Clinical trials: Critically Ill, Mechanically Ventilated
Sepsis, Critical Illness
Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients
Patients admitted to the ICU with diagnosis of sepsis and requiring mechanical ventilation for at least 24-hours and receiving enteral or parenteral nutrition will be prospectively randomized to one of two arms.
- Conditions
- Sepsis, Critical Illness, Respiratory Failure, Nutrition Disorders
- Trial name
- NCT03440593
- Testing
- Caloric delivery will target results of IC measurement.
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Baylor Research Institute
Hemodynamic Instability, Hypovolemia
Comparison of PPV and LVOT VTI During Passive Leg Raising to Predict Fluid Responsiveness
Hemodynamic instability remains one of the leading causes of morbidity and mortality among critically ill patients in intensive care units. One major contributor to this instability is intravascular fluid deficit.
- Conditions
- Hemodynamic Instability, Hypovolemia, Critical Illness, Pulse Pressure Variation
- Trial name
- NCT07304661
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Izmir Katip Celebi University
Hypotension, Shock
Trendelenburg as a First-line Intervention in Critically Ill, Sedated, Invasively Mechanically Ventilated, Hypotensive Patients
A pilot randomized controlled trial to evaluate the efficacy and safety of Trendelenburg position in critically ill patients with hypotension, mainly patients with septic shock and post operative vasoplegia.
- Trial name
- Trend (NCT05209737)
- Testing
- Trendelenburg position, Semirecumbent position
- Where
- 2 sites in Russia
- Volunteers
- 10 people
- Sponsor
- Negovsky Reanimatology Research Institute
Critical Illness
Parenteral Nutrition With Intravenous and Oral Fish Oil for Intensive Care Patients
The primary objective is to assess the effect of fish oil-enriched enteral and parenteral nutrition on blood oxygenation in critically ill patients.
- Trial name
- NCT01162928
- Testing
- Nutriflex Omega special + Oxepa, Nutriflex Lipid special + Pulmocare
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- B. Braun Melsungen AG
Critical Illness, Respiratory Failure
Sedation in the Intensive Care Unit
High-risk critically ill patients often require mechanical ventilation either to primarily support the respiratory function or when the ventilation is insufficient to maintain adequate gas exchanges as a result of other organ…
- Trial name
- NCT00221520
- Testing
- midazolam with 2 different levels of sedation scores
- Where
- Switzerland
- Volunteers
- 126 people
- Sponsor
- University Hospital, Geneva
Critical Care, Mechanical Ventilation
Prevention of Ventilator Associated Pneumonia With Toothbrushing in Oral Care of Critically Ill Mechanically Ventilated Patients
Effect of toothbrushing in oral care of mechanically ventilated critically ill patients on prevention of ventilator associated pneumonia
- Conditions
- Critical Care, Mechanical Ventilation, Ventilator Associated Pneumonia Prevention, Toothbrushing
- Trial name
- NCT02400294
- Testing
- Toothbrushing
- Where
- France
- Volunteers
- 2,030 people
- Sponsor
- University Hospital, Clermont-Ferrand
Critically Ill, Mechanically Ventilated
Treatment of Invasively Ventilated Adults With Early Activity and Mobilisation
The aim of this study is to evaluate the effect of early activity and mobilisation during prolonged IMV on the composite outcome "days alive and out of hospital to day 180".
- Trial name
- TEAM(III) (NCT03133377)
- Testing
- Early activity and mobilisation
- Where
- 49 sites in Australia, Germany and 3 more
- Volunteers
- 750 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Neurosurgery, Mechanical Ventilation
Lung and Heart USG for Predicting Weaning in Neurosurgical Patients
Ultrasonography is a commonly used diagnostic and procedural adjunctive modality in intensive care. Weaning of neurosurgical patients off ventilatory support is a critical procedure, fraught with risks of hypoxia and hypercapnia.
- Conditions
- Neurosurgery, Mechanical Ventilation, Extubation
- Trial name
- NCT03580993
- Testing
- Lung Ultrasound
- Where
- India
- Volunteers
- 27 people
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Gastro-esophageal Reflux
Safety & Initial Efficacy of the LunGuard PFT Sys. on Enteral-Fed, Sedated and Mechanically Ventilated Patients Peristaltic Feeding Tube
This study is designated to test the safety and initial efficacy of the LunGuard's PFT device for reduction of GER. Enterally-Fed, Sedated and Mechanically Ventilated Critically Ill Patients in the ICU will have the PFT…
- Trial name
- PFT (NCT02609620)
- Testing
- Peristaltic Feeding Tube, ConvaTec Levin Duodenal Tube
- Volunteers
- 20 people
- Sponsor
- LunGuard Ltd.
Respiratory Failure, Critical Illness
Double Triggering Asynchrony in Mechanically Ventilated Patients.
This observational study examined double triggering asynchrony in28ICU patients on mechanical ventilation. Researchers collected data on patient characteristics, health conditions, and outcomes to understand how this problem…
- Conditions
- Respiratory Failure, Critical Illness, Mechanical Ventilation
- Trial name
- NCT07380607
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Mansoura University
Indirect Calorimetry, Mechanical Ventilation
Effect of PEEP on Indirect Calorimetry in Critically Ill Patients
Indirect calorimetry is used in intensive care to measure how much oxygen a patient consumes and how much carbon dioxide is produced.
- Conditions
- Indirect Calorimetry, Mechanical Ventilation, Positive End-Expiratory Pressure
- Trial name
- IC-PEEP (NCT07796698)
- Testing
- Protocolized PEEP Adjustment
- Volunteers
- 20 people
- Sponsor
- Vastra Gotaland Region
VAP - Ventilator Associated Pneumonia
Efficiency and Safety of the Prolonged Use of Heat and Moisture Exchangers in ICU
FILTRex is a single-centre, controlled, randomised, prospective, non-inferiority clinical trial to compare the efficiency and safety of prolonged (72-hours) versus standard (24-hours) duration of use for Heat and Moisture…
- Trial name
- FILTRex (NCT06410664)
- Testing
- 72-hour HME exchange interval group, 24-hour HME exchange interval group
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Charles University, Czech Republic
Critical Illness; Mechanical Ventilation; Shock
REMIMID-ICU: Remimazolam vs Midazolam for Deep Sedation in Hemodynamically Unstable, Mechanically Ventilated Adults
This trial evaluates whether remimazolam provides superior sedation quality compared with midazolam in adults receiving invasive mechanical ventilation with ongoing vasopressor support.
- Trial name
- REMIMID-ICU (NCT07155265)
- Testing
- Remimazolam Besylate, Midazolam
- Volunteers
- 180 people
- Sponsor
- Yancheng First People's Hospital
Critical Illness
Daily Sedative Interruption in Critically Ill Patients Being Managed With a Sedation Protocol.
The purpose of this study is to determine whether the use of both a nurse-driven sedation protocol and daily sedative interruption, compared with a sedation protocol alone, result in better outcomes for mechanically ventilated…
- Trial name
- SLEAP (NCT00675363)
- Testing
- Protocolized Sedation, Protocolized sedation, with daily interruption
- Where
- 16 sites in United States, Canada
- Volunteers
- 410 people
- Sponsor
- Mount Sinai Hospital, Canada
Ventilator-associated Pneumonia
A Pharmacokinetic-pharmacodynamic Dose Comparison Study of 8 mg/kg of Inhaled or Parenteral Gentamicin in 12 Mechanically Ventilated Critically Ill Patients Treated for Ventilator-associated Pneumonia
Ventilator associated pneumonia (VAP) remains in the intensive care unit the infection associated with the highest morbidity and mortality. Respiratory infection with resistant organism are increasing in prevalence.
- Trial name
- GENTAERO (NCT02515448)
- Testing
- gentamicin
- Where
- 2 sites in France
- Volunteers
- 12 people
- Sponsor
- Poitiers University Hospital
Mechanical Ventilation, Nonverbal Communication
Brain Computer Interface for Communication in Ventilated Patients
Objectives: Specific Aim 1: To demonstrate the feasibility of using a Steady State Visual Evoked Potential (SSVEP) based Brain Computer Interface (BCI) device to facilitate communication of common patient needs in alert…
- Conditions
- Mechanical Ventilation, Nonverbal Communication, Intratracheal Intubation, Critical Illness
- Trial name
- NCT02791425
- Testing
- Brain Computer Interface (BCI) device, Communication picture board
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Michigan
Respiratory Insufficiency
Ventil Device Usefulness in Mechanically Ventilated ICU Patients
During Covid-19 pandemic many patients require mechanical ventilation due to disastrous impact of SARS-CoV-2 on lungs. In several countries there is a shortage of ICU beds and ventilators.
- Trial name
- NCT04355754
- Testing
- Ventil - a gas flow divider
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Gdansk