Clinical trials: Craniofacial Injuries
Skin Condition, Cleft Lip and Palate
Online Psychosocial Support for Young People With a Visible Difference: A Randomised Control Study
A visible difference can have a profound impact in a society with a massive emphasis on appearance and "looks". A vulnerable group is adolescents with a condition affecting their appearance as a result of injuries (burns…
- Conditions
- Skin Condition, Cleft Lip and Palate, Burns, Other Conditions Leading to a Visible Difference
- Trial name
- UNGFaceIT (NCT03165331)
- Testing
- Ung Face IT
- Where
- Norway
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Cleft Palate, Plasma Rich in Growth Factors
Role of Plasma Rich Growth Factor in Repair Primary Cleft Palate
Does the plasma-rich growth factor (PRGF) with primary cleft palate repair accelerate wound healing and prevent post-operative oronasal fistula occurrence?
- Trial name
- PRGF (NCT06889181)
- Testing
- Plasma Rich in Growth Factors (PRGF)
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Facial Injuries, Traumatic Wounds and Injuries
Human Craniomaxillofacial Allotransplantation
Background: The human face is critically important for breathing, eating, seeing, and speaking/ communicating, but its most important job may be to look like a human face.
- Conditions
- Facial Injuries, Traumatic Wounds and Injuries, Craniofacial Injuries, Craniofacial Defects
- Trial name
- NCT01889381
- Testing
- Bone marrow cell-based therapy & 1-drug immunosuppression.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Marfan Syndrome, Turner Syndrome
National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions
The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of…
- Conditions
- Marfan Syndrome, Turner Syndrome, Ehlers-Danlos Syndrome, Loeys-Dietz Syndrome
- Trial name
- GenTAC (NCT01322165)
- Where
- 7 sites in United States
- Volunteers
- 3,706 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Face Injuries, Hand Injuries
Craniomaxillofacial and Upper Extremity Allotransplantation
The purpose of this study is to evaluate functional and aesthetic outcomes of combined facial and upper extremity composite tissue allografts on patients who have not achieved functional and aesthetic outcomes with conventional…
- Conditions
- Face Injuries, Hand Injuries, Craniofacial Injuries, Upper Extremity Injuries
- Trial name
- NCT04057638
- Testing
- Combined Craniomaxillofacial and Upper Extremity Allotransplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Brain Injuries, Skull Fractures
Association Between Craniofacial Fractures and Brain Injuries: Diagnostic and Therapeutic Considerations
This study evaluates the association between traumatic brain injuries and craniofacial or/and skull fractures. Purpose is to find out the amount of missed diagnoses and improve primary diagnostics of trauma patients.
- Trial name
- NCT02418169
- Volunteers
- 1,000 people
- Sponsor
- Turku University Hospital
Orthognathic Surgery, Maxillofacial Abnormalities
Study Evaluating the Performance and Safety of Global D Implants Indicated for Orthognathic Surgery
This study is set up within the framework of the European Union regulation 2017/745 on medical devices. Its objective is to confirm the performance and safety of the Global D implants (ORTRAUTEK® and MINITEK®) used for…
- Conditions
- Orthognathic Surgery, Maxillofacial Abnormalities, Maxilla Fracture
- Trial name
- CMF-ORTHO (NCT05271383)
- Testing
- Orthognathic surgery using Global D's implants.
- Where
- France
- Volunteers
- 198 people
- Sponsor
- Global D
Facial Injuries, Tissue Injury
Effect of Concentrating Endogenous Stromal Cells in the Fat Graft Using TGI Device
The overall purpose of this research is to evaluate the physical changes that occur over time after fat grafting for craniofacial trauma.
- Trial name
- AFIRM-TGI (NCT01924364)
- Testing
- Tissue Genesis Cell Isolation System™ (TGI CIS), Standard of care fat grafting
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- J. Peter Rubin, MD
Cleft Lip, Cleft Palate +/- Lip
Comparative Study of Regional Nerve Blocks in Primary Cleft Palate Repair
This study will evaluate whether adding a suprazygomatic maxillary nerve block to the standard palatal nerve block improves pain control after cleft palate repair surgery in children.
- Conditions
- Cleft Lip, Cleft Palate +/- Lip, Pain Management, Wound Dehiscence, Surgical
- Trial name
- NCT07892963
- Testing
- Palatal Nerve Block, Suprazygomatic Maxillary Nerve Block
- Volunteers
- 144 people
- Sponsor
- Children's National Research Institute
Craniofacial Injuries
Use of Concentrated Endogenous Autologous Adipose Stromal Cells in Fat Grafts for Craniofacial Trauma
Traumatic facial injuries, especially those sustained in military combat, are characterized by destruction of bone and soft tissue.
- Trial name
- ARM5 (NCT01633892)
- Testing
- Fat Grafting
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Wounds and Injuries, Wound Infection
Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
This study will evaluate the use of free autologous dermal fat grafting (also called free dermal fat autografting) to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts…
- Conditions
- Wounds and Injuries, Wound Infection, Facial Bones Fracture, Soft Tissue Injuries
- Trial name
- FTFDT2 (NCT03880188)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dufresne, Craig, MD, PC
Neuromotor Impairments, Cerebral Palsy
The FBRI VTC Neuromotor Research Clinic
The FBRI VTC Neuromotor Research Clinic was established and opened in May of 2013 to provide intensive therapeutic services to individuals with motor impairment secondary to neuromotor disorders. It is direct by Dr.
- Conditions
- Neuromotor Impairments, Cerebral Palsy, Microcephaly, Autism
- Trial name
- NCT03325946
- Testing
- ACQUIRE Therapy
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Virginia Polytechnic Institute and State University
Facial Injuries, Adipose Tissue
Structural Fat Grafting for Craniofacial Trauma: Repeat Fat Grafting Injection-5 Subject Cohort
Fat grafting represents a technique with great potential to improve outcomes in minimally invasive facial reconstruction. Fat grafting has already been demonstrated as a safe and minimally invasive technique over decades of…
- Trial name
- BTIPlusUp (NCT01822301)
- Testing
- Repeat Fat grafting
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pittsburgh
Surgical Complication, Paresthesia
Trial of Bilateral Sagittal Split Osteotomy Induced Paresthesia Using Ultrasonic vs. Reciprocating Saw Instrumentation
The aim of this prospective study is to analyze the postoperative paresthesias experienced in patients who undergo bilateral sagittal split osteotomies (BSSO) using an ultrasonic saw, versus a reciprocating saw.
- Conditions
- Surgical Complication, Paresthesia, Fracture, Nerve Injury
- Trial name
- NCT05205616
- Testing
- Sonopet ultrasonic saw, Reciprocating saw
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Mandibular Neoplasms, Maxillary Neoplasms
Three-Dimensional Printing of Patient-Specific Titanium Plates in Jaw Surgery: A Pilot Study
Medical titanium plates are routinely used in fixing mobilized bone segments in jaw surgeries. Generally these plates are commercialized with standard construction specifications.
- Conditions
- Mandibular Neoplasms, Maxillary Neoplasms, Dentofacial Deformities, Maxillofacial Injuries
- Trial name
- 3DJP16 (NCT03057223)
- Testing
- 3D-printed patient-specific titanium plates
- Where
- Hong Kong
- Volunteers
- 96 people
- Sponsor
- The University of Hong Kong
Hydrocephalus in Children, Epilepsy
Myelin Imaging Changes In Patients With Neurosurgical Diseases
Investigate myelin alterations in patients with neurosurgical diseases
- Conditions
- Hydrocephalus in Children, Epilepsy, Craniosynostoses, Traumatic Brain Injury
- Trial name
- McDESPOT (NCT03698838)
- Testing
- McDESPOT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Memorial Healthcare System
Hemifacial Microsomia, Distraction of Bone
Evaluation of Effect of Bone Marrow Aspirate Concentrate on Distracted Mandibular Bone Properties
Maxillofacial Distraction Osteogenesis (DO) has a lot of draw backs; mostly related to long distraction and consolidation time. Rapid rate DO was proposed to decrease the distraction time to avoid consequences of long procedure.
- Trial name
- NCT03861650
- Testing
- Bone Marrow Aspirate Concentrate, Saline
- Volunteers
- 12 people
- Sponsor
- Yasser Mohamed Nabil Ahmed Khirat El Hadidi
Acute Respiratory Distress Syndrome ARDS
Driving Pressure-guided Tidal Volume Ventilation in the Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is associated with high mortality, some of which can be attributed to ventilator-induced lung injury (VILI) when artificial ventilation is not customized to the severity of lung injury.
- Trial name
- DRIVENT (NCT06322758)
- Testing
- Tidal volume customization in the acute respiratory distress syndrome
- Volunteers
- 750 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cleft Palate, Trauma
Cell Therapy for Craniofacial Bone Defects
The purpose of this research is to determine if a patient's own bone marrow tissue can help regenerate bone in the area of the jaw where an implant will be placed. The name of the process is called Bone Repair Cell (BRC) Therapy.
- Trial name
- NCT01616953
- Testing
- Ixmyelocel-T, Autogenous Bone Grafting
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Facial Injuries
Structural Fat Grafting for Craniofacial Trauma Using Manual Technique for Processing Fat Graft Material
This study will examine the impact of the fat grafting procedure on facial appearance and quality of life over time by precisely measuring soft tissue volume with CT scans, assessing appearance with 2D and 3D photography and…
- Trial name
- BTI++ (NCT02267187)
- Testing
- Fat Grafting, General Anesthesia, Coleman Cannulas
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pittsburgh