Clinical trials: Critically Ill, Mechanically Ventilated
Brain Injury, Intracranial Pressure
Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion
The purpose of this study is to evaluate brain injury when two different drugs (propofol and precedex) are used to sedate patients who need a neurologic exam.
- Trial name
- PrePARE (NCT00538616)
- Testing
- Dexmedetomidine, Propofol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Carmelo Graffagnino
Traumatic Brain Injury
A Comparison of Propofol Versus Midazolam to Sedate Critically Brain Injury; Measurement of Cytokine Response and Assessment of Function
This is a prospective randomized controlled pilot study in traumatic brain injury (TBI) patients who are sedated with either propofol or midazolam to compare the cytokine response and neuropsychological outcomes with and without…
- Trial name
- NCT01712477
- Testing
- Intravenous sedation using propofol, Intravenous sedation with midazolam
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Michigan State University
Mechanical Ventilation, Critical Illness
Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)
This is a randomized controlled trial to compare propofol to dexmedetomidine for prolonged sedation (> 24 hours) in critically ill patients who require mechanical ventilation.
- Trial name
- NCT01059929
- Testing
- Dexmedetomidine, Propofol, Fentanyl
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Chicago
Pneumonia, Ventilator Associated
Pilot Study of Lateral Rotation Interventions for Efficacy and Safety in ICU Care
Intensive care unit (ICU) patients on respirators are at high risk for preventable pulmonary complications (PPC). Turning these patients from side to side may reduce PPC, but carries the burden of decreases in blood pressure and…
- Trial name
- NCT00542321
- Testing
- Manual turn, kinetic therapy bed
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center, Houston
Critical Illness, Sleep Deprivation
Improving the Sleep and Circadian Rhythms of Mechanically Ventilated Patients
The goal of this project is to determine whether the sleep and circadian rhythms of critically ill patients undergoing mechanical ventilation can be improved through practical strategies that can be employed at the bedside.
- Conditions
- Critical Illness, Sleep Deprivation, Respiratory Failure, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT01284140
- Testing
- Sleep and circadian rhythm promotion, Usual care
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Brian Gehlbach
Sedation, Critical Illness
Musical Intervention and Physiological Stress and Inflammatory Biomarkers in Mechanically Ventilated ICU Patients
This randomized clinical trial evaluates the effects of a musical intervention on hormonal and inflammatory biomarkers in sedated adult patients undergoing invasive mechanical ventilation in an intensive care unit.
- Conditions
- Sedation, Critical Illness, Respiration, Artificial, Inflammation
- Trial name
- NCT06120660
- Testing
- Music Therapy
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- University of Oviedo
Nonverbal Communication, Critical Illness
Vidatalk Communication Application: Usability, Acceptability and Efficacy Study
This Phase II Small Business Technology Transfer Research (STTR) will deliver a comprehensive patient communication solution for communication-impaired patients in the intensive care unit that may help decrease days in delirium…
- Trial name
- NCT02921776
- Testing
- Aim 1 - VidaTalk - post-extubation, Aim 2 - VidaTalk - intubated, Aim 3 - VidaTalk tablet app
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Ohio State University
Critical Illness
Body Positioning and Pulmonary Aeration During Mechanical Ventilation
The present randomized crossover clinical trial aims to evaluate the influence of different body postures on pulmonary aeration among mechanically ventilated critically ill patients.
- Trial name
- NCT04176445
- Testing
- Orthostatic board posture, Bedside sitting posture
- Where
- 2 sites in Brazil
- Volunteers
- 19 people
- Sponsor
- Hospital Moinhos de Vento
Respiratory Failure, Critical Illness
Sleep and Circadian Rhythms in Mechanically Ventilated Patients
This study examines the feasibility of assessing sleep and circadian rhythmicity in critically ill patients undergoing mechanical ventilation.
- Trial name
- NCT01276652
- Testing
- Environmental modification
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Iowa
Acute Respiratory Failure Requiring Mechanical Ventilation
Eye-Control Trial: Wearable Eye-Tracking Device as Means of Communication
The purpose of this study is to evaluate the feasibility of use of a wearable communication device for critically ill patients who are admitted to the intensive care unit (ICU) and mechanically ventilated.
- Trial name
- NCT04582149
- Testing
- EyeControl Eye-tracking Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Intensive Care Unit, Muscle Weakness
Use of Neuromuscular Electrostimulation (NMES) for Treatment or Prevention of ICU-Associated Weakness
The purpose of this study is to investigate whether neuromuscular electrostimulation (NMES) will decrease ICU-associated weakness.
- Trial name
- NMES (NCT00709124)
- Testing
- Neuromuscular Electrostimulation (NMES) CareStim Muscle Stimulation Device (Care Rehab; McLean, VA)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Johns Hopkins University
Mechanical Ventilation, Airway Patency
The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures
Impairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency.
- Conditions
- Mechanical Ventilation, Airway Patency, Respiratory Depression
- Trial name
- NCT01969227
- Testing
- Subanesthetic ketamine
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Ventilator-associated Pneumonia
Study of Biotene OralBalance Gel for Oral Care in Critically-Ill Mechanically Ventilated Neonates
The goal of this pilot study is to test the hypothesis that mechanically ventilated infants receiving Biotene OralBalance® gel for oral care would have a reduced intubation time compared to infants receiving oral care placebo.
- Trial name
- NCT01314742
- Testing
- Biotene OralBalance® gel, Sterile Water moisten cotton tipped applicator
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Wake Forest University Health Sciences
Dexmedetomidine, Mechanical Ventilation Complication
DOSE Trial of Opioid Sparing Effect
Multicenter, double blind randomized controlled trial of fentanyl vs. fentanyl + dexmedetomidine as the initial regimen for maintenance of sedation in mechanically-ventilated, critically ill children.
- Conditions
- Dexmedetomidine, Mechanical Ventilation Complication, Critically Ill
- Trial name
- DOSE (NCT03938857)
- Testing
- Fentanyl, Dexmedetomidine
- Where
- 19 sites in United States
- Volunteers
- 30 people
- Sponsor
- Duke University