Clinical trials: Critically Ill, open to volunteers
Electrolytes Abnormalities, Children
Serum Electrolyte Abnormalities as Prognostic Factor for Outcome in Critically Ill Children
The aim of this study is to evaluate the clinical profile and outcome of children with serum electrolyte abnormalities admitted at Pediatric Intensive Care Unit in Assuit University Children Hospital.
- Conditions
- Electrolytes Abnormalities, Children, Prognostic Factors
- Trial name
- NCT07205562
- Volunteers
- 200 people
- Sponsor
- Assiut University
Enteral Nutrition, Enteral Nutrition Feeding
Stepwise Enteral Nutritional Algorithm and Patient Outcomes in Pediatric Intensive Care Units
The aim of the study to evaluate the effectiveness and patient's outcome after implementing enteral nutrition algorithm designed to achieve optimal enteral nutrition delivery in the pediatric intensive care unit and to evaluate…
- Conditions
- Enteral Nutrition, Enteral Nutrition Feeding, Enteral Nutrition Intolerance in Critically Ill Patients
- Trial name
- NCT07307027
- Testing
- Stepwise Enteral Nutritional Algorithm
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Prolonged Mechanical Ventilation, Critical Illness
Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure
The main objective of the study is to determine whether a subnormal serum creatinine value upon admission to the Post-ICU Care Unit predicts the need for prolonged ventilatory support.
- Trial name
- SECRET-VENT (NCT07177183)
- Testing
- Dietary supplement creatine, No intervention
- Where
- 2 sites in Czechia
- Volunteers
- 492 people
- Sponsor
- University Hospital Ostrava
Fungal Infection, Aspergillosis
Isavuconazole in Critically Ill Patients: Efficacy and Safety
Due to factors such as disease status, gastrointestinal conditions, commonly used medications (e.g., vasopressors), and cardiac output, the plasma concentration of isavuconazole in critically ill patients may differ from that in…
- Conditions
- Fungal Infection, Aspergillosis, Mucormycosis
- Trial name
- NCT07080359
- Testing
- Isavuconazole treatment
- Volunteers
- 75 people
- Sponsor
- Shanghai 10th People's Hospital
Respiration Failure, Cardio Vascular Disease
COMPARE-VENT Feasibility Pilot Study
Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20%…
- Conditions
- Respiration Failure, Cardio Vascular Disease, Cardiogenic Pulmonary Oedema, Critical Illness
- Trial name
- NCT07656259
- Testing
- Volume Controlled Mode, Pressure Controlled Mode
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Mayo Clinic
Severe Pneumonia
Detection and Characterization of Lower Respiratory Infections in Critically Ill Patients
This study is a prospective observation study for lower respiratory tract infections in medical intensive care unit. Microbiologic and clinical characteristics and outcomes of patients with severe pneumonia in medical intensive…
- Trial name
- NCT01068990
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Asan Medical Center
Intensive Care Medicine, Respiratory Distress Syndrome (RDS)
Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol
Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable.
- Conditions
- Intensive Care Medicine, Respiratory Distress Syndrome (RDS), Sedation and Analgesia, ExtraCorporeal Membrane Oxygenation (ECMO)
- Trial name
- ECMO-SED (NCT07032987)
- Testing
- Not an intervention study
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Fluid Balance, Acute Kidney Injury
Fluid Balance in Acute Kidney Injury in Critically Ill Patients
This prospective observational cohort study evaluates if fluid balance in the first 48 hours of ICU admission is linked to acute kidney injury (AKI) in critically ill adults.
- Conditions
- Fluid Balance, Acute Kidney Injury, Critically Ill Acute Kidney Injury, Critically Ill
- Trial name
- NCT07338734
- Volunteers
- 120 people
- Sponsor
- Assiut University
Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP)
Resistance-Optimised Antimicrobial Dosing in Critically Ill Patients, a Randomised Controlled Trial
Critically ill people who need a breathing machine often develop hospital-acquired lung infections. These infections are commonly treated with the antibiotics piperacillin/tazobactam or meropenem.
- Conditions
- Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP), Nosocomial Respiratory Infection, Critical Illness
- Trial name
- ROAD-RCT (NCT07820501)
- Testing
- Resistance-Optimised Precision Dosing, Standard Care Dosing
- Volunteers
- 610 people
- Sponsor
- The University of Queensland
Critically Ill
Parasternal Intercostal Muscle Thickening as an Additive Weaning Criterion
Increased days of MV are not without hazards, including barotraumas and ventilator-associated pneumonia. Similarly, premature separation of MV is associated with increased mortality secondary to adverse cardiorespiratory events.
- Trial name
- NCT07143695
- Testing
- Parasternal intercostal thickening fraction
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
Probiotic, Ventilator Associated Pneumonia
Probiotic Role in Prevention of Ventilator Associated Pneumonia in Critically- Ill Children Admitted at Pediatric Intensive Care Unit
The aim of the work is to evaluate the impact of Probiotics supplementation on prevention of ventilator associated pneumonia in critically ill children admitted at Pediatric Intensive Care Unit at Tanta University Hospitals.
- Conditions
- Probiotic, Ventilator Associated Pneumonia, Critically- Ill Children
- Trial name
- NCT07848165
- Testing
- Probiotics, Standard management
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Tanta University
Analgesia, Post Operative Pain
The Analgesic Efficacy of Vitamin B Complex in Critically Ill Obstetrics After Caesarean Section
We aim to investigate the value of vitamin B (B1, B6, B9, B12) on post-cesarean section analgesia in addition to the standard opioid-sparing multimodal regimen to achieve more robust analgesia with minimal side effects.
- Conditions
- Analgesia, Post Operative Pain, Cesarean Section
- Trial name
- NCT06446830
- Testing
- multimodal analgesia and vitamin B, standard multimodal analgesia
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Shock, Acute Respiratory Distress Syndrome
Correlation Between EIT-based Pulse Wave Method for Pulmonary Perfusion Monitoring and Pulmonary Artery Catheter-based Stroke Volume Measurement
The goal of this clinical study is to learn if a new, non-invasive monitoring method called EIT Pulse Wave can accurately measure blood flow to the lungs (pulmonary perfusion) and predict heart stroke volume (SV) in critically…
- Trial name
- EIT-Cath Corre (NCT07385963)
- Testing
- Synchronous Data Acquisition of EIT and Pulmonary Artery Catheter
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Critically-ill Patients
Immunosuppression and Intensive Care Unit-acquired Multidrug-resistant Bacteria
Antimicrobial resistance AMR is an emerging global threat to human health, and intensive care units (ICUs) are a 'hot spot' for the emergence and diffusion of multidrug-resistant (MDR) bacteria.
- Trial name
- TANGERINE (NCT06652126)
- Testing
- Microbiological examinations.
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Lille
Carbapenem-Resistant Acinetobacter Baumannii Infection
Targeted Antimicrobial Comparison for Treatment Individualization in Critically Ill Patients With CRAB Infection
The goal of this prospective, multicenter observational study is to learn which antibiotic treatment strategies are associated with better outcomes in critically ill adults with severe infections caused by carbapenem-resistant…
- Trial name
- TACTIC-CRAB (NCT07905235)
- Testing
- Antibiotic Therapy for CRAB Infection
- Volunteers
- 1,000 people
- Sponsor
- Central South University
Post Intensive Care Syndrome (PICS), Critical Illness
"PROTECT-ICU: Impact of an Educational Intervention
Brief Summary The goal of this study is to learn if a structured training program for intensive care unit (ICU) staff can reduce health problems after a stay in the ICU in adults.
- Trial name
- PROTECT-ICU (NCT07542613)
- Testing
- Standardized Training on the ABCDEF Care Bundle (A-F), Standardized training on the expanded ABCDEF care bundle (A-Z)
- Where
- 2 sites in Spain
- Volunteers
- 900 people
- Sponsor
- Carola Giménez-Esparza Vich
Prevalence of Airway Closure, in Adults in Intensive Care
Abbreviated Title: Airway Opening Pressure in Mechanically VENTilated Patients
Context: Mechanical ventilation is an essential treatment for patients admitted to intensive care. It is estimated that approximately 50% of adult patients admitted to intensive care require invasive mechanical ventilation.
- Conditions
- Prevalence of Airway Closure, in Adults in Intensive Care, Mechanical Ventilation in Controlled Mode
- Trial name
- AOP-VENT (NCT07512713)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sarcopenia, Critical Illness
Prevalence of Sarcopenia in Patients Admitted to ICU and Its Progression During Hospitalization.
This is a prospective, observational study at the ICU of Hospital Mútua de Terrassa, running from May to December 2025. The primary goal is to determine the prevalence of sarcopenia in adult patients requiring more than 48 hours…
- Conditions
- Sarcopenia, Critical Illness, Intensive Care (ICU) Myopathy, Body Composition Measurement
- Trial name
- SARC-ICU (NCT07303335)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Mutua de Terrassa
Icu Delirium, Post Intensive Care Syndrome
ABCDEF Bundle Compliance and ICU Outcomes in Latin America
The goal of this observational study is to evaluate the degree of compliance with the ABCDEF bundle and its relationship with clinical outcomes in adult patients (aged 18 and older) admitted to intensive care units (ICUs) in…
- Conditions
- Icu Delirium, Post Intensive Care Syndrome, Critical Illness
- Trial name
- NCT07783035
- Testing
- ABCDEF Bundle Compliance Assessment
- Volunteers
- 580 people
- Sponsor
- Hospital H+ Queretaro
Critical Care, Critical Illness
Early Multimodal Therapy and Mechanical Ventilation
To assess the association between early multimodal therapy and the duration of invasive mechanical ventilation in the Intensive Care Unit at Fundación Santa Fe de Bogotá.
- Trial name
- NCT06133504
- Testing
- Early Multimodal Therapy, Late Multimodal Therapy
- Volunteers
- 74 people
- Sponsor
- Fundación Santa Fe de Bogota