Clinical trials: Craniotomy Surgery
Astrocytoma, Brain Cancer
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S
This is a multi-center, open-label, dose escalation study to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and maximum tolerated dose (MTD) of QBS10072S in patients with advanced or metastatic cancers…
- Conditions
- Astrocytoma, Brain Cancer, Brain Metastases, Bladder Cancer
- Trial name
- NCT04430842
- Testing
- QBS10072S
- Where
- 2 sites in Australia
- Volunteers
- 15 people
- Sponsor
- Quadriga Biosciences, Inc.
Aneurysm Cerebral
Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy
This study is looking at how taking aspirin regularly affects bleeding during and after brain surgery. Specifically, it focuses on patients who are having elective surgery to clip a brain aneurysm.
- Trial name
- ASPRIN (NCT07086183)
- Testing
- Observation
- Where
- 3 sites in United States, Italy and 1 more
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Sepsis
Incidence of Sepsis After Craniocerebral Operation
To investigate the incidence and outcome of sepsis in critical patients undergoing craniotomy.
- Trial name
- NCT03803813
- Where
- China
- Volunteers
- 907 people
- Sponsor
- Jianfang Zhou
Intensive Care, Surgical
Postoperative Delirium in Adult Patients After Elective Craniotomy Under General Anaesthesia
Postoperative delirium may result in many adverse complications. At present little is known about postoperative delirium in patients after crniotomy because they may manifest similar symptoms to definitely delirium for some…
- Conditions
- Intensive Care, Surgical, Postoperative Care, Neurosurgery
- Trial name
- NCT03087838
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Capital Medical University
Glioma
Strategic Intervention on Preserving Motor Function During Awake Craniotomy
This study aims to compare the motor functions after traditional or a new surgical plan during awake glioma resection surgery.
- Trial name
- NCT05143788
- Testing
- Awake craniotomy
- Volunteers
- 60 people
- Sponsor
- Beijing Neurosurgical Institute
Intracranial Aneurysm
Supraphysiologic Insulin to Improve Outcomes After Surgical Treatment of Unruptured Cerebral Aneurysms
We hypothesize that in patients undergoing surgical treatment of unruptured intracranial aneurysms, the increase in blood sugar as a result of surgical stress is detrimental to outcome, as measured by blood levels of proteins…
- Trial name
- NCT00615381
- Testing
- Insulin
- Where
- United States
- Sponsor
- Northwestern University
Surgery, Anesthesia; Functional
Effectiveness of Continous Adjuvant Lidocaine on General Anaesthesia on Tumor Craniotomy Surgery
This study aims to investigate the effect of adjuvant continuous lidocaine in General Anesthesia on Depth of Anesthesia (qCON), Pain Response (qNOX), and Blood Sugar Levels in Elective Primary Tumor Craniotomy Surgery
- Conditions
- Surgery, Anesthesia; Functional, Haemodynamic Instability
- Trial name
- NCT06249113
- Testing
- NaCl 0.9%, Adjuvant lidocaine continous
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Brain Tumor, Brain Cancer
A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors
The neurosurgical standard of care for treating a patient with a tumor invading hand primary motor cortex (M1) includes performing a craniotomy with intraoperative direct electrical stimulation (DES) mapping and to resect as much…
- Conditions
- Brain Tumor, Brain Cancer, Motor Cortex; Lesion
- Trial name
- NCT05023434
- Testing
- Intraoperative Brain Simulation - Alternate Stimulation Parameters
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Craniotomy Surgery, Preventive Health Care
The Effect of Bundle Application on Surgical Site Infection
Surgical site infections (SSI) are the most common complications after surgical operations and are in the top three in Healthcare Associated Infections (HIE).
- Trial name
- NCT06724354
- Testing
- The Surgical Site Infections Precaution Package Form includes the parameters that should be applied to patients before, during and after surgery.
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Epilepsy
Conscious Sedation for Epilepsy Surgery
Sixty patients were randomly allocated into two groups, group PD and group PR, thirty patients in each group. Patients in PD group received propofol and dexmedetomidine intravenous infusion and patients in PR group received…
- Trial name
- NCT02988050
- Testing
- Remifentanil, Dexmedetomidine, Propofol
- Volunteers
- 60 people
- Sponsor
- Menoufia University
Craniotomy, Brain Surgery
The Efficacy of Intravenous Acetaminophen During Perioperative Neurosurgery Period
This is a prospective randomized double blinded trial study involving 128 patients undergoing any craniotomy procedure at Evanston Hospital. The patients will be randomized by the sealed envelope technique.
- Trial name
- NCT01739699
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Endeavor Health
Postoperative Complications, Intracranial Surgery
Blood Viscosity and Outcomes After Elective Craniotomy
This prospective observational study aims to evaluate the association between intraoperative blood viscosity and postoperative clinical outcomes in adult patients undergoing elective intracranial craniotomy.
- Trial name
- NCT07530393
- Testing
- Observational Assessment of Blood Viscosity
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Asan Medical Center
Posterior Fossa Hemorrhage
The Treatment Effect of Endoscopic Evacuation Versus Suboccipital Craniotomy for Spontaneous Intracerebellar Hemorrhage.
The purpose of the present study is to compare the effectiveness and safety of two surgery evacuation methods (endoscopic surgery and suboccipital craniotomy) in the treatment of acute spontaneous cerebellar hemorrhage (SCH).
- Trial name
- NCT04991233
- Testing
- Endoscopic surgery, Suboccipital craniotomy surgery
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Tang-Du Hospital
Brain Cancer
Surgery Versus Stereotactic Radiosurgery in the Treatment of Single Brain Metastasis: A Randomized Trial
Study Objectives: To compare the survival (overall, systemic, and neurological) of patients with single cerebral metastases treated with either conventional surgical resection or stereotactic radiosurgery.
- Trial name
- NCT00460395
- Testing
- Surgery, Stereotactic radiosurgery
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- M.D. Anderson Cancer Center
Fear, Anxiety
Patients' Conscious Experience and Psychological Consequences of Awake Surgery for Intracerebral Lesions
This study aims to investigate patients' experience of awake surgery of the brain. Patients therefore must suffer a disease that makes the technique of awake craniotomy necessary.
- Conditions
- Fear, Anxiety, Stress
- Trial name
- NCT02622529
- Testing
- Screening through questionnaires
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Cantonal Hospital of St. Gallen
Postoperative Nausea and Vomiting
Effectiveness of Triple Therapy With Palonosetron for PON Prophylaxis
Postoperative nausea and vomiting (PONV) is a displeasing experience that distresses surgical patients during the first 24 hours after a surgical procedure.
- Trial name
- NCT02635828
- Testing
- Palonosetron 0.075 mg IV, Dexamethasone 10 mg IV, Promethazine 25 mg IV
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Brain Injury, Brain Tumors
Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery
Postoperative pain is prevalent after intracranial surgery. Patients undergoing craniotomy are typically managed with short acting opioids to enable early and reliable post-operative neurological exam as well as avoid the risk of…
- Conditions
- Brain Injury, Brain Tumors, Craniotomy Surgery, Pain
- Trial name
- NCT06810336
- Testing
- Remifentanil, Methadone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
ERAS, Craniotomy
A Greek-designed ERAS Protocol in Elective Craniotomy
The implementation of ERAS protocol in elective cranial neurosurgical cases in a tertiary hospital.
- Trial name
- ERAS (NCT05962684)
- Testing
- ERAS
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Thessaly
Children With Craniosynostoses
Nautilus: Dynamic Craniotomy; New Surgical Technique and Preliminary Results
Being the craniostenoses sutural basically a disease, the fact that the brain being trapped in an enclosure that does not have complacency required to accompany their growth constitutes the challenge of treatment, which aims to…
- Trial name
- Nautilus (NCT01672619)
- Testing
- dynamic craniotomy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Nucleo de Plastica Avancada