Clinical trials: Death, Cardiac
Heart Failure With Reduced Ejection Fraction
This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure
The study will evaluate the efficacy and safety of LCZ696 compared to enalapril on morbidity and mortality in patients with chronic heart failure (NYHA Class II - IV and EF =< 35%).
- Trial name
- PARADIGM-HF (NCT01035255)
- Testing
- LCZ696 200 mg BID, Enalapril 10 mg BID
- Where
- 1,031 sites in United States, Argentina and 45 more
- Volunteers
- 8,442 people
- Sponsor
- Novartis Pharmaceuticals
Neoplasms, Pulmonary Disease, Chronic Obstructive
Outlook: An Intervention to Improve Quality of Life in Serious Illness
This study will demonstrate whether an end-of-life preparation and completion intervention reduces anxiety, depression, pain and other symptoms and improves functional status, spiritual well-being, and quality of life.
- Conditions
- Neoplasms, Pulmonary Disease, Chronic Obstructive, Heart Failure, Renal Disease
- Trial name
- NCT00939146
- Testing
- Outlook Attention Control, Outlook Intervention
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Duke University
Inflammation, Death, Sudden, Cardiac
The Effects of Enzymes and Flavonoids on Inflammation and Coagulation After Marathon
The aim of the present study is to investigate changes in inflammatory status and incidence of infection after extreme aerobic physical stress (participation in a marathon).
- Conditions
- Inflammation, Death, Sudden, Cardiac, Death, Heart Diseases
- Trial name
- Enzy-MagIC (NCT01916408)
- Testing
- Wobenzym plus, PL 1
- Where
- Germany
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Chronic Heart Failure
Primary Prevention of Sudden Cardiac Death (PREV-DEATH)
The efficacy of implantable cardioverter-defibrillators (ICD) in primary prevention of sudden cardiac death (SCD) is well demonstrated but pivotal studies have been published more than 10 years ago and implantation's conditions…
- Trial name
- PREV-DEATH (NCT02894580)
- Where
- France
- Volunteers
- 336 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Stillbirth, Neonatal Respiratory Depression
Newborn Heart Rate as a Catalyst for Improved Survival
Heart rate (HR) is not routinely assessed during newborn resuscitations in low- and lower-middle income countries (LMICs). Many non-breathing newborns classified as fresh stillbirths have a heartbeat and are live born.
- Conditions
- Stillbirth, Neonatal Respiratory Depression, Neonatal Bradycardia, Neonatal Resuscitation
- Trial name
- NCT03799861
- Testing
- Epoch 2: HBB with NeoBeat, Epoch 3: HR-guided HBB
- Where
- 3 sites in Democratic Republic of the Congo
- Volunteers
- 24,034 people, healthy volunteers welcome
- Sponsor
- American Academy of Pediatrics
Ventricular Tachycardia, Ventricular Arrythmia
Preventive VT Substrate Ablation in Ischemic Heart Disease
The investigators hypothesize that preventive VT substrate ablation in patients with chronic ICM, previously selected based on imaging criteria (BZC mass) for their likely high arrhythmic risk, is safe and effective in preventing…
- Conditions
- Ventricular Tachycardia, Ventricular Arrythmia, Sudden Cardiac Death, Sudden Cardiac Death Due to Cardiac Arrhythmia
- Trial name
- PREVENT-VT (NCT04675073)
- Testing
- Ventricular tachycardia substrate-based radiofrequency ablation
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Centro Medico Teknon
Atrial Fibrillation, Supraventricular Arrhythmia
Implanted Loop Recorders for Detection and Management of Arrhythmia With Bruton Tyrosine Kinase Inhibitors
This study will enroll patients initiating Bruton Tyrosine Kinase (BTK) inhibitors without history of documented arrhythmia while on therapy using the Medtronic LINQ-2 insertable cardiac monitor (ILR).
- Conditions
- Atrial Fibrillation, Supraventricular Arrhythmia, Ventricular Arrhythmias and Cardiac Arrest, Chronic Lymphocytic Leukemia
- Trial name
- NCT05643235
- Testing
- Medtronic LINQ-2 Insertable Cardiac Monitor (ILR)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Sudden Cardiac Arrest
Educational Videos to Improve Patient Decision Making and Race Disparities in Implantable Cardioverter Defibrillator Use
The investigators will examine whether an educational video increases patient knowledge about heart failure and the risk of sudden cardiac arrest and leads to greater satisfaction with information provided as compared to usual…
- Trial name
- VIVID-01 (NCT00918125)
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Duke University
Postpartum Depression (PPD), Cardiac Event
Living Healthy for Moms RCT
LHMoms is a novel integrated care intervention that focuses intensively on care continuity and community-to-healthcare linkages for postpartum birthing individuals.
- Trial name
- LHMoms (NCT06666400)
- Testing
- LHMoms Intervention, No intervention
- Where
- 4 sites in United States
- Volunteers
- 21 people
- Sponsor
- Columbia University
Ventricular Tachycardia, Sudden Cardiac Death
Intravenous n-3 Fatty Acids and Ventricular Tachycardia in Patients With Implantable Cardioverter Defibrillator (ICD)-Pacemaker
The long-chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), appear to offer protection against sudden cardiac death and ventricular arrhythmias.
- Trial name
- NCT00534300
- Testing
- Omegaven, Isotonic saline
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Aalborg University Hospital
Cardiovascular Diseases, Coronary Disease
Anxiety and Vagal Control of the Heart in Coronary Disease
To examine the role of reduced vagal control of heart rate in the increased risk of cardiac mortality associated with anxiety in a population with established coronary artery disease (CAD).
- Conditions
- Cardiovascular Diseases, Coronary Disease, Depression, Heart Diseases
- Trial name
- NCT00006311
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Epilepsy, Seizures
Genetic Markers of Cardiovascular Disease in Epilepsy
Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age.
- Conditions
- Epilepsy, Seizures, Syncope, Channelopathy
- Trial name
- NCT02824822
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Mayo Clinic
Sudden Cardiac Arrest
HeartStart FRx Defibrillator Event Registry
This post market clinical follow-up study is a multi-center, non-randomized, unblinded, observational registry of the performance of the FRx Automated external defibrillator (AED) used in conjunction with electrodes with or…
- Trial name
- NCT04250857
- Testing
- HeartStart FRX
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- Heartstream US LLC
Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)
The STEPCARE-MAKE study is a predefined sub-study of the large Sedation, TEmperature and Pressure after Cardiac Arrest and REsuscitation (STEPCARE) trial, which evaluates the effects of three interventions in comatose adult…
- Conditions
- Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU, Sedation in Intensive Care Unit Patients, Sedation in the ICU
- Trial name
- STEPCARE-MAKE (NCT07579390)
- Testing
- Feedback-controlled temperature device, High MAP, Deep sedation
- Where
- 52 sites in Australia, Belgium and 12 more
- Volunteers
- 3,500 people
- Sponsor
- Helsinki University Central Hospital
Ventricular Tachycardia, Cardiovascular Diseases
Genetic Substudy of the Alternans Before Cardioverter Defibrillator (ABCD) Trial
The ABCD clinical study (ClinicalTrials.gov Identifier NCT00187291) was designed to determine if a T-Wave Alternans (TWA) test is equivalent to an Electrophysiology Study (EPS) in predicting life-threatening heart rhythms in…
- Conditions
- Ventricular Tachycardia, Cardiovascular Diseases, Arrythmia, CVD
- Trial name
- ABCD (NCT00583297)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- CardioDx
Cardiac Arrest, Sudden
Impact of the Organization of the First Responders in the Remote Areas on Cardiac Arrest Victim Survival
Emergency medical services (EMS) provide emergency care not only in the urban but also in the remote areas which could be up to 40 minutes from the EMS station.
- Trial name
- NCT04485390
- Testing
- Basic life support witn use of an AED before EMS
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Maribor
Infective Endocarditis (IE), Heart Valve Disease
The Study Tests if Preoperative Dental Screening is Superior to no Preoperative Dental Screening in Improving the Outcome of Patients Undergoing Surgical Cardiac Valve Replacement or Transcatheter Cardiac Valve Implantation.
This randomized, multicenter, open-label trial evaluates whether preoperative dental screening improves outcomes in patients undergoing surgical or transcatheter cardiac valve intervention.
- Trial name
- SMILE (NCT07511673)
- Testing
- Preoperative dental screening, No preoperative dental screening
- Where
- 5 sites in Sweden
- Volunteers
- 1,300 people
- Sponsor
- Region Skane
Cardiomyopathies, Primary, Arrhythmia
An Arrhythmia Risk Stratification and Genetic Trial
The prospective EUTrigTreat multi-center study is an observational, advanced diagnostics and genetic risk stratification trial in patients with standard indications for ICD treatment, with and without myocardial infarction in…
- Conditions
- Cardiomyopathies, Primary, Arrhythmia, Sudden Cardiac Death, Calcium Metabolism Disorders
- Trial name
- EUTrigTreat (NCT01209494)
- Where
- 4 sites in Belgium, Germany and 2 more
- Volunteers
- 672 people
- Sponsor
- University Medical Center Goettingen
Congenital Heart Surgery, Congenital Heart Defects
Death Following Congenital Heart Surgery
The purpose of this study is to elucidate the patterns of death following congenital heart surgery.
- Trial name
- NCT00215072
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Healthcare of Atlanta
Long QT Syndrome, ADHD
Drug-induced Repolarization ECG Changes
Studies have shown that the risk of developing heart arrhythmias, is increased in patients receiving medication for Attention-deficit hyperactivity disorder (ADHD) and depression.
- Conditions
- Long QT Syndrome, ADHD, Depression, Death
- Trial name
- NCT03642405
- Testing
- Electrocardiogram examination, Echocardiography, Blood Samples
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital at Herlev