Clinical trials: Critical Ill Patients
Vitamin D Deficiency, Critical Illness
Effects of Enteral Supplement Vitamin D Incritically Ill Patients
At present, there is no clinical reference data on how much the concentration of calcifediol in the blood increases after supplementing with vitamin D for Taiwanese ICU patients.
- Trial name
- NCT04292873
- Testing
- Vitamin D supplement
- Where
- Taiwan
- Volunteers
- 61 people
- Sponsor
- National Taiwan University Hospital
Central Line-associated Bloodstream Infection (CLABSI), Catheter-related Bloodstream Infection
Effect of Vancomycin After Catheter Replacement
Randomized controlled trial of the effect of a single-dose intravenous Vancomycin after catheter replacement for suspected central line-associated bloodstream infection on resolution of infection in critically ill patients.
- Trial name
- VanCat (NCT04856878)
- Testing
- Vancomycin
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Withdrawal Syndrome, Iatrogenic Disease
AduLt iatrogEnic withdRawal sTudy in the ICU (ALERT-ICU)
Withdrawal from opioids and sedatives administered for medical purposes (i.e. iatrogenic withdrawal) often goes unrecognized in the critically ill, but its prevalence is high.
- Trial name
- NCT04422808
- Where
- United States
- Volunteers
- 2,437 people
- Sponsor
- Wilkes University
Critical Illness
Measuring Total Energy Expenditure in Critically Ill Patients Using the Doubly Labelled Water Method
Critically ill patients, such as those with trauma or sepsis, experience high rates of malnutrition (up to 75%). Malnutrition worsens outcomes by increasing infection rates, hospital stays, mortality, and healthcare costs.
- Trial name
- IC-TEE (NCT07256340)
- Testing
- DLW-based energy assessment
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Maastricht University Medical Center
Sepsis
Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS): A New Horizon for Surgical Critical Care and Induced Frailty
The purpose of this study is to define the natural history and causes of chronic critical illness (CCI) in surgical intensive care patients who have had sepsis.
- Trial name
- NCT02711709
- Testing
- Frailty Measurements, Modified Minnesota Leisure Time Activities, Computed tomography morphometrics
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Florida
Sepsis, Critical Illness
Lung Ultrasound Score and Inferior Vena Cava Diameter Compared to Pulse Pressure Variation
Evaluation and management of intravascular volume are a central challenge for the critical ill patients. Hypotensive patients are commonly resuscitated with intravenous crystalloid fluid as a recommendation for treatment of many…
- Trial name
- NCT05980494
- Testing
- normal Saline, lung ultrasound, inferior vena cava measurements
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Fayoum University Hospital
Critically Ill
Directed Immuno Nutrition by L-arginine for Critically Ill Patients
The main objective of this proof-of-concept study is to demonstrate that the only administration of L-arginine, based on a suspected deficit monitored by nasal nitric oxide measurement, can improve immune functions in critically…
- Trial name
- Immunolarg (NCT01038622)
- Testing
- L-arginine
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Delirium, Acute Kidney Injury
Neurocognitive Outcomes for ICU Patients With Acute Kidney Injury
Introduction. Initiation of acute kidney replacement therapy (KRT) is common in critically ill adults admitted to the intensive care unit (ICU), and is associated with increased morbidity and mortality.
- Conditions
- Delirium, Acute Kidney Injury, Critical Illness, Cognitive Impairment
- Trial name
- INCOGNITOAKI (NCT04722939)
- Testing
- Cerebral oxygenation
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Dr. Gordon Boyd
Renal Function Disorder, Critical Illness
Transcutaneous Electrical Nerve Stimulation for Tissues Perfusion
The aim of this study is to determine the effect of transcutaneous electrical nerve stimulation in mechanically ventilated patients on the lower limb and renal tissue perfusion.
- Conditions
- Renal Function Disorder, Critical Illness, Critical Illness Myopathy
- Trial name
- NCT04069871
- Testing
- trans-cutaneous electrical nerve stimulation.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Sars-CoV2, Critical Illness
COVID-19 and ICU-acquired MDR Bacteria
This multicenter before-after study aimed to determine the impact of infection related to SARS-CoV-2 on the incidence of ICU-acquired multidrug resistant (MDR) bacteria.
- Trial name
- COVID-BMR (NCT04378842)
- Where
- 7 sites in France
- Volunteers
- 368 people
- Sponsor
- University Hospital, Lille
Critical Illness
Glycocalyx Damage in Critically Ill Patients
The hypothesis to be tested: GCX damage and its dynamics correlate to various patient related factors and to using organ-supporting measures. There is a correlation between length of organ support and GCX damage.
- Trial name
- NCT03146585
- Testing
- PBR assessment
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital Hradec Kralove
Critically Ill, Mechanical Ventilation
The TEAM Long-Term Cohort Study (A Sub-study of TEAM(III))
This study is a prospective cohort study to evaluate the long-term effects of early activity and mobilisation compared to standard care on disability, function and health status for patients at 1, 2 and 5 years after recruitment…
- Conditions
- Critically Ill, Mechanical Ventilation, Long Term Outcome
- Trial name
- NCT05298982
- Testing
- Early activity and Mobilisation Intervention
- Where
- 16 sites in Australia
- Volunteers
- 250 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Systemic Inflammation
Influence of In-line Microfilters on Systemic Inflammation in Adult Critically Ill Patients
Studies showed that infusion or injection of drugs and fluids results in introduction of microparticles into the bloodstream. These microparticles may cause organ damage and stimulate the immune system thus aggravating the…
- Trial name
- NCT01534390
- Testing
- In-line microfilter (Supor IV Filter; Pall Corporation, Port Washington, New York)
- Where
- Austria
- Volunteers
- 504 people
- Sponsor
- University of Salzburg
ARDS
Ventilatory Efficiency in Critically Ill COVID-19 Patients
The new severe acute respiratory syndrome coronavirus 2019 (SARS-CoV-2) causes the illness named COVID-19, which is primarily characterized by pneumonia.
- Trial name
- NCT04694742
- Testing
- data collecting
- Where
- 4 sites in Italy
- Volunteers
- 100 people
- Sponsor
- ASST Fatebenefratelli Sacco
Venous Thromboembolism
Fondaparinux in Critically Ill Patients With Renal Failure
The primary objective of this study is to determine whether a dose-adjusted prophylaxis fondaparinux regimen of 2.5 milligrams (mg) subcutaneously administered every (q) 48 hours (hr) in patients with renal failure achieves peak…
- Trial name
- NCT01467583
- Testing
- Fondaparinux
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Wayne State University
Augmented Renal Clearance, Critically Ill
Iohexol Clearance in Critically Ill Patients With Augmented Renal Creatinine Clearance
Evaluation of glomerular filtration rate using iohexol plasma clearance in critically ill patients with augmented renal creatinine clearance
- Trial name
- GFR-ARC (NCT04776486)
- Testing
- Iohexol
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critically Ill
Ultrasound of the Diaphragm in ICU Patients
Diaphragmatic dysfunction is an important complication of mechanical ventilation. Critically ill patients admitted in a teaching hospital intensive care unit will be evaluated with diaphragm ultrasound to investigate predictors…
- Trial name
- NCT01952262
- Testing
- diaphragm ultrasound
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università Vita-Salute San Raffaele
Delirium, Intensive Care Unit Delirium
Partnering With Family Members to Prevent, Detect and Manage Delirium in Critically Ill Patients.
Almost half of critically ill patients experience delirium. Delirium is associated with impaired cognition, mortality, and increased healthcare costs.
- Conditions
- Delirium, Intensive Care Unit Delirium, Post Intensive Care Unit Syndrome, Post Intensive Care Unit Syndrome Family
- Trial name
- NCT04099472
- Testing
- Delirium Education, Prevention, and Management, Standard Care
- Where
- 4 sites in Canada
- Volunteers
- 128 people
- Sponsor
- University of Calgary
Covid19, SARS-CoV Infection
Steroids and Unfractionated Heparin in Critically Ill Patients With Pneumonia From COVID-19 Infection
SARS-CoV-2 infection seems to induce in most critical cases an excessive and aberrant hyper-inflammatory host immune response that is associated with a so-called "cytokine storm", moreover pro-thrombotic derangements of…
- Conditions
- Covid19, SARS-CoV Infection, Pneumonia, Viral, Coagulopathy
- Trial name
- STAUNCH-19 (NCT04528888)
- Testing
- Enoxaparin, Methylprednisolone, unfractionated heparin
- Where
- Italy
- Volunteers
- 210 people
- Sponsor
- Massimo Girardis
Small Intestinal Bacterial Overgrowth, Critical Illness
Small Intestinal Bacterial Overgrowth in Critically Ill Patients
Small intestinal bacterial overgrowth (SIBO) syndrome, though associated with potentially serious complications, has not been adequately studied to date in critically ill patients hospitalized in intensive care units (ICU).
- Conditions
- Small Intestinal Bacterial Overgrowth, Critical Illness, Intensive Care Unit
- Trial name
- NCT05765994
- Testing
- Modified hydrogen breath test
- Where
- Greece
- Volunteers
- 52 people
- Sponsor
- University of Ioannina