Clinical trials: Cross Infection
Pseudomonas Aeruginosa, Colonization, Asymptomatic
Carbapenem-resistant Pseudomonas Aeruginosa: the SAMPAN Study.
Pseudomonas aeruginosa causes severe infections in hospitalized patients. The worldwide emergence of carbapenem-resistant P. aeruginosa (CRPA) makes infections by these pathogens almost untreatable.
- Conditions
- Pseudomonas Aeruginosa, Colonization, Asymptomatic, Nosocomial Infection
- Trial name
- SAMPAN (NCT05282082)
- Where
- 3 sites in Indonesia, Italy and 1 more
- Volunteers
- 2,105 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Carbapenemase-Producing Enterobacterales (CPE) Colonization
Impact of Implementing a Rapid PCR-based Algorithm for Carbapenemase-producing Enterobacterales (CPE) and Infection Control Bundle in a Tertiary Hospital
Purpose: Carbapenemase-producing Enterobacterales (CPE) are a growing cause of healthcare-associated infections, linked to high morbidity, mortality, and cost.
- Trial name
- NCT07397416
- Testing
- Rapid PCR-based algorithm for CPE detection
- Volunteers
- 800 people
- Sponsor
- Hospital Italiano de Buenos Aires
Hospital Infection, Standardized Antibiotic Prescribing Ratio (SAR)
InPART RX - Epicenters
InPART Rx is a collaborative research study to measure the impact of a planned quality improvement initiative to reduce unnecessary antibiotic prescribing by the Hospital Medicine Service through a process of receiving…
- Trial name
- InPART RX (NCT07368660)
- Testing
- Messaging Hospitalists, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Emory University
Staphylococcus Aureus Colonization, Surgical Site Infections
Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients
The purpose of the study is to determine the effectiveness, safety, and health-care utilization and costs of a preoperative Staphylococcus aureus (SA) screening and decolonization bundle, (5 days of nasal mupirocin ointment…
- Conditions
- Staphylococcus Aureus Colonization, Surgical Site Infections, Healthcare Associated Infections
- Trial name
- NCT06378359
- Testing
- Screening and decolonization for SA carriers with the 3 drug bundle, No screening for SA, no screening
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Minnesota
Infection Wound, Gastrointestinal Complication
Tranexamic Acid to Reduce Infection After Gastrointestinal Surgery
This international, multicentre, pragmatic, double-blind, placebo-controlled, randomised trial of TxA versus placebo will enrol 3,300 patients throughout Australia and internationally.
- Conditions
- Infection Wound, Gastrointestinal Complication, Anesthesia, Bleeding
- Trial name
- TRIGS (NCT04192435)
- Testing
- Tranexamic Acid
- Where
- Australia
- Volunteers
- 3,300 people
- Sponsor
- Bayside Health
Nosocomial Infection
Diagnostic of D-lactate in Cerebrospinal Fluid Level in Patients With Suspected Ventriculostomy-related Meningitis
The TOTEM study is a single-center study designed to evaluate the performance of the D-lactate assay in cerebrospinal fluid (CSF) for the diagnosis of ventriculostomy-related nosocomial meningitis.
- Trial name
- TOTEM (NCT06482463)
- Testing
- CSF sample
- Where
- France
- Volunteers
- 185 people
- Sponsor
- University Hospital, Toulouse
Ventilator Associated Pneumonia, Pulmonary Aspergillosis Invasive
Incidence of Invasive Pulmonary Aspergillosis in Ventilator-associated Pneumonia
Mechanically ventilated patients are at risk of developing ventilator-associated pneumonia (VAP). Invasive pulmonary aspergillosis (IPA), the diagnosis of which motivates the implementation of specific treatments, is one of the…
- Trial name
- ASPIC (NCT05671328)
- Testing
- Biological examinations performed on blood and BAL
- Where
- France
- Volunteers
- 263 people
- Sponsor
- University Hospital, Lille
Septic Shock, Severe Trauma
REAnimation Low Immune Status Markers
The fact that sepsis disrupts immune system homeostasis by inducing an initial cytokine storm, that participates to occurrence of organ failures and early death, followed by a compensatory anti-inflammatory response leading to…
- Conditions
- Septic Shock, Severe Trauma, Severe Burn, Major Surgery
- Trial name
- REALISM (NCT02638779)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Infection, Skin and Subcutaneous Tissue Bacterial Infections
Study of Accuracy of New Diagnostic Technology to Determine Guide Rapid Antibiotic Treatment for Serious Infections
Military service members and the U.S. veteran population face a growing and serious health threat: widespread antibiotic resistance resulting from resistant bacteria and a dwindling pipe-line of sufficiently potent antibiotics.
- Conditions
- Infection, Skin and Subcutaneous Tissue Bacterial Infections, Healthcare-associated Infection, Infection Due to Resistant Bacteria
- Trial name
- RAMPED (NCT02060513)
- Where
- 3 sites in United States
- Volunteers
- 2,298 people
- Sponsor
- Connie Price
Hand Hygiene Training, Infection Prevention and Control
Effectiveness of an Edge AI-based Augmented Reality System for Hand Hygiene Training: a Multi-centre, Mixed-methods Cluster Randomised Controlled Trial
This multi-centre, mixed-methods cluster randomised controlled trial (cRCT) aims to evaluate the effectiveness of an edge artificial intelligence (AI)-based augmented reality (AR) training and assessment system for improving hand…
- Conditions
- Hand Hygiene Training, Infection Prevention and Control, Healthcare-Associated Infections (HAIs), Health Education
- Trial name
- HANDHEART (NCT07280026)
- Testing
- Instructional Video + Scanner Feedback, Edge AI-based AR Hand Hygiene Training System
- Where
- 3 sites in China, Hong Kong
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Taurolidine Lock Solution
Survey of Practices Regarding the Use of Taurolidine Lock Solutions in Patients With Insertion of a Peripherally Inserted Central Catheter (PICC) in a Vascular Access Unit
The primary objective of this study is to describe current practices regarding the administration of taurolidine lock solutions in relation to medical prescriptions for patients who have undergone peripherally inserted central…
- Trial name
- TAURO-USE2 (NCT07259421)
- Volunteers
- 45 people
- Sponsor
- University Hospital, Grenoble
Epidural Catheter-Related Infection, Hospital-Acquired Infection
Epidural Catheter and Port-Related Infections in Pain Clinic Patients
This retrospective observational study aims to evaluate the incidence and risk factors of infection associated with epidural catheter and port applications performed in the Pain Clinic of Mersin University Faculty of Medicine.
- Conditions
- Epidural Catheter-Related Infection, Hospital-Acquired Infection, Procedural Complication
- Trial name
- NCT07242560
- Where
- Turkey (Türkiye)
- Volunteers
- 351 people
- Sponsor
- Mesut Bakır
Pneumonia Ventilator Associated, Pneumonia Neonatal
Reduction of the Incidence of NAV in Neonatal Units (INBERNAV-Neo)
The aim of this project is to achieve useful, universal and standardized definitions for the diagnosis and prevention of ventilator-associated neumonia in patients in the Neonatal Intensive Care Unit (NICU).
- Conditions
- Pneumonia Ventilator Associated, Pneumonia Neonatal, Healthcare-associated Infections
- Trial name
- INBERNAV-Neo (NCT07240038)
- Testing
- Multimodal intervention to reduce the incidence of ventilator-associated pneumonia by training the health care team in specific and general evidence-based good clinical practices., Technique with a blind-protected catheter
- Where
- 39 sites in Spain
- Volunteers
- 1,500 people
- Sponsor
- Biobizkaia Health Research Institute
Enterobacteriaceae Infections, Hospital-Acquired Infection
Nosocomial Outbreak of BHRe in an Intensive Care Unit During SARS-CoV-2 Pandemic
Multidrug Resistant (MDR) bacteria have become a major worldwide public health challenge and hospitals are now increasingly faced with management of local outbreaks involving such pathogens.
- Trial name
- BHReICU (NCT05055479)
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cross Infection, Bacteriuria
Prevention of Nosocomial E. Coli Infections After Placement of an Indwelling Catheter During Pelvic Surgery: an Evaluation of Cranberry Gel Capsules
Indwelling urinary catheters are a primary site for nosocomial infections. The purpose of this study is to evaluate the anti-adhesive properties of Cranberry type A pro anthocyanidine gel capsules in the prevention Escherichia…
- Trial name
- NosoPink (NCT01114347)
- Testing
- cranberry type A pro anthocyandines
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Nosocomial Infection
The Prophylactic Effect of Garlic Tablets to Prevent Nosocomial Infections in Intensive Care Unit Patients.
The goal of this clinical trial is to learn if garlic tablets works to prevent nosocomial infections in hospitalized patients in ICU.
- Trial name
- NCT06833125
- Testing
- Garlic powder standardized to allicin
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Alexandria University
Infection, Hospital
Organosilane for Surface Cleaning in Intensive Care Units
The purpose of this study is to evaluate if surface disinfection with organosilane associated with traditional cleaning reduces the incidence of healthcare-associated infections (HAIs) in intensive care units when compared with…
- Trial name
- ORG-CLEAN (NCT05673226)
- Testing
- Surface disinfection with Organosilane
- Where
- 14 sites in Brazil
- Volunteers
- 10,301 people
- Sponsor
- Hospital Israelita Albert Einstein
Cross Infection (Hospital-Acquired Infections), Critical Illness
Probiotics for Preventing ICU-Acquired Infections in Critically Ill Patients: A Pilot Study
This pilot randomized clinical trial investigated the effect of probiotic supplementation on the incidence of intensive care unit-acquired infections (ICU-AIs) in critically ill patients.
- Conditions
- Cross Infection (Hospital-Acquired Infections), Critical Illness, Probiotic Intervention
- Trial name
- NCT07144124
- Testing
- Biopro-max 8 Billion Probiotics (Bioserv Healthcare)
- Where
- Saudi Arabia
- Volunteers
- 25 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Central Line Associated Blood Stream Infections (CLABSI)
Machine Learning Prediction of Possible Central Line Associated Blood Stream Infections and Rate of Reduction
Prospective, multi-center, cluster-randomized trial of a hospital Infection Preventionist (IP)-led quality improvement study to provide clinical teams with just-in-time clinical education and reinforcement of existing best…
- Trial name
- CLABSI AI (NCT07108660)
- Testing
- Infection Preventionist Led Best Practices Reminders
- Where
- 19 sites in United States
- Volunteers
- 17,800 people
- Sponsor
- Swedish Medical Center
Patient With Influenza Like Illness
Effect of Influenza Vaccination of Healthcare Workers (HCW) on the Risk of Influenza in Patients Hospitalized in Short Stays Units
Hospital acquired influenza is associated with significant morbidity and mortality in hospitalized patients notably elderly patients. Vaccination of HCW is recommended to prevent influenza transmission in healthcare setting.
- Trial name
- NCT02198638
- Testing
- A nasal swab
- Where
- 2 sites in France
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon