Clinical trials: Critically Ill
Sepsis, ARDS
Early Severe Illness TrAnslational BioLogy InformaticS in Humans
Advanced stages of the response to life-threatening infection, severe trauma, or other physiological insults often lead to exhaustion of the homeostatic mechanisms that sustain normal blood pressure and oxygenation.
- Conditions
- Sepsis, ARDS, Critical Illness, Neurocognitive Dysfunction
- Trial name
- ESTABLISH (NCT05591924)
- Testing
- Phelebotomy, Broncheoalveolar Lavage, Tracheal Aspirate
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Arterial Puncture
Simple Psychological Interventions and Cryoanalgesia
This study aims to explore the effect of using simple psychological interventions and cryoanalgesia for reducing arterial punctures pain and anxiety in critically ill patients
- Trial name
- NCT06661187
- Testing
- Cryoanalgesia, Psychological instructions, Routine care
- Where
- 2 sites in Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Surgery, Critical Illness
Predictive Ability of PEEP Induced Changes in CVP to Predict Volume Responsiveness in Mechanically Ventilated Patients After Major Abdominal Surgery
Interventional study which will assess whether an positive end expiratory pressure induced increase of central venous pressure is a valid predictor of volume responsiveness in mechanically ventilated patients after major…
- Conditions
- Surgery, Critical Illness, Cardiac Output, Low
- Trial name
- NCT04191408
- Testing
- PEEP increase
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Dubrava
ICU Acquired Weakness
ICU CONNECT: Study Comparing EMG in Healthy Volunteers and ICU Patients.
This study is testing whether a non-invasive nerve monitoring device (TetraGraph) can accurately detect early signs of ICU-acquired weakness by comparing readings from the device with standard nerve conduction/EMG tests done by a…
- Trial name
- ICU CONNECT (NCT07699562)
- Testing
- TetraGraph, Electromyography, Nerve conduction studies
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Muscle Wasting in Critically Ill
Protein Delivery in Intermittent and Continuous Enteral Nutrition in ICU Patients
Acute skeletal muscle wasting in ICU patients is associated with functional impairment and with increased risk of death. Of what we know today, physical disability can persist up to 5 years.
- Trial name
- ProBoNo (NCT03587870)
- Testing
- Enteral nutrition with Fresubin Intensive
- Where
- Switzerland
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Critical Illness, Sars-CoV2
Anxiety and Work Resilience Among Tertiary University Hospital Workers During the COVID-19 Outbreak: An Online Survey
For limiting COVID-19 spreading, the World Health Organisation (WHO) recommended worldwide confinement on 2010. In France, unessential institutions were closed on March 14th and population confinement was decided on March 17th.
- Conditions
- Critical Illness, Sars-CoV2, SARS Pneumonia, Coronavirus Infection
- Trial name
- PSY_CO_CHU (NCT04358640)
- Where
- France
- Volunteers
- 1,784 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Critical Illness
Self-Management Behaviors of Caregivers of the Chronically Critically Ill
For family members of chronically critically ill (CCI) patients, an ICU admission marks a significant milestone in the patient's illness trajectory that highlights the onset of end of-life issues and an abrupt need for family…
- Trial name
- ASSIST (NCT03065829)
- Testing
- ASSIST, Attention-Control
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Shock, Sepsis
Surrogate of Adequate Perfusion: Bladder Tissue Oxygen Monitoring
The extent and duration of tissue hypoxia is a major determinant of outcome following major, high-risk surgery and in critical illness.
- Conditions
- Shock, Sepsis, Surgery
- Trial name
- SoAP-BOx (NCT03935477)
- Testing
- WellBeing catheter
- Where
- United Kingdom
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Respiratory Failure, Anxiety
Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention
A growing number of patients are surviving a stay in the intensive care unit (ICU) but may experience long-lasting psychological problems, but research evaluating such treatment for ICU patients is scant.
- Conditions
- Respiratory Failure, Anxiety, Critical Illness
- Trial name
- SMARA (NCT06341972)
- Testing
- Cognitive behavioral therapy based self-management for anxiety
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Hypoglycaemia
Mechanisms of Insulin Resistance in Critical Illness: Role of Systemic Inflammation and GLP-1
The purpose of this study is to determine the role of inflammation and the insulin regulating hormone GLP-1 during critical illness.
- Trial name
- NCT01347801
- Testing
- GLP-1, TNF-alfa, OGTT
- Where
- 2 sites in Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Aging Well, Decision Making
A Novel E-health Platform
The purpose of the current trial is to evaluate a novel e-health platform. Overall Hypothesis: Participants who receive Plan Well Guide (PWG) 2.0 will make more progress in their 'preparations' as measured by "Preparedness for…
- Conditions
- Aging Well, Decision Making, Illness, Critical
- Trial name
- PWG (NCT05024903)
- Testing
- Serious illness medical planning plus the novel e-health platform (PWG 2.0), Standard of care
- Where
- Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Daren K. Heyland
Critical Illness, Protein Metabolism
Local Effects of Amino Acids and 3-hydroxybutyrate in the Bilaterally Perfused Human Leg
Introduction: Protein loss during critical illness is an important problem and is shown to predict overall survival. In animal studies, infusion of leucine is shown to increase the synthesis of muscle protein by 30-40% and…
- Conditions
- Critical Illness, Protein Metabolism, Pharmaconutrients
- Trial name
- NCT01461603
- Testing
- Vamin (Fresenius Kabi), 3hydroxybutyrate
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sedation
Impact of a Nurse Implemented Sedation and Analgesia Algorithm in Surgical Intensive Care Unit
To show that the nurse implementation of a sedation and analgesia algorithm is beneficial to the patient in terms of sedative drugs reduction and thus overall decrease in duration of mechanical ventilation and the morbidity and…
- Trial name
- ALGOSEDA (NCT03186521)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Coagulation Disorder, COVID 19 Associated Coagulopathy
Coagulation Disturbances in COVID-19 Septic Patients
Objective of this study was to determine the relationship between CAC and septic condition in COVID-19 critically ill patients. Data including age, sex, comorbidities, quick Sequential Organ Failure Assessment (qSOFA) score…
- Conditions
- Coagulation Disorder, COVID 19 Associated Coagulopathy, Sepsis, Septic Shock
- Trial name
- NCT05496816
- Testing
- CAC in septic patients
- Where
- Bosnia and Herzegovina
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital Zenica
Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP)
Innate Immune Immunoparalysis and Ventilator-Associated Pneumonia in Critically Ill Elderly Patients
This prospective observational cohort study aims to evaluate the role of innate immune immunoparalysis in the development of ventilator-associated pneumonia (VAP) in critically ill mechanically ventilated patients.
- Conditions
- Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP), Immunoparalysis
- Trial name
- IMP-VM (NCT07551258)
- Where
- Spain
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Critical Illness, Muscle Loss
Investigating the Anabolic Response to Resistance Exercise After Critical Illness (ARTIST-2)
ICU survivors often suffer from long-term functional disability. An attenuated response to physical exercise in skeletal muscle after critical illness may contribute to persisting weakness.
- Trial name
- ARTIST-2 (NCT05261984)
- Testing
- Resistance exercise, Oral protein supplementation
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Sepsis, Septic Shock
Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients
Alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Respiratory Acidosis
- Trial name
- ENTERPRISE (NCT03966664)
- Testing
- In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in isolated plasma., In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in whole blood, Biomolecular analysis of plasma proteins.
- Where
- 2 sites in Czechia, Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Critical Illness, Death, Sudden
Critical Health Assessment and Outcomes Score/Study
CHAOS is based on the investigator's new and exciting results from pre-clinical and large longitudinal multi-center observational clinical studies of critically ill patients and asymptomatic community-based adults with little or…
- Trial name
- CHAOS (NCT02766166)
- Where
- 3 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Simulation of Physical Illness, COVID-19 Respiratory Infection
In Situ Simulation Training in Transferring Critically Ill COVID-19 Patients
This study aimed to determine the role of in situ simulation training during a pandemic by using standard and high-fidelity mannequins to improve interprofessional communication, skills, and teamwork in transferring critically…
- Trial name
- NCT05113823
- Testing
- Simulation Training
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Covid19, Respiratory Disease
COVID-19 Longitudinal Biomarkers in Lung Injury
Profile known and novel biomarkers in blood in COVID19 patients to characterize the host response to SARS-CoV-2 over time and in response to treatment. The investigators aim to: Better understand the disease.
- Conditions
- Covid19, Respiratory Disease, Critical Illness
- Trial name
- COLOBILI (NCT04747782)
- Testing
- no interventions performed. Just collecting data, blood samples and post-mortem biopsies.
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dr. Andrew Baker