Clinical trials: Critically Ill
Medical Device Site Erosion
Nursing Interventions on Prevention Medical Device Related Pressure Injury (MDRPI)
This study aims to assess the effect of implementing nursing interventions on preventing medical device related pressure injury in critically ill patients.
- Trial name
- MDRPI (NCT06513936)
- Testing
- The skin care Bundle, Routine care
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Critical Illness
Use of suPAR Algorithm for the ED Decision Making
Will the use of a clinical decision algorithm in the ED improve discharge or admission decisions.
- Trial name
- EDsuPAR (NCT04402281)
- Testing
- suPAR algoritm
- Where
- Finland
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Clinical Reasoning, Critical Illness
The Effect of Case-Based Education on the Development of Nursing Students' Clinical Reasoning Skills
Aim: This study was conducted to determine the effect of case-based education on the development of clinical reasoning skills of nursing students in critical illnesses.
- Trial name
- NCT05504824
- Testing
- Case-based education
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ankara University
Systemic Inflammatory Response Syndrome (SIRS)
Myostatin and Irisin Levels in Predicting the Outcome of Patients With Systemic Inflammation: A Prospective Observational Study
Systemic inflammatory response syndrome (SIRS) is associated with severe metabolic stress that can lead to rapid breakdown of skeletal muscle and the development of stress-related malnutrition.
- Trial name
- NCT07476391
- Where
- Czechia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Safety
Intensive Care Nurses' Training Package on the Safety Culture of Geriatric Patients
This study aims to determine the effect of intensive care nurses' training package on the safety culture of critically ill geriatric patients.
- Trial name
- NCT05910918
- Testing
- Intensive Care Nurses' Training Package
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Critical Illness
Sublingual Microcirculation Monitoring in ICU
Prospective observational study designed to implement a daily monitoring of microcirculation and tissue oxygenation in all critically ill patients admitted to the ICU in the period of nine months, in order to assess the…
- Trial name
- MICRODAIMON (NCT02649088)
- Testing
- Microscan, NIRS from Hutchinson
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Università Politecnica delle Marche
Colonic Neoplasms, Rectal Neoplasms
Endoscopically Assisted Colostomy With Colopexy for Critically Ill Patients Without General Anesthesia or Laparotomy
Indications for colostomy are rectal or anal cancer, diverticular disease, radiation enteritis, complex perirectal fistulas, anorectal trauma, severe incontinence, motility and functional disorders.
- Conditions
- Colonic Neoplasms, Rectal Neoplasms, Fecal Incontinence
- Trial name
- EACC (NCT02308631)
- Testing
- ENDOSCOPICALLY ASSISTED COLOSTOMY WITH COLOPEXY
- Where
- Brazil
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Renal Failure, Impaired Renal Function
Linezolid Pharmacokinetics In Patients With Impaired Renal Function (PPT6)
Renal failure patients were treated with linezolid (LZD) for proven or suspected infections by multiresistant Gram-positive cocci.
- Trial name
- LZDPPT6 (NCT02087566)
- Testing
- 600 mg linezolid
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Critically Ill, Colorectal Surgery
Muscle Function After Intensive Care
Final objective of critical care is no longer only survival. The role of medical and paramedical teams should also be to restore functional capacities, autonomy and quality of life.
- Conditions
- Critically Ill, Colorectal Surgery, Healthy, Muscle Strength
- Trial name
- NCT03922113
- Testing
- Patient follow up
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Liege
Critical Illness
SC2i VIPER: EnVenomation Investigation Pilot to Evaluate Recovery
The purpose of this study is to pilot data for a systematic molecular characterization of pathophysiologic perturbations incurred by snake envenomation and compare this to other inflammatory physiologic states such as trauma and…
- Trial name
- VIPER (NCT03170297)
- Testing
- Research interventions of blood sampling and data collection
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Critical Illness, Protein Metabolism
Local Effects of Amino Acids and 3-hydroxybutyrate in the Bilaterally Perfused Human Leg
Introduction: Protein loss during critical illness is an important problem and is shown to predict overall survival. In animal studies, infusion of leucine is shown to increase the synthesis of muscle protein by 30-40% and…
- Conditions
- Critical Illness, Protein Metabolism, Pharmaconutrients
- Trial name
- NCT01461603
- Testing
- Vamin (Fresenius Kabi), 3hydroxybutyrate
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Systemic Inflammatory Response Syndrome, Sepsis
Vitamin D and Critically Ill Patients
The higher rate of vitamin D deficiency is spotted among patients being hospitalized or in critical condition. Especially, vitamin D level below normal prolongs hospital stay and increases incidence of adverse prognosis and…
- Trial name
- NCT01636232
- Where
- China
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Arterial Puncture
Simple Psychological Interventions and Cryoanalgesia
This study aims to explore the effect of using simple psychological interventions and cryoanalgesia for reducing arterial punctures pain and anxiety in critically ill patients
- Trial name
- NCT06661187
- Testing
- Cryoanalgesia, Psychological instructions, Routine care
- Where
- 2 sites in Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Sepsis, Septic Shock
IL-40 and IL-41 Levels in Sepsis, Septic Shock, and Healthy Individuals
This study aims to investigate the blood levels of two recently identified immune-related proteins, Interleukin-40 (IL-40) and Interleukin-41 (IL-41), in patients with sepsis and its more severe form, septic shock.
- Conditions
- Sepsis, Septic Shock, Inflammation, Biomarkers
- Trial name
- NCT06963541
- Testing
- No intervention; Observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Melahat Yalcin Solak
Critical Illness Polyneuropathy, Critical Illness Myopathy
Validation of Simplified Electrophysiological Examination in the Diagnosis of Critical Illness Myopathy or Neuropathy
Evaluate the accuracy, in the diagnosis of critical illness myopathy and / or neuropathy, of the simplified peroneal nerve test performed by a neurophysiopathology technician or by a neurophysiopathology doctor (as the gold…
- Trial name
- CRIMINE-3 (NCT04193943)
- Where
- Italy
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Brescia
Hyperglycemia
Fat Based Enteral Nutrition for Blood Glucose Control in ICU
In this randomized, double-blind clinical trial, eligible hospitalized ICU patients with EN will be included. Patients will be divided into two groups.
- Trial name
- NCT02584907
- Testing
- High Fat Enteral Nutrition
- Where
- Iran
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Sepsis, ARDS
Early Severe Illness TrAnslational BioLogy InformaticS in Humans
Advanced stages of the response to life-threatening infection, severe trauma, or other physiological insults often lead to exhaustion of the homeostatic mechanisms that sustain normal blood pressure and oxygenation.
- Conditions
- Sepsis, ARDS, Critical Illness, Neurocognitive Dysfunction
- Trial name
- ESTABLISH (NCT05591924)
- Testing
- Phelebotomy, Broncheoalveolar Lavage, Tracheal Aspirate
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
ICU, Comfort
Comfort Care Bundle
Intensive care units (ICUs) are specialized units where numerous complex treatment and care procedures are applied. In these units, critically ill patients are exposed to stressful conditions and experience significant pain and…
- Conditions
- ICU, Comfort, Bundle Care, Nursing Care
- Trial name
- NCT07366021
- Testing
- Comfort Care Bundle
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Psychomotor Agitation
Quetiapine for Delirium Prophylaxis in High-risk Critically Ill Patients
Scheduled, low-dose quetiapine is effective in preventing delirium in high-risk critically ill, trauma/surgical patients. Prophylaxis also reduced ventilator duration and ICU length of stay.
- Trial name
- NCT02612948
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Intubation; Difficult or Failed, Intubation Complication
Expert Consensus Statements for the Management of a Physiologically Difficult Airway Using the Delphi Method (PDADelphi)
The aim of this study is to review/identify the existing definition and management strategies for a physiologically difficult airway (PDA), to generate expert consensus on the various aspects of managing a patient with a PDA…
- Conditions
- Intubation; Difficult or Failed, Intubation Complication, Hemodynamic Instability, Critical Illness
- Trial name
- PDADelphi (NCT05762068)
- Testing
- Delphi procedure
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center