Clinical trials: Crosslinking
Alveolar Bone Resorption
Lateral Ridge Augmentation Around Implants
The rehabilitation of dentoalveolar defects and tooth loss has seen remarkable advancements over time. Extraction of tooth leads to reduction in physiologic dimension of bone and it is imperative to evaluate the site before…
- Trial name
- NCT04197128
- Testing
- Resorbable Collagen membrane with bone graft for augmentation, Ribose cross linked collagen matrix for augmentation
- Where
- India
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Bone Regeneration
Comparative Study of Three Collagen Membranes: 1 Non-cross-linked and 2 Cross-linked
This study is being done to compare how quickly three different types of collagen membranes break down when they are exposed to the mouth.
- Trial name
- NCT06944639
- Testing
- Membrane Jason MB GmbH Non-cross-linked (NCL), Membrane BioMend Extend Glutaraldehyde cross-linked, Membrane OSSIX Agile Ribose cross-linked (RCL)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Andrea Ravida
Aesthetic, Aesthetic Rejuvenation
Clinical Investigation of the Medical Device "Alexa Volume" for Correction of Midface Volume Loss
This is a post-marketing, open-label, non-comparative, multi-center clinical investigation to evaluate the effectiveness and safety of the medical device "Alexa Volume" (DIACO BIOFARMACEUTICI S.r.l., Italy), based on cross-linked…
- Conditions
- Aesthetic, Aesthetic Rejuvenation, Midface Volumization, Age-related Volume Deficit in the Mid-face
- Trial name
- NCT06984419
- Testing
- Cross-linked hyaluronic acid dermal filler
- Where
- 4 sites in Poland, Ukraine
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Institute Hyalual GmbH
Dry Eye Syndrome
Cross-linked Hyaluronic Acid and Coenzyme Q10 in the Treatment of Dry Eye
Background: Dry eye disease (DED) is a common condition causing burden on visual function and reducing quality of life. Corticosteroids and/or cyclosporine eye drops are able to improve DED symptoms, however, side effects of…
- Trial name
- DEDCO (NCT03074344)
- Testing
- XLHA+CoQ10, Hyaluronic acid (HA)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Wound Healing After Tooth Extraction
Comparing Cross-Linked and Non-Cross-Linked Hyaluronic Acid for Early Healing After Tooth Extraction
This study compares early healing after a non-surgical tooth extraction in adults. Participants are assigned by chance to one of three groups: cross-linked hyaluronic acid placed in the extraction site using a gelatin sponge…
- Trial name
- NCT07898163
- Testing
- Cross-linked sodium hyaluronate 1%, Non-cross-linked low-molecular-weight hyaluronic acid, Gelatin sponge
- Where
- Cyprus
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cyprus Health and Social Sciences University
Basic Science: Safety, Tolerability, Efficacy of CLP
Evaluation of Cross-Linked Polyelectrolyte (CLP) in Healthy Volunteers
This is a dose-escalation study to determine the effect of CLP in normal healthy volunteers.
- Trial name
- NCT01944007
- Testing
- Cross-Linked Polyelectrolyte (CLP)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sorbent Therapeutics
Keratoconus
Safety and Effectiveness of the PXL-Platinum 330 System for Cornea Crosslinking in Eyes With Cornea Thinning
This study study is to determine the effectiveness of cornea cross linking in patients with Keratoconus or other cornea thinning conditions.
- Trial name
- CXL (NCT05516004)
- Testing
- PXL Platinum 330 system
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Cohen Laser and Vision Center
Tooth Movement
OC and ICTP in Gingival Crevicular Fluid During Piezocision Accelerated Orthodontic Treatment
The aim of this study was to evaluate the tooth movement with and without piezocision with regard to the levels of osteocalcin and cross-linked C-terminal telopeptides of type I collagen in the gingival crevicular fluid.
- Trial name
- NCT04611984
- Testing
- Piezocision, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Marmara University
Dermal Filler, Volume Deficiency of the Midface
An Interventional Study to Evaluate the Safety and Performance of Crosslinked Hyaluronic Acid Hydrogel
The aim of this interventional, pre-market, double- blinded, controlled, two stages study is to evaluate the performance and safety of Crosslinked Hyaluronic Acid (CLHA) Hydrogel (with and without Lidocaine) for the Treatment of…
- Trial name
- NCT05853224
- Testing
- Crosslinked Hyaluronic Acid (CLHA) Hydrogel with and without Lidocaine
- Where
- Italy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Biopolimeri Srl