Clinical trials: Damage Control Surgery
Cerebral Palsy, Muscle
How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery.
Cerebral palsy (CP) is a motor disorder caused by an injury to the immature brain. Even though the brain damage does not change, children with CP will have progressively weaker, shorter and stiffer muscles that will lead to…
- Conditions
- Cerebral Palsy, Muscle, Muscle Contracture, Muscle Spasticity
- Trial name
- CPTDBiopsy (NCT05506228)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eva Ponten
Cerebral Palsy, Hip Dysplasia
Peri-operative Use of a Pain Injection in Pediatric Patients With Cerebral Palsy
Pain management in pediatric patients presents a difficult challenge. Unlike adults, pediatric patients often cannot communicate their pain management needs clearly.
- Conditions
- Cerebral Palsy, Hip Dysplasia, Pain, Postoperative
- Trial name
- NCT04074265
- Testing
- Ropivacaine injection, normal saline
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of California, Los Angeles
Abdominal Trauma, Damage Control Surgery
Clinical Outcomes of Non-Indicated Staged Laparotomies in Abdominal Trauma
The goal of this observational study is to understand how often staged operations are performed in abdominal trauma patients without meeting standard clinical criteria, and to explore related clinical characteristics and…
- Conditions
- Abdominal Trauma, Damage Control Surgery, Laparotomy
- Trial name
- NCT07110350
- Testing
- Laparotomy refers to a definitive single-stage exploratory abdominal surgery. Damage Control Surgery refers to a staged surgical approach including initial abbreviated laparotomy followed by planned.
- Where
- Taiwan
- Volunteers
- 350 people
- Sponsor
- Far Eastern Memorial Hospital
Diverticulitis
Damage Control Surgery in the Treatment of Complicated Diverticulitis
To evaluate the use of damage control surgery by performing bowel resection and laparostomy in the treatment of Hinchey III or IV diverticulitis.
- Trial name
- DACSCOD (NCT03337984)
- Where
- 9 sites in Italy
- Volunteers
- 121 people
- Sponsor
- University of Roma La Sapienza
Cerebral Palsy
Outcomes of Orthopaedic Surgery Using Gait Laboratory Versus Observational Gait Analysis in Children With Cerebral Palsy
The purpose of this pilot trial is to determine whether the addition of gait laboratory analysis for surgical decision making, compared with the use of observational analysis alone, results in improved functional outcomes in…
- Trial name
- NCT00419432
- Testing
- Routine Observational Analysis (prior to procedure), Routine Observational analysis supplemented with Gait Lab Information (prior to procedure)
- Where
- 6 sites in Canada
- Volunteers
- 60 people
- Sponsor
- The Hospital for Sick Children
Liver Damage, Surgery
Effectiveness of the Use of the New Hemostatic Patch Hemopatch ® in Patients Undergoing Surgical Liver Resection
This prospective randomized study aims to determine the influence of the use of local hemostatic on the incidence of local complications derived from the edge of transection: biliary fistula or bleeding, after scheduled hepatic…
- Trial name
- HEMOPATCH (NCT02769754)
- Testing
- Hemopatch, Control
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Diverticular Perforation, Open Abdomen
Damage Control Surgery Over the World in Acute Diverticulitis (DACOSAD)
To analyze the possible benefit of damage control surgery by performing bowel resection, open abdomen, and delayed anastomosis in the treatment of Hinchey III or IV diverticulitis.
- Trial name
- DACOSAD (NCT06428370)
- Testing
- Damage Control Surgery
- Where
- 9 sites in Chile, Italy
- Volunteers
- 300 people
- Sponsor
- Link Campus University
Corneal Endothelial Cell Loss, Corneal Endothelial Damage Following the Hard Nuclear Cataract Surgery
A Study of CA201A Eye Drops to Prevent Corneal Endothelial Cell Loss in Patients Undergoing Cataract Surgery
This study is designed to assess whether an investigational eye drop called CA201A can help protect the cornea (the outer covering of the eye) and reduce damage to corneal endothelial cells following cataract surgery, without…
- Trial name
- NCT07694375
- Testing
- Ophthalmic solution (matching formulation without ascorbic acid), Ascorbic acid ophthalmic solution 5%
- Where
- 8 sites in Australia
- Volunteers
- 200 people
- Sponsor
- Caravel Oculus Pty Ltd
Cerebral Palsy
Knotless Versus Conventional Sutures for Wound Closure in Cerebral Palsy Multilevel Surgery
This study compares two standard ways of closing surgical incisions in children and adults with cerebral palsy who are having multilevel surgery on both legs (single-event multilevel surgery, or SEMLS).
- Trial name
- NCT07880197
- Testing
- Knotless barbed suture, Conventional suture
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, Los Angeles
Coronary Artery Bypass Surgery
Reduction of Ischemia-Reperfusion Mediated Cardiac Injury in Subjects Undergoing Coronary Artery Bypass Graft Surgery
This clinical trial will investigate the safety and effectiveness of IK-1001 (the liquid form of sodium sulfide) when used in Coronary Artery Bypass Graft (CABG) patients to potentially reduce the damage done to the heart during…
- Trial name
- NCT00858936
- Testing
- IK-1001, Normal Saline
- Where
- 8 sites in Australia, Canada
- Volunteers
- 6 people
- Sponsor
- Mallinckrodt
Peritoneal Dessication Damage and Inflammation, Peri-operative Hypothermia
Warm Humid Gas Insufflation for Appendix Removal by Minimally Invasive Surgery Warm Humid Insufflation for Appendix Removal by Minimally Invasive Surgery Trial (WARMIST)
In laparoscopic (key-hole) surgery, the use of cold dry carbon dioxide gas to inflate the abdominal cavity for the creation a clear operating field, results in damage to the cavity lining, known as the peritoneum.
- Trial name
- WARMIST (NCT01027455)
- Testing
- Fisher and Paykel Insuflow (MR 860) Surgical Humidification Device, Laparoscopic Appendicectomy
- Where
- New Zealand
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Cerebral Palsy, Gait Disorders, Neurologic
Serious Game-based Intervention in Gait Rehabilitation for Children With Cerebral Palsy
Cerebral palsy (CP) is defined as a group of movement and posture disorders that cause activity limitation due to brain damage during fetal development or in the first year of life.
- Trial name
- NCT04837105
- Testing
- Serious game ARROW CP, Treadmill
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Fondation Ellen Poidatz
Damage Control
Damage Control Surgery in Acute Mesenteric Ischemia
Acute mesenteric ischemia (AMI) is a rare but catastrophic abdominal vascular emergency associated with daunting mortality comparable to myocardial infarction or cerebral stroke.
- Trial name
- NCT03966430
- Testing
- damage control surgery, non-damage control surgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Gao Tao
Abdominal Injuries, Wounds and Injuries
Predictors of In-Hospital Mortality in Severe Abdominal Trauma
Severe abdominal trauma is a leading cause of early death from bleeding and of later death from sepsis and organ failure. Clinicians use scoring systems to estimate the risk of dying, but most of these scores were developed and…
- Conditions
- Abdominal Injuries, Wounds and Injuries, Wounds, Nonpenetrating, Wounds, Penetrating
- Trial name
- NCT07843628
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Cerebral Palsy, Post-operative Pain
The Post-Operative Pain in Cerebral Palsy (POPPIES) Trial
Cerebral palsy is common. It affects approximately 3 per 1000 children. Hip displacement due to muscle tightness (spasticity) occurs in up to half of the more severely affected children, and many of these children require major…
- Trial name
- POPPIES (NCT01437644)
- Testing
- botulinum toxin intramuscular injection
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Open Heart Surgery
Ilofotase Alfa for Prevention of Renal Damage After Cardiac Surgery
The aim of this clinical trial is to evaluate the efficacy and safety of two intravenous administrations of ilofotase alfa in patients at risk for renal damage following open heart surgery.
- Trial name
- NCT06168799
- Testing
- Ilofotase alfa
- Where
- 13 sites in Belgium, Germany and 3 more
- Volunteers
- 271 people
- Sponsor
- AM-Pharma
Articular Cartilage Disorder of Knee, Cartilage Damage
Human ECM Implanted Within Microfracture Interstices & the Cartilage Defect in the Knee to Regenerate Hyaline Cartilage
HST003 is a human extracellular matrix designed for injection into the subchondral bone following microfracture surgery by an injection into the interstices created by the surgical awl and filling the full defect to help…
- Conditions
- Articular Cartilage Disorder of Knee, Cartilage Damage, Microfractures
- Trial name
- hECM;HST003 (NCT05082831)
- Testing
- microfracture surgery + HST003
- Where
- 5 sites in United States
- Volunteers
- 1 people
- Sponsor
- Histogen
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Neocartilage Implant to Treat Cartilage Lesions of the Knee
ISTO Technologies, Inc. is proposing a clinical study with 225 subjects, to establish the safety and efficacy of the Neocartilage Implant for the treatment of ICRS Grade 3 and 4 articular cartilage lesions of the knee compared to…
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01400607
- Testing
- Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft), Microfracture
- Where
- 9 sites in United States
- Volunteers
- 14 people
- Sponsor
- ISTO Technologies, Inc.
Hepatocellular Injury, Blood Loss
Effect of Intermittent Pedicle Clamping on Hepatocellular Injury During Liver Surgery
In order to prevent excessive blood loss during liver surgery, an intermittent Pringle manoeuvre (IPM) can be applied. This implies a temporary clamping of the portal vein and hepatic artery in the hepatoduodenal ligament in…
- Trial name
- NCT01099475
- Testing
- Pringle manoeuvre 15 minutes, Pringle manoeuvre 30 minutes
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Maastricht University Medical Center
Ischemia Reperfusion Injury
Sevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery.
Endothelial damage has been reported after ischemia-reperfusion events. This can be characterized by measurements of glycocalyx and endothelial components that are released to blood after the insult.
- Trial name
- NCT03772054
- Testing
- Sevoflurane, Propofol
- Where
- Chile
- Volunteers
- 16 people
- Sponsor
- University of Chile