Clinical trials: Crosslinking
Dry Eye Disease
IIT Assessing OC-01Nasal Spray on Symptoms of DED Following CXL
A Randomized, Controlled, Double-Masked, Two-Arm Investigator-Initiated study to Assess the Efficacy of OC-01 (varenicline) Nasal Spray on signs and symptoms of Dry Eye Disease in subjects following Corneal Collagen Crosslinking…
- Trial name
- NCT05136924
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision - MT
Intrauterine Adhesion
Efficacy and Safety of Crosslinked Hyaluronan Gel for Preventing Intrauterine Adhesion
Intrauterine adhesion (IUA) is the adhesion of intrauterine tissues due to the exposure of myometrial tissues caused by the endometrial basal injury.
- Trial name
- NCT02220621
- Testing
- Crosslinked hyaluronic acid gel, Foleys balloon catheter
- Where
- 3 sites in China
- Volunteers
- 120 people
- Sponsor
- Xiaozheng Shu
Pterygium of Conjunctiva and Cornea
Recurrence Rate of Mini-SLET vs. Limbal-Conjunctival Autograft in Primary Pterygium Excision
To study the efficacy and safety of amniotic membrane transplantation as an adjunctive therapy after surgical excision of primary pterygium and compare the clinical outcomes with conjunctival autograft
- Trial name
- NCT03363282
- Testing
- Pterygium Excision
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Hyperopia
PiXL for Correction of Hyperopia
This clinical study aims to investigate the efficacy and safety of PiXL in the refractive correction of low hyperopia.
- Trial name
- NCT03805425
- Testing
- PiXL
- Where
- Czechia
- Volunteers
- 25 people
- Sponsor
- Gemini Eye Clinic
Maxillary Cyst, Bone Loss of Substance
Treatment Of Maxillary Bone Cysts With Autologous Bone Mesenchymal Stem Cells (MSV-H)
This trial pretends to validate for clinical use a bioengineered product composed of MSV cells (mesenchymal stem cells produced by IBGM, Valladolid, which have already been approved by the Spanish Regulatory Agency for three…
- Trial name
- BIOMAX (NCT01389661)
- Testing
- MSV treatment
- Where
- 3 sites in Spain
- Volunteers
- 11 people
- Sponsor
- Red de Terapia Celular
Alveolar Bone Resorption
Lateral Ridge Augmentation Using Two Graft Combination and a Cross-linked Collagen Membrane
To treat resorbed alveolar ridges, many surgical procedures are available in the literature such as ridge splitting, distraction osteogenesis, block grafting techniques and guided bone regeneration, which is the most documented…
- Trial name
- NCT06523686
- Testing
- Guided bone regeneration
- Where
- Lebanon
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Keratoconus, Corneal Ectasia
Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia
This randomized study compares 2 variations of corneal crosslinking for treatment of keratoconus or corneal ectasia.
- Trial name
- NCT07841470
- Testing
- Riboflavin 0.1% ophthalmic solution and pulsed light, Riboflavin 0.1% ophthalmic solution and non-pulsed light
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Price Vision Group
Knee Osteoarthritis
Safety and Effectiveness Study of a Non-Crosslinked HA Alkylamide HYADD(TM) 4 Hydrogel for Osteoarthritis of the Knee
The purpose of this study is to determine whether intra-articular hyaluronic acid provides symptomatic relief of osteoarthritis of the knee.
- Trial name
- NCT02187549
- Testing
- HYMOVIS
- Where
- 21 sites in United States
- Volunteers
- 332 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Myomas, Ovary Cysts
The Efficacy and Safety Study of a New Cross-linked Hyaluronan Hydrogel in the Reduction of Postsurgical Peritoneal Adhesions
The purpose of this study was to determine whether the new crosslinked hyaluronan hydrogel was safe to use, and was effective for the prevention/reduction of adhesion formation following gynecological surgery
- Conditions
- Myomas, Ovary Cysts, Endometriotic Cysts, Adhesions
- Trial name
- BAP (NCT02166554)
- Testing
- Saline, Cross-linked Hyaluronan Hydrogel
- Where
- 7 sites in China
- Volunteers
- 216 people
- Sponsor
- BioRegen Biomedical (Changzhou) Co., Ltd
Keratoconus, Ectasia
Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia
This prospective, randomized study is being conducted to evaluate the safety and effectiveness of corneal cross-linking (CXL) in patients with keratoconus or post-refractive ectasia (post-LASIK or PRK) utilizing two techniques…
- Trial name
- CXL (NCT03080077)
- Testing
- Ricrolin+, Epi-Off
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Degenerative Joint Disease
Large Head X3 Study
The purpose of this study is to explore the benefit of X3 polyethlene inserts with larger diameter heads used in the Japanese population.
- Trial name
- NCT02543437
- Testing
- Trident Acetabular X3 Insert
- Where
- 4 sites in Japan
- Volunteers
- 120 people
- Sponsor
- Stryker Japan K.K.
Keratoconus
Corneal Changes After Crosslinking in Keratoconus Patients Compared to the Untreated Fellow Eye
The purpose of this retrospective study is to assess corneal changes (keratometry, pachymetry) and change in visual acuity (VA) in keratoconus patients after unilateral crosslinking treatment compared to the untreated fellow eye.
- Trial name
- NCT02428166
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- Heidelberg University
Osteoarthritis, Arthritis
Study Comparing Marathon Polyethylene and Enduron Polyethylene Acetabular Liners Used in Total Hip Arthroplasty
The purpose of the study is to determine whether crosslinked Marathon and standard Enduron polyethylene liners show differences in bone loss around the hip implant.
- Conditions
- Osteoarthritis, Arthritis, Joint Diseases, Musculoskeletal Diseases
- Trial name
- NCT01121146
- Testing
- Total Hip Replacement
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Anderson Orthopaedic Research Institute
Keratoconus, Crosslinking
Riboflavin at 4ºC for the Management of Pain After Crosslinking for Keratoconus Patients
Background: The objective of corneal collagen crosslinking (CXL) is to increase the binding of intrafibrillary and interfibrillary covalent bonds to improve the mechanical stability of the cornea and thus to stop the progression…
- Trial name
- NCT03760770
- Testing
- corneal collagen crosslinking
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Progressive Keratoconus
Corneal Crosslinking Treatment Study
Three different protocols for inducing corneal crosslinks in subjets with progressive keratoconus will be evaluated in this randomised clinical study.
- Trial name
- NCT04427956
- Testing
- Corneal crosslinking: CXL (UVA 9mW/cm2), Isotonic riboflavin, Hypotonic riboflavin
- Where
- Sweden
- Volunteers
- 54 people
- Sponsor
- Region Skane
Keratoconus
Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking
This study aims to compare the use of Dextenza, an FDA-approved intracanilular drug-eluting insert that is designed to deliver a tapered dose of dexamethasone to the ocular surface for 30 days, to the standard of care, or the use…
- Trial name
- NCT06235567
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, topical prednisolone acetate 1% (PredForte) eye drops
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Maanasa Indaram, MD
Keratoconus
Conventional Collagen Crosslinking in Young Keratoconus
Keratoconus is a chronic progressive non - inflammatory disorder characterised by progressive steepening and thinning of cornea and high myopic astigmatism, accounting for poor visual acuity in such individuals.
- Trial name
- PED-CXL (NCT02008175)
- Testing
- Conventional CXL
- Where
- India
- Volunteers
- 21 people
- Sponsor
- Vasan Eye Care Hospital
Dental Surgery
Evaluation of a Non-cross-linked Porcine Acellular Dermal Matrix Used in Dental Surgery
The general objective of the study is to confirm the medium/long-term safety and clinical performance of the CELLIS Dental membrane used in dental surgery and to identify emerging risks in comparison to clinical data related to…
- Trial name
- NCT05435976
- Testing
- CELLIS Dental (Porcine Acellular Dermal Matrix, PADM)
- Where
- 5 sites in France
- Volunteers
- 50 people
- Sponsor
- Meccellis Biotech
Intrauterine Adhesion
The Efficacy of A New Crosslinked Hyaluronan Gel in Prevention of Intrauterine Adhesion
Using American Fertility Society classification of intrauterine adhesions, the efficacy of a new crosslinked hyaluronan gel in reducing intrauterine adhesion formation after dilatation and curettage for delayed miscarriage in…
- Trial name
- NCT03353909
- Testing
- new crosslinked hyaluronan gel
- Volunteers
- 300 people
- Sponsor
- BioRegen Biomedical (Changzhou) Co., Ltd
Gingival Recession
MCAT With HA and sCTG Compared With sCTG Alone for Treatment of Multiple Gingival Recession: Clinical Trial
Microsurgical tunneling flap procedures using connective tissue grafts (CTG) are predictable for treating teeth with gingival recessions.
- Trial name
- NCT05045586
- Testing
- The tunnel technique for root coverage with CTG without Cross-linked Hyaluronic Acid, The tunnel technique for root coverage with CTG andCross-linked Hyaluronic Acid
- Where
- Poland
- Volunteers
- 15 people
- Sponsor
- Medical University of Warsaw