Clinical trials: Crohn Disease of Intestine
Ulcerative Colitis, Crohn's Colitis
RCT: HDWL vs Virtual Chromoendoscopy in the Detection of Intraepithelial Neoplasia in Longstanding Colitis
Colitis is inflammation of the large bowel and it is often caused by conditions known as ulcerative colitis and Crohn's disease.
- Trial name
- VIRTUOSO (NCT02822352)
- Testing
- Chromoendoscopy
- Where
- United Kingdom
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Crohn Disease
Effect of Prebiotic FOS on Intestinal Abundance of Faecalibacterium Prausnitzii in Patients With Crohn´s Disease
FOS improve gut colonization by Faecalibacterium prausnitzii in patients with Crohn's disease
- Trial name
- NCT02539849
- Testing
- FOS, Adalimumab
- Where
- 5 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Crohn Disease, Colitis, Ulcerative
A Study of Continued Use of Guselkumab in Participants With Crohn's Disease and Ulcerative Colitis in Real World Setting
The purpose of this study is to find out how long a participant keeps taking guselkumab or continues with their treatment plan without stopping (treatment persistence) in participants with moderate to severe Crohn's disease (CD)…
- Trial name
- GusTaCon (NCT07746765)
- Volunteers
- 35 people
- Sponsor
- Janssen Sciences Ireland UC
Inflammatory Bowel Diseases, Crohn Disease
Telemonitoring for IBD Goodness Examination in Russia
This is a prospective, randomized study to assess the impact of telemedicine (telemonitoring, tele-education and tele-consultation) on the patients with Inflammatory Bowel Disease (IBD).
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- TIGE-Rus (NCT05994716)
- Testing
- Telemonitoring
- Where
- Russia
- Volunteers
- 62 people
- Sponsor
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Crohn's Disease
Safety and Tolerability of FITC-Adalimumab Administration During Confocal Laser Endomicroscopy of the Gut
The scientific objective of the project is to evaluate if the topical administration of Fluoresceinisothiocyanate (FITC)-Adalimumab during the endomicroscopic examination of the gut in Crohn's disease (CD) patients shows an…
- Trial name
- FA-Crohn (NCT01275508)
- Testing
- FITC-Adalimumab
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Inflammatory Bowel Diseases, Colitis, Ulcerative
Lipid Mediators in Colonic Biopsies as Biomarkers of Disease Activity of Inflammatory Bowel Diseases
We will quantify one of the lipid compounds (5,6 epoxy eicosatrienoic acid (5,6 EET), 5,6- EpoxyEicosaTrienoic acid) in colonic biopsies of Inflammatory Bowel Disease patients.
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease
- Trial name
- MICILIP (NCT01990716)
- Testing
- Colonic Biopsy
- Where
- France
- Volunteers
- 124 people
- Sponsor
- University Hospital, Toulouse
Crohn Disease
Reverse Engineering of Exclusive Enteral Nutrition
Primary: Nutritional therapy in the form of a whole-food based smoothie can be used to induce remission of active Crohn's disease.
- Trial name
- RE-EEN (NCT03508193)
- Testing
- Nutritional therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Dale Lee
Crohns Disease
Oral N-acetylglucosamine in Crohn's Disease
Protein glycosylation is a critical post-translational modification that regulates protein trafficking and protein-protein interactions impacting a host of physiological processes.
- Trial name
- NAGIC (NCT07225998)
- Testing
- N-Acetylglucosamine (GlcNAc)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Crohn Disease
Study of Treat to Target Versus Routine Care Maintenance Strategies in Crohn's Disease Patients Treated With Ustekinumab
The purpose of this study is to evaluate the efficacy of a treat to target strategy coupled with early endoscopic assessment versus a clinically driven (routine care) approach in achieving endoscopic response.
- Trial name
- STARDUST (NCT03107793)
- Testing
- Ustekinumab
- Where
- 107 sites in Belgium, Czechia and 10 more
- Volunteers
- 500 people
- Sponsor
- Janssen-Cilag Ltd.
Arthritis, Rheumatoid, Spondylitis, Ankylosing
Post Marketing Surveillance Study of Remicade in Patients With Chronic Inflammatory Diseases (P04840)
This study will be performed to evaluate and document the safety and efficacy of infliximab (Remicade®) in the treatment of chronic inflammatory diseases in big cohorts in the daily routine practice of rheumatologists…
- Conditions
- Arthritis, Rheumatoid, Spondylitis, Ankylosing, Arthritis, Psoriatic, Psoriasis
- Trial name
- REMission (NCT00727298)
- Testing
- Infliximab
- Volunteers
- 4,485 people
- Sponsor
- Merck Sharp & Dohme LLC
Crohn Disease, Stricture; Bowel
Efficacy of Ustekinumab Therapy in Patients With Symptomatic Stricturing Crohn's Disease
This study intends to select patients with confirmed moderate-to-severe Crohn's disease (CD) and obstructive symptoms of intestinal stenosis, who have clear evidence of lumen stenosis caused by the disease itself through…
- Conditions
- Crohn Disease, Stricture; Bowel, Intestinal Stricture
- Trial name
- NCT05387031
- Testing
- Ustekinumab
- Where
- 8 sites in China
- Volunteers
- 239 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Crohn Disease
Effect of Acupuncture on the Microbiota-gut-brain Axis in Crohn's Disease
Multidisciplinary techniques such as multimodal neuroimaging, microbiology, and bioinformatics were applied to study the differences in correlation characteristics between gut microbes, functional brain networks, and peripheral…
- Trial name
- NCT06364722
- Testing
- Acupuncture treatment
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Intestinal Failure, Inflammatory Bowel Diseases
Changing the Future of Intestinal Failure in Intestinal Chronic Inflammation (INT-FAIL)
This is an interventional, prospective, no profit study that will be performed at CEMAD, from FONDAZIONE POLICLINICO GEMELLI IRCCS, Rome (UO1) and U.O.C.
- Conditions
- Intestinal Failure, Inflammatory Bowel Diseases, Crohn Disease
- Trial name
- INT-FAIL (NCT06777251)
- Testing
- analysis of predictive factors of IF in patients with Crohn's disease through the characterization of "multiomics" parameters
- Where
- Italy
- Volunteers
- 254 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Crohn's Disease, Ulcerative Colitis
Predicting Response to Vedolizumab in Pediatric Inflammatory Bowel Diseases
Vedolizumab (VDZ) is a humanized immunoglobulin G1 monoclonal antibody acting against α4β7 integrin which modulates lymphocyte trafficking in the gut.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease
- Trial name
- NCT02862132
- Testing
- Vedolizumab
- Where
- 15 sites in United States, Denmark and 4 more
- Volunteers
- 142 people
- Sponsor
- Shaare Zedek Medical Center
Crohn's Disease
Efficacy Study of T2 Versus AZA to Maintain Clinical and Endoscopic Remission in Postoperative Crohn's Disease
The purpose of this study is to see whether T2 versus Azathioprine is able to maintain the clinical and endoscopic remission in subjects with Crohn's disease after surgery-induced remission.
- Trial name
- T2 (NCT01015391)
- Testing
- T2, Azathioprine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jinling Hospital, China
Crohn's Disease
Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients
The purpose of this study is to evaluate the efficacy of guselkumab in healing of all layers of the digestive tract (transmural healing) with the help of a score called Magnetic Resonance Index of Activity (MaRIA) based on a scan…
- Trial name
- REASON (NCT06408935)
- Testing
- Guselkumab
- Where
- 84 sites in United States, Australia and 12 more
- Volunteers
- 120 people
- Sponsor
- Janssen-Cilag Ltd.
Crohn Disease
Non-invasive Vagus Nerve Stimulation in the Treatment of Crohn's Disease - A Pilot Study
To assess the safety and efficacy of transcutaneous vagal stimulation in adult patients with active Crohn's disease.
- Trial name
- VNS (NCT05165108)
- Testing
- Vagal Nerve Stimulator
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University
Crohn's Disease
Oral Budesonide vs. Oral Mesalazine in Active Crohn's Disease (CD)
The purpose of this study is to determine whether mesalazine or budesonide is more active in the treatment of active Crohn's disease.
- Trial name
- NCT00300118
- Testing
- budesonide, mesalazine
- Where
- Germany
- Volunteers
- 311 people
- Sponsor
- Dr. Falk Pharma GmbH
Crohn's Disease, Recurrence
Crohn's Extent of Resection Trial
The trial will investigate if removing an additional length of small bowel will result in lower risk of recurrence at the surgical join (anastomosis), thereby decreasing the need for further surgery in the future.
- Trial name
- CERT (NCT01876264)
- Testing
- Extended resection, Conventional resection
- Where
- United Kingdom
- Sponsor
- Oxford University Hospitals NHS Trust
Inflammatory Bowel Disease, Crohn Disease
High Dose Interval Vitamin D Supplementation in Patients With Inflammatory Bowel Disease Receiving Biologic Therapy
The investigators will be administering oral high dose interval vitamin D, concurrently when participants are receiving biologic therapy for their inflammatory bowel disease.
- Conditions
- Inflammatory Bowel Disease, Crohn Disease, Ulcerative Colitis, Vitamin D Deficiency
- Trial name
- NCT04331639
- Testing
- vitamin D3
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
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