Clinical trials: Cryotherapy
Injection Site Pain, Pain
Comparing Pre-Anesthetic Approaches in Dentistry
The main purpose of this study is to find out which pre-treatment method works best to reduce pain from dental anesthesia injections in adult patients.
- Trial name
- NCT07703553
- Testing
- 10% lidocaine spray, Ice Pen (Cryotherapy)
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Harran University
Skin Temperature Change, Adverse Effects
Prolonged Cryocompression and Skin Temperature: a Safety and Feasibility Pilot
Guidelines for treatment duration for cold and compression therapy after knee surgery are typically based on the use of ice packs for 30 minutes.
- Conditions
- Skin Temperature Change, Adverse Effects, Safety of Intervention, Cryotherapy
- Trial name
- NCT06673277
- Testing
- Prolonged (2-hour) cryocompression therapy
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Winchester
Post-endodontic Pain
Effect of Submucosal Cryotherapy on Postoperative Endodontic Pain
The goal of this clinical trial is to compare submucosal Cryotherapy with different anti-inflammatory drugs in the reduction of post-endodontic pain in upper premolars with symptomatic irreversible pulpitis.
- Trial name
- NCT06090500
- Testing
- Cryotherapy, Diclofenac sodium, Dexamethasone sodium phosphate
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Exercise-Induced Fatigue, Recovery
Whole-Body Cryotherapy and Isokinetic Performance After Exercise-Induced Fatigue
This randomized crossover study investigated the effects of whole-body cryotherapy (WBC) on isokinetic knee performance following running-induced fatigue in physically active healthy male university students.
- Trial name
- WBC-ISO (NCT07617857)
- Testing
- Whole-Body Cryotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Biruni University
Cryotherapy Effect
Intraoral Cryotherapy in Root Canal Retreatment
The aim of this study was to evaluate the effect of intraoral cryotherapy application on postoperative pain in single and multiple visit retreatment of teeth with symptomatic or asymptomatic apical periodontitis.
- Trial name
- NCT05091554
- Testing
- intraoral ice pack application
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Post-operative Pain, Vital Pulp Therapy
Compare the Impact of Sodium Hypochlorite and Saline Irrigation Protocols With and Without Cryotherapy on Post-operative Pain Following Pulpotomy in Permanent Mandibular Molar Teeth.
The aim of the present study will compare the impact of sodium hypochlorite and saline irrigation protocols with and without cryotherapy on post-operative pain following pulpotomy in permanent mandibular molar teeth.Will the use…
- Trial name
- NaOCl/VPT/MTA (NCT07764666)
- Testing
- VPT /pulpotomy, VPT/complete pulpotomy, vital pulp therapy /complete pulpotomy
- Where
- Egypt
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Abdelrahman Refaat Khalaf Ahmed
Skin Laxity
Dermal Cryotherapy in Patients Undergoing Abdominoplasty
A prospective, interventional, single-arm study to evaluate histologic changes in skin following cryotherapy with the study device.
- Trial name
- NCT02763306
- Testing
- Dermal Cooling System
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- R2 Dermatology
Barrett's Esophagus
Endoesophageal Cryotherapy For Ablating Barrett's Esophagus and Early Stage Esophageal Cancer
In this prospective single center study, up to 25 patients with Barrett's esophagus with LGD or no dysplasia (Group 1), 25 patients with HGD/IMCA (Group 2), 25 patients with esophageal carcinoma confined to the esophageal wall…
- Trial name
- NCT00628784
- Testing
- Endoscopic spray cryotherapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Inflammation, Oxidative Stress
Antioxidants Combined With Cryotherapy on Inflammatory Response After Resistance Exercise in Untrained Volunteers
Acutely resistance exercise induces inflammatory responses and leukocytosis arising of oxidative stress, that clinically manifested by pain and/or delayed onset muscle soreness (DOMS).
- Conditions
- Inflammation, Oxidative Stress, Pain
- Trial name
- NCT02902315
- Testing
- Cryotherapy, Vitamins C and E, Vitamins C and E associated with cryotherapy
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Root Canal Infection, Pain, Postoperative
Effect of Cryotherapy and LLLT on Postoperative Pain After Root Canal Treatment
The aim of this study is to evaluate the effect of low-level laser therapy (LLLT) and intracanal cryotherapy applications on postoperative pain in endodontic interventions of primary molar teeth with apical periodontitis.
- Conditions
- Root Canal Infection, Pain, Postoperative, Cryotherapy Effect, Laser
- Trial name
- NCT05476445
- Testing
- Control, Laser, Cryotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Healthy, Topical Anesthesia
Cryotherapy as a Topical Anesthetic in Healthy Children
In this study, the investigators aimed to compare the effects of topical anesthetic materials and cold application on pain perception.
- Conditions
- Healthy, Topical Anesthesia, Pediatric Dentistry, Cryotherapy
- Trial name
- NCT07198022
- Testing
- Cryotherapy, topical anesthetic, Topical anesthetic gel
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Lentigo Solar
Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots PROOF OF CONCEPT
CRYO (N° 21D588A0001) study aims to evaluate the tolerance and adjust the mode of administration of a cyto-selective difluoroethane-based cryotherapy in the treatment of brown spots.
- Trial name
- CRYO-EC4 (NCT05014321)
- Testing
- EC16 medical device (CE marked), device prototype (810A-v1), device prototype (810B-v1)
- Where
- Ukraine
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cryonove Pharma
Carious Teeth
The Effect of Cryotherapy on Treatment Outcomes for Pulpotomy
The goal of this clinical trial is to investigate the effect of cryotherapy on treatment outcome for pulpotomny in permanent mature carious posterior teeth.
- Trial name
- NCT07303010
- Testing
- Addition of Cryotherapy on pulpotomy
- Where
- Thailand
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sirawut Hiran-us
Cryotherapy Effect, Pectus Excavatum
Percutaneous Intercostal Cryoneuromodulation Onset Timing.
Percutaneous Intercostal Cryoneurolysis is a promising technique that addresses acute postoperative pain after Nuss procedure for pectus excavatum. However its onset timing has not yet been determined.
- Trial name
- NCT07081620
- Testing
- Physical examination of chest skin
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Papa Giovanni XXIII Hospital
Sacroilitis
Efficacy of Extracorporeal Shock Wave Therapy, LASER Therapy and Cryotherapy in Patients Having Sacroiliitis
This research aimed to determine the effect of extracorporeal shock wave therapy, LASER therapy and cryotherapy on PPT, Pain and functional disability in patients having Sacroiliitis.
- Trial name
- NCT06569615
- Testing
- shock wave therapy, LASER Therapy, Cryotherapy
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Najran University
Verruca Vulgaris
A Trial Examining the Treatment of Common Warts With Combination Liquid Nitrogen (LN2) and Cantharidin
The purpose of the study was to see if liquid nitrogen, a commonly used treatment for warts, is more effective if it is used alone, or if it is more effective if combined with cantharidin, a topical treatment also commonly used…
- Trial name
- NCT01084824
- Testing
- Liquid nitrogen and cantharidin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- North Idaho Dermatology
Humans, Young Adults
Analysis of the Effects on Human Tissues After Application of Therapeutic Modalities.
As a therapeutic modality, cryotherapy is highly used for soft tissue damage control during acute and subacute stages. Cryotherapy is able to reduce pain, inflammatory condition, muscle spasm, nerve conduction, metabolic rate…
- Conditions
- Humans, Young Adults, Health
- Trial name
- NCT03414346
- Testing
- Exclusively ice pack, Ice pack added 10% of water, Ice pack added 100% of water
- Where
- Brazil
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Alessandro Haupenthal
Symptomatic Periapical Periodontitis
Influence of Intra-Canal Cryotherapy on Post-Endodontic Pain and Interleukin-6 Expression Using Different Irrigation Protocols: A Randomized Clinical Trial
the study was to evaluate the effect of intra-canal cryotherapy on post-endodontic pain and interleukin-6 expression in teeth with symptomatic apical periodontitis using different irrigation protocols.
- Trial name
- NCT04324398
- Testing
- Cryotherapy
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
MTA Vital Tooth Pulpotomy
Clinical & Radiographic Efficacy Using LLLT & CRYO on M.P.M Pulpotomy
This in-vivo study aims to evaluate the efficacy of the low level laser therapy and cryotherapy in treatment of vital pulpotomy in mature permanent molar evaluating the post operative pain and the radiographic changes in pulpal…
- Trial name
- NCT06711081
- Testing
- low level laser device cryotherapy
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tanta University
Non-Genital Warts
Efficacy and Safety of Platelet-rich Plasma, Metformin and Cryotherapy in Treatment of Non-genital Warts
1. Evaluation of the efficacy and safety of intralesional injection of autologous platelet-rich plasma in treatment of various types of cutaneous non genital warts 2.
- Trial name
- NCT06691542
- Testing
- platelet-rich plasma, Metformin, cryotherapy
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Assiut University