Clinical trials: Critical Ill Patients
Post Intensive Care Unit Syndrome
Long-term Follow up in Survivors of Critical Illness
Survivors of critical illness may suffer from persistent physical, cognitive and mental impairments, such as muscle weakness, dysfunction in the memory and executive domains, post-traumatic stress disorders, depression, and…
- Trial name
- NCT04608994
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Feeding Patterns, Critical Illness
The Effect of Sequential Feeding for Circadian Rhythm and Gut Flora Rhythm in Critically Ill Patients
Circadian rhythms plays an important role for healthy. And critical illness contributes to the disruption of circadian rhythms. Not only right but also feeding can affect the circadian clock gene expression.
- Conditions
- Feeding Patterns, Critical Illness, Circadian Rhythm Disorders
- Trial name
- NCT06083831
- Testing
- feeding type
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Qingdao University
Critical Illness, Intensive Care (ICU)
PRotEin Provision in Critical IllneSs -2
When patients survive a life-threatening condition in the intensive care unit (ICU), they often face a prolonged recovery process marked by persistent health issues that significantly reduce their quality of life.
- Trial name
- PRECISe-2 (NCT07529522)
- Testing
- enteral nutrition
- Where
- 15 sites in Belgium, Netherlands
- Volunteers
- 1,026 people
- Sponsor
- Ziekenhuis Oost-Limburg
Fluid Shifts, Critical Care
Effects of Fluid Balance Control in Critically Ill Patients
Most ICU patients develop a positive fluid balance, mainly during the two first weeks of their stay. The causes are multifactorial: a reduced urine output subsequent to shock state, positive pressure mechanical ventilation, acute…
- Trial name
- POINCARE (NCT02765009)
- Testing
- diuretics, albumin, fluid restriction
- Where
- 11 sites in France
- Volunteers
- 1,411 people
- Sponsor
- Central Hospital, Nancy, France
Aged, Critical Care
Impact of the Intervention of Pharmacists and Geriatrician on Drug Prescription in Elderly Patients in a Surgical ICU
In order to optimize drug prescription and to reduce potentially inappropriate medications, a pharmaceutical analysis activity is conducted in our establishment for several years.
- Trial name
- IATROAGE (NCT03706092)
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Critical Illness
The Effects of Different Gastric Residual Volume Thresholds for Holding Feeding in Internal Medicine.
This is a randomized control trial with a parallel design. Eligible patients will be randomly assigned into two groups: a control group which will be holding tube feeding when the GRV reaches 200 mL, and an experimental group…
- Trial name
- NCT06113393
- Testing
- GRV thresholds
- Where
- Taiwan
- Volunteers
- 230 people
- Sponsor
- National Taiwan University Hospital
Critically Ill
Evaluation of the Perception of Quality of Care of Patients Admitted to a Medical-Surgical ICU
The objective of this prospective observational cohort study is to describe the perception of quality of care of patients or reference companions admitted to a medical-surgical ICU.
- Trial name
- NCT05931809
- Testing
- Serqual tool
- Volunteers
- 200 people
- Sponsor
- Hospital Sao Domingos
Critical Illness
Single Dose Omeprazole Versus High Dose in High-risk Critically Ill Patients.
Upper gastrointestinal (GIT) bleeding is common in high risk critically ill patients. Hyperacidity has been identified as one of the main reasons for bleeding.1 2 Antacids with different treatment modalities have been studied to…
- Trial name
- NCT03388463
- Testing
- Omeprazole
- Volunteers
- 110 people
- Sponsor
- Menoufia University
Critical Illness, Respiratory Distress Syndrome, Adult
The Study of Pharmacokinetics and Pharmacodynamics of Cisatracurium
Pathophysiological changes influenced by multiple factors in critically ill patients, has a significant impact on pharmacokinetics (PK) and pharmacodynamics (PD) of cisatracurium.
- Conditions
- Critical Illness, Respiratory Distress Syndrome, Adult, Neuromuscular Blockade, Respiratory Failure
- Trial name
- NCT03337373
- Testing
- cisatracurium
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Mahidol University
Critical Illness, Inspiratory Muscle Strength
Respiratory Muscle Training in ICU Patients
Respiratory muscle weakness is common after mechanical ventilation and occurs early. This can limit functional recovery. Respiratory muscle training is often neglected in clinical practice.
- Conditions
- Critical Illness, Inspiratory Muscle Strength, Mechanical Ventilation, Respiratory Muscle Training
- Trial name
- NCT04507451
- Testing
- inspiratory and expiratory muscle training, inspiratory and expiratory exercises
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University of Liege
Fluid Therapy, Vasopressor Therapy
Practice of Fluid Therapy in Critically Ill Invasively Ventilated Patients
The goal of this woldwide observational study is to investigate various aspects of fluid and vasopressor therapy in critically ill invasively ventilated patients.
- Conditions
- Fluid Therapy, Vasopressor Therapy, Critical Illness, Invasive Ventilation
- Trial name
- PRoFLUID (NCT05968066)
- Where
- Netherlands
- Volunteers
- 2,508 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Critically Ill, Hemodialysis
Pharmacokinetics of Daptomycin in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis (CVVHD)
Daptomycin is an antibiotic that is affective against many strains of antibiotic resistant microorganisms. This antibiotic would be appropriate for use in the intensive care unit (ICU) considering the severity of illness and high…
- Trial name
- NCT00663403
- Testing
- Daptomycin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Michigan
Mechanical Ventilation, Expiratory Muscle
Expiratory Muscle Function in Critically Ill Ventilated Patients
Inspiratory muscle weakness develops rapidly in ventilated critically ill patients and is associated with adverse outcome, including prolonged duration of mechanical ventilation and mortality.
- Conditions
- Mechanical Ventilation, Expiratory Muscle, Critical Illness, Muscle Atrophy or Weakness
- Trial name
- EMFIC (NCT04333186)
- Testing
- Data from ultrasound measurements
- Where
- Netherlands
- Volunteers
- 113 people
- Sponsor
- Amsterdam UMC, location VUmc
Critically Ill, Suspected Invasive Candidiasis
Optimal Dosage of Caspofungin in Critically Ill Patients
Intensive care unit (ICU) patients are especially at risk for invasive candidiasis due to the presence of risk factors. It is known that in critically ill patients, alterations in function of various organs and body systems can…
- Trial name
- NCT01994096
- Testing
- Caspofungin
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Critical Illness, Multiple Organ Dysfunction Syndrome
AI-Based Precision Transfusion Prediction Model in Critically Ill Patients
This multicenter observational study aims to develop and validate an artificial intelligence-based precision transfusion prediction model for critically ill patients.
- Conditions
- Critical Illness, Multiple Organ Dysfunction Syndrome, Blood Transfusion
- Trial name
- NCT07762131
- Testing
- Red Blood Cell Transfusion Exposure
- Volunteers
- 2,598 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Critically Ill
Role of Polymorphisms in the Dectin-1 Gene in Determining the Risk of Candida Colonization and Infection in Critically Ill Patients
The principal aim of this study is to establish if a polymorphism in a gene important for innate immunity to fungi represents a significant risk factor for the development of Candida colonisation and subsequent invasive…
- Trial name
- Dectin-1 (NCT01482988)
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- Cardiff and Vale University Health Board
Critical Illness, Nutrition Disorders
Replacing Protein Via Enteral Nutrition in Critically Ill Patients
The investigator will investigate the effect of supplemental enteral protein (1.2 g/kg/day) added to standard formula to achieve high amount of enteral protein (range 2-2.4 g/kg/day) given from ICU day 5 until ICU discharge up to…
- Trial name
- REPLENISH (NCT04475666)
- Testing
- Replenish protein group, Standard protein group
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 2,502 people, healthy volunteers welcome
- Sponsor
- King Abdullah International Medical Research Center
Critical Ill Patients, Patients Needing Continuous Renal Replacement Therapy
Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients
CRRT patients are generally critical ill patients with unstable conditions, such as low blood pressure,severe SIRS,et al. Acute kidney injury(AKI)is especially prevalent,with even two or more organ failure.
- Trial name
- NCT02355873
- Testing
- AN69ST hemofilter, AN69 hemofilter
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Critically Ill Patients
High Protein Intake and Early Exercise in Adult Intensive Care Patients
This study analyse the impact of high protein intake associated to early programed exercise on functional outcomes of adult intensive care patients.
- Trial name
- NCT03469882
- Testing
- High protein nutrition, Cycle ergometry exercise, Usual care group
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- Hospital Sao Domingos
Ischemic Stroke, Ischaemic Stroke With Coma
Decision Aid Feasibility Trial for Families of Critically Ill Stroke Patients
Severe strokes, including large artery acute ischemic stroke and intracerebral hemorrhage, continue to be the leading cause of death and disability in adults in the U.S.
- Conditions
- Ischemic Stroke, Ischaemic Stroke With Coma, Intracerebral Hemorrhage, Hemorrhagic Stroke
- Trial name
- NCT04143113
- Testing
- Decision Aid
- Where
- 2 sites in United States
- Sponsor
- University of Massachusetts, Worcester