Clinical trials: Critically Ill, Mechanically Ventilated
Mechanically Ventilated, Critically Ill Children
Sedation Efficacy of Dexmedetomidine Versus Midazolam in Critically Ill Ventilated Children
There is a significant lack of adequately powered randomized clinical trial (RCT) data to determine the comparative safety and effectiveness of sedative treatments in pediatric patients.
- Trial name
- NCT04082767
- Testing
- Precedex, Midazolam
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Douglas Fraser
Critical Illness
Topical Application of Silver Nanoparticles and Oral Pathogens in Ill Patients
The purpose of this study is to determine whether oral topic silver nanoparticles are effective to reduce potential pathogen microbial loads in mechanical ventilation patients.
- Trial name
- NCT02761525
- Testing
- silver nanoparticles
- Volunteers
- 50 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Critically Ill, Subacute Adult Patients, Mechanically Ventilation
Effect of Inspiratory Muscle Training on Ventilated Patients in an Intensive Care Unit
The goal of this clinical trial is to learn if inspiratory muscle training facilite the liberation of mechanical ventilation. The main questions it aims to answer are: Does inspiratory muscle training facilitate weaning from…
- Trial name
- NCT06611683
- Testing
- Inspiratory muscle training, Routine care
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung University
Polysomnographic Sleep Characteristics
Sleep in Critically Ill Patients on Mechanical Ventilation in ICU
15 patients with sepsis, 15 patients with COPD and 15 surgical patients will undergo polysomnographic sleep monitoring up to 24 hours in order to define if there are common sleep features within the groups
- Trial name
- NCT02434341
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- University of Southern Denmark
Critical Illness, Mechanical Ventilation
Nutritional Needs and Intake on Clinical Outcomes in Mechanically Ventilated Critically Ill Elderly Patients
The purposes of this study were to investigate the caloric requirement and clinical outcomes in mechanically ventilated critically ill elderly patients and identify those at high nutritional risk who require high protein formula…
- Conditions
- Critical Illness, Mechanical Ventilation, Elderly
- Trial name
- NCT02374203
- Testing
- high protein enteral nutrition
- Where
- Taiwan
- Volunteers
- 190 people
- Sponsor
- Mackay Memorial Hospital
Mechanical Ventilation
The Geniohyoid Muscle in Critical Illness
Many patients lose muscle due to being unwell in an intensive care unit. This muscle loss can lead to weakness of the arms and legs when they leave the unit, and when they go home.
- Trial name
- NCT07606690
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Warrington Hospital
COVID-19, Respiratory Failure
Compartmental Inflammation in Mechanically Ventilated Patients With COVID-19
The aim of the present study is to examine the inflammatory response in the pulmonary compartment and blood of critically ill patients admitted to the ICU with COVID-19.
- Trial name
- COV2ICU-DK (NCT04354584)
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Hvidovre University Hospital
Chronic Respiratory Failure With Acute Decompensation Requiring Mechanical Ventilation for More Than 48 Hours
Early Chair Sitting Exercise in Mechanically Ventilated Critically Ill Patients
The occurrence of an acute respiratory failure necessitates mostly admission to ICU and mechanical ventilation (MV). Rapid and safe discontinuation of MV should be the objective for the majority of patients.
- Trial name
- RehabVent (NCT02021227)
- Testing
- Early chair sitting exercise
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Montpellier
Critical Illness and Mechanical Ventilation
Early Goal-Directed Sedation Compared With Standard Care in Mechanically Ventilated Critically Ill Patients
The Use of sedative drugs in intensive care is widespread. A cohort study conducted in Australia and New Zealand in 2010 revealed a high prevalence of deep sedation within the first 48 hours of mechanical ventilation which was…
- Trial name
- SPICE III RCT (NCT01728558)
- Testing
- Early goal Directed Sedation, Standard care sedation
- Where
- 74 sites in Australia, Ireland and 6 more
- Volunteers
- 4,000 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Pneumonia
Pulmonary-Specific Enteral Nutrition in Mechanically Ventilated Patients With Pneumonia
Pneumonia is a major cause of critical illness and respiratory failure, particularly among patients requiring invasive mechanical ventilation.
- Trial name
- NCT07892521
- Testing
- Pulmonary-Specific Enteral Nutrition, Standard Hospital Enteral Nutrition
- Where
- Indonesia
- Volunteers
- 56 people
- Sponsor
- Universitas Indonesia
Alcoholism, Respiration, Artificial
Pilot Study Evaluating Stress Response and Immune Function in Mechanically Ventilated Patients With Alcohol Use Disorders Treated With Propofol or Midazolam
The aim of this study is to evaluate the effects of the sedatives propofol and midazolam on stress response and immune function in critically ill patients with alcohol use disorders who are undergoing mechanical ventilation.
- Trial name
- NCT00871039
- Testing
- Propofol, Midazolam
- Where
- 2 sites in United States
- Sponsor
- Virginia Commonwealth University
Critical Illness, Invasive Mechanical Ventilation
MOdifiable facTors to Improve VentilAtion ThErapy in ICU
ABSTRACT Introduction: Invasively ventilated patients in low and middle-income countries (LMICs) experience significantly higher mortality compared to those in High income countries (HICs).
- Conditions
- Critical Illness, Invasive Mechanical Ventilation, ICU Mortality, Developing Countries
- Trial name
- MOTIVATE-ICU (NCT06288724)
- Volunteers
- 625 people
- Sponsor
- Nat Intensive Care Surveillance - MORU
Weaning Failure, Fluid Overload
Fluid unLoading On Weaning (FLOW)
The purpose of this study is to determine if testing preload responsiveness, the normal physiologic state that means that changes in preload determine changes in cardiac output, allows an earlier and physiologically safer weaning…
- Conditions
- Weaning Failure, Fluid Overload, Cardiac Failure Acute
- Trial name
- FLOW (NCT04496583)
- Testing
- Fluid depletion strategy
- Where
- Chile
- Volunteers
- 46 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Acute Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
The Feasibility of Pulmonary Perfusion Assessment Using Sodium Bicarbonate Contrast With Electrical Impedance Tomography: A Prospective Pilot Study
The goal of this observational pilot study is to learn if sodium bicarbonate can be used safely and effectively as a contrast agent to map lung blood flow using electrical impedance tomography (EIT) in adults on mechanical…
- Conditions
- Acute Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Pneumonia, Critical Illness
- Trial name
- NCT07542366
- Where
- China
- Volunteers
- 41 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Brain Injury, Intracranial Pressure
Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion
The purpose of this study is to evaluate brain injury when two different drugs (propofol and precedex) are used to sedate patients who need a neurologic exam.
- Trial name
- PrePARE (NCT00538616)
- Testing
- Dexmedetomidine, Propofol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Carmelo Graffagnino
Respiratory Failure, Acute Hypoxemic Respiratory Failure
Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
A multimodal educational intervention to target an oxygen saturation target range (SpO2 90-96%) will reduce ventilator length of stay and reduce occult hypoxemia by increased awareness and adherence to a designated oxygen…
- Conditions
- Respiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxic Respiratory Failure, Hypoxemia
- Trial name
- NCT06501118
- Testing
- Education, Epic notification alert
- Where
- United States
- Volunteers
- 3,600 people
- Sponsor
- University of Colorado, Denver
Pneumonia, Ventilator-Associated Healthcare-associated Pneumonia Respiration, Artificial
Combined Strategy Using Automated Subglottic Secretion Drainage and Continuous Cuff Pressure Monitoring to Prevent Microaspiration: a Multicenter Randomized Controlled Trial.
This trial will study the impact of a combined strategy to prevent microaspiration of oropharyngeal secretions or gastric content using automated subglottic secretion drainage and/or continuous cuff pressure monitoring.
- Trial name
- cosmic (NCT07555236)
- Testing
- Combined strategy, Automated subglottic secretion drainage, Automated continuous cuff pressure monitoring
- Volunteers
- 800 people
- Sponsor
- University Hospital, Lille
Traumatic Brain Injury
A Comparison of Propofol Versus Midazolam to Sedate Critically Brain Injury; Measurement of Cytokine Response and Assessment of Function
This is a prospective randomized controlled pilot study in traumatic brain injury (TBI) patients who are sedated with either propofol or midazolam to compare the cytokine response and neuropsychological outcomes with and without…
- Trial name
- NCT01712477
- Testing
- Intravenous sedation using propofol, Intravenous sedation with midazolam
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Michigan State University
Gastric Emptying, Mechanically Ventilation
Metoclopramide on Gastric Emptying in Mechanically Ventilated Patients
The aim of this study is to evaluate the prokinetic effect of metoclopramide on gastric emptying in critically ill mechanically ventilated patients .
- Conditions
- Gastric Emptying, Mechanically Ventilation, Randomized Controlled Trial, Metoclopramide
- Trial name
- NCT05641051
- Testing
- Metoclopramide
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Mechanical Ventilation, Critical Illness
Acupressure for Agitation, Pain, and Sleep in Mechanically Ventilated ICU Patients
Mechanically ventilated intensive care unit (ICU) patients commonly experience agitation, pain, and sleep disturbances, which may negatively affect recovery and increase the need for sedative medications.
- Conditions
- Mechanical Ventilation, Critical Illness, Agitation, Pain
- Trial name
- CALM-ICU (NCT07619326)
- Testing
- Acupressure, Light Touch
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Yang Yun Shiuan