Clinical trials: Critical Ill Patients
Critically Ill
Pilot Study on Gastro-intestinal (GI) Enteral Nutrition (EN) Tolerance in Intensive Care Unit Patients
Specifically designed enteral formulations may improve the gastrointestinal tolerance during early enteral nutrition in the critically ill patient.
- Trial name
- SPIRIT (NCT01581957)
- Testing
- Specific Enteral Nutrition, Standard Enteral Nutrition
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- Société des Produits Nestlé (SPN)
Critical Illness, Metabolism Disorders
Development of a Novel Algorithm for Real-Time Bedside Assessment of Insulin Resistance in Critically Ill Patients Based on Continuous Glucose Monitoring Data
This study aims to develop and validate a novel algorithm for the real-time assessment of insulin resistance in critically ill patients using Continuous Glucose Monitoring (CGM).
- Conditions
- Critical Illness, Metabolism Disorders, Insulin Resistance
- Trial name
- NCT07385391
- Where
- China
- Volunteers
- 179 people
- Sponsor
- Chinese Medical Association
Sleep, Critical Illness
A Pilot Study of Effect of Dexmedetomidine on Sleep and Inflammation in Critically Ill Patients
The purpose of this study is to assess the short-term effect of sympatholysis on sleep quality and inflammation in critically ill patients.
- Trial name
- NCT00405847
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Arizona
Critical Illness
Efficacy and Safety of Colloids Versus Crystalloids for Fluid Resuscitation in Critically Ill Patients
Background: Two recent systematic reviews of the literature and meta-analyses have suggested that colloids administration might be deleterious in critically ill patients.
- Trial name
- NCT00318942
- Testing
- Crystalloids, Colloids
- Where
- 67 sites in Belgium, Canada and 3 more
- Volunteers
- 2,857 people
- Sponsor
- University of Versailles
Infection, Sepsis
Bacterial Infection Diagnosis Using Blood DNA
Sepsis is a common cause of morbidity and death in intensive care units. Clinical and laboratory signs of systemic inflammation, including changes in body temperature, tachycardia, or leukocytosis, are neither sensitive nor…
- Trial name
- NCT00698919
- Testing
- Observational study
- Where
- 5 sites in France
- Volunteers
- 400 people
- Sponsor
- Delafontaine Hospital
Critical Illness
Prognostic Significance of Red Blood Cell
Red blood cell (RBC) distribution width (RDW), calculated by dividing the standard deviation of RBC volume by the mean corpuscular volume and multiplied by 100, is routinely reported as part of the complete blood count (CBC)…
- Trial name
- NCT04763239
- Where
- Egypt
- Volunteers
- 111 people
- Sponsor
- Sohag University
Critical Illness
Parenteral Nutrition With Intravenous and Oral Fish Oil for Intensive Care Patients
The primary objective is to assess the effect of fish oil-enriched enteral and parenteral nutrition on blood oxygenation in critically ill patients.
- Trial name
- NCT01162928
- Testing
- Nutriflex Omega special + Oxepa, Nutriflex Lipid special + Pulmocare
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- B. Braun Melsungen AG
Critical Ill Patients
Glycated Hbg Index and RDW as Prognstic Indicator in Critical Ill Patients
The aim of this study was to evaluate the impact of GHI and RDW as prognostic indicator in critically ill Patients.
- Trial name
- NCT07057154
- Testing
- Hbg and RDW
- Volunteers
- 97 people
- Sponsor
- Assiut University
Heart Rate Variability
Heart Rate Variability in Extracorporeal Membrane Oxygenation (ECMO) Patients
National Taiwan University Hospital is the leading center for care of patients with extracorporeal membrane oxygenation (ECMO). The predictable factors associated with outcomes are still lacking in patients with the ECMO support.
- Trial name
- NCT01247727
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Acute Respiratory Failure
Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness
The objective of this study is to determine the effect of thiamine therapy on oxygen consumption in critically-ill patients. The investigators will evaluate this by measuring VO2 before and after thiamine administration in…
- Trial name
- VO2 (NCT01462279)
- Testing
- Thiamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Sepsis, Acute Respiratory Distress Syndrome
Corticosteroids in Hyperinflammatory Phenotype of Critical Illness
The goal of this clinical trial is to learn whether methylprednisolone improves outcomes in critically ill patients with a hyperinflammatory phenotype. It will also evaluate the safety of methylprednisolone at different doses.
- Trial name
- CHIP (NCT07511582)
- Testing
- Methylprednisolone (MP)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Bin Du
Covid19, Critical Illness
Sex Hormone Dysregulations Are Associated With Critical Illness in COVID-19 Patients
Males develop more severe SARS-CoV-2 infection related disease outcome than females. Herein, sex hormones were repeatedly proposed to play an important role in Covid-19 pathophysiology and immunity.
- Trial name
- HAM-SEX-C19 (NCT04979091)
- Testing
- Sex Hormones
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Stroke, Critically Ill
Study of Prognostic Factors in Patients Admitted to ICU for Stroke
Outcome of stroke patients admitted to the intensive care unit the intensive care unit (ICU) is poor and haemorrhagic stroke, fixed dilated pupil(s) and GCS <10 are associated with increased mortality and poor functional outcome.
- Trial name
- REAVC (NCT04434287)
- Where
- France
- Volunteers
- 204 people
- Sponsor
- University Hospital, Brest
Critically Ill, Acute Lung Injury
Respiratory Mechanics and Pleural Effusion
The investigators aim to compare the respiratory mechanics in acute lung injury (ALI)/acute respiratory diseases syndrome (ARDS) patients with and without pleural effusion.
- Conditions
- Critically Ill, Acute Lung Injury, ARDS
- Trial name
- NCT00258518
- Testing
- mechanical ventilation/CT Scan
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Policlinico Hospital
Neuromuscular Blockade, Critical Illness
Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients
The goal of this clinical trial is to compare the effect of use of reversal agents for neuromuscular blockade in critically ill patients on time for neurological assessment after endotracheal intubation The main questions it aims…
- Conditions
- Neuromuscular Blockade, Critical Illness, Neurologic Findings
- Trial name
- NCT05993390
- Testing
- Sugammadex, Neostigmine
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Sleep Deprivation, Critically Ill
Impact of Gabapentin on Slow Wave Sleep in Adult Critically Ill Patient
The investigators proposed that gabapentin will increase slow-wave sleep in adult critically ill patients. Increasing slow-wave sleep will improve the patients' outcomes (shortening ICU length of stay, improving ventilator free…
- Trial name
- GASWAC (NCT04818450)
- Testing
- Gabapentin
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Critical Illness
Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients
The purpose of this study is to evaluate the efficacy and safety of fospropofol disodium for injection compared to propofol for deep sedation in mechanically ventilated ICU patients.
- Trial name
- NCT05870514
- Testing
- Fospropofol disodium for injection, Propofol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaobo Yang, MD
Cirrhosis, Mechanical Ventilation Complication
Extubation Failure in Critically Ill Cirrhotic Patients.
Although a life-saving intervention, invasive mechanical ventilation (MV) prone to complications and side effects. Cirrhotic patients with a need of prolonged MV have a poor prognosis in ICU compared to general population of…
- Conditions
- Cirrhosis, Mechanical Ventilation Complication, Critical Illness
- Trial name
- FREELIVER (NCT05244005)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Critical Illness Myopathy, Respiration, Artificial
Electrical Stimulation of the Quadriceps and Diaphragm in Critically Ill Patients
Subjects in MV will be included, divided into 3 groups: (a) Control Group (CG), (b) Stimulation of Quadriceps (Quadriceps Group - QG), (c) Stimulation of Diaphragm (Diaphragm Group - DG).
- Trial name
- NCT03352102
- Testing
- Electrical stimulation
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- Pericles Almeida Delfino Duarte
Critical Care, Rehabilitation
Neuromuscular Electrical Stimulation in Critically Ill Patients.
The study will investigate the effects of neuromuscular electrical stimulation (NMES) in critically ill patients. The objective of this study will be investigate the effects of neuromuscular electrical stimulation (NMES) in…
- Trial name
- NCT03815994
- Testing
- Neuromuscular Electrical Stimulation
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo