Clinical trials: Craniofacial
Orofacial Myofunctional Disorders, Myo Munchee
Trial to Compare the Effects of Myo Munchee Therapy and Oral Motor Therapy (OMT) in Pediatric Patients to Treat Maxillary Deficiency and Orofacial Myofunctional Dysfunction (OMD).
Multi-center, 6-month, randomized, and controlled trial to compare the effects of Myo Munchee therapy and Oral Motor Therapy (OMT) in pediatric patients (aged 3-5 years) to treat maxillary deficiency and orofacial myofunctional…
- Conditions
- Orofacial Myofunctional Disorders, Myo Munchee, Oral Motor Therapy, Maxillary Deficiency
- Trial name
- NCT07088055
- Testing
- Chewing device only, Myo Munchee and Oral Motor Therapy Treatment, Oral Motor Therapy Treatment Arm
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Myo Munchee (Operations) Pty Ltd
Microcephaly
Guangzhou Surveillance and Clinical Study in Microcephaly (GSCSM)
Screening for microcephaly is important at birth and during early childhood. The Guangzhou Surveillance and Clinical Study in Microcephaly (GSCSM) aims to establish a multicentric surveillance system for microcephaly in newborns…
- Trial name
- NCT03651687
- Where
- China
- Volunteers
- 47,369 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Malocclusion, Craniofacial Morphology
Research on Deep Learning-Based Intelligent Diagnosis and Treatment
This study aims to develop and evaluate deep learning-based artificial intelligence models for craniomaxillofacial multi-modal imaging analysis and clinical decision support.
- Conditions
- Malocclusion, Craniofacial Morphology, Dentofacial Deformities
- Trial name
- NCT07551622
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
22Q11 Deletion Syndrome
Mindfulness Program for Adolescents With 22q11DS
The goal of this study is to evaluate the effectiveness of the Aware Program, an online mindfulness education program, with adolescents with 22q11DS and their parents.
- Trial name
- NCT05849441
- Testing
- Aware Program
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Innovation Research & Training
Jaw Deformity, Facial Asymmetry
Computational Modeling for Prediction of Acoustic Changes in Vowel Production Due to Orthognathic Surgery
A computational model of human sound production based on high quality anatomic measurements and physical laws of sound propagation cannot be accomplished without a comprehensive data set including both 3D-images of the speaker's…
- Trial name
- PUMA (NCT01887977)
- Testing
- MRI examination
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Cleft Palate
Pilot Study Evaluating Characteristic Closure Patterns of the Normal Velopharyngeal Portal
This prospective research study seeks to determine how the normal velopharyngeal mechanism compares, both anatomically and physiologically, with previous data obtained on subjects with submucous cleft palate (SMCP) in…
- Trial name
- NCT00773994
- Testing
- Normal Velopharyngeal Mechansim
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Fragile X Syndrome, Angelman Syndrome
Parent and Infant Inter(X)Action Intervention (PIXI)
The objective is to develop and test, through an iterative process, an intervention to address and support the development of infants with a confirmed diagnosis of a neurogenetic disorder with associated developmental delays or…
- Conditions
- Fragile X Syndrome, Angelman Syndrome, Prader-Willi Syndrome, Dup15Q Syndrome
- Trial name
- NCT03836300
- Testing
- Parent-Infant Inter(X)action Intervention (PIXI)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- RTI International
Bilateral Complete Cleft Lip And/or Alveolus and Acrylic Splint, and, Maxillary Deficiency
Evaluating the Impact of Prefabricated Acrylic Splints on Premaxillary Stability in Alveolar Cleft Bone Graft Repairs: a Randomized Controlled Trial
Rationale for conducting the research: Bilateral alveolar clefts pose significant management challenges, with current treatments like autogenous bone grafting showing instability in up to 40% of cases within a year, risking graft…
- Conditions
- Bilateral Complete Cleft Lip And/or Alveolus and Acrylic Splint, and, Maxillary Deficiency, Stability
- Trial name
- RCT (NCT06807645)
- Testing
- Clinical Trial Intervention Description General Study Setup Objective: To compare the efficacy of using a custom-made prefabricated acrylic splint versus no splint in maintaining premaxillary stabilit
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Plagiocephaly, Positional
Effectiveness of a Prenatal Educational Intervention to Prevent Positional Occipital Plagiocephaly
Positional occipital plagiocephaly (POP) is a morphological abnormality of the cranium which, in the absence of early synostosis of the cranial sutures, is caused by external forces acting on the skull, which is highly malleable…
- Trial name
- POP2019 (NCT07182604)
- Testing
- educational program on the POP prevention
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Meyer Children's Hospital IRCCS
Oral Mucosal Disease
Clinical Research Core Dental Screening Protocol
This study will screen patients for eligibility in studies sponsored by the Craniofacial Genetics Section (HCGS), the Clinical Research Core (CRC), and other branches located within the National Institute of Dental and…
- Trial name
- NCT00090818
- Where
- United States
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Maxillofacial Abnormalities
Mandibular Stability and Dentofacial Deformity
The present study intends to clarify whether there is positional mandibular stability in patients to be submitted to orthognathic surgery.
- Trial name
- NCT01486069
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Danon Disease, Fabry Disease
Precision Diagnosis and Risk Stratification of Rare Cardiomyopathies Based on Novel Cardiac Magnetic Resonance Techniques
What is this study about? This research is focused on improving the care for people with rare heart muscle diseases, known as rare cardiomyopathies.
- Conditions
- Danon Disease, Fabry Disease, Cardiac Amyloidosis, Noonan Syndrome
- Trial name
- NCT07336394
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Cleft Palate, Plasma Rich in Growth Factors
Role of Plasma Rich Growth Factor in Repair Primary Cleft Palate
Does the plasma-rich growth factor (PRGF) with primary cleft palate repair accelerate wound healing and prevent post-operative oronasal fistula occurrence?
- Trial name
- PRGF (NCT06889181)
- Testing
- Plasma Rich in Growth Factors (PRGF)
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Development, Infant, IMAGE
3D Craniofacial Morphologic Development of Healthy Infants
Healthy infants were enrolled to receive three dimensional craniofacial photography regularly at their age of one month, two month, four month, six month, nine month and twelve month.
- Conditions
- Development, Infant, IMAGE, Craniofacial Asymmetry, Plagiocephaly
- Trial name
- NCT05004597
- Testing
- three dimensional photography using a 3dMDHead System (3dMD, Atlanta, GA, USA)
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Autism Spectrum Disorders
Genetics, Brain Structure and Thinking Skills in Autism
The purpose of this research is to better understand the genetic, biochemical, cognitive and behavioral symptom abnormalities that contribute to autism spectrum disorders.
- Trial name
- NCT01451983
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Pain
Assessment of Peripheral GABA Receptors for Local Pain Relief
The effect of peripheral GABAA receptor activation on pain and sensitivity in healthy human subjects has never been investigated.
- Trial name
- NCT02928328
- Testing
- GABA oral solution, Intramuscular GABA, Pain modulation
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Healthy
Craniofacial Dimensions as Determinants of the Fitted Performance of Common Face Masks (FACEFIT 2.0)
This study examines the role of craniofacial dimensions and self-evaluation thereof in the protection afforded by masks commonly worn by the public as protection against aerosol contaminants.
- Trial name
- NCT06425588
- Testing
- Surgical/Procedure Mask Fit Testing, KN95 Mask Fit testing
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Craniosynostoses
Neurodevelopmental Outcomes in Craniosynostosis Repair
Context: Craniosynostosis is a common craniofacial abnormality which can be associated with various clinical syndromes. Though it has been established that children with craniosynostosis score lower on certain developmental…
- Trial name
- NCT04072783
- Testing
- MRI,DTI, functional MRI
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Cleft Palate
Fistiulation Rate Following Primary Cleft Repair≤
Aim : The aim of present study was to evaluate the buccinator flap utilization in primary cleft palatoplasty on fistulation rate.
- Trial name
- NCT05166408
- Testing
- Buccinator myomucosal flap, Bardach two flap palatoplasty
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Maternal-Fetal Relations, Microcephaly
Fetal and Maternal Head Circumference During Pregnancy in Israeli Population
In this study, measurements of fetal and maternal head circumference will be collected. This data will be presented in table or graph form.
- Trial name
- NCT02510170
- Testing
- no intervention
- Where
- Israel
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services