Clinical trials: Critical Ill Patients
Anemia
Assess Functional Outcomes in Anemic, Critically Ill, Trauma Patients When Taking Epoetin Alfa
The purpose of this trial is to evaluate the physical function outcomes in anemic, critically ill, trauma subjects treated with epoetin alfa (PROCRIT®) compared to placebo.
- Trial name
- NCT00210626
- Testing
- PROCRIT
- Where
- 21 sites in United States
- Volunteers
- 192 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Intensive Care Unit Acquired Weakness, Intensive Care Unit (ICU) Acquired Weakness (ICU - AW)
Functional Assessment in Critically Ill Patients
This longitudinal, prospective observational study aims to evaluate functional status in critically ill adult patients in the Intensive Care Unit using the Chelsea Critical Care Physical Assessment Tool (CPAx).
- Trial name
- NCT07191743
- Where
- Brazil
- Volunteers
- 186 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Critical Illness, Surgery
Diluted and Undiluted Enteral Nutrition
Adult patients after elective major abdominal surgeries who are planned to be admitted to the Intensive Care Unit (ICU) can be included in the trial. Each patient will be fed via the gastrointestinal tract.
- Conditions
- Critical Illness, Surgery, Enteral Feeding Intolerance, Gastro-Intestinal Disorder
- Trial name
- NCT06516835
- Testing
- Enteral fluid, Intravenous fluid
- Where
- 5 sites in Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lublin
Neurosurgery, Critical Ill
Pharmacokinetic Study in Neurosurgical ICU Patients -Using Vancomycin as an Example
Neurosurgical ICU patients often receive hyperosmotic diuretics or cerebrospinal fluid (CSF) drainage to decrease their intracranial pressure.
- Trial name
- NCT01940029
- Volunteers
- 16 people
- Sponsor
- National Taiwan University Hospital
Carbapenem Resistant Klebsiella Pneumoniae
Dose Optimization by Pharmacokinetic/Pharmacodynamic of Antibiotics to Improve Clinical Outcome of Carbapenem Resistant Klebsiella Pneumoniae Bloodstream Infections in Critically Ill Patients at Phramongkutklao Hospital
The patients who infected with Carbapenem resistant Klebsiella pneumoniae were high mortality rate. Appropriate antibiotics therapy adjusted by Pharmacokinetic/Pharmacodynamic plays an important role in determining outcomes in…
- Trial name
- NCT05862402
- Testing
- Dose-adjustment by PKPD
- Where
- Thailand
- Volunteers
- 76 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
COVID-19, ARDS
Assessment of Analgesics and Sedatives in Mechanically Ventilated Patients With COVID-19
The analgesic and sedation requirements in critically ill patients with COVID-19 have yet to be described. There are various factors that are likely affecting the agents being utilized for analgesia and sedation in these patients…
- Conditions
- COVID-19, ARDS, Withdrawal Syndrome, Iatrogenic Disease
- Trial name
- NCT05336656
- Where
- United States
- Volunteers
- 353 people
- Sponsor
- Wilkes University
Kidney Failure, Acute, Critical Illness
Comparison of Femoral Versus Jugular Routes for Temporary Hemodialysis in Seriously Ill Patients
The purpose of this study is to determine whether a jugular route leads to a lower rate of complications as compared with a femoral route for catheterization in patients admitted in several intensive care units in France who…
- Trial name
- CATHEDIA (NCT00277888)
- Testing
- Femoral route for hemodialysis, Jugular route for hemodialysis
- Where
- 10 sites in France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Caen
Delirium, Cognitive Impairment
The SOMNUS Study: Sedative Optimization Via Monitoring Neurological Status
A combined strategy of Richmond Agitation and Sedation Scale (RASS) clinical targeting plus bispectral index (BIS) guided sedation in mechanically ventilated, critically ill patients will decrease time on mechanical ventilation…
- Conditions
- Delirium, Cognitive Impairment, Critically Ill
- Trial name
- SOMNUS (NCT00469482)
- Testing
- Sedation,RASS Targeted plus BIS Monitoring, Sedation, RASS Targeted
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Vanderbilt University Medical Center
Coronavirus Infection, Critical Illness
Clinical Characteristics of Critically Ill Patients With COVID-19
Critically ill patients with COVID-19 have hospitalized in an ICU due to the closer monitoring and therapy. In fact, ICU admissions are dependent on the severity of illness and the ICU capacity of the health-care system.
- Conditions
- Coronavirus Infection, Critical Illness, Characteristics Disease
- Trial name
- NCT04413435
- Testing
- File Scanning
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Nevsehir Public Hospital
Acute Kidney Injury
Changes of Renal Resistive Index in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy.
The aim of the study is to determine whether there is a correlation between changes in the renal resistive index and the restoration of kidney function in critically ill patients undergoing continuous renal replacement therapy.
- Trial name
- NCT06174610
- Testing
- Measurement of Renal Resistive Index
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Intra-abdominal Infection, Critical Illness
Innate Immune Response Monitoring Via Monocyte HLA-DR in Severe Intra-abdominal Infections at Risk of Fungal Infection
Intra-abdominal candidiasis (IAC) is a frequent and severe fungal infection in critically ill patients, often diagnosed late. Its pathophysiology remains unclear, particularly regarding why some patients develop invasive…
- Conditions
- Intra-abdominal Infection, Critical Illness, Post-Op Infection, Immunization; Sepsis
- Trial name
- CANDIRIS (NCT07130799)
- Testing
- Immunomonitoring
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Type 2 Myocardial Infarction, Coronary Artery Disease
Coronary Angiography in Critically Ill Patients With Type II Myocardial Infarction
Study type: prospective cohort and randomized trial. Duration: estimated 2 years. Indications: Type II myocardial infarction in critically ill patients. Purpose: 1.
- Conditions
- Type 2 Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention, Critical Illness
- Trial name
- NCT04043091
- Testing
- percutaneous coronary intervention (stenting)
- Where
- Slovenia
- Sponsor
- University Medical Centre Ljubljana
Intensive Care Units
Immediate Effects of Automatic Lateralization in Critically Ill Patients
New devices have been used in intensive care to optimize respiratory function in critically ill patients, such as automatic lateralization therapy.
- Trial name
- NCT07087600
- Testing
- Automatic lateralization therapy, Supine Positioning
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Pernambuco
Critical Illness
Glucontrol Study: Comparing the Effects of Two Glucose Control Regimens by Insulin in Intensive Care Unit Patients
Glucontrol is a prospective, randomized, controlled, multi-centric study. The present study will compare the effects of two regimens of insulin therapy, respectively titrated to achieve a blood sugar level between 4.4 and 6.1…
- Trial name
- NCT00107601
- Testing
- Insulin
- Where
- 11 sites in Belgium, France and 5 more
- Volunteers
- 3,500 people
- Sponsor
- University of Liege
Injury of Diaphragm, Mechanical Ventilation Complication
Using Ultrasound to Study Respiratory Muscle Function in Critically Ill Patients
Mechanical ventilation can be life saving strategy for patients with respiratory failure due to a variety of reasons. Once the underlying illness has resolved, intensive care doctors have to take a decision on when the patient is…
- Conditions
- Injury of Diaphragm, Mechanical Ventilation Complication, Critical Illness
- Trial name
- NCT03139695
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Post Intensive Care Syndrome, PICS
Impact of a COVID-19 Related ICU Stay on Mental Health for Patients and Their Relatives
As ICU mortality has been significantly decreased over the last two decades, the focus has been shifting from short term (such as ICU and hospital mortality) to long-term outcome.
- Conditions
- Post Intensive Care Syndrome, PICS, COVID-19, Critically Ill
- Trial name
- PICOVIDS (NCT05348720)
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- General Hospital Groeninge
Acute Kidney Injury, Critical Illness
Definition of Acute Kidney Injury by Urine Output in Critically Ill Patients
The goal of this observational study is to explore the association between urine output and acute kidney injury in severely ill patients admitted to intensive care units.
- Conditions
- Acute Kidney Injury, Critical Illness, Critical Care, Intensive Care, Critical Care, Fluid Resuscitation
- Trial name
- NCT06722924
- Volunteers
- 15,000 people
- Sponsor
- Uppsala University
Critical Illness, Malnutrition
Comparative Effect of Protein Prescription Strategies on Nitrogen Balance and Upshots in Critically Ill Patients
This is Interventional clinical trail will be conducted in Internationale hospital ICU s patients with higher nutrition risk. two doses of protein 1 g/kg/day Vs 2 g/ kg day will be given and its outcome will be checked on…
- Conditions
- Critical Illness, Malnutrition, Protein
- Trial name
- NCT04468503
- Testing
- Two differnt protien prescription (ig per kg per day and 2g per kg /day )will be assigned to each group interventional
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Allama Iqbal Open University Islamabad
Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients
Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients
This is a pilot feasibility study examining the use of immersive virtual reality (VR) in adult intensive care unit (ICU) patients.
- Conditions
- Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients, Agitation Associated With Critical Illness, Anxiety Acute
- Trial name
- NCT07649876
- Testing
- Virtual reality (VR) therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Platelet Transfusion, Critical Illness
Platelet Transfusions in Critically Ill Patient
Between 10 and 15% of critically ill patients require platelet transfusion within their intensive care unit (ICU). Platelets (PLT) are given to prevent bleeding in thrombocytopenic patients or to treat bleeding as part of massive…
- Trial name
- RE-CCIP (NCT03325140)
- Where
- 7 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest