Clinical trials: Covid19 Sequelae
COVID-19, Critical Illness
Impact and Sequelae of High Ventilatory Drive in Critically Ill COVID-19 Patients
Critically ill COVID-19 patients with acute respiratory failure, in the intensive care unit (ICU), often feature high respiratory drive, determining large inspiratory efforts resulting in high pressures and global and regional…
- Conditions
- COVID-19, Critical Illness, Hypoxemic Respiratory Failure, Neurocognitive Dysfunction
- Trial name
- NCT05363332
- Where
- 3 sites in Spain
- Volunteers
- 126 people
- Sponsor
- Corporacion Parc Tauli
Emotional Regulation, Affect
Brief, Scaleable Intervention for Coronavirus (COVID-19) Mental Health Sequelae in College Students
The major aim of this pilot study is to evaluate a brief coping skills intervention for college students, based on an evidence-based treatment and delivered remotely via 14 short daily videos.
- Trial name
- NCT04558411
- Testing
- Dialectical Behavioral Therapy (DBT) Skills
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Systemic Inflammation, Neuroinflammation
Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2
Background: COVID-19 can cause problems in different parts of the body. For most people, it causes fevers or trouble breathing. Some people might not recover all the way.
- Conditions
- Systemic Inflammation, Neuroinflammation, Microvascular Thrombosis
- Trial name
- NCT05350774
- Testing
- IV normal saline, IV immunoglobulin
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Anxiety Depression, Post Traumatic Stress Disorder
Neuropsychological Sequelae and Long COVID-19 Fatigue
An association of fatigue with post-viral neuropsychological disturbs has been reported. Among patients hospitalized with COVID-19 there is an increased incidence of anxiety and depression symptoms.
- Conditions
- Anxiety Depression, Post Traumatic Stress Disorder, Mental Fatigue, COVID-19
- Trial name
- PostCoV2Psy (NCT05323318)
- Testing
- Neuropsychological Sequelae
- Where
- 6 sites in Portugal
- Volunteers
- 200 people
- Sponsor
- Centro Hospitalar Universitario do Algarve
SARS-CoV-2 Acute Respiratory Disease, Myalgic Encephalomyelitis
Does a Technology Enabled Multi-disciplinary Team-based Care Model for the Management of Long COVID and Other Fatiguing Illnesses Improve Clinical Care of Patients and Represent a Sustainable Approach Within a Federally Qualified Health Center?
The primary objective of the present research is to determine the effectiveness of Family Health Center of San Diego's Long COVID and Fatiguing Illness Recovery Program (LC\&FIRP) on clinician- and patient-level outcomes.
- Conditions
- SARS-CoV-2 Acute Respiratory Disease, Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, Post-acute Sequelae of SARS-COV-2 Infection
- Trial name
- LC&FIRP (NCT05167227)
- Testing
- Extension for Community Healthcare Outcomes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Family Health Centers of San Diego
Covid19
Rehabilitation Program for the Sequelae of COVID 19 Infection
SUBPROJECT 1: Describe the situation of post-Covid patients in terms of muscle (skeletal and respiratory), cognitive, emotional and health-related quality of life in the 1st visit of the multidisciplinary post-covid…
- Trial name
- ISIS (NCT04852718)
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Long COVID, Long Covid19
RECOVER-ENERGIZE Platform Protocol
This is a platform protocol designed to be flexible so that it is suitable for a range of interventions and settings within diverse health care systems and community settings with incorporation into clinical COVID-19 management…
- Conditions
- Long COVID, Long Covid19, Long Covid-19
- Trial name
- NCT06404047
- Testing
- Personalized Cardiopulmonary Rehabilitation, Structured Pacing, Education
- Where
- 42 sites in United States
- Volunteers
- 660 people
- Sponsor
- Duke University
Long COVID
Sauna for Long Covid
Research suggests that Whole Body Hyperthermia in a sauna-like environment can reduce symptoms related to post-acute sequelae of SARS-CoV-2 (PASC), or Long Covid.
- Trial name
- NCT05931497
- Testing
- whole body hyperthermia
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Myalgic Encephalomyelitis
Long-term Sequelae of COVID-19 (Myalgic Encephalomyelitis): An International Cross-Sectional Study
The term recovery from COVID-19 caused by SARS-CoV-2 is unverified because the infection leaves many symptoms due to permanent effects on multiple organs; The primary objective of this research is to understand acute and chronic…
- Trial name
- ME (NCT05059184)
- Testing
- This is an observational cross-sectional study, there is no need for intervention
- Where
- Egypt
- Volunteers
- 2,450 people, healthy volunteers welcome
- Sponsor
- Alexandria University
PASC Post Acute Sequelae of COVID-19
Multiparametric [18F]F-AraG Imaging in Post-Acute Sequelae of COVID-19 (PASC)
This study uses total-body [¹⁸F]F-AraG PET/CT imaging to investigate immune activation and vascular changes in individuals with post-acute sequelae of SARS-CoV-2 infection (PASC), also known as Long COVID.
- Trial name
- NCT07076862
- Testing
- A.1 - [¹⁸F]F-AraG PET/CT (90-min dynamic + 4-h static), A.2 - [¹⁸F]F-AraG PET/CT (60-min dynamic only), B.1 - [¹⁸F]F-AraG PET/CT (90-min dynamic + 4-h static)
- Where
- 2 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Post-Acute COVID-19, Post Acute COVID-19 Syndrome
Safety and Dosage of a Computerized Cognitive Training Program for Cognitive Dysfunction After COVID-19
The goal of this Phase I/II clinical trial is to assess the safety and maximum tolerated training time of a self-administered computerized cognitive training (CCT) in individuals with cognitive dysfunction as a consequence of…
- Conditions
- Post-Acute COVID-19, Post Acute COVID-19 Syndrome, Cognitive Dysfunction, Cognitive Impairment
- Trial name
- CCTLongCOVID (NCT05582603)
- Testing
- CCT Long COVID
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Antonio de Nebrija
Long COVID, Long Covid19
RECOVER-NEURO: Platform Protocol, Appendix_A to Measure the Effects of BrainHQ, PASC CoRE and tDCS Interventions on Long COVID Symptoms
This platform protocol is designed to be flexible so that it is suitable for a wide range of settings within health care systems, for remote settings, and in community settings where it can be integrated into COVID-19 programs…
- Conditions
- Long COVID, Long Covid19, Long Covid-19
- Trial name
- NCT05965739
- Testing
- BrainHQ/Active Comparator Activity, BrainHQ, PASC CoRE
- Where
- United States
- Volunteers
- 328 people
- Sponsor
- Duke University
Dysexecutive Syndrome, Post-Acute Sequelae of COVID-19
Home-based Brain Stimulation Treatment for Post-acute Sequelae of COVID-19 (PASC)
The main goal of this study is to improve dysexecutive symptoms (e.g., sustained attention, processing speed) in patients exhibiting post-acute sequelae of COVID-19 (PASC) through home-based transcranial direct current…
- Trial name
- NCT05092516
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Massachusetts General Hospital
COVID
Long-term Impact of Infection With Novel Coronavirus (COVID-19)
LIINC is a study of volunteers who were previously infected with SARS-CoV-2 (also known as novel coronavirus or COVID-19) who have recovered from acute infection.
- Trial name
- LIINC (NCT04362150)
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of California, San Francisco
Long COVID
Evaluating the Neuromodulatory Effect of Ketamine in Long COVID-19
Plain Language Summary: This study is a clinical trial to see if ketamine can help treat symptoms of Long COVID, especially fatigue and problems with thinking clearly (often called "brain fog").
- Trial name
- NCT06821087
- Testing
- Ketamine only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas at Austin
Post-Acute COVID-19 Syndrome
A Study of Positive Emotions With Long COVID-19
This study is testing a new brief mindfulness practice for people suffering from long COVID-19 symptoms. People suffering from long COVID are particularly vulnerable to negative emotions, as they must also cope with the long-term…
- Trial name
- NCT05676008
- Testing
- Microdosing of mindfulness
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of California, Davis
Long COVID, Long Covid19
Understanding the Long-term Impact of COVID-19 in Adults
Long COVID (LC) affects an estimated 5-10% of individuals with SARS-CoV-2 causing a persistent physical, cognitive, and functional impairment with potentially severe socioeconomic consequences.
- Trial name
- NCT07498504
- Where
- United States
- Volunteers
- 5,205 people
- Sponsor
- NYU Langone Health
COVID-19, Fibrosis
Covid-19 Respiratory Sequelae French Cohort
As the investigators need data on long term outcome of Covid-19, especially respiratory sequelae, a national cohort is required.
- Conditions
- COVID-19, Fibrosis, Cohort, Follow-up
- Trial name
- PNEUMOCOVID (NCT05075785)
- Where
- France
- Volunteers
- 2,933 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Post-Acute COVID-19 Syndrome
Role of OMT in the Management of the Persistent Post-COVID-19 Symptoms
The goal of this observational study is to determine the feasibility of conducting a large-scale study on the effect of using osteopathic manipulative treatment (OMT) to treat patients with post-COVID-19 symptoms.
- Trial name
- ROMPS (NCT06016543)
- Testing
- osteopathic manipulative treatment (OMT)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- A.T. Still University of Health Sciences
COVID-19, Chronic Liver Failure
Evaluation of Long Haul COVID-19 and Vaccine Immunogenicity in Patients With Liver Disease
The project is essential to understand the impact of the COVID-19 pandemic in patients with Chronic Liver Disease (CLD). The impact has been felt due to direct risk of COVID infection in self, or in caregivers, lack of access to…
- Conditions
- COVID-19, Chronic Liver Failure, Cirrhosis, Liver, Portal Hypertension
- Trial name
- EvaLongCovid (NCT05107271)
- Testing
- COVID-19 serosurvey
- Where
- India
- Volunteers
- 252 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh