Clinical trials: Critical Illness, completed
Critical Illness, Muscle Atrophy
The Use of Computed Tomography (CT) to Measure Skeletal Muscle Quantity and Quality in Patients Receiving ECMO
This is a retrospective, observational study and will investigate the clinical predictive value of and change in muscle quantity and quality in critically ill patients with severe respiratory failure requiring veno-venous…
- Trial name
- NCT03269825
- Where
- United Kingdom
- Volunteers
- 215 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Muscle Weakness
Evaluation of Effectiveness of Combining High Protein Intake With Early Physical Exercise During Critical Illness
Assessment of Effectiveness of combined high protein intake with early physical exercise by ultrasound measurement of rectus femoris muscle thickness in Intensive Care Unite mechanically ventilated patients.
- Trial name
- NCT05877989
- Testing
- Amino Acid, Physical exercise
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Cardiac Failure, Critical Illness
Blend to Limit Oxygen in ECMO: A Randomised Controlled Registry Trial
To determine in patients requiring venoarterial (V-A) ECMO, whether the use of a conservative as compared with liberal oxygen strategy, results in a greater number of ICU-free days at day 28.
- Trial name
- BLENDER (NCT03841084)
- Testing
- Oxygen
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Acute Kidney Injury
Dynamic Change of Doppler-based Renal Resistive Index in Predicting Renal Recovery
The goal of this observational study is to observe the correlation between dynamic changes in the Doppler-based renal resistive index (RI) and the occurrence of persistent acute kidney injury (AKI) in critically ill patients.
- Trial name
- DRRRI (NCT05866250)
- Testing
- Doppler-based renal resistive index
- Where
- 7 sites in China
- Volunteers
- 467 people
- Sponsor
- The First Hospital of Jilin University
Mortality, Shock
Hydrogen Sulfide as Prognostic Factor
Hydrogen sulfide (H2S), better known as a poisonous gas, has emerged as the third gaseous transmitter in mammals, next to nitric oxide (NO) and carbon monoxide (CO).
- Trial name
- H2S-1 (NCT01088490)
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Sepsis
Pharmacokinetic and Pharmacodynamic Evaluation of Doripenem in Critically Ill Trauma Patients
The study hypothesis is to measure how the drug doripenem is cleared from the body of critically ill trauma patients. The investigators will measure blood drug concentrations and calculate how much the drug distributes in the…
- Trial name
- NCT01027897
- Testing
- Doripenem
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Post Intensive Care Unit Syndrome, Malnutrition
Micronutrient Levels and Nutritional Status in Critical Illness
Rationale: A significant proportion of patients admitted to the Intensive Care Unit (ICU) is unable to fully recover, even when the initial cause of their illness has been treated.
- Trial name
- NUTRI-ICU (NCT06119711)
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 79 people
- Sponsor
- Frisius Medisch Centrum
Critical Illness
Responsiveness Index Versus the RASS Based Method for Adjusting Sedation in Critically Ill Patients
Systematic evaluation of pain, agitation and delirium in ICU-patients is recommended and deep sedation should be avoided. Sedation is still monitored with clinical assessments, like RASS.
- Trial name
- NCT03250481
- Testing
- Propofol
- Where
- Finland
- Volunteers
- 32 people
- Sponsor
- Helsinki University Central Hospital
Delirium
Effect of Early Cognitive Stimulation Interventions on Delirium Among Critically Ill Patients
Delirium is an acute change in attention and awareness that develops over a relatively short time interval and associated with additional cognitive deficits such as memory deficit, disorientation, or perceptual disturbances.
- Trial name
- NCT06115863
- Testing
- Early Cognitive Stimulation Interventions
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Hyperglycemia, Cardiac Surgery
Continuous Glucose Monitoring Combined With Computer Algorithm for Intensive Insulin Therapy in Cardiosurgical Patients
The purpose of this study is to evaluate the safety and efficacy of a system combining continuous glucose measurement with a computer-based algorithm for insulin delivery in patients undergoing elective cardiac surgery.
- Trial name
- NCT00996099
- Testing
- Continuous glucose monitoring system combined with enhanced model predictive control algorithm for intensive insulin treatment, Intensive insulin therapy using standard protocol
- Where
- Czechia
- Volunteers
- 24 people
- Sponsor
- Charles University, Czech Republic
Vitamin D Deficiency, Critical Illness
Prevalence of Deficiency of Vitamin D in Critically Ill Patients
Vitamin D has been shown to related to clinical outcomes in critically ill patients. The object of this study is to investigate the prevalence of Vitamin D deficiency in critically ill patients with various length of ICU stay .
- Trial name
- NCT03639584
- Where
- Taiwan
- Volunteers
- 662 people
- Sponsor
- National Taiwan University Hospital
Disseminated Intravascular Coagulation, Critical Illness
Thrombomodulin-modified Thrombin Generation Assay (TGA-TM) in Patients With Critical Infections
Inflammation and abnormalities in laboratory coagulation tests are inseparably tied. For example, coagulation abnormalities are nearly universal in septic patients.
- Conditions
- Disseminated Intravascular Coagulation, Critical Illness, Sars-CoV2, Viral Infection
- Trial name
- NCT04356144
- Testing
- Thrombin Generation Assay (TGA), Thrombomodulin Modified Thrombin Generation Assay (TGA-TM)
- Where
- Austria
- Volunteers
- 58 people
- Sponsor
- Medical University of Vienna
Critically Ill Black Patients
Usefulness of Non-invasive Pulse Co-oximetry Haemaglobin Measurements in Critically Ill Black Patients
To answer the question whether a non-invasive haemaglobin measurement is clinically useful, reliable and accurate as compared to taking a blood sample and checking the haemaglobin level at the laboratory or in a blood gas…
- Trial name
- NCT02035306
- Testing
- non invasive co-oximetry haemaglobin measurement
- Where
- South Africa
- Volunteers
- 149 people
- Sponsor
- Chris Hani Baragwanath Academic Hospital
Systemic Inflammatory Response Syndrome, Sepsis
Vitamin D and Critically Ill Patients
The higher rate of vitamin D deficiency is spotted among patients being hospitalized or in critical condition. Especially, vitamin D level below normal prolongs hospital stay and increases incidence of adverse prognosis and…
- Trial name
- NCT01636232
- Where
- China
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Vitamin D Deficiency, Critical Illness
Effects of Enteral Supplement Vitamin D Incritically Ill Patients
At present, there is no clinical reference data on how much the concentration of calcifediol in the blood increases after supplementing with vitamin D for Taiwanese ICU patients.
- Trial name
- NCT04292873
- Testing
- Vitamin D supplement
- Where
- Taiwan
- Volunteers
- 61 people
- Sponsor
- National Taiwan University Hospital
Critical Illness, Sepsis
Cerebral Oxygen Challenge of Passive Leg Raising Test in Sepsis
Sepsis related cerebral dysfunction was underestimated in critical illness setting, and inflammatory response of brain could not be monitored directly and cerebral oximetry offered information of cerebral dysfunction.
- Conditions
- Critical Illness, Sepsis, Cerebral Injury
- Trial name
- NCT03523169
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Acute Kidney Injury
A Sample Collection Study to Validate the Astute Medical NephroCheck Test in Critically Ill Subjects at Risk for Acute Kidney Injury
The objective of this sample collection study is to collect blood and urine samples. This study is observational and will have no impact on the medical management of the subject.
- Trial name
- NCT01573962
- Where
- 23 sites in United States
- Volunteers
- 420 people
- Sponsor
- Astute Medical, Inc.
Enteral Feeding Intolerance
Ultrasound Meal Accommodation Test for Enteral Feeding in the Critically Ill
Within the context of intensive care units (ICU), enteral nutrition (NE) is an essential tool in the management of critical patients.
- Trial name
- UMATI (NCT03851354)
- Testing
- Ultrasound meal acommodation test
- Where
- Mexico
- Volunteers
- 61 people
- Sponsor
- Grupo Mexicano para el Estudio de la Medicina Intensiva
Shock
Effects of Hemodynamic Monitoring Using the ImaCor Single Use Transesophageal Echocardiography Probe in Critically Ill Patients
Hemodynamic management of critically ill patients is a constant challenge in the intensive care unit (ICU). Commonly used monitoring parameters to guide hemodynamic management generally consist of measurements of pressures…
- Trial name
- ImaCor II (NCT02048566)
- Testing
- ImaCor PM, ImaCor SM, Control PM
- Where
- Switzerland
- Volunteers
- 550 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hand Muscle Strain
Effects of Parenteral Protein Concentrations in Critically Ill Patients
Sixty patients who need Parenteral nutrition for more than 48h will be assigned into two groups .Group A (n=30) patient will receive 1g/kg/day protein and group B n=30) patient will receive 2g /kg/day.
- Trial name
- NCT04961866
- Testing
- parenteral protein 1 g/kg, Parenteral nutrition 2 g/kg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
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