
- Testing
- Cytokines measurement, Cellular response, TLRs activation measurement
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- Asociacion para el Estudio de las Enfermedades Infecciosas
COVID-19 Pneumonia
Randomized, Unicentric, Open, Controlled Clinical Trial, in Phase Iii, to Demonstrate the Effectiveness of Tocilizumab
Randomized, open, single-center, controlled clinical trial, with 2 treatment arms that seeks to demonstrate the effectiveness of tocilizumab against systemic corticosteroids, both treatments added to supportive treatment in…
- Trial name
- NCT05002517
- Testing
- Tociliziumab group, Methylprednisolone group
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Biogipuzkoa Health Research Institute
COVID, Acute Kidney Injury
Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19 and High Risk of Acute Kidney Injury
The aim is to describe the epidemiology and determine the independent risk factors for mortality and acute organ injury in AKI and to assess the impact of different treatment strategies on survival.
- Conditions
- COVID, Acute Kidney Injury, Critical Illness
- Trial name
- NCT04445259
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Covid19, Myopathy
Safety and Efficacy of Inactivated SARS-CoV-2 Vaccine in Immune-related Myopathy (Myasthenia Gravis and Inflammatory Myopathy) Patients ：a Prospective Observational Study
This study is a prospective observational study. We aim to investigate the safety and efficacy of inactivated SARS-CoV-2 vaccine between immune-related myopathy (myasthenia gravis and inflammatory myopathy) patients and health…
- Trial name
- NCT04941079
- Testing
- no intervention
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Covid19
VIR-7831 for the Early Treatment of COVID-19 in Outpatients
This is a phase 2/3 study in which subjects with coronavirus disease 2019 (COVID-19) will receive VIR-7831 or placebo and will be assessed for safety, tolerability, efficacy, and pharmacokinetics.
- Trial name
- COMET-ICE (NCT04545060)
- Testing
- VIR-7831 (sotrovimab)
- Where
- 91 sites in United States, Austria and 5 more
- Volunteers
- 1,057 people
- Sponsor
- Vir Biotechnology, Inc.
COVID-19
StEroids in hospitaLized patiEnts With Covid-19 in The Netherlands.
Rationale: In patients with COVID-19 admitted to the hospital, large heterogeneity exists in patients, timing and dosing of steroid therapy. It is unclear how to treat patients who fail dexamethasone therapy.
- Trial name
- SELECT (NCT05403359)
- Testing
- Steroids
- Where
- Netherlands
- Volunteers
- 2,465 people
- Sponsor
- Henrik Endeman
Patient Engagement
The Effect of Aromatherapy With Thyme Oil on Disease Symptoms, Vital Signs, Hemodynamic Parameters in COVID-19 Patients
Coronavirus, which is a common infectious disease, is characterized by symptoms such as severe pain, cough, shortness of breath, dizziness, secretion, diarrhea, nausea-vomiting, weakness, runny nose, changes in sense of taste and…
- Trial name
- NCT05197569
- Testing
- thyme oil
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Inonu University
SARS-CoV2
Methylene Blue Treatment of COVID-19
Despite enormous progress in understanding COVID-19, there is little evidence that a solution, therapeutic or preventive, is close to being achieved.
- Trial name
- NCT04635605
- Testing
- Methylene Blue, Control Test
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- Fondazione Epatocentro Ticino
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