Clinical trials: Critical Illness, completed
COVID19, Coronavirus Infection
Convalescent Plasma Collection and Treatment in Pediatrics and Adults
This is a prospective study, using plasma to help fight off infections of those suffering from COVID-19 in accordance with collection guidelines for plasma and FDA IND requirements.
- Conditions
- COVID19, Coronavirus Infection, Coronavirus, Virus Diseases
- Trial name
- NCT04376034
- Testing
- Convalescent Plasma
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- West Virginia University
COVID-19
SARS-CoV-2 Antibodies Based IVIG Therapy for COVID-19 Patients
Severe and critically ill patients will be enrolled in the study (50 patients) after duly filled consent forms. Recipients shall be divided in to 5 groups with 10 patients per group to compare clinical efficacy and safety of…
- Trial name
- NCT04521309
- Testing
- SARS-CoV-2 antibody based IVIG therapy
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Dow University of Health Sciences
Critical Illness, Nutritional Disorder
Nutritional Status, Muscle Wasting and Fraility in Intensive Care Patients
The risk of muscle wasting is high in the intensive care unit patients during the treatment process and this condition is associated with adverse clinical outcomes.
- Trial name
- NCT04709198
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Karadeniz Technical University
COVID-19
Brainstem Dysfunction in COVID-19 Critically Ill Patients: a Prospective Observational Study
The purpose of this study is to determine the prevalence of brainstem dysfunction in critically ill ventilated and deeply sedated patients hospitalized in the Intensive Care Unit (ICU) for a SARS-CoV-s2 infection.
- Trial name
- BRAINSTEM-COV (NCT04527198)
- Testing
- Brainstem Responses Assessment Sedation Score (BRASS), Electroencephalogram with EKG lead
- Where
- 2 sites in France
- Volunteers
- 52 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Linezolid, Antioxidant
Efficacy of Intravenous N-Acetylcysteine in Preventing Linezolid-Induced Thrombocytopenia in Critically Ill Patients
Study the effect of acetylcysteine on decreasing the incidence of LIT in critically ill patients. Study the impact of acetylcysteine on the time to onset of LIT and the time to recovery of platelets.
- Conditions
- Linezolid, Antioxidant, Thrombocytopenia, Critical Illness
- Trial name
- NCT05944458
- Testing
- N acetyl cysteine
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Helwan University
ICU Mortality
Comparison of Simplified Acute Physiology Score (SAPS II) , Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation) APACHE II Scoring Systems for Predicting Mortality of Critically Ill Patients Admitted in a Tertiary Hospital Intensive Care Unit.
This is a descriptive analytical prospective study to compare the performance of SOFA score, SAPSII score and APACHE II score in ICU mortality prediction.
- Trial name
- SAPS II SOFA (NCT07780617)
- Where
- Nepal
- Volunteers
- 201 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Critical Illness, Multiple Organ Failure
Impact of Human Blood Serum From Critically Ill Patients on Human Colon Neuronal Networks.
Critical illness in the ICU setting has high medical and socioeconomic importance. Critically ill patients frequently develop severe neurologic impairment during their course of disease, typically presenting as…
- Conditions
- Critical Illness, Multiple Organ Failure, Polyneuropathy, Myopathy
- Trial name
- NCT02706314
- Where
- Germany
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Rostock
COVID-19 Pneumonia
N-Acetylcysteine as an Adjuvant Therapy in Critically Ill COVID-19 Patients:
In this study, we retrospectively will investigate safety and efficacy of NAC dose given in paracetamol toxicity as an adjuvant therapy in critically ill COVID-19 patients with acute respiratory distress and determine whether NAC…
- Trial name
- NCT05504655
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Critical Illness
Effect of Combined IV Bolus Amino Acid Supplementation and Mobilisation on Skeletal Muscle During the First 10 Days in the ICU: A RCT
A single-centre, two-arm, parallel randomised controlled trial (RCT) to compare the combined effect of early intravenous bolus amino acid supplementation and mobilisation versus standard of care on changes in muscle mass over the…
- Trial name
- ProMob-ICU (NCT04099108)
- Testing
- Combined cycle ergometry and bolus amino acid supplementation
- Where
- South Africa
- Volunteers
- 50 people
- Sponsor
- University of Stellenbosch
Acute Kidney Injury, Hemorrhage
Efficacy and Safety of Heparin-grafted Membrane for CRRT
The investigators hypothesize that the use of heparin-grafted membrane versus conventional membrane in critically-ill patients with bleeding-risk undergoing continuous renal replacement therapy, will effectively prolong the…
- Conditions
- Acute Kidney Injury, Hemorrhage, Coagulopathy
- Trial name
- CARROM (NCT01779635)
- Testing
- oXiris as first filter, M150 as first filter
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- National University Hospital, Singapore
Central Venous Catheter Thrombosis, Critical Illness
Daily Ultrasound-screening for CVC-related Thrombosis
The central venous catheters (CVC) related thrombosis is an issue of importance to ICU clinicians.This study conducts the daily ultrasound-screening for CVC-related thrombosis (DUCT).Its aim is to evaluate the characteristic and…
- Conditions
- Central Venous Catheter Thrombosis, Critical Illness, Ultrasonography
- Trial name
- DUCT (NCT03327376)
- Testing
- ultrasound-screening
- Where
- China
- Volunteers
- 1,262 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Critical Illness
Efficacy and Mechanisms of GLN Dipeptide in the SICU
Relative glutamine (GLN) deficiency may contribute to morbidity and mortality in surgical intensive care unit (SICU) patients. During critical illness, GLN utilization by the immune system, gut mucosa and other tissues exceeds…
- Trial name
- GLND (NCT00248638)
- Testing
- Glutamine dipeptide with 15% Clinisol, 15% Clinisol
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Emory University
Critical Illness
Prevalence of Microcirculatory Alterations in Intensive Care Patients
Recent research has focused on the investigation of sublingual microcirculatory alterations in different patient categories, like cardiac surgery and sepsis.
- Trial name
- NCT01179243
- Where
- 4 sites in Netherlands
- Volunteers
- 500 people
- Sponsor
- Frisius Medisch Centrum
Pediatric Disorder, Critical Illness
Attitudes to Decisions to Withdraw or Withhold Life-sustaining Treatments in Critically Ill Children
The aim of this study is to investigate attitudes on decisions to withdraw or withhold life-sustaining treatments in critically ill children in Swedish intensive care units.
- Conditions
- Pediatric Disorder, Critical Illness, Ethics, Narrative
- Trial name
- LSTPedSurvey (NCT06281743)
- Testing
- Survey
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Göteborg University
Intensive Care Unit Syndrome
High Protein Intake in Critically Ill Ventilated Patients
This prospective interventional randomized control study was conducted on forty patients with respiratory failure; all patients were intubated and mechanically ventilated for at least three days.
- Trial name
- NCT04977440
- Testing
- Whey protein
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Sepsis, Shock
Noninvasive Assessment of Tissue Perfusion Status in Critically Ill Pediatric Patients
Investigators are conducting research about oxygen levels in the body and whether it is possible to use a device to measure oxygen in the body's tissues noninvasively, without blood draws or a catheter (a plastic tube placed in a…
- Trial name
- NCT01760044
- Testing
- Tissue oxygenation monitoring
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
COVID-19, Delirium
HD-Tdcs and Pharmacological Intervention For Delirium In Critical Patients With COVID-19
The goal of this clinical trial Is conducted to evaluate the efficacy and safety of active or sham HD-tDCS in combination with dexmedetomidine in patients with moderate to severe ARDS due to COVID-19 with delirium in intensive…
- Conditions
- COVID-19, Delirium, Critical Illness
- Trial name
- COVID-19 (NCT05963958)
- Testing
- Active HD-tDCS
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Suellen Andrade
Ventilator Associated Pneumonia
Oral Care Interventions and Ventilator Associated Pneumonia in Critically Ill Children
This experimental study aims to verify the influence of the oral hygiene performance with chlorhexidine digluconate 0.12% in the development of VAP in children.
- Trial name
- NCT01083407
- Testing
- 0.12% Chlorhexidine Digluconate, Toothbrushing
- Volunteers
- 146 people
- Sponsor
- Federal University of São Paulo
Critical Illness Polyneuropathy, Acquired Brain Injury
Effects of Early Stepping Verticalization + FES on CIP
Background: Intensive Care Unit (ICU) survivors often develop an acquired weakness due to a Critical Illness Polyneuropathy (CIP).
- Trial name
- NCT03616314
- Testing
- stepping verticalization plus functional electrical stimulation, stepping verticalization, conventional physiotherapy
- Where
- Italy
- Volunteers
- 39 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Critical Illness, COVID-19
Neurocognitive Impairment in Patients With COVID-19
Delirium and acute neurocognitive impairment are increasingly observed in adult and pediatric patients with COVID-19. Prospective clinical studies combining clinical and laboratory examinations including specific biomarkers of…
- Conditions
- Critical Illness, COVID-19, Central Nervous System Injury, Delirium
- Trial name
- NCoV (NCT04359914)
- Where
- Germany
- Volunteers
- 118 people
- Sponsor
- University of Rostock
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